New insight into the role of the pathway NLRP1 and NLRP3 inflammasomes and IL-33 in ultraviolet-induced cutaneous carcinogenesis by Aleksandra Lesiak, Aleksandra Lesiak, Karolina Wodz, Justyna Ceryn, Dorota Sobolewska-Sztychny, Dorota Sobolewska-Sztychny, Igor Bednarski, Janusz Piekarski, Marta Pabianek, Dariusz Nejc, Izabela Dróżdż, Joanna Narbutt, Marcin Noweta, Magdalena Ciążyńska, Magdalena Ciążyńska

“…The precise molecular mechanisms underlying the activation of these inflammasomes remain unclear. …”
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Investigation on the effects of total organic carbon content and maturity of coal measure shale on biomethane production performance in the anaerobic digestion system by Qianwen RUAN, Qian WANG, Xianbo SU, Weizhong ZHAO, Fubo GAO

“…However, the systematic studies on the methanogenesis mechanism of coal measure shale in the anaerobic digestion system are still limited, and the characteristics of biological methane production and its controlling factors remain unclear, which hinders its development and application. …”
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In Vitro Study on the Regulation of Annexin IV and VEGF by hCG in the Human Endometrium by Shaoyuan Xu, Jie Li, Xiaoyan Chen, Beiyu Liu

“…Whether changes in vascular endothelial growth factor (VEGF) and annexin IV during implantation are regulated through the LH/hCG-R needs further research. To investigate the mechanism of hCG on the expression of annexin IV and VEGF in human endometrial cells. …”
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Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…Understanding of the mechanisms underlying productive HEV infection remains incomplete and would benefit from technological advances improving current model systems. …”
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Oral manifestations of dengue virus infection: a scoping review for clinical dental practice by Lucas Peixoto de Araújo, Stefan Kickhofel Weisshahn, Eduarda Thome do Carmo, Bruna Cavalcante Chaves, Mateus de Azevedo Kinalski, Nícolas Kickhofel Weisshahn, Sarah Arangurem Karam

“…Further research is needed to explore the pathophysiological mechanisms underlying these manifestations and to develop standardized protocols for clinical assessment and management. …”
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NF-κB-Specific Suppression in Cardiomyocytes Unveils Aging-Associated Responses in Cardiac Tissue by Letícia Aparecida Lopes Morgado, Larissa Maria Zacarias Rodrigues, Daiane Cristina Floriano Silva, Bruno Durante da Silva, Maria Claudia Costa Irigoyen, Ana Paula Cremasco Takano

“…<b>Background/Objectives</b>: Aging is associated with structural and functional changes in the heart, including hypertrophy, fibrosis, and impaired contractility. Cellular mechanisms such as senescence, telomere shortening, and DNA damage contribute to these processes. …”
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COVID-19 vaccine uptake in Zimbabwe and Sierra Leone: an application of Health Belief Model constructs by Simon Ssentongo, Alex Muhereza, Morie Mustapha, Ruth Gemi, Dennis Cherian, Rebecca Waugh, Benjamin Crookston, Cougar Hall, Mary Linehan, Hayden Borg, Joshua West

“…They highlight the importance of relying on well-established theories to grasp decision-making mechanisms and to shape suggestions for behavior modification. …”
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Antioxidative Reactivity of L-Ascorbic Acid and D-Isoascorbic Acid Species towards Reduction of Hexachloroiridate (IV) by Han Zhang, Yanqing Xia, Peng Zhang, Liqian Hou, Ying Sun, Zhaozhan Lu, Yunfeng Tang, Hongwu Tian, Tiesheng Shi

“…Spectrophotometric titration experiments revealed a well-defined 1 : 2 stoichiometry, namely Δ[AA] : Δ[Ir(IV)] or Δ[IAA] : Δ[Ir(IV)] = 1 : 2, indicating that L-dehydroascorbic acid (DHA) and D-dehydroisoascorbic acid (DHIA) were the oxidation products of AA and IAA, respectively. A reaction mechanism is suggested involving parallel reactions of [IrCl6]2– with three protolysis species of AA/IAA (fully protonated, monoanionic, and dianionic forms) as the rate-determining steps and formation of ascorbic/isoascorbic and ascorbate/isoascorbate radicals; in each of the steps, [IrCl6]2– acquires an electron via an outer-sphere electron transfer mode. …”
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Booster Vaccination against Yellow Fever in Gambian children-(BoVY) -a Phase 3 clinical trial to establish safety and immunogenicity of repeated YF vaccination in healthy Gambian c... by David Jeffries, Caitlin Pley, Beate Kampmann, Mam Nabou Leigh, Julia Strandmark, Ed Clarke, Peter Ndow, Ebrima Kanteh, Amadou Faal, Elishia Roberts

“…Secondary objectives are to characterise the rate of sero-reversion (change from seropositive to seronegative) over a period of 9 months to 8 years following single primary vaccination and to profile the immune response to the booster to explore underlying mechanisms for the longevity of vaccine-induced antibody. …”
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Heat shock transcription factor 1 facilitates liver cancer progression by driving super‐enhancer‐mediated transcription of MYCN by Yizhe Liu, Qili Shi, Yue Su, Zhiao Chen, Xianghuo He

“…Conclusion The HSF1‐MYCN axis constitutes a transcription‐dependent regulatory mechanism that may function as both a prognostic indicator and a promising therapeutic target in liver cancer. …”
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A cross-lagged analysis of the relationship between marital quality and depression among the older adults: gender effects of socioeconomic status by Bi-Ji Fang, Kai-Seng Leong, Hong-Xiu Tan

“…ObjectiveThis study aimed to explore the mechanism and gender effect of socioeconomic status on the relationship between marital quality and depression among the older adults, with the intention of providing a practical foundation for enhancing the quality of life of the older adults.MethodsThe data sourced from the third (conducted in 2015, denoted as the first survey) and fourth (carried out in 2018, regarded as the second survey) installments of the China Health and Retirement Longitudinal Survey (CHARLS) were meticulously analyzed through the utilization of cross-lagged analytical techniques and moderating effect examination methodologies.ResultsAmong the older adults, there exists a reciprocal causal relationship between marital quality and the level of depression. …”
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Impact of bone quality on surgical decision-making in total hip arthroplasty: a qualitative analysis in the UK by Stella Mavroveli, Justin Cobb, Sanjeeve Sabharwal, Monil Karia, Alex Abouharb

“…Further work to identify intraoperative and preoperative imaging metrics that correlate with bone mechanical properties could enhance surgical decision-making.…”
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Myelitis associated with glial fibrillary acidic protein IgG: characterization and comparison with aquaporin-4 IgG and myelin oligodendrocyte glycoprotein IgG myelitis by Yinyin Xie, Wanwan Zhang, Aoya Han, Wenlin Sun, Xinru Zhou, Yi Xie, Yunqing Ma, Yajun Lian, Cui Wang, Nanchang Xie

“…Features favoring GFAP-IgG over the other types included presence of fever and neck stiffness, requirement of intensive care and mechanical ventilation, higher monocyte-to-lymphocyte ratio (MLR), presence of hyponatremia, markedly elevated CSF leukocyte counts, increased CSF total protein levels, and decreased CSF glucose levels. …”
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Evaluating GRU Algorithm and Double Moving Average for Predicting USDT Prices: A Case Study 2017-2024 by RAHMAT, Munirul ula, Zara Yunizar

“…GRU, a deep learning-based recurrent neural network, processes sequential data using a gating mechanism, making it effective for capturing short-term price dynamics. …”
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Relationship between Internet use and offline leisure activities among Chinese older adult people: a moderated mediation model by Shuai Xiang, Qinwen Deng, Boli Chen

“…Nevertheless, there is a need for further empirical research in this area.PurposeThis study aimed to examine the mechanisms and interaction processes, as well as the relationship between Internet use and offline leisure activities among Chinese older adults. …”
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Promoting Wellness Among Orthopaedic Surgeons by Phara P. Ross, BS, Lauren C. Okafor, MD, Mia V. Rumps, MS, Mary K. Mulcahey, MD

“…Addressing burnout through coping mechanisms and better work-life balance is essential. …”
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metaRange: A framework to build mechanistic range models by Stefan Fallert, Lea Li, Juliano Sarmento Cabral

“…Their consideration of underlying mechanisms relaxes the species‐environment equilibrium assumed by correlative approaches, while also generating conservation‐relevant indicators, such as range‐wide abundance time series and migration rates if demographically explicit. …”
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Effects of Nicotinamide Riboside Supplementation on Postmortem Mitochondrial Functionality and Apoptotic Activation by Chen Zhu, Luke A. Whitcomb, Adam J. Chicco, Morgan E. Gravely, Hanna M. Alcocer, Daniela A. Alambarrio, John M. Gonzalez, Colton L. Smith, Mahesh N. Nair, Huey Yi Loh, Terry E. Engle, Arya Niraula, Chaoyu Zhai

“…Nicotinamide riboside (NR) supplementation to pigs prior to harvest can improve pork color stability, but its mechanism remains unclear. This study aimed to evaluate the impact of NR supplementation on early postmortem mitochondrial functionality and apoptosis. …”
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Determinants of Enrolment and Renewing of Community-Based Health Insurance in Households With Under-5 Children in Rural South-Western Uganda by Emmanuel, Nshakira-Rukundo, Essa, Mussa Chanie, Nathan, Nshakira, Nicolas, Gerber, Joachim, von Braun

“…Conclusion: While socioeconomic factors remain important predictors of participation in insurance, mechanisms to promote inclusion should be devised. Improving the participation of communities can enhance trust in insurance and eventual coverage. …”
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Assesment of Plastic Waste on Agricultural Land in Kashambya Sub-County Rukiga District. by Hazaara, Annah

“…However, it was necessary to institute strong environmental management bylaws and mechanisms for enforcing compliance.…”
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