Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan by Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou

“…Recent developments in targeted protein degradation have provided great opportunities to eliminating extracellular protein targets using potential therapies with unique mechanisms of action and pharmacology. Among them, Lysosome-Targeting Chimeras (LYTACs) acting through mannose 6-phosphate receptor (M6PR) have been shown to facilitate degradation of several soluble and membrane-associated proteins in lysosomes with high efficiency. …”
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Biomechanical Analysis and Solution Suggestions of Screw Replacement Scenarios in Femoral Neck Fracture Surgeries: Finite Element Method by Yılmaz Güvercin, Murat Yaylacı, Ayberk Dizdar, Mehmet Emin Özdemir, Sevil Ay, Ecren Uzun Yaylacı, Umitcan Karahasanoğlu, Hüseyin Uygun, Gökhan Peker

“…When the results are evaluated, it is seen that the MBP has a decreasing effect on the results. Mechanical evaluation of six different options used in femoral neck fractures was performed. 85 mm CCS applied to our standard model gave the best results, while the use of 80 mm CCS in the same model showed promising results compared to other models. …”
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Functional Characterization of the <i>PoWHY1</i> Gene from <i>Platycladus orientalis</i> and Its Role in Abiotic Stress Tolerance in Transgenic <i>Arabidopsis thaliana</i> by Chun Ou, Zhiyu Dong, Xudong Zheng, Wenhui Cheng, Ermei Chang, Xiamei Yao

“…The important role of the <i>PoWHY1</i> gene in regulating plant growth and adaptation to environmental stress has become a hot research topic. However, the mechanism of the <i>PoWHY1</i> gene in <i>Platycladus orientalis</i> under abiotic stress is still unclear. …”
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Activation of ClO₂ by Nanoscale Zero-Valent Iron for Efficient Soil Polycyclic Aromatic Hydrocarbon Degradation: New Insight into the Relative Contribution of Fe(IV) and... by Xiaojun Hu, Xiaorong Xing, Fan Zhang, Bingzhi Li, Senlin Chen, Bo Wang, Jiaolong Qin, Jie Miao

“…However, the related activation mechanisms are still not clear. Herein, the variation of iron species and ClO₂, the generated reactive oxygen species, and the toxicity of the degradation intermediates were explored and evaluated with nanoscale zero-valent iron (nFe⁰) being employed to activate ClO₂ for soil polycyclic aromatic hydrocarbon (PAH) removal. …”
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N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1 by Toru Miwa, Toru Miwa, Akihito Tarui, Akihito Tarui, Teppei Kouga, Yasunori Asai, Yasunori Asai, Hideaki Ogita, Hideaki Ogita, Taro Fujikawa, Nobuhiro Hakuba, Nobuhiro Hakuba

“…Future research should explore mechanisms underlying SIRT1-induced cochlear damage and strategies to maintain balanced SIRT1 expression. …”
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Cinnamic acid alleviates endothelial dysfunction and oxidative stress by targeting PPARδ in obesity and diabetes by Yizhen Bai, Dechao Tan, Qiaowen Deng, Lingchao Miao, Yuehan Wang, Yan Zhou, Yifan Yang, Shengpeng Wang, Chi Teng Vong, Wai San Cheang

“…This study was aimed to study the potential protective effects of CA against diabetes-associated endothelial dysfunction and its underlying mechanisms. Methods High-fat diet (HFD) with 60 kcal% fat was used to induce obesity/diabetes in C57BL/6 mice for 12 weeks. …”
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Abuse of patent rights for pharmaceuticals in wartime conditions by A.O. Kodynets, O.F. Doroshenko, I.P. Volynets, G.K. Dorozhko, V.O. Petrenko, V.V. Belitsky

“…The need for updating and improving the legislative mechanism for regulating the validity of invention patents has been emphasized.…”
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Optimizing the Morphology and Optical Properties of MoS₂ Using Different Substrate Placement: Numerical Simulation and Experimental Verification by Feng Liao, Yuhan Zeng, Qingqing Xie, Yupeng Yang, Shuangyi Linghu, Li Liang, Zewen Zuo

“…Visualization based on numerical simulation, which illustrates the impact of growth parameters on deposited products, is helpful to understand formation mechanisms and modify growth conditions. In this work, we construct two models with two different substrate placements, where the substrate is parallel or perpendicular to gas flow direction. …”
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Ursolic acid attenuates obesity-related metabolic dysfunction via modulation of peroxisome proliferator activated receptor-gamma in male Wistar rats fed with high-carbohydrate high... by Oluwatosin O. Omodara, Mohammed U. Kawu, Ibrahim G. Bako, Daniel H. Mhya, Theophilus T. Dawus

“…The present study aimed to elucidate the molecular mechanisms underlying the preventive effects of dietary UA supplementation on obesity-related metabolic disorders and inflammation in male Wistar rats fed with HCHFD. …”
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A comprehensive analysis of the acromial morphology and etiological factors of partial rotator cuff tears by Yukihiro Kajita, MD, PhD, Yohei Harada, MD, PhD, Ryosuke Takahashi, MD, Ryosuke Sagami, MD, Yusuke Iwahori, MD, PhD

“…Tears are caused by extrinsic, intrinsic, or traumatic factors; however, the mechanisms by which partial tears occur remain unknown. …”
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The Efficacy of Moxibustion on the Serum Levels of CXCL1 and β-EP in Patients with Rheumatoid Arthritis by Siyu Tao, Xue Wang, Chenxi Liao, Yan Xiong, Jie Tang, Nannan Jiang, Yuan Li, Xinyue Hu, Rouxian Shuai, Yueyue Wang, Ping Wu

“…This study aims to evaluate the efficacy of moxibustion on joint swelling and pain and the levels of C-X-C motif chemokine ligand 1 (CXCL1), β-endorphin (β-EP) in serum of rheumatoid arthritis (RA) patients and to investigate the anti-inflammatory and analgesic mechanism of moxibustion on improving RA. Methods. …”
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Disrupting of IGF2BP3-stabilized CLDN11 mRNA by TNF-α increases intestinal permeability in obesity-related severe acute pancreatitis by Lihui Lin, Yansong Lin, Xianwen Guo, Ruoyi Zhang, Xin Ling, Zewen Zhang, Rong Lin, Zhen Ding

“…However, the role and mechanism of CLDN11 in the intestinal permeability of obesity-related SAP remain unclear. …”
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The pattern of antibiotic utilisation among intensive care unit patients hospitalised in a Gauteng (South African) provincial tertiary hospital: Comparing findings before and durin... by L Spinickum, Z Booth, S Leigh-de Rapper

“… Background. Various mechanisms may contribute to and direct the progression of antibiotic resistance. …”
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Genome-Wide Identification and Expression Analysis of bHLH-MYC Family Genes from Mustard That May Be Important in Trichome Formation by Jianzhong Li, Guoliang Li, Caishuo Zhu, Shaoxing Wang, Shifan Zhang, Fei Li, Hui Zhang, Rifei Sun, Lingyun Yuan, Guohu Chen, Xiaoyan Tang, Chenggang Wang, Shujiang Zhang

“…This finding provides a basis for elucidating the roles of bHLH-MYC family members in plant growth and development, and the molecular mechanisms underlying trichome development in mustard leaves.…”
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Valine potentiates cefoperazone-sulbactam to kill methicillin-resistant Staphylococcus aureus by Shao-hua Li, Yuan Tao, Zhi-cheng Yang, Huan-zhe Fu, Hui-yin Lin, Xuan-xian Peng, Hui Li

“…The combined effect of SCF and valine was demonstrated in clinical MRSA isolates and in mouse systemic and thigh infection models. Underlying mechanisms were attributed to valine-induced the activation of the pyruvate cycle/the TCA cycle and fatty acid biosynthesis. …”
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Bibliometric analysis of glycolysis and prostate cancer research from 2004 to 2024 by Congxu Zhu, Jingjing Yang, Lumei Liu, Bonan Li, Tiansong Sun, Wen Sheng, Qinghu He

“…By modulating glycolytic mechanisms, there is potential to increase resistance in PCa. …”
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The efficacy and safety of qiwei baizhu san in the treatment of type 2 diabetes mellitus: a systematic review and meta-analysis by Quan Zhang, Hongyan Liu, Jiahong Zhang, Yujie Ouyang, Xiaoxu Fu, Xiaoxu Fu, Xiaoxu Fu, Chunguang Xie, Chunguang Xie, Chunguang Xie

“…Heterogeneity sources were examined via subgroup analyses, the robustness of the results was determined by sensitivity analyses, publication bias was evaluated using funnel plots and Egger’s test, evidence quality was appraised with GRADEpro, and possible mechanisms of QWBZS for T2DM were categorized and summarized.ResultsThis analysis encompassed 14 qualifying trials with a total of 1,169 subjects. …”
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The Effect of Lithium on Inflammation-Associated Genes in Lipopolysaccharide-Activated Raw 264.7 Macrophages by Raymond T. Makola, Vusi G. Mbazima, Matlou P. Mokgotho, Vincent S. Gallicchio, Thabe M. Matsebatlela

“…Thus, the intention of this study is to delineate the regulatory mechanisms of lithium on oxidative stress in lipopolysaccharide- (LPS-) activated macrophages by evaluating its effects on nuclear factor-κB (NF-κB) activity and mRNA expression of multiple oxidative stress-related NF-κB genes. …”
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The Effect of Annealing in a Magnetic Field on the Microstructures and Magnetic Properties of (Nd_0.8RE_0.2)_2.2Fe₁₂Co₂B (RE = L... by Xiaohua Tan, Xuanbo Shi, Shiqi Zhang, Hui Xu

“…In comparison to melt-spun (Nd_0.8Ce_0.2)_2.2Fe₁₂Co₂B alloy, the B_r and (BH)_max of the magnetic field-annealed alloy are improved by 5% and 8%. The underlying mechanism of improved magnetic properties of La- and Ce-substituted alloys is different. …”
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Effects of prolonged NaHCO3 exposure on the serum immune function, antioxidant capacity, intestinal tight junctions, microbiota, mitochondria, and autophagy in crucian carp (Carass... by Jia Liu, Faye Zhang, Zihao Yan, Zhengyao Guo, Yuqian Lu, Baolan Yao, Yuehong Li, Wenfa Lv

“…The results of this study have characterized the molecular mechanisms of intestinal injury in crucian carp caused by NaHCO3 stress, and thus provide empirical support for aquaculture in saline-alkali waters.…”
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