Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment by Qing Liu, Ye Sun, Baodong He, Haodong Chen, Lijing Wang, Gaojie Wang, Kang Zhang, Ximeng Zhao, Xinzhe Zhang, Dongchao Shen, Xue Zhang, Liying Cui

“…Abstract Mutations in the ANXA11 gene, encoding an RNA-binding protein, have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), but the underlying in vivo mechanisms remain unclear. This study examines the clinical features of ALS patients harboring the ANXA11 hotspot mutation p.P36R, characterized by late-onset motor neuron disease and occasional multi-system involvement. …”
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How prepared is Nigeria digital payment for health workers? A landscape analysis by Folashayo Peter Adeniji, David Ayobami Adewole, Segun Bello, Elizabeth Ekirapa, Juliet Aweko, Vincent Michael Kiberu, Charles Opio, Peter Waiswa, Olufunmilayo Ibitola Fawole

“…Results Digital payment systems for health personnel described in the reviewed documents included the direct disbursement mechanisms, direct bank transfers and mobile money. …”
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Jianpi Yiqi Busui prescription alleviates myasthenia gravis by regulating Th17 through the TAK1/P38 MAPK/eIF-4E signaling pathway by Zhuming Chen, Jing Lu, Tianying Chang, Dongmei Zhang, Yibin Zhang, Miao Liu, Tong Wu, Peng Xv, Jian Wang

“… Jianpi Yiqi Busui Prescription (JYBP), a traditional Chinese medicine (TCM) formula, is used in the treatment of myasthenia gravis (MG). However, its mechanisms of action still require further clarification. …”
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Genetic structure and evolutionary diversity of mating-type (MAT) loci in Hypsizygus marmoreus by Gang Wang, Yuanyuan Wang, Lianfu Chen, Hongbo Wang, Lin Guo, Xuan Zhou, Meijie Dou, Baiyu Wang, Jingxian Lin, Lei Liu, Zhengchao Wang, Youjin Deng, Jisen Zhang

“…Further collinear analysis of HD loci in interspecific species found that HD loci contains conserved recombination hotspots showing major rearrangements in Coprinopsis cinerea and Schizophyllum commune, suggesting different mechanisms for evolution of physically linked MAT loci in these groups. …”
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Effect of Exogenous Melatonin Administration in Critically Ill Patients on Delirium and Sleep: A Randomized Controlled Trial by Judith Bellapart, Vinesh Appadurai, Melissa Lassig-Smith, Janine Stuart, Christopher Zappala, Rob Boots

“…Medical and surgical patients were in a recovery phase, all weaning from mechanical ventilation. Randomized allocation to placebo or enteral melatonin, using a previously described regimen (loading dose of 3 mg at 21 h, followed by 0.5 mg hourly maintenance dose until 03am through a nasogastric tube). …”
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Associations between nutrient intake and osteoarthritis based on NHANES 1999 to 2018 cross sectional study by Xiaofeng Lv, Xinmin Deng, Rui Lai, Shanshan Liu, Zihao Zou, Xuechun Dai, Yalan Luo, Jian Luo, Ying Li

“…Further research is needed to confirm these findings and clarify the underlying mechanisms.…”
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Enhancement of Cytomegalovirus-Specific Cytokine Production after Modulation of the Costimulation in Kidney Transplant Patients by Theresa Dornieden, Benjamin Wilde, Johannes Korth, Kai Werner, Peter A. Horn, Oliver Witzke, Monika Lindemann

“…Besides immunosuppressive treatment, additional mechanisms may reduce CMV-specific immunocompetence such as enhanced negative costimulation. …”
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The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development by Pralay Mukhopadhyay, Hesham A. Abdullah, Joanna B. Opalinska, Prani Paka, Eric Richards, Katja Weisel, Suzanne Trudel, Maria-Victoria Mateos, Meletios Athanasios Dimopoulos, Sagar Lonial

“…It considers how incorporating longer follow-up in DREAMM-3 may have better captured the clinical benefits of belantamab mafodotin, particularly given its multimodal, immune-related mechanism of action with responses deepening over time. …”
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Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis by EBENEZER OLUWAKEMI, BODEDE OLUSOLA, AWOLADE PAUL, JORDAAN MARYAM A., OGUNSAKIN ROPO E., SHAPI MICHAEL

“…The information obtained included botanical information, extraction method and extracts concentrations, as well as the proposed mechanisms. Fourteen articles describing 30 different plants met our eligibility criteria. …”
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Adipose-derived stem cells promote the recovery of intestinal barrier function by inhibiting the p38 MAPK signaling pathway by Mei Yang, Wangbin Xu, Chaofu Yue, Rong Li, Xian Huang, Yongjun Yan, Qinyong Yan, Shisheng Liu, Yuan Liu, Qiaolin Li

“…This study aimed to explore the mechanism by which adipose-derived stem cells (ADSCs) repair intestinal barrier damage. …”
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Optimization of fermentation conditions to increase the production of antifungal metabolites from Streptomyces sp. KN37 by Xiaoyue Yang, Lijing Yuan, Muhammad Zeeshan, Chuntian Yang, Wen Gao, Guoqiang Zhang, Chunjuan Wang

“…Transcriptomic analysis further elucidated molecular mechanisms behind these changes with the expression of salicylic acid dehydrogenase (SALD) was significantly down-regulated, which was only 0.48 times compared to that before optimization. …”
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Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO by Vidya Narayanaswami PhD, Kenneth Dahl PhD, Vadim Bernard-Gauthier PhD, Lee Josephson PhD, Paul Cumming PhD, Neil Vasdev PhD

“…On the other hand, chronic neuroglial activation is a major pathological mechanism in neurodegenerative diseases, likely contributing to neuronal dysfunction, injury, and disease progression. …”
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GC-derived exosomal circMAN1A2 promotes cancer progression and suppresses T-cell antitumour immunity by inhibiting FBXW11-mediated SFPQ degradation by Yikai Shen, Jie Lin, Tianlu Jiang, Xusheng Shen, Ying Li, Yiwang Fu, Penghui Xu, Lang Fang, Zetian Chen, Hongxin Huang, Yiwen Xia, Zekuan Xu, Linjun Wang

“…PKH-67 staining was used to label the exosomes. The molecular mechanism of exosomal circMAN1A2 was investigated via mass spectrometry, immunoprecipitation, Western blot, and single-cell RNA-sequencing data analyses. …”
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Beef cattle performance and hair cortisol accumulation in silvopastoral and pastoral systems: a 2-year assessment by A. Ripamonti, G. Foggi, A. Mantino, L. Turini, J. Goracci, A. Silvi, M. Finocchi, M. Mele

“…A decrease of glucose levels in PA group was determined but further research is needed to clarify the effects of heat stress on physiological mechanisms that lead to a change in glucose levels. …”
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Advanced Path Planning for UAV Swarms in Smart City Disaster Scenarios Using Hybrid Metaheuristic Algorithms by Mohammed Sani Adam, Nor Fadzilah Abdullah, Asma Abu-Samah, Oluwatosin Ahmed Amodu, Rosdiadee Nordin

“…The findings reveal that the APC-GA adaptive clustering and path planning mechanisms effectively navigate propagation challenges, interference, and non-line-of-sight (NLOS) conditions, ensuring reliable connectivity in the most demanding environments. …”
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The indirect effects of school bullying on mathematics achievement: the mediating roles of teacher-student relationships, sense of belonging and differences between genders by Rongrong Ren, Wei Chen, Shouying Zhao

“…However, few studies explored the underlying mechanism between bullying and mathematics achievement. …”
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Combining In Vitro, In Vivo, and In Silico Approaches to Explore the Effect of <i>Ceratonia siliqua</i> and <i>Ocimum basilicum</i> Rich Phenolic Formula on Lipid Metabolism and Pl... by Mohammadine Moumou, Amani Tayebi, Abderrahmane Hadini, Omar M. Noman, Abdulsalam Alhalmi, Hamza Ahmoda, Souliman Amrani, Hicham Harnafi

“…An in silico study was carried out to predict underlying mechanisms. Results: The HPLC analysis revealed gallic acid, cinnamic acid, and naringenin as major phenolics of the carob pod aqueous extract. …”
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Multidimensional analysis and enhancement strategies for ecological environment quality at the county level under dual carbon goals: a case study of Shaanxi Province, China by Jianfeng Li, Jianfeng Li, Jianfeng Li, Yongxin Hu, Yongxin Hu, Jian Li, Liangyan Yang, Liangyan Yang, Jie Yan

“…Using the Google Earth Engine (GEE) platform and MODIS imagery, along with methods such as the Remote Sensing Ecological Index (RSEI), Hurst exponent, and GeoDetector, this study analyzed the evolutionary characteristics and driving mechanisms of county-level EEQ, and explored improvement and management strategies for different types of county EEQ within the framework of dual carbon goals. …”
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Development of monoclonal antibodies against P. gingivalis Mfa1 and their protective capacity in an experimental periodontitis model by Mingya Cao, Siyu Wang, Shengke Zhou, Min Yan, Yu Zou, Yuan Cui, Xinyu Lou, Yichang Gao, Ying Chen, Zijing Han, Yi Qian, Jingying Chen, Xia Li

“…However, the role of anti-Mfa1 antibodies and the underlying protective mechanisms remain largely unexplored. Here, we developed and characterized the monoclonal antibodies (mAbs) targeting the Mfa1 protein of P. gingivalis. …”
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Phytochemical Characterization and Biological Activity of Two <i>Anacardiaceae</i> Species from Guinea-Bissau by Quintino Malú, Maryam Malmir, Gonçalo Infante Caldeira, Sofia Encarnação, Katelene Lima, Luís Catarino, Beatriz Silva Lima, João Rocha, Olga Silva

“…The aim of the present study was to evaluate the anti-inflammatory activity of the standardized hydroethanolic (70%) extracts of these plants and to investigate the underlying mechanisms, with a focus on their antioxidant properties. …”
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