Identifying a Serum Exosomal-Associated lncRNA/circRNA-miRNA-mRNA Network in Coronary Heart Disease by Jia Mao, Yufei Zhou, Licheng Lu, Ping Zhang, Runhua Ren, Yaqiong Wang, Jing Wang

“…However, exosomal-associated competing endogenous RNA- (ceRNA-) mediated regulatory mechanisms in CHD are largely unexplored. The present study aimed to explore exosomal-associated ceRNA networks in CHD. …”
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Acute Concurrent Exercise Improves Inhibitory Control Without Mediating the Role of Lactate: An Event-Related Potential Study by Ruei-Hong Li, Tai-Rui Chen, Nicholas D. Gilson, Marius Brazaitis, Yi-Ting Cheng, Hui-Fang Wu, Ji-Hang Lee, Yu-Kai Chang

“…Moreover, exploring the mechanisms underlying the effects of acute exercise on EFs contributes to scientific comprehension, with lactate recognized as a crucial candidate positively correlated with EFs. …”
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Healthcare resource utilisation and costs of hospitalisation and primary care among adults with COVID-19 in England: a population-based cohort study by Carmen Tsang, Robert Wood, Tendai Mugwagwa, Kiran K Rai, Jingyan Yang, Theo Tritton, Jennifer L Nguyen, Kathleen Michelle Andersen, Maya Reimbaeva, Leah J McGrath, Poppy Payne, Bethany Emma Backhouse, Diana Mendes, Rebecca Butfield, Kevin Naicker, Mary Araghi

“…While few (6.0%) patients in critical care required mechanical ventilation, its use was higher in older adults (50–74 years: 8.3%; <50 years: 4.3%). …”
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Restraint stress effects on glutamate signaling protein levels in the rats’ frontal cortex: Does β1 adrenoceptor activity matter? by Agnieszka Zelek-Molik, Anna Gądek-Michalska, Michał Wilczkowski, Adam Bielawski, Katarzyna Maziarz, Grzegorz Kreiner, Irena Nalepa

“…In the first part, rats were exposed to RS for 3, 7, or 14 days, and the expression of glutamate signaling proteins (p(S845)/t GluA1, p(Y1472)/t GluN2B, VGLUT1, and VGLUT2) in the FC was analyzed to determine the optimal RS duration for studying the mechanisms of hypofrontality. In the second part, rats were exposed to RS for 14 days, and BET (5 mg/kg, p. o.) was administered during the last 8 days immediately after RS. …”
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Glucagon, rather than Glucagon-Like Peptide 1, Mediates Higher Post-Lunch Glucose Excursions during Breakfast Skipping in Asian Indian Patients with Uncontrolled Type 2 Diabetes Me... by Yash V. Chauhan, Mahesh D. Hakke, Prudwiraj Sanamandra, Jugal V. Gada, Sukirti Misra, Sachin S. Rahate, Namrata Varekar, Anagha V. Palekar, Premlata K. Varthakavi, Nikhil M. Bhagwat

“…Introduction: The effect and mechanism of skipping breakfast on glycemic control in type 2 diabetes mellitus (T2DM) in Asian-Indians is unknown. …”
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Association of Combined Low Physical Activity and Low Dietary Diversity with Mild Cognitive Impairment among Community-Dwelling Japanese Older Adults by Yuto Kiuchi, Hyuma Makizako, Mika Kimura, Yuki Nakai, Yoshiaki Taniguchi, Shoma Akaida, Mana Tateishi, Takuro Kubozono, Toshihiro Takenaka, Hiroyuki Shimada, Mitsuru Ohishi

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Role of plasminogen/plasmin system components and matrix metalloproteases in retinal artery occlusion following cardiac surgery by L.V. Natrus, N.Ia. Kovalchuk, I.S. Tanasiichuk, Iu.O. Panchenko

“…Of these, 23 patients older than 60 years who had conventional-access mechanical prosthetic valve replacement with cardiopulmonary bypass were stratified into the group of high risk (HR) for RAO. …”
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Acute administration of NLX-101, a Serotonin 1A receptor agonist, improves auditory temporal processing during development in a mouse model of Fragile X Syndrome by Xin Tao, Katilynne Croom, Adrian Newman-Tancredi, Mark Varney, Khaleel A. Razak

“…The differential effects of serotonin modulation on ERP, background power and temporal processing suggest different developmental mechanisms leading to these phenotypes. Conclusions These results suggest that NLX-101 could constitute a promising treatment option for targeting post-synaptic 5-HT1A receptors to improve auditory temporal processing, which in turn may improve speech and language function in FXS.…”
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Automatic cervical lymph nodes detection and segmentation in heterogeneous computed tomography images using deep transfer learning by Wenjun Liao, Xiangde Luo, Lu Li, Jinfeng Xu, Yuan He, Hui Huang, Shichuan Zhang

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GATA1-mediated macrophage polarization via TrkB/cGMP–PKG signaling pathway to promote the development of preeclampsia by Wushan Li, Fei Hou, Di Cheng, Fengchun Gao, Jin Wang, Baoxia Cui

“…Recent studies have indicated that the transcription factor GATA1 may be implicated in the pathological processes of PE, but the underlying mechanism remains elusive. NTRK2/cGMP–PKG signaling pathway plays a crucial role in regulating the function and polarization of macrophages, which are key immune cells at the maternal–fetal interface. …”
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UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer by Yunjie Tian, Ruoyu Dong, Yingxia Guan, Ying Wang, Wei Zhao, Jun Zhang, Shan Kang

“…Conclusions Overall, this study elucidated the role of plasma cells and revealed UBE2J1 as a novel oncogene in HGSOC, uncovering new mechanisms related to HGSOC tumorigenesis and promising therapeutic targets for HGSOC patients.…”
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Identification and verification of autophagy-related gene signatures and their association with immune infiltration and drug responsiveness in epilepsy by Han-han He, Xiao-ge Zhang, Fen-fang Chen

“…However, the precise mechanisms by which autophagy deficiencies involved in epileptogenesis are still not fully understood.MethodsTwo datasets of epilepsy (GSE143272 and GSE256068) were downloaded from the Gene Expression Omnibus (GEO) database. …”
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Experimental Thermal Assessment of a Trombe Wall Under a Semi-Arid Mediterranean Climate of Mexico by Iván Hernández-Pérez, Álan Rodriguez-Ake, Daniel Sauceda-Carvajal, Irving Hernández-López, Balaji Kumar, Ivett Zavala-Guillén

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Development and validation of a prognostic model for critically ill type 2 diabetes patients in ICU based on composite inflammatory indicators by Lin Liu, Yan-Bo Zhao, Zhuo-Ting Cheng, Ya-Hui Li, Yang Liu

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Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbi... by Wang H, Huang W, Pan X, Tian M, Chen J, Liu X, Li Q, Qi J, Ye Y, Gao L

“…Haiou Wang,1 Wenkang Huang,1 Xiaoya Pan,1 Meizi Tian,1 Jiahui Chen,1 Xiaotong Liu,1 Qin Li,1 Jianhua Qi,2 Yiping Ye,1 Lijuan Gao1 1School of Pharmacy, Hangzhou Medical College, Hangzhou, 310013, People’s Republic of China; 2College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People’s Republic of ChinaCorrespondence: Lijuan Gao; Yiping Ye, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou, Zhejiang, 310013, People’s Republic of China, Email gaolijuan04141002@126.com; yeyiping2005@163.comPurpose: To explore the protective effect and underlying mechanism of Quzhou Aurantii Fructus flavonoids (QAFF) on Ulcerative colitis (UC).Methods: The constituents of QAFF were accurately determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). …”
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Characterization and utilization of trichoderma sp. for efficient management of oil palm empty fruit bunch waste in plantations by N. Nurmiati, P. Periadnadi, K. Kartiwan, T.W. Edelwis

“…., this study examined the mechanisms associated with efficacy in bioconversion processes and waste remediation.METHODS: A survey method was used to determine sampling locations, and purposive sampling was utilized in the field. …”
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Optimization of fatigue life of the seismic vibrator baseplate considering the coupling effect of welding residual stress by Zhen Chen, Qiaomu Wang, Shulong Nie, Shuang Jing, Bo Kong, Nan Luan

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Design and Analysis of Floater Structures using Composite Material in 19 Seaters Aircraft by Andi Muhdiar Kadir, Arief Setyawan, Fithri Nur Purnamasari, Nurhadi Pramana, Muhammad, Ilham Akbar Adi Satriya, Riza Wirawan, Budi Sampurno

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Integration of histone modification-based risk signature with drug sensitivity analysis reveals novel therapeutic strategies for lower-grade glioma by Jingyuan Wang, Shuai Yan

“…We further conducted comprehensive analyses of molecular mechanisms, immune microenvironment, and drug sensitivity associated with the risk stratification.ResultsWe identified distinct histone modification patterns across five major cell populations in LGG and developed a robust 20-gene HMRS from 129 candidate genes that effectively stratified patients into high- and low-risk groups with significantly different survival outcomes (training set: AUC = 0.77, 0.73, and 0.71 for 1-, 3-, and 5-year survival; P < 0.001). …”
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Midgut immune profiling and functional characterization of Aedes aegypti ABC transporter gene(s) using systemic and local bacterial challenges by Vikas Kumar, Shilpi Garg, Diksha Sisodia, Lalita Gupta, Sanjeev Kumar, Vishal Saxena

“…Interestingly, Toll and IMD immune pathways actively participated in the late hours of local bacterial challenges, suggesting that the route of infection influences these immune responses; however, the molecular mechanism behind these phenomena still needs to be explored. …”
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