Fatty acid metabolism-related signature suggests an oncogenic role of TEKT1 in endometrial cancer by Zhikai Xiahou, Hong Xiao, Yafeng Song, Xin Xu

“…Co-immunoprecipitation and Western blot were performed to determine the mechanism of TEKT1. Results: A prognostic signature based on 10 FAMRGs (ACACB, PTGIS, BMPR1B, DHCR24, FAAH, GPX1, GPX4, INMT, PON3, PPT2) was generated using Lasso Cox hazards regression analysis in TCGA. …”
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Exploitation of the genetic potential of <i>Thinopyrum</i> and <i>Agropyron</i> genera to protect wheat from diseases and environmental stresses by L. Ya. Plotnikova, V. V. Knaub

“…Wheat samples with the tall wheatgrass genes Lr19, Lr38, Sr24, Sr25 and Sr26 showed defence mechanisms similar to nonhosts resistance. Their influence led to disruption of the development of surface infection structures and fungal death when trying to penetrate the stomata (prehaustorial resistance or stomatal immunity). …”
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Extrapolating empirical measurements of wastewater exfiltration from sanitary sewers to estimate watershed-scale fecal pollution loading in urban stormwater runoff by Joshua A. Steele, Adriana González-Fernández, John F. Griffith, Darcy Ebentier McCargar, Sierra Wallace, Kenneth C. Schiff

“…Future work is needed to better understand subsurface transport mechanisms of exfiltrated sewage and to test this approach, and the assumptions used, in other watersheds and sewer systems.…”
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Comparative analysis of sloshing effects on elevated water tanks’ dynamic response using ANN and MARS by Tahera, Neethu Urs, K. Shashi Raj, Rakesh Kumar, Harish Soundalgekar, T. Deepa, Mohd Asif Shah

“…By optimizing water levels to 60% capacity, the study explores sloshing as a potential damping mechanism to mitigate structural vibrations. In comparison to empty tanks, this leads to better damping throughout velocity, acceleration, and displacement responses, which speeds up stabilization and lowers dynamic loads. …”
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Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells by Christian Sávio-Silva, Stephany Beyerstedt, Poliana E. Soinski-Sousa, Expedito B. Casaro, Maria Theresa A. Balby-Rocha, Antônio Simplício-Filho, Jamille Alves-Silva, Érika B. Rangel

“…Diabetic kidney disease (DKD) is a microvascular complication of diabetes mellitus (DM) and comprises multifactorial pathophysiologic mechanisms. Despite current treatment, around 30-40% of individuals with type 1 and type 2 DM (DM1 and DM2) have progressive DKD, which is the most common cause of end-stage chronic kidney disease worldwide. …”
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Profiles of Killer Systems and Volatile Organic Compounds of Rowanberry and Rosehip-Inhabiting Yeasts Substantiate Implications for Biocontrol by Iglė Vepštaitė-Monstavičė, Juliana Lukša-Žebelovič, Violeta Apšegaitė, Raimondas Mozūraitis, Robertas Lisicinas, Ramunė Stanevičienė, Laima Blažytė-Čereškienė, Saulius Serva, Elena Servienė

“…The performed studies deepen our understanding of potential yeast biocontrol mechanisms, highlight the importance of produced antimicrobials and volatiles in ensuring antagonistic efficacy, and prove the relevance of isolated biocontrol yeasts for improving food safety.…”
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Tissue-Specific Autoantibodies Improve Diagnosis of Primary Sjögren’s Syndrome in the Early Stage and Indicate Localized Salivary Injury by Yuebo Jin, Jing Li, Jiali Chen, Miao Shao, Ruijun Zhang, Yichen Liang, Xia Zhang, Xiaoying Zhang, Qin Zhang, Fangting Li, Yaobin Cheng, Xiaolin Sun, Jing He, Zhanguo Li

“…In conclusion, TSAs improve diagnosis of pSS in the early stage, especially in anti-SSA-negative patients, and their tissue-specific nature indicates localized salivary injury, which deserves further studies to clarify the mechanism.…”
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An Adaptive Finite Resolution Selection Scheme for RIS Assisted NOMA Networks by Shady M. Ibraheem, Mona Shokair, Mohamed E. Nasr, Nancy Alshaer

“…Regarding channel state information (CSI), the adaptation mechanism determines which user can be considered as a near user and the other as a far user with respect to RIS. …”
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Antiviral and anti-inflammatory activities of favipiravir and quinine sulfate against dengue virus serotype 1 in vitro by Regita Aulia Rosalina, Beti Ernawati Dewi, Fithriyah Fithriyah

“…Further studies are needed to explore the antiviral and anti-inflammatory mechanism of FVP and QS in the DENV-infected models. [ J Adv Biotechnol Exp Ther 2025; 8(1.000): 150-162]…”
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Quasi-weekly oscillation of regional PM_2.5 transport over China driven by the synoptic-scale disturbance of the East Asian winter monsoon circulation by Y. Bai, T. Zhao, K. Meng, Y. Zhou, J. Xiong, X. Sun, L. Shen, Y. Yue, Y. Zhu, W. Hu, J. Yao

“…These findings provide new insights into the understanding of regional PM<span class="inline-formula">_2.5</span> transport with the source–receptor relationship and the meteorological mechanism in atmospheric environment change.</p>…”
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miR-223-3p Inhibits Antigen Endocytosis and Presentation and Promotes the Tolerogenic Potential of Dendritic Cells through Targeting Mannose Receptor Signaling and Rhob by Hao-Cheng Tang, Yin-Yan Lai, Jing Zheng, Hong-Yan Jiang, Geng Xu

“…This study is aimed at investigating the effect of miR-223-3p on the antigen uptake and presentation capacities of DCs and the underlying molecular mechanism. Methods. FITC-OVA antigen uptake and cell surface markers in bone marrow-derived DCs (BMDCs) were analyzed by flow cytometry. …”
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Polymorphism of the LCT gene regulatory region in Turkicspeaking populations of the Altay-Sayan region (southern Siberia) by I. V. Pilipenko, M. S. Pristyazhnyuk, V. F. Kobzev, M. I. Voevoda, A. S. Pilipenko

“…Ascertainment of the molecular-genetic causes of lactase persistence has made this trait one of the most convenient for studying mechanisms of human population adaptation to environmental conditions. …”
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Low-Dose Irradiation Differentially Impacts Macrophage Phenotype in Dependence of Fibroblast-Like Synoviocytes and Radiation Dose by Lisa Deloch, Jana Fuchs, Michael Rückert, Rainer Fietkau, Benjamin Frey, Udo S. Gaipl

“…We now examined for the first time how LD-RT influences FLS and bone marrow-derived macrophages in co-culture systems of an experimental model of RA to reveal further mechanisms of immune modulatory effects of low and intermediate dose of ionizing radiation. …”
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Preliminary characterization and evaluation of local concrete sludges for use as supplementary cementitious materials by Ashfaque Ahmed Jhatial, Iveta Nováková, Eirik Gjerløw, Christian John Engelsen

“…An increase in the specific surface area and a decrease in the particle size of CS were observed after grinding, showing the potential for mechanical activation of CS as a potential SCM. However, prolonged pulverization beyond 30 minutes is not recommended, as only marginal improvement beyond 30 minutes of pulverization were observed. …”
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Exploration and characterization of lipid-degrading bacteria from palm oil mill effluent by P. Periadnadi, N. Nurmiati, F.W. Siregar, T.W. Edelwis

“…This study provided valuable insights for future investigations aimed at unraveling the intricate mechanisms governing lipid degradation and fostering environmentally friendly solutions for industrial waste management.…”
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Potential biomarkers and immune infiltration linking endometriosis with recurrent pregnancy loss based on bioinformatics and machine learning by Jianhui Chen, Qun Li, Xiaofang Liu, Fang Lin, Yaling Jing, Jiayan Yang, Lianfang Zhao

“…Epidemiologic data have suggested the correlation between EMs and recurrent pregnancy loss (RPL), but the pathological mechanism is unclear. This study aims to investigate the potential biomarkers and immune infiltration in EMs and RPL, providing a basis for early detection and treatment of the two diseases.MethodsTwo RPL and six EMs transcriptomic datasets from the Gene Expression Omnibus (GEO) database were used for differential analysis via limma package, followed by weighted gene co-expression network analysis (WGCNA) for key modules screening. …”
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Integrating machine learning and structure-based approaches for repurposing potent tyrosine protein kinase Src inhibitors to treat inflammatory disorders by Muhammad Waleed Iqbal, Muhammad Shahab, Zakir ullah, Guojun Zheng, Irfan Anjum, Gamal A. Shazly, Atrsaw Asrat Mengistie, Xinxiao Sun, Qipeng Yuan

“…Orlistat, acarbose and afatinib were identified as the potent leads, demonstrating stable conformations and stronger interactions, validated by root mean square deviation (RMSD), root mean square fluctuation (RMSF), radius of gyration (RoG), and hydrogen bond analyses. Molecular Mechanics/Generalized Born Surface Area (MMGBSA) analysis validated their binding affinities by providing comparably lower binding free energies for orlistat (− 33.4743 ± 3.8908), acarbose (− 19.5455 ± 5.4702), and afatinib (− 36.4944 ± 5.4929) than the control, dasatinib (− 13.7785 ± 5.8058). …”
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Evaluating the Performance of Aluminum Oxide Nanoparticle-Modified Asphalt Binder and Modelling the Viscoelastic Properties by Using Artificial Neural Networks and Support Vector M... by Mustafa Alas, Sani Isah Abba, Shaban Ismael Albrka Ali, Abdur Rahim, Nur Izzi Md. Yusoff

“…In addition, heuristic modelling techniques, artificial neural networks (ANN), and support vector machines (SVM) were employed to predict the performance characteristics of AC by using the mechanical testing conditions. The frequency sweep test and multiple stress creep recovery (MSCR) test results revealed that the optimum composition of Al2O3 was at 5% concentration considering the high temperature performance characteristics since further addition of the Al2O3 resulted in degradation in the enhanced properties due to agglomeration of the nanoparticles in the blend. …”
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A review of approaches to the integration of humanitarian and development aid: the case of drought management in the Horn of Africa by Tahira Shariff Mohamed, Todd Andrew Crane, Samuel Derbyshire, Guyo Roba

“…It surveys implications that arise in relation to the question of how best to address persistent drought in the Horn of Africa. Interrogating mechanisms for enhancing aid efficiency and effectiveness including crisis modifiers and contingency planning, the paper examines what progress has been made in transitioning from reactive, short-term emergency response to long-term development and what barriers still exist. …”
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The role of CGIAR Germplasm Health Units in averting endemic crop diseases: the example of rice blast in Bangladesh by Yuji Enriquez, Melinda Smale, Nelissa Jamora, Mohammod Hossain, Lava Kumar

“…The Germplasm Health Units (GHUs) of the CGIAR are phytosanitary mechanisms put in place to help ensure safe (from pests and diseases) and efficient international transfer of germplasm among genebanks and breeding programs around the world. …”
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