Functional characterization of endocytic signals in the SynDIG/PRRT family members SynDIG1 and SynDIG4 in heterologous cells and neurons by David J. Speca, Chun-Wei He, Christina M. Meyer, Erin C. Scott, Erin C. Scott, Elva Díaz

“…These results provide important insight into the mechanisms by which SynDIG proteins are targeted to endosomal compartments as a step in understanding SynDIG-mediated regulation of AMPAR trafficking.…”
Get full text

Trade-Off Between Enzymatic Antioxidant Defense and Accumulation of Organic Metabolite Affects Salt Tolerance of White Clover Associated with Redox, Water, and Metabolic Homeostase... by Min Zhou, Yuting Wu, Yuchen Yang, Yan Yuan, Junnan Lin, Long Lin, Zhou Li

“…This study aims to investigate the difference in the mechanism of salt tolerance in relation to osmotic adjustment, enzymatic and nonenzymatic antioxidant defenses, and organic metabolites remodeling between salt-tolerant PI237292 (Trp004) and salt-sensitive Korla (KL). …”
Get full text

Designing a human resource scorecard: An empirical stakeholder-based study with a company culture perspective by Hasan Boudlaie, Hannan Amoozad Mahdiraji, Sabihe Shamsi, Vahid Jafari-Sadeghi, Alexeis Garcia-Pereze

“…To identify strategic goals and a human resource strategy map, 187 main topics, 39 organizational topics, and 12 global themes were identified after transcription of the interviews, including (1) the development of family policies (2) promoting the well-being, health, and well-being of employees (3) improving productivity HR department (4) promoting the human dignity of the staff (5) developing an organizational culture based on customer orientation and innovation (6) empowering employees (7) development HR information system (8) strategic recruitment and retention of employees (9) performance management and development employees (10) strategic transformation of HRM based on research and process reform (11) adjusting the allocation and use of the HR budget to the organization's strategy and (12) improving the accounting mechanism for the personnel budget. This study is innovative due to the proposed approach to redesign the strategy map and the balanced scorecard from a human resource management perspective, methodically, due to adopting a combined thematic analysis process and constructing related narratives and stakeholder approaches from a corporate culture perspective.…”
Get full text

Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer by Xiang Pan, Kailai Chen, Wei Gao, Meiqi Xu, Fanlong Meng, Mengyuan Wu, Zi Qi Wang, Yun Qi Li, Wanhai Xu, Manjie Zhang, Yakun Luo

“…However, the functional effects and regulatory mechanisms of circRNAs in metastatic CRPC (mCRPC) remain largely unknown. …”
Get full text

Role of the professional critical care team in improving the quality of critical care in the hospital (危重症专业小组在提升医院危重症护理水平中的作用探讨) by PENG Jine (彭金娥), WANG Siyi (王思懿), WU Xuehua (吴雪花)

“…Results After the training, the quality assessment of critical care, nursing satisfaction with the professional critical care team and the qualified rate of oral care of the patients with mechanical ventilation were significantly higher than those before the training (P＜0. 05). …”
Get full text

The prevalence of hand pathology in regional orthopaedic hospitals in KwaZulu-Natal: A cross-sectional study by S Thabit, M O'Connor, W Parker, T Mashishi, K Moodley, A Peer, K Matanzima, A J de Villiers, O Adewusi, R Aboobaker, A Rocher

“…For HP patients, additional detail was collected regarding diagnosis, mechanism, admission and management. The prevalence of HP was calculated as a factor of all orthopaedic presentations. …”
Get full text

Phytochemical investigation and assessment of the anti-inflammatory activity of four Heracleum taxa growing in Turkey by Ekin Kurtul, Esra Küpeli Akkol, Büşra Karpuz Ağören, Büşra Yaylacı, Özlem Bahadır Acıkara, Eduardo Sobarzo-Sánchez, Eduardo Sobarzo-Sánchez

“…Further investigations are necessary to identify the active compounds and elucidate the mechanisms of action of these plants, potentially leading to the discovery of novel therapeutic options for the treatment of inflammation.…”
Get full text

Changes in oxygen uptake kinetics after exercise caused by differences in loading pattern and exercise intensity by Yuri Ichikawa, Tomoko Maeda, Tetsuya Takahashi, Kohei Ashikaga, Shiori Tanaka, Yuki Sumi, Haruki Itoh

“…We used these two types of loading patterns to investigate the effects of low‐intensity, medium‐intensity, and high‐intensity exercises on the half time (T1/2) of recovery‐period VO2 and the mechanism. Methods and results Ten healthy men aged 21.2 ± 0.9 years underwent symptom‐limited cardiopulmonary exercise tests with the ramp protocol to determine their anaerobic threshold. …”
Get full text

Anxiety and burnout in infectious disease nurses: the role of perceived stress and resilience by Yalan Huang, Zonghua Wang, Yongguang Li, Zhihan Zhao, Weiyi Wang, Changxia Cai, Xiushuang Wu, Li Liu, Mengting Chen

“…However, prior to this study, no research had delved into the underlying mechanism linking anxiety to burnout symptoms among infectious disease nurses. …”
Get full text

Water woes: the institutional challenges in achieving SDG 6 by Jaivime Evaristo, Yusuf Jameel, Cecilia Tortajada, Raymond Yu Wang, James Horne, Howard Neukrug, Carlos Primo David, Angela Maria Fasnacht, Alan D. Ziegler, Asit Biswas

“…Current models often suffer from fragmented policies, inadequate public-private partnerships, and weak engagement mechanisms. A glaring gap exists between academic advancements in water management and their practical implementation in policymaking. …”
Get full text

Calcium hydroxide nanoparticles induce cell death, genomic instability, oxidative stress and apoptotic gene dysregulation on human HepG2 cells by Hanan R. H. Mohamed, Esraa H. Ibrahim, Shahd E. E. Shaheen, Nesma O. E. Hussein, Ayman Diab, Gehan Safwat

“…However, exposure to the IC50 concentration was non-genotoxic to normal HSF cells while selectively inducing genotoxicity and apoptosis in HepG2 cancer cells through DNA breaks and ROS-mediated mechanisms. Further studies are required to explore the biological and toxicological properties and therapeutic potential of Ca(OH)2NPs in hepatic cancer treatment.…”
Get full text

Predictors of a Good Outcome after Endovascular Stroke Treatment with Stent Retrievers by Ozcan Ozdemir, Semih Giray, Zulfikar Arlier, Demet Funda Baş, Yusuf Inanc, Ertugrul Colak

“…The goal of the study was to identify the predictors of a good outcome after mechanical thrombectomy with stent retrievers. Methods. …”
Get full text

Longitudinal DNA methylation profiles in saliva of offspring from mothers with gestational diabetes: associations with early childhood growth patterns by Teresa M. Linares-Pineda, Alfonso Lendínez-Jurado, Alberto Piserra-López, María Suárez-Arana, María Pozo, María Molina-Vega, María José Picón-César, Sonsoles Morcillo

“…Epigenetic modifications, specifically DNA methylation, have emerged as mechanisms by which early environmental exposures can predispose offspring to metabolic diseases. …”
Get full text

Longitudinal exploration of cancer-related cognitive impairment in patients with newly diagnosed aggressive lymphoma: protocol for a feasibility study by Vincent Dore, Christopher C Rowe, Meinir Krishnasamy, Haryana Dhillon, Adam K Walker, Karla Gough, Priscilla Gates, Carlene Wilson, Eliza Hawkes, Yuliya Perchyonok, Janette L Vardy, Michiel de Ruiter

“…Blood cell-based inflammatory markers and neuroimaging including a positron emission tomography (PET) with 18F-labelled fluoro-2-deoxyglucose (18F-FDG) and CT (18F-FDG-PET/CT) and a MRI will explore potential inflammatory and neuroanatomical or functional mechanisms and biomarkers related to CRCI. The primary intent of analysis will be to assess the feasibility of collecting longitudinal data on cognition using subjective reports and objective tasks from patients during treatment and recovery for lymphoma. …”
Get full text

The palmitoyl-CoA ligase Fum16 is part of a Fusarium verticillioides fumonisin subcluster involved in self-protection by Fabio Gherlone, Katarina Jojić, Ying Huang, Sandra Hoefgen, Vito Valiante, Slavica Janevska

“…These findings enhance our understanding of mycotoxin self-protection mechanisms and could inform strategies for predicting biological activity of unknown secondary metabolites, managing mycotoxin contamination, and developing resistant crop cultivars.…”
Get full text

Modulating the anti-inflammatory and barrier protective effects on intestinal epithelial cells utilizing an aqueous Aspalathus linearis extract in vitro by Shana De Bruyn-Orr, Stefan Abel, Mariam Rado, Mariska Lilly

“…This is attributed to the differences in the polyphenol content of each extract and demonstrating the unique activity mechanisms of different rooibos extracts to reduce onset of early inflammation.…”
Get full text

Proteasome inhibition enhances oncolytic reovirus therapy in multiple myeloma independently of its direct cytotoxic effects by Ada Alice Dona, Theophilus Tandoh, Lokesh Nigam, Mahmoud Singer, Enrico Caserta, Mariam Murtadha, Yinghui Zhu, Milad Moloudizargari, Preeti Sharma, Ottavio Napolitano, Janet Winchester, Arnab Chowdhury, Alex Pozhitkov, James F. Sanchez, Hawa Vahed, Guido Marcucci, Matt Coffey, Gerard Nuovo, Douglas W. Sborov, Flavia Pichiorri, Craig C Hofmeister

“…The combination with proteasome inhibitors (PIs) has shown to enhance RV therapeutic activity, but the mechanisms of action have not been fully elucidated. …”
Get full text

First-principles calculations for the effect of irradiation-induced point defects on the hydrogen dissolution and diffusion in γ-Al2O3 by Xin-Dong Pan, Xiao-Chun Li, Jing Wang, Rongmei Yu, Chunying Pu, Hai-Shan Zhou, Guang-Nan Luo

“…In fusion reactors, high-energy neutrons generate a large number of irradiation-induced defects, significantly affecting the performance of γ-Al2O3. The underlying mechanism is still unclear. This study focuses on the influence of irradiation-induced point defects on the dissolution and diffusion of H in γ-Al2O3 using first-principles theory. …”
Get full text

CT45A1‐mediated MLC2 (MYL9) phosphorylation promotes natural killer cell resistance and outer cell fate in a cell‐in‐cell structure, potentiating the progression of microsatellite... by Hao‐Wei Teng, Hsiang‐Yueh Huang, Chun‐Chi Lin, Yuh‐Ching Twu, Wen‐Hao Yang, Wen‐Chun Lin, Hsin‐Yi Lan, Yen‐Yu Lin, Wei‐Lun Hwang

“…Clinicopathological characterization of formalin‐fixed paraffin‐embedded (FFPE) MSI‐H CRC specimens was performed to explore the underlying mechanisms involved. We showed that cancer/testis antigen family 45 member A1 (CT45A1) expression was upregulated in MSI‐H CRC patients with poor survival outcomes. …”
Get full text

Development and validation of a novel risk-predicted model for early sepsis-associated acute kidney injury in critically ill patients: a retrospective cohort study by Bo Li, Kun Zhang, Cong-Cong Zhao, Zi-Han Nan, Yan-Ling Yin, Li-Xia Liu, Zhen-Jie Hu

“…The external validation cohort was generated from a single-centre ICU database from China.Participants A total of 7179 critically ill patients with sepsis were included in the development cohort and 269 patients with sepsis were included in the external validation cohort.Results A total of 12 risk factors (age, weight, atrial fibrillation, chronic coronary syndrome, central venous pressure, urine output, temperature, lactate, pH, difference in alveolar-arterial oxygen pressure, prothrombin time and mechanical ventilation) were included in the final prediction model. …”
Get full text