The Human Milk-derived Peptide Drives Rapid Regulation of Macrophage Inflammation Responses in the Neonatal IntestineSummary by Fuqiang Yuan, Xu Han, Masha Huang, Yinglin Su, Yiting Zhang, Mengyuan Hu, Xiang Yu, Weilai Jin, Yun Li, Le Zhang

“…Protein-protein interaction (PPI) analysis, single-cell RNA-seq (scRNA-seq), and co-immunoprecipitation (co-IP) experiments were conducted to explore the mechanism underlying CASB135-150 function. Results: CASB135-150 significantly mitigated intestinal injury in the rat NEC model. …”
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UNEXPECTED FINDINGS DURING LAPAROTOMY SURGERY AND URGENT SURGICAL INDICATIONS ARE ASSOCIATED WITH POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH CROHN’S DISEASE by Guilherme Zupo TEIXEIRA, Magaly Gemio TEIXEIRA, Marina Carla GIMENEZ, Silvia Caroline Neves RIBEIRO, Nathacia Bernardo CHIMELLO, Vania Aparecida LEANDRO-MERHI

“…RESULTS: There was an association regarding the history of adalimumab use (p=0.04, OR 2.8, 95%CI 1.03-7.65), previous use of prednisone (p<0.01, OR 2.03, 95%CI 2.00-2.05), urgent surgery indications (p<0.01, OR=4.32, 95% CI=1.58-11.82), mechanical anastomosis (p=0.02, OR=0.22, 95%CI 0.06-0.80), unexpected intraoperative findings (p=0.02, OR 10.46, 95%CI 1.50-72.99), length of hospital stay greater than 10 days (p<0.01, OR 16.86, 95%CI 2.99-94.96), unplanned intensive care unit (ICU) admission (p=0.01, OR 15.06, 95%CI 1.96-115.70), and planned ICU admission (p<0.01, OR 18.46, 95%CI 3.60-94.51). …”
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The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ETA Receptor in Mouse Mesenteric Arteries by Xi Xie, Chen Chen, Cang-Bao Xu, Jie Lin, Lei Cao, Gen Chen, Jie Li

“…Understanding the effect of mmLDL on the ETA receptor and the underlying mechanisms may provide a new idea for the prevention and treatment of cardiovascular diseases.…”
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Insulin-Sensitizing Properties of Decoctions from Leaves, Stems, and Roots of <i>Cucumis prophetarum</i> L. by Zewdie Mekonnen, Giuseppe Petito, Getasew Shitaye, Gianluca D’Abrosca, Belete Adefris Legesse, Sisay Addisu, Maurizio Ragni, Antonia Lanni, Roberto Fattorusso, Carla Isernia, Lara Comune, Simona Piccolella, Severina Pacifico, Rosalba Senese, Gaetano Malgieri, Solomon Tebeje Gizaw

“…Since existing treatments often present side effects based on different mechanisms, alternative therapeutic options are needed. …”
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Predicting rapid decline in kidney function among type 2 diabetes patients: A machine learning approach by Eri Nakahara, Kayo Waki, Hisashi Kurasawa, Imari Mimura, Tomohisa Seki, Akinori Fujino, Nagisa Shiomi, Masaomi Nangaku, Kazuhiko Ohe

“…Albuminuria is a known kidney damage biomarker for DKD, yet RD cases do not always show changes in albuminuria, and the exact mechanism of RD remains unclear. Previous studies focused on a limited number of laboratory tests, no comprehensive study targeting a wide range of laboratory tests has been done. …”
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Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma by Nailya Kubysheva, Marina Boldina, Tatyana Eliseeva, Svetlana Soodaeva, Igor Klimanov, Anastasia Khaletskaya, Venera Bayrasheva, Valery Solovyev, Luis Alfonso Villa-Vargas, Marco Antonio Ramírez-Salinas, Moisés Salinas-Rosales, Dmitry Yu. Ovsyannikov, Ildar Batyrshin

“…These findings indicate that IL-17, IL-18, and TNF-α can participate in the mechanisms of systemic inflammation and the genesis of disorders of airway obstruction in COPD, AСO, and BA. …”
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Characteristics of glaucoma therapy with prostaglandin analogues nowadays by I.B. Alekseev, A.V. Volkova, L.I. Alekseeva

“…This drug implements the described mechanism of drug storage and delivery. The review presents a meta-analysis on the comparative efficacy and tolerability of travoprost. …”
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Compact 999.6 nm Actively Q-Switched Yb3+:LuAlO for Laser-Induced Breakdown Spectroscopy Laser by A. Rudenkov, V. Kisel, A. Yasukevich, K. Hovhannesyan, A. Petrosyan, N. Kuleshov

“…Yttrium aluminate crystal YAlO3 (YAP) is a well-known host with good thermal and mechanical properties (thermal conductivity for undoped crystal is about 11 W/m·K and about 8 W/m·K for Yb(5 at.%):YAP) similar to those of YAG. …”
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Comparison of the Disposable Streamlined Liner of the Pharynx Airway and the Disposable I-gel in Anaesthetized, Paralyzed Adults: A Randomized Prospective Study by Khaled EL-Radaideh, Ala"a Alhowary, Diab Bani Hani

“…Both devices had similar mechanical ventilation and oxygenation characteristics and comparable hemodynamic stability. …”
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The bioinfomatics analysis of the M1 macrophage-related gene CXCL9 signature in cervical cancer by Wenxin Liao, Tingting Liu, Yang Li, Hua Liang, Juexiao Deng, Fujin Shen

“…Meanwhile, CXCL9 may had clinical significance for the drug response in cervical cancer, possibly mediating resistance to chemotherapy and targeted drug therapy.Conclusion Our findings may provide new insight into the M1 macrophage coexpression gene network and molecular mechanisms in cervical cancer, and indicated that M1 macrophage association gene CXCL9 may serve as a good prognostic gene and a potential therapeutic target for cervical cancer therapies.…”
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MAF1 inhibits hepatocarcinogenesis by fostering an immunostimulatory tumor microenvironment by Di Cao, Shi-Juan Mai, Hui-yun Wang, Ge Ren, Yue-Ning Wang, Chao-Yue Sun, Haojiang Li, Yu-Feng Zhou, Mei-Yin Zhang, Shuo-Cheng Wang

“…Understanding the underlying mechanisms by which MAF1 enhances anti-tumor immunity in HCC is crucial for developing novel immunotherapy strategies and enhancing clinical responses to treatment for patients with HCC.Methods Mice were subjected to hydrodynamic tail vein injections of transposon vectors to overexpress AKT/NRas, or c-Myc, with or without wild-type (WT) or mutant-activated (−4A) MAF1, or short-hairpin MAF1 (shMAF1). …”
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Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells agains... by Weiting Liao, Ge Gao, Xia He, Pei Shu, Qizhi Ma, Benxia Zhang, Diyuan Qin, Yongsheng Wang

“…However, the functional significance of S1PR3 in T-cell-based immunotherapies and the molecular mechanisms have not been fully understood.Methods Here, we studied the combination of EpCAM-specific CAR T-cell therapy with pharmacological blockade of S1PR3 against solid tumor. …”
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The evolution process between the earthquake swarm beneath the Noto Peninsula, central Japan and the 2024 M 7.6 Noto Hanto earthquake sequence by Zhigang Peng, Xinglin Lei, Qing-Yu Wang, Dun Wang, Phuc Mach, Dongdong Yao, Aitaro Kato, Kazushige Obara, Michel Campillo

“…Several physical mechanisms of earthquake nucleation, such as pre-slip, cascade triggering, aseismic slip, and fluid-driven models, have been proposed. …”
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Development of a Dual-Targeted Oral Delivery System for Mesalazine and Acetaminophen by Fatemeh Soltani, Reihaneh Arghand, Ghazaleh Mehdipour, Hossein Shahdadi Sardou, Ali Mohammadi, Abbas Akhgari

“…Thermal analysis, infrared spectroscopy, mechanical testing and scanning electron microscopy were performed to evaluate the physicochemical properties and investigate potential interactions. …”
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Newly identified c-di-GMP pathway putative EAL domain gene STM0343 regulates stress resistance and virulence in Salmonella enterica serovar Typhimurium by Kaifeng Chen, Lili Li, Nanwei Wang, Zhouping Zhou, Peng Pan, Chenggang Xu, Dage Sun, Jiayi Li, Changzhi Dai, Dai Kuang, Ming Liao, Jianmin Zhang

“…This study provides insights into the regulatory mechanisms by which STM0343 reduces the stress resistance and pathogenicity of S. …”
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A review on techno-economic analysis of lignocellulosic biorefinery producing biofuels and high-value products by Ronak Patel, T.S. Rajaraman, Paresh H. Rana, Nikita J. Ambegaonkar, Sanjay Patel

“…Finally, the role of policy mechanisms, Artificial Intelligence (AI) and other data-driven technologies are also discussed in the biorefinery context.…”
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Efficacy of the Bushen Jianpi Huoxue Formula on Beclin-1/Bcl-2-mediated autophagy and apoptosis in osteoblasts by Yanping Lin, Yanping Lin, Rui Zhao, Rui Zhao, Jiachun Huang, Tongying Chen, Tongying Chen, Haolin Yang, Haolin Yang, Haiwei Guo, Lei Wan, Zhihai Zhang, Ying Li, Genfu Zhu, Hongxing Huang, Hongxing Huang

“…Additionally, it initially explores the functional mechanism of Beclin-1/Bcl-2-related apoptosis.MethodsOsteoblasts were isolated from the calvaria of three-day-old Sprague-Dawley female rats. …”
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Exploring the interactions and driving factors among typical ecological risks based on ecosystem services: A case study in the Sichuan-Yunnan ecological barrier area by Weijie Li, Jinwen Kang, Yong Wang

“…However, previous studies have focused more on the improvement and practical application of assessment methods, while the interactions between different ER and their driving mechanisms remain unclear. Thus, this paper examined the Sichuan-Yunnan ecological barrier area and constructed an ER characterization method based on the relative loss of ecosystem services, analyzed the dynamic changes of single risk (i.e., soil conservation risk (SC_R), grain production risk (GP_R), carbon storage risk (CS_R), water yield risk (WY_R), habitat quality risk (HQ_R)) and comprehensive risk from 2000 to 2020, and explored the interactions between ER and their driving factors by using correlation analysis, spatial autocorrelation, self-organization method and geo-detector. …”
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The subventricular zone neurogenic niche provides adult born functional neurons to repair cortical brain injuries in response to diterpenoid therapy by Ricardo Pardillo-Díaz, Patricia Pérez-García, María Ortego-Domínguez, Ricardo Gómez-Oliva, Nora Martínez-Gómez, Samuel Domínguez-García, Francisco García-Cózar, Juan Pedro Muñoz-Miranda, Rosario Hernández-Galán, Livia Carrascal, Carmen Castro, Pedro Nunez-Abades

“…Results We have found that EOF2 treatment of adult mice with mechanical cortical injuries facilitates the delivery of neuroblasts into these injuries. …”
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Exacerbation of diabetes due to F. Nucleatum LPS-induced SGLT2 overexpression in the renal proximal tubular epithelial cells by Aiko Seki, Koichiro Kajiwara, Jumpei Teramachi, Masahiko Egusa, Takuya Miyawaki, Yoshihiko Sawa

“…Abstract Background Diabetes treatments by the control of sodium-glucose cotransporter 2 (SGLT2) is commonly conducted while there are still uncertainties about the mechanisms for the SGLT2 overexpression in kidneys with diabetes. …”
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