Diseño de losas de hormigón con geometría optimizada Design of concrete pavement with optimized slab geometry by Juan Pablo Covarrubias V.

“…Critical tensile stresses have been calculated by employing the finite elements analysis for different conditions of mechanical and thermal loads at different positions. …”
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Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model by Zhuo-ma Dawa, Zhuo-ma Dawa, Ting Zhai, Ting Zhai, Chuan-chuan Liu, Chuan-chuan Liu, Hai-ning Fan, Hai-ning Fan

“…However, the in-depth mechanism by which PAB acts against E. multilocularis remains unclear.MethodsTo evaluate the effect of a PAB intervention on protoscoleces, metacestode vesicles and germinal cells in E. multilocularis in vitro. …”
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Cathepsin G promotes arteriovenous fistula maturation by positively regulating the MMP2/MMP9 pathway by Lemei Hu, Changqing Zheng, Ying Kong, Zhiqing Luo, Fengzhang Huang, Zhigang Zhu, Quhuan Li, Ming Liang

“…A more comprehensive understanding and study of the mechanisms of AVF maturation is urgently needed.Methods and results In this study, we downloaded the publicly available datasets (GSE119296 and GSE220796) from the Gene Expression Omnibus (GEO) and merged them for subsequent analysis. …”
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Effects of Compressive and Tensile Strain on Macrophages during Simulated Orthodontic Tooth Movement by Agnes Schröder, Paul Käppler, Ute Nazet, Jonathan Jantsch, Peter Proff, Fabian Cieplik, James Deschner, Christian Kirschneck

“…Our results indicate that macrophages respond early on to compressive and tensile strain occurring during OTM with an enhanced gene expression of proinflammatory cytokines, which could affect PDL fibroblasts, osteoblasts, and immune cells triggering or enhancing the biological mechanisms and osteoclastogenesis underlying OTM.…”
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Mesenchymal stromal cells-derived extracellular vesicles in cartilage regeneration: potential and limitations by María Piñeiro-Ramil, Iván Gómez-Seoane, Ana Isabel Rodríguez-Cendal, Isaac Fuentes-Boquete, Silvia Díaz-Prado

“…Further research is necessary to elucidate the mechanisms underlying sEVs-mediated cartilage regeneration and to facilitate their translation into effective OA therapies.…”
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Evaluating the dual impact of microbial activity and aged refuse layers on landfill leachate clogging: An experimental and LCA perspective by Zhaobin Li, Waifan Tang, Shulun Mak, Siukei Lam, Qingwen Li

“…Traditional control methods often fail to address these underlying processes, necessitating a deeper understanding of clogging mechanisms and effective mitigation strategies. Significance: This study provides an in-depth analysis combining a review of existing literature and experimental insights into the role of microbial communities in clogging formation and the effectiveness of aged refuse layers as a mitigation measure.To provide a comprehensive assessment, a life cycle assessment (LCA) framework is employed to analyze the environmental impacts of various clogging control methods.This study contributes to theoretical advancements by integrating a comprehensive review of LCA frameworks in the context of landfill management, addressing a gap in current literature. …”
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Biocomposite Active Whey Protein Films with Thyme Reinforced by Electrospun Polylactic Acid Fiber Mat by Andreea (Lanciu) Dorofte, Iulia Bleoanca, Florentina Ionela Bucur, Gabriel Mustatea, Daniela Borda, Felicia Stan, Catalin Fetecau

“…While TEO bioactivity is mainly related to its antimicrobial and antioxidant properties, the PLA fiber mat uplifted the composite mechanical and barrier properties of films. The bi-layer films obtained were characterized by SEM, showing the distribution of the electrospun fiber mat and an increased thickness of the PLA layer from WF/G1 to WF/G4, while FTIR spectra showed the structural vibrations of the functional groups. …”
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Combined metabolomic and transcriptomic analysis to reveal the response of rice to Mn toxicity stress by Feng Li, Yushuang Yao, Jiapeng Ma, Zhengwei Wu, Dianfeng Zheng, Yingbin Xue, Ying Liu

“…Rice plants are particularly susceptible to Mn toxicity stress in acidic soil; however, the underlying molecular mechanisms are so far unclear. This study used transcriptomic and metabolomic sequencing to examine roots and leaves of rice plants subjected to Mn toxicity stress. …”
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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome by Kira A Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Meaghan CS Courvan, Taylor Jones, Deepa Ajit, Matthew D Galbraith, Joaquín M Espinosa, David Bentley, Mary Ann Allen, Robin D Dowell, Dylan J Taatjes

“…Mediator-associated kinases CDK8 and CDK19 drive inflammatory responses through incompletely understood mechanisms. Using sibling-matched cell lines with/without T21, we investigated Mediator kinase function in the context of hyperactive IFN in DS over a 75 min to 24 hr timeframe. …”
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Depressive and Negative Symptoms in the Early and Established Stages of Schizophrenia: Integrating Structural Brain Alterations, Cognitive Performance, and Plasma Interleukin 6 Lev... by Fabiana Corsi-Zuelli, Gary Donohoe, Siân Lowri Griffiths, Cristina M. Del-Ben, Andrew J. Watson, Tom Burke, Paris A. Lalousis, Declan McKernan, Derek Morris, John Kelly, Colm McDonald, Saahithh R. Patlola, Carmine Pariante, Nicholas M. Barnes, Golam M. Khandaker, John Suckling, Bill Deakin, Rachel Upthegrove, Maria R. Dauvermann

“…Methods: We evaluated whether higher plasma interleukin 6 (IL-6) levels would be associated with more severe negative or depressive symptoms in schizophrenia and explored illness stage utilizing early (BeneMin [Benefit of Minocycline on Negative Symptoms of Psychosis: Extent and Mechanism], n = 201, 72.8% male) and established (iRELATE [Immune Response & Social Cognition in Schizophrenia], n = 94, 67.3% male) schizophrenia cohorts. …”
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CRISPR/Cas9 mutagenesis reveals an essential role of PI4KB in promoting growth and resisting hemorrhagic disease caused by GCRV-II infection in juvenile grass carp by Jie Zhang, Liqiang Zhang, Xiaoman Wu, Minhui Tao, Yang Chen, Mingxian Chang

“…Altogether, the present study suggests the mechanism of gcPI4KB in facilitating GCRV replication, the signaling pathways regulated by gcPI4KB, and the possibility to obtain grass carp resistant to hemorrhagic disease via gene editing of PI4KB.…”
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miR‐224‐5p Suppresses Non‐Small Cell Lung Cancer via IL6ST‐Mediated Regulation of the JAK2/STAT3 Pathway by Jiao Tian, Yiming He, Zihui Zhang, Yuxin Zhu, Haixia Ren, Liang Zhang, Lei Li, Wei Li, Weidong Zhang, Ting Xiao, Honggang Zhou, Xiaoping Li

“…ABSTRACT Background Our study aimed to explore the specific functions and potential mechanisms of miR‐224‐5p in non‐small cell lung cancer (NSCLC). …”
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Evolution characteristics and driving factors of rural living space system in the Three Gorges reservoir area:A case study of Santuo Village in Chongqing Municipality by YAN Yan, YANG Qingyuan, HU Baoqing

“…In the context of rural transformation and development, focusing on the rural living space system at the village scale, exploring their changes, and clarifying the driving mechanisms of their change provide a theoretical basis and case support for enhancing the capacity of rural spatial governance and modernizing the governance system. …”
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Analysis of the spatiotemporal dynamics of vascular injury and regeneration following experimental Spinal Cord Injury by Christian J. Entenmann, Emily J. von Bronewski, Lilly Waldmann, Lea Meyer, Katharina Kersting, Laurens T. Roolfs, Lasse M. Schleker, Melina Nieminen-Kelhä, Irina Kremenetskaia, Frank L. Heppner, Michael G. Fehlings, Peter Vajkoczy, Vanessa Hubertus

“…Understanding these mechanisms is crucial for developing therapeutic interventions. …”
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Effect of intermittent theta burst stimulation combined with acoustic startle priming motor training on upper limb motor function and neural plasticity in stroke individuals: study... by Jing Zhang, Yu Chen, Mingzhu Wang, Nan Xia, Jinghong Li, Weiqiang Liang, Yangyang Yin, Linhan Zhai, Qiuxia Wang

“…Introduction Stroke is a major cause of acquired disability globally, yet the neural mechanisms driving motor recovery post-stroke remain elusive. …”
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Heart–brain microvascular MRI study: protocol for a multicentre, observational, cohort study in the UK assessing associations between small vessel disease of the heart and brain by Colin Berry, Alex McConnachie, Peter Kellman, Terry Quinn, Paul Donnelly, Vanessa Orchard, Robert A Sykes, Gemma McKinley, Conor Patrick Bradley, Jodi Watt, Natasha Fullerton

“…It has also been demonstrated that coronary microvascular dysfunction and CSVD share common vascular risk factors and pathophysiological mechanisms of disease. This has led to a link between the conditions being hypothesised, however, there is an evidence gap clearly demonstrating this relationship. …”
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Oxytocin as a physiological correlate of dyadic music therapy relationships — a randomized crossover pilot study by Paula Kristin Busse, Lutz Neugebauer, Götz Kaschubowski, Dennis Anheyer, Dennis Anheyer, Dennis Anheyer, Thomas Ostermann

“…RationaleMusic therapy has been in practice for years. However, the mechanism of action of music or music therapy is not well understood. …”
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Deep learning enhanced transmembranous electromyography in the diagnosis of sleep apnea by Ross Mandeville, Hooman Sedghamiz, Perry Mansfield, Geoffrey Sheean, Chris Studer, Derrick Cordice, Ghodsieh Ghanbari, Atul Malhotra, Shamim Nemati, Jejo Koola

“…To overcome this issue, we explored the use of transformers, a deep learning (DL) model architecture with attention mechanisms, to model tmEMG data and distinguish between electromyographic signals from a cohort of control, neurogenic, and sleep apnea patients. …”
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Adipose Tissue-Derived Stromal Cells Induce a Highly Trophic Environment While Reducing Maturation of Monocyte-Derived Dendritic Cells by Morten Juhl, Bjarke Follin, Monika Gad, Jesper Larsen, Jens Kastrup, Annette Ekblond

“…However, in vitro models are required to explore and identify cell interactions and mechanisms of action, to ensure sufficient and sustained effects, and to document these. …”
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Discovery of anti-Ebola virus multi-target inhibitors from traditional Chinese medicine database using molecular screening, biophysical investigation, and binding free energy calcu... by Abbas Khan, Abrar Mohammad Sayaf, Anwar Mohammad, Fahad M. Alshabrmi, Tarek Benameur, Dong-Qing Wei, Kar Kheng Yeoh, Abdelali Agouni

“…Conclusions: Our findings provide valuable insights into the molecular mechanisms driving the efficacy of TCM drugs against EBOV and suggest novel approaches for the development of anti-EBOV therapies.…”
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