ASSESSMENT OF THE REGION'S INVESTMENT ENVIRONMENT AND POLICY INSTRUMENTS FOR THE IMPLEMENTATION OF ITS INVESTMENT POTENTIAL IN WARTIME by Ruslan Boiko, Roman Martsenyuk, Arsen Protsykevych

“…The following methods of economic analysis were used in the study: analysis and synthesis (to ensure a systematic approach when characterising the investment environment of the region), statistical analysis and calculation (when analysing the volume, dynamics and structure, factors and functional features of the formation of the investment environment of the regional economy), strategic management (to determine the strategic goal, objectives, mechanisms, instruments and expected results of the regional investment policy in wartime). …”
Get full text

Construction of a Novel Necroptosis-Related Signature in Rat DRG for Neuropathic Pain by Liu Y, Hao S, Hao H, Zheng G, Bing J, Kang L, Li J, Zhao H, Hao H

“…Significantly enriched KEGG and GO pathways, drug target prediction and non-coding RNAs related to the signature holded promise for advancing our understanding of potential avenues for treatment and the mechanisms underlying neuropathic pain. Immune infiltration analysis revealed which types of immune cells related to the NRDEGs signature played an important role in the occurrence and development of neuropathic pain. …”
Get full text

Could Infectious Agents Play a Role in the Onset of Age-related Macular Degeneration? A Scoping Review by Petra P. Larsen, MD, PhD, Virginie Dinet, PhD, Cécile Delcourt, PhD, Catherine Helmer, MD, PhD, Morgane Linard, MD, PhD

“…Numerous potential pathophysiological mechanisms have been discussed, including (1) an indirect role of infectious agents (i.e. a role of infections located distant from the eye, mainly through their interactions with the immune system) and (2) a direct role of some infectious agents implying potential infection of various cells types within AMD-related tissues. …”
Get full text

Inflammatory Monocyte Subsets Correlation with Iron Levels in Low Vitamin D Pediatric Transfusion-Dependent Thalassemia by Ghozali M, Matahari M, Cahyadi AI, Agustini SD, Ghrahani R, Reniarti L, Setiabudiawan B, Panigoro R

“…Blood monocytes, identified by their CD14 and CD16 expression, show functional diversity during injury or inflammation. Considering the mechanisms of vitamin D activation and its potential interaction with monocytes, further investigation of its immunomodulatory role in transfusion-dependent thalassemia is essential.Purpose: This study evaluated monocyte subsets, population, and surface receptor expression (CD14, CD16, and HLA-DR), and their association with iron status and vitamin D levels in patients with transfusion-dependent thalassemia.Patients and Methods: Fifty lysed erythrocyte-heparinized whole blood samples from transfusion-dependent thalassemia patients were analyzed by flow cytometry and classified into three monocyte subsets: CD14++CD16- (classical), CD14++CD16+ (intermediate), and CD14+CD16++ (non-classical). …”
Get full text

Blockchain Technology Applications in Healthcare Supply Chains—A Review by Sarthak Dhingra, Rakesh Raut, Koteswararao Naik, Kamalakanta Muduli

Get full text

Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats by Xianbin Wang, Yingxue Fu, Xianglian Yang, Yan Chen, Ni Zeng, Shouxing Hu, Shuai Ouyang, Xiao Pan, Shuang Wu

“…In order to elucidate the specific mechanism, the impact of miR145-5p on the MAPK/Erk pathway and its role in apoptosis in lung cells were confirmed through miR145-5p overexpression and knockdown experiments. …”
Get full text

LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy by Yan Y, Duan T, Xue X, Yang X, Liu M, Ma B, Duan X, Su C

“…In addition, further confirmed the mechanisms by how TLR4 and MGL synergistic pathway endow the nanovaccines towards dendritic cells (DCs). …”
Get full text

A meta-analysis of MHC diversity in Pan troglodytes verus by Christelle Vangenot, Alicia Sanchez‑Mazas

“…This gives us an original focus on MHC evolution and its mechanisms and helps us to understand the specificities of the human and chimpanzee lineages, respectively.…”
Get full text

Cultivating Limnospira fusiformis from Lake Solenoye, Omsk by 10.21603/2074-9414-2023-4-2469, Olga P. Bazhenova

“…Europolitext KV-06 or mechanical mixing could prevent sedimentation of phosphates after 20 days of cultivation. …”
Get full text

Poor Glycemic Control in Carbapenem-Resistant Klebsiella pneumoniae Infections: Impact on Epidemiological Features, Mortality Risks, and Polymyxin Resistance by Wang Q, Yan T, Ma C, Teng X, Shen C, Wang N, Yu K, Chu W, Zhou Q, Liu Z

“…Logistic regression analysis identified age, glycosylated hemoglobin (HbA1c) ≥ 7%, CKD, tumor, mechanical ventilation, and sepsis as independent risk factors for death associated with CRKP infection. …”
Get full text

Pore Structure and Its Fractal Dimension: A Case Study of the Marine Shales of the Niutitang Formation in Northwest Hunan, South China by Wei Jiang, Yang Zhang, Tianran Ma, Song Chen, Yang Hu, Qiang Wei, Dingxiang Zhuang

Get full text

Analysis of the Influence of Upper Protective Layer Mining on the Effect of Pressure Relief and Protection of Coal and Rock Masses between the Lower Overburden Layers by Jiaxin Dang, Min Tu, Xiangyang Zhang, Qingwei Bu

“…On the basis of an analysis of concrete engineering projects, a mechanical model was constructed for the pressure relief protection effect of upper protective seam mining on the coal and rock mass between underlying beds. …”
Get full text

Elucidating the Role of HIF-1α/YAP Signaling Pathway in Regulating Inflammation in Human Periodontal Stem Cells: An in vitro Study by Zhao HW, Liu ST, Wang XJ, Zhang XM, Ma X

“…Hui-Wei Zhao,1 Shu-Tai Liu,2 Xiang-Jin Wang,1 Xue-Mei Zhang,1 Xiang Ma1 1Department of Periodontology, The Affiliated Yantai Stomatological Hospital, Binzhou Medical University, Yantai, 264000, People’s Republic of China; 2Department of Periodontology, Shenzhen Stomatology Hospital, Shenzhen, 518000, People’s Republic of ChinaCorrespondence: Xiang Ma, Department of Periodontology, The Affiliated Yantai Stomatological Hospital, Binzhou Medical University, 148 North Road, YanTai, People’s Republic of China, Email MaXiang900218@163.comBackground and Objective: Periodontitis is a chronic inflammatory disease caused by dental plaque accumulation, leading to damage of periodontal tissues and potential tooth loss. Understanding the mechanisms of periodontitis, particularly the role of hypoxia in inflammation, is critical for identifying novel therapeutic strategies. …”
Get full text

Enhancing food security while reducing environmental impacts: Life cycle assessment of cultivation-irrigation systems and yield gap closure in paddy fields by Abdullah Darzi-Naftchali, Markus Berger, Fereshteh Batoukhteh, Ali Motevali

Get full text

Associations between lipid-lowering drugs and urate and gout outcomes: a Mendelian randomization study by Min Liu, Na Yin, Yuhang Zhu, Aili Du, Chunyuan Cai, Pengyuan Leng

“…The study’s exposures encompassed genetic variants within drug target genes (HMGCR, PCSK9, NPC1L1), each representing distinct lipid-lowering mechanisms. Causal effects were estimated using the inverse variance weighting (IVW) method, while the Summary Data-based Mendelian Randomization (SMR) method, leveraging pooled data, was applied to compute effect estimates. …”
Get full text

Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study by Hongwei Wang, Fangying Tian, Caizheng Yang, Xinyu Cui, Yongxia Ding, Ming Zhao, Xueyu Wang, Shanshan Ge

“…Conclusions Our study suggests that there is a causal effect between Hp infection and Mets diagnosis and its composition, and further studies are needed to understand the mechanism of its influence.…”
Get full text

Different expression of circulating microRNA profile in tibetan OSAHS with metabolic syndrome patients by Xue-feng Shi, Xiang He, Ze-rui Sun, Jie Duo, Hao Yang

“…This study identifies distinctive miRNA signatures in OSAHS with Metabolic Syndrome (Mets) patients from healthy subjects, that could serve as diagnostic biomarkers or describe differential molecular mechanisms with potential therapeutic implications. …”
Get full text

Blood Lead Levels among Blood Donors and High-Risk Occupational Groups in a Mining Area in Ghana: Implications for Blood Transfusion among Vulnerable Populations by Veronica Agyemang, Joseph K. Acquaye, Samuel B. E. Harrison, Felix B. Oppong, Stephany Gyaase, Kwaku P. Asante, Edeghonghon Olayemi

“…We enrolled 40 participants each from the following high-risk occupational groups: small scale miners, painters/sprayers, drivers/fuel station attendants, and auto-mechanics as well as 40 healthy blood donors (made up of teachers, traders, and office workers). …”
Get full text

Seven Immune-Related Genes’ Prognostic Value and Correlation with Treatment Outcome in Head and Neck Squamous Cell Carcinoma by Rui Mu, Yuehong Shen, Chuanbin Guo, Xinyun Zhang, Hongyu Yang, Huijun Yang

“…The protein-protein interaction (PPI) network and functional enrichment pathway investigations were utilized to explore possible potential molecular mechanisms. Finally, the hub gene’s differential mRNA expression levels were evaluated by means of the Gene Expression Profiling Interactive Analysis (GEPIA), and the Human Protein Atlas (HPA) was utilized for the validation of their translational levels. …”
Get full text

STABILITY ANALYSIS OF A SHIPBORNE LARGE APERTURE TELESCOPE TRACKING FRAME by LI YingJie, YANG LiBao, CHEN Tao, LI HongWen

Get full text