Electroacupuncture Improves Clearance of Amyloid-β through the Glymphatic System in the SAMP8 Mouse Model of Alzheimer’s Disease by Pei-zhe Liang, Li Li, Ya-nan Zhang, Yan Shen, Li-li Zhang, Jie Zhou, Zhi-jie Wang, Shu Wang, Sha Yang

“…After EA treatment, Morris water maze (MWM) test was used to evaluate the cognitive function; HE and Nissl staining was performed to observe the brain histomorphology; ELISA, contrast-enhanced MRI, and immunofluorescence were applied to explore the mechanisms underlying EA effects from Aβ accumulation, glymphatic system function, reactivity of astrocytes, and AQP4 polarization, respectively. …”
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Serum metabolome associated with novel and legacy per- and polyfluoroalkyl substances exposure and thyroid cancer risk: A multi-module integrated analysis based on machine learning by Fei Wang, Yuanxin Lin, Lian Qin, Xiangtai Zeng, Hancheng Jiang, Yanlan Liang, Shifeng Wen, Xiangzhi Li, Shiping Huang, Chunxiang Li, Xiaoyu Luo, Xiaobo Yang

“…Additionally, little is known about the potential mechanisms underlying the association. Objectives: Explore the effects of PFAS exposure on the serum metabolome and its correlation with TC. …”
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IGF2BP2 Regulates the Progression of Alzheimer's Disease Through m6A‐Mediated NLRP3 Inflammasome by Wu Jingrui, Yang Haihui, Yan Jinjin, Fang Le

“…ABSTRACT Background Recent studies show that N6‐methyladenosine (m6A) plays an important role in the pathogenesis of the Alzheimer's disease (AD), while the mechanisms involved were studied insufficiently. Aims The present study aimed to explore the effect of human insulin‐like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2), one of the m6A‐binding proteins on the progression of AD. …”
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Determinants of burnout syndrome among undergraduate nursing students in Poland: a cross-sectional study by Katarzyna Szwamel, Wiesława Kowalska, Ewa Mazur, Anna Janus, Iwona Bonikowska, Justyna Jasik-Pyzdrowska

“…Depending on the results of the tests, implementation of interventions aiming at reducing the negative outcomes of burnout syndrome and promoting well-being and adaptive management mechanisms should be considered.…”
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Children’s Eating Behavior Questionnaire Correlated with Body Compositions of Thai Children and Adolescents with Obesity: A Pilot Study by Ekkarit Panichsillaphakit, Yuda Chongpison, Puthita Saengpanit, Tanisa Kwanbunbumpen, Jaraspong Uaariyapanichkul, Sirinuch Chomtho, Chitsanu Pancharoen, Chonnikant Visuthranukul

“…Additional study with a larger sample size needed to explore underlying mechanisms and findings can be used to develop future behavior modification program.…”
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Assessing safety culture and second victim experience following adverse events among Romanian nurses: a cross-sectional study by Mirabela Ioana Istrate, Alina Ioana Forray, Marius-Ionuț Ungureanu, José Joaquín Mira, Sorana Alexandra Constantinescu, Răzvan Mircea Cherecheș

“…With a limited body of research on patient safety, adverse events, and second victims (SVs) in Romania, this study addresses a crucial gap, highlighting the need for enhanced safety culture and support mechanisms for SVs. Methods A cross-sectional study in Romania targeted healthcare professionals, focusing on nurses. …”
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Synthesis and protective effect of pyrazole conjugated imidazo[1,2-a]pyrazine derivatives against acute lung injury in sepsis rats via attenuation of NF-κB, oxidative stress, and a... by Zang Binbin, Wang Lihui

“…The current work was conducted to elucidate the pharmacological effect of pyrazole-conjugated imidazo[1,2-a]pyrazine derivatives against acute lung injury in rats in sepsis and their mechanism of action. Various pyrazole-conjugated imidazo[1,2-a]-pyrazine derivatives have been synthesized in a straightforward synthetic route. …”
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Bioinformatic identification of important roles of COL1A1 and TNFRSF12A in cartilage injury and osteoporosis by Muzi Liu, Shiguo Gong, Xin Sheng, Zihong Zhang, Xichun Wang

“…Objective The aim of this study was to identify the key regulatory mechanisms of cartilage injury and osteoporosis through bioinformatics methods, and to provide a new theoretical basis and molecular targets for the diagnosis and treatment of the disease.Methods Microarray data for cartilage injury (GSE129147) and osteoporosis (GSE230665) were first downloaded from the GEO database. …”
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Potential Medicinal Fungi from Freshwater Environments as Resources of Bioactive Compounds by Ilenia Cicero, Giulia Mirabile, Giuseppe Venturella

“…Several studies are available in the literature about in vitro and in vivo mechanisms of actions of such bioactive compounds. Most of these surveys are focused on macrofungi belonging to the genera <i>Pleurotus</i>, <i>Ganoderma</i>, or specific taxa such as <i>Agaricus bisporus</i>, <i>Agaricus blazei</i>, <i>Boletus eduliInonotus obliquus</i>, <i>Hericium erinaceus</i>, <i>Lentinula edodes</i>, and <i>Grifola frondose</i>. …”
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Evaluation of Competency-Based Medical Education (CBME) curriculum implementation for Phase II Medical undergraduates: A qualitative study by KRISHNAMURTHY SOUNDARIYA, ANANDABASKAR NISHANTHI, RAJALAKSHMI MAHENDRAN, MOUROUGUESSINE VIMAL

“…The key outcome of the study was establishing various subcommittees within the Curriculum Committee and Medical Education Unit to facilitate the implementation of various CBME components, supported by regular feedback mechanisms. Also, the action plan was shared with the Medical Education Unit to organize appropriate faculty development programs.…”
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Patient perspectives on stress after ICU and a short primary care based psychological intervention – results from a qualitative sub‑study of the PICTURE trial by Antina Beutel, Linda Sanftenberg, Chris M. Friemel, Robert Philipp Kosilek, Maggie Schauer, Thomas Elbert, Ulf-Dietrich Reips, Tomke Schubert, Sabine Gehrke-Beck, Konrad Schmidt, Jochen Gensichen, for the PICTURE study group

“…All of them had experienced an ICU stay with mechanical ventilation and severe organ failure in the previous two years. …”
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Carbapenem resistance in gram-negative pathogens in an Iranian hospital: high prevalence of OXA-type carbapenemase genes by Setareh Mamishi, Reihaneh Hosseinpour Sadeghi, Sadaf Sajedi Moghaddam, Babak Pourakbari, Shiva Poormohammadi, Maryam Sotoudeh Anvari, Shima Mahmoudi

“…Purpose This study aimed to investigate the prevalence of carbapenem resistance in gram-negative bacteria isolated from patients at the Children's Medical Center Hospital, Tehran, Iran, to understand the molecular mechanisms underlying this resistance. Methods During the period spanning from June 2019 to June 2020, 777 gram-negative bacterial strains were isolated. …”
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Machine learning-based identification and validation of amino acid metabolism related genes as novel biomarkers in chronic kidney disease by Guoqing Zhang, Hongyan Luo, Xiaohua Lu, Yonghua Liu, Mei Wang, Bo Li, Haixia Lu, Yali Zheng

“…Also, we mapped the ROC curves.Meanwhile, in order to determine the underlying mechanism and relevant biological features of CKD, we conducted differential analysis between high and low risk subgroups in CKD. …”
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Long non-coding RNA OSTM1-AS1 promotes renal cell carcinoma progression by sponging miR-491-5p and upregulating MMP-9 by Jun-Feng Chen, Sha-Zhou Ye, Ke-Jie Wang, Xiang-yu Meng, Bin-bin Yang, Ke Rong Wu, Qi Ma

“…Here, we examined OSTM1-AS1 functional roles and mechanism in RCC development. OSTM1-AS1 expression was significantly highly expressed among RCC tissue specimens and cell lines. …”
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The Experience of Women with Obstetric Fistula following Corrective Surgery: A Qualitative Study in Benadir and Mudug Regions, Somalia by Adam A. Mohamed, Abiodun O. Ilesanmi, M. David Dairo

“…These were challenges of living with OBF which include “wounds around genitalia, bad odour, incontinences of urine and feces, stigma, isolation, divorce, powerlessness, dependency, financial constraints, and loss of healthy years” and coping mechanisms which include “withdrawal from the community and improved personal hygiene.” …”
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Phenotypic and Genotypic Antibiotic Resistance of Staphylococcus warneri and Staphylococcus pasteuri Isolated from Stuffed Mussels by Nermin Berik, Dilek Kahraman Yılmaz

“…Therefore, it is necessary to clarify the disease effects and mechanisms of the pathogens identified in stuffed mussels.…”
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Comparative Structural and Biophysical Investigation of <i>Lycosa erythrognatha</i> Toxin I (LyeTx I) and Its Analog LyeTx I-b by Amanda Neves de Souza, Gabriele de Azevedo Cardoso, Lúcio Otávio Nunes, Christopher Aisenbrey, Evgeniy Salnikov, Kelton Rodrigues de Souza, Ahmad Saad, Maria Elena de Lima, Jarbas Magalhães Resende, Burkhard Bechinger, Rodrigo Moreira Verly

“…<b>Methods</b>: To understand the mechanisms behind these enhanced properties, comparative analyses of the structural, topological, biophysical, and thermodynamic aspects of the interactions between each peptide and phospholipid bilayers were evaluated. …”
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Biofilm as a supracellular organization of pathogenic bacteria by B.P. Kuzminov, K.D. Mazhak

“…The search for new active substances with anti-biofilm activity based on the analysis of literature data on the structure of bacterial biofilms, mechanisms of their resistance to antimicrobial agents was the purpose of this work. …”
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Binding of LncDACH1 to dystrophin impairs the membrane trafficking of Nav1.5 protein and increases ventricular arrhythmia susceptibility by Genlong Xue, Jiming Yang, Yang Zhang, Ying Yang, Ruixin Zhang, Desheng Li, Tao Tian, Jialiang Li, Xiaofang Zhang, Changzhu Li, Xingda Li, Jiqin Yang, Kewei Shen, Yang Guo, Xuening Liu, Guohui Yang, Lina Xuan, Hongli Shan, Yanjie Lu, Yang Baofeng, Zhenwei Pan

“…The findings provide novel insights into the mechanism of Nav1.5 membrane targeting and the development of ventricular arrhythmias.…”
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Improving long-term postoperative survival in a porcine cardiac valve surgery model utilizing cardiopulmonary bypass via left thoracotomy: a single-center experience sharing insigh... by Qingping Xia, Yong Cao, Jialuan Li, Jie Jiang, Xuan Lu, Li Deng

“…Automatic heart resumption occurred in 63.8% of pigs, while the remainder required electrical defibrillation or cardiac massage. The postoperative mechanical ventilation time was 2.44 ± 0.58 min, and the average drainage volume at 2 h postoperatively was 27.50 ± 9.70 ml. …”
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