Exercise medicine as adjunct therapy during RADIation for CAncer of the prostaTE to improve treatment efficacy – protocol for the ERADICATE study: a phase II randomised controlled... by Oliver Schumacher, Robert U. Newton, Colin Tang, Raphael Chee, Sjoerd B. Vos, Ronny S. Low, David Joseph, Dennis R. Taaffe, Daniel A. Galvão

“…Discussion The ERADICATE study will investigate exercise as a novel therapeutic approach for sensitising prostate cancer to EBRT by targeting a known mechanism of treatment resistance. Improving treatment efficacy of EBRT with exercise may result in better patient outcomes clinically, while also addressing adverse effects of treatment and quality of life in prostate cancer patients. …”
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Investigating the neuroprotective effects of Dracocephalum moldavica extract and its effect on metabolomic profile of rat model of sporadic Alzheimer's disease by Marjan Talebi, Seyed Abdulmajid Ayatollahi, Mohammad Ali As’Habi, Farzad Kobarfard, Mona Khoramjouy, Farzaneh Niki Boroujeni, Mehrdad Faizi, Alireza Ghassempour

“…Alzheimer's disease (AD) is a progressive condition marked by multiple underlying mechanisms. Therefore, the investigation of natural products that can target multiple pathways presents a potential gate for the understanding and management of AD. …”
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Green building development utilising modified fired clay bricks and eggshell waste by Wafaa Soliman, Yasser M. Z. Ahmed, Ahmed Ghitas, Abdel‑Hamid El‑Shater, M. Abdelhamid Shahat

“…The results highlight significant improvements in thermal conductivity, diffusivity, and effusivity, alongside favorable changes in porosity, bulk density, and mechanical strength. The XRD analysis revealed that once the firing temperature rises, a high insulation feature arises due to siliceous melt formation. …”
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The Architecture of BaTiO₃ Nanoparticles Synthesis via Temperature-Responsive for Improved Oil Recovery: A Molecular Dynamics Simulation and Core-Flooding Experimental S... by Surajudeen Sikiru, Hassan Soleimani, Amir Rostami, Leila Khodapanah

“…The study focuses on using ferroelectric nanofluid in combination with an electromagnetic field to enhance oil recovery mechanisms. Three concentrations of BaTiO₃ nanofluid were prepared, and their effects on pressure and recovery factors were examined. …”
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Genetic Nurture Effects on Type 2 Diabetes Among Chinese Han Adults: A Family-Based Design by Xiaoyi Li, Zechen Zhou, Yujia Ma, Kexin Ding, Han Xiao, Tao Wu, Dafang Chen, Yiqun Wu

“…This study aimed to investigate the genetic nurture effect on type 2 diabetes and reveal the potential underlying mechanism using publicly available data. <b>Methods</b>: Whole-genome genotyping data of 881 offspring and/or their parents were collected. …”
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Etoposide targets 2A protease to inhibit enterovirus 71 replication by Qinqin Liang, Sai Shi, Qingjie Zhang, Yaxin Wang, Sheng Ye, Binghong Xu

“…We revealed a novel mechanism that Etoposide inhibits EV71 proliferation by targeting 2Apro, and the interactions with Y89 and P107 are of great importance. …”
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The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats by Steve Mabry, Jessica L. Bradshaw, Jennifer J. Gardner, E. Nicole Wilson, Janak Sunuwar, Hannah Yeung, Sharad Shrestha, J. Thomas Cunningham, Rebecca L. Cunningham

“…There is evidence that alterations in protease activity and neuronal activation are associated with cognitive dysfunction, are dependent on sex, and may be brain region-specific. However, the mechanisms mediating OSA-induced cognitive impairments are unclear. …”
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Phylogeographic breaks and how to find them: An empirical attempt at separating vicariance from isolation by distance in a lizard with restricted dispersal by Rancilhac, Loïs, Miralles, Aurélien, Geniez, Philippe, Mendez-Aranda, Daniel, Beddek, Menad, Brito, José Carlos, Leblois, Raphaël, Crochet, Pierre-André

“…However, a misleading signal of phylogeographic break can arise in the absence of barrier to gene flow, under mechanisms of isolation by distance (IBD). How and under which conditions phylogeographic breaks can be reliably differentiated from populations evolving under IBD remain unclear. …”
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Safety profiles of IDH inhibitors: a pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database by Ximu Sun, Han Zhou, Yanming Li, Yanhui Luo, Qixiang Guo, Yixin Sun, Chenguang Jia, Bin Wang, Maoquan Qin, Peng Guo

“…In the future, it will be necessary to validate our findings in prospective large-scale studies and to investigate the underlying mechanisms.…”
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Identification of major hemorrhage in trauma patients in the prehospital setting: diagnostic accuracy and impact on outcome by Nigel R M Tai, Evangelia Kyrimi, Jared M Wohlgemut, Zane B Perkins, William Marsh, Michael Christian, Erhan Pisirir, Rebecca S Stoner, Thomas Hurst

“…Factors associated with missed diagnosis were penetrating mechanism (OR 2.4, 95% CI 1.2 to 4.7) and major abdominal injury (OR 4.0; 95% CI 1.7 to 8.7). …”
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Effect of polishing methods on Candida albicans adhesion and contributing factors in heat-cured acrylic dentures: an in-vitro comparative study by Shahrukh Ali Khan, Zulfiqar Ali Mirani, Taimur Khalid, Engr Muhammad Wasiq Ali Khan, Ziaullah Choudhary, Syed Murtaza Raza Kazmi

“…This study explores the impact of Mechanical Polishing (MP) and Chemical Polishing (CP) methods on these surface properties and their potential to reduce Candida albicans adhesion. …”
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TNF-α Enhances the Therapeutic Effects of MenSC-Derived Small Extracellular Vesicles on Inflammatory Bowel Disease through Macrophage Polarization by miR-24-3p by Huikang Xu, Jiamin Fu, Lijun Chen, Sining Zhou, Yangxin Fang, Qi Zhang, Xin Chen, Li Yuan, Yifei Li, Zhenyu Xu, Charlie Xiang

“…Inflammatory bowel disease (IBD) is a chronic idiopathic intestinal inflammation, the etiology and mechanism of which are unclear. At present, the existing therapeutic methods are ineffective for many patients and have obvious side effects. …”
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Antidiabetic agent use and clinical outcomes in patients with diabetes hospitalized for COVID-19: a systematic review and meta-analysis by Jordan N. Keels, Isabella R. McDonald, Christopher S. Lee, Andrew A. Dwyer, Andrew A. Dwyer

“…Further work is needed to uncover mechanism(s) and clarify medical management approaches.…”
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Correlation analysis of the impact of Clonorchis sinensis juvenile on gut microbiota and transcriptome in mice by Xueling Deng, Shitao Li, Yuhong Wu, Jiali Yao, Wei Hou, Jiangyao Zheng, Boying Liang, Xiaole Liang, Qiping Hu, Zhanshuai Wu, Zeli Tang

“…This study aimed to investigate their relationship and potential pathogenic mechanisms. The BALB/c mouse model of early infection with C. sinensis juvenile was constructed. …”
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Methyltransferase-like 7B participates in bladder cancer via ACSL3 m6A modification in a ferroptosis manner by Jiani He, Changming Dong, Xiandong Song, Zhongkai Qiu, Hao Zhang, Yuanjun Jiang, Tao Liu, Xiaojun Man

“…We, here, examined that ectopic METTL7B expression abolished ferroptosis markers in cells raised by Erastin treatment, including the production of lipid ROS, the increased cellular iron and MDA content, the decreased gene expression of ACSL3, FANCD2, and FADS2, as well as the mitochondrial injury observed by electron microscopy. Mechanically, ectopic METTL7B expression promoted m6A modification on ACSL3 mRNA. …”
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Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma by Wei Gao, Tong Ding, Beicheng Sun, Nan Li, Fang Gao, Meng Jia, Mitchell Ho, Na Li, Luan Sun, Zhanhui Gao, Lei Ao, Sujuan Ma, Peihua Lu, Shaochang Jia

“…Therefore, sGPC3 acted as dominant negative regulators when competed with cell surface GPC3 to bind anti-GPC3 CAR-T cells, leading to an inhibitory effect on CAR-T cells in HCC.Conclusions We provide a proof-of-concept study demonstrating that GPC3 shedding might cause worse response to CAR-T cell treatment by competing with cell surface GPC3 for CAR-T cell binding, which revealed a new mechanism of tumor immune escape in HCC, providing a novel biomarker for patient enrolment in future clinical trials and/or treatments with GPC3-targeted CAR-T cells.…”
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Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis by Flavia Ignuta, Adrian Vlad, Teodor Cerbulescu, Stana Loredana, Felix Bratosin, Ovidiu Rosca, Lavinia Stelea, Daciana Nistor

“…Clinical outcomes included ICU admission, need for mechanical ventilation, length of stay, and in-hospital mortality. …”
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Association of C1q/TNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease by Zexuan Li, Yunhui Du, Lixin Jia, Jingyao Fan, Ruifeng Guo, Xinliang Ma, Xiao Wang, Shaoping Nie, Yongxiang Wei

“…Obstructive sleep apnea (OSA) is closely related to the incidence and progression of coronary artery disease (CAD), and the mechanisms linking OSA and CAD are multifactorial. C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that protects the heart against ischemic injury and ameliorates cardiac remodeling. …”
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Functional near-infrared spectroscopy for the assessment and treatment of patients with disorders of consciousness by Nan Wang, Nan Wang, Nan Wang, Yifang He, Sipeng Zhu, Dongsheng Liu, Xiaoke Chai, Xiaoke Chai, Qiheng He, Tianqing Cao, Jianghong He, Jingqi Li, Juanning Si, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Jizong Zhao, Jizong Zhao

“…Specifically, it investigates the potential value of combining fNIRS with brain-computer interfaces (BCIs) and closed-loop neuromodulation systems for patients with DoC, aiming to elucidate mechanisms that promote neurological recovery.MethodsA systematic analysis was conducted on 155 studies published between January 1993 and October 2024, retrieved from the Web of Science Core Collection database.ResultsAnalysis of 21 eligible studies on neurological diseases involving 262 DoC patients revealed significant findings. …”
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Investigation on acute chromium poisoning accident occurred in process of electroplating tank cleaning by Jinbin LUO, Qiang CHEN, Tao LI, Wenlong LI, Binbin ZHU, Fangjun WANG

“…BackgroundElectroplating technology is widely used in the mechanical manufacturing industry. Electroplating workers may be exposed to occupational hazards such as chromium, zinc, cyanides, and sulfuric acid. …”
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