Experimental Validation of Antiobesogenic and Osteoprotective Efficacy of Ginsenoside CK via Targeting Lipid and Atherosclerosis Pathways by Md. Niaj Morshed, Reshmi Akter, Imran Mahmud, Ah-Yeong Gwon, Jin Woo Jeang, Yeong-Geun Lee, Dae Won Park, Deok Chun Yang, Yeon Ju Kim, Se-Chan Kang

“…These encouraging results demonstrate the possible use of CK as an innovative treatment for controlling obesity and osteoporosis, targeting the underlying mechanisms of obesogenic and bone loss. Further studies are necessary to explore the clinical implications of these results and the potential of CK in future treatment strategies. …”
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Genome-wide identification and characterization of the bZIP family in the Mangrove Plant Kandelia obovata and its role in response to stress by Yuchong Yi, Yuting Qiu, Hongyao Hu, Dandan Qin, Hechen Huang, Taiping Chen, Wenqi Zha, Yingjia Shen

“…The mangrove plant Kandelia obovata, native to subtropical and tropical coastal intertidal zones, has evolved various adaptive mechanisms to cope with unstable muddy substrates, tidal fluctuations, saltwater intrusion, and intense ultraviolet radiation. …”
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Lodging in wheat: genetic and environmental factors and ways of overcoming by E. V. Ageeva, I. N. Leonova, I. E. Likhenko

“…The diameter of the stem, its thickness and weight, a large number of vascular bundles and a wide ring of mechanical tissues correlate with resistance to lodging. …”
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Skin Closure Technique and Postprocedural Pain after Spinal Cord Stimulator Implantation: A Retrospective Review by Markus A. Bendel, Ryan S. D’Souza, Taylor J. North, Thomas P. Pittelkow, Jonathan M. Hagedorn

“…The most efficacious mechanism of surgical closure—specifically a running suture closure compared to a surgical staple closure—is debated. …”
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Soil total carbon as a key factor affects soil biota attributes in plant mixtures over time: A meta-analysis by Huiling Zhang, Jinshan Cai, Xu Yang, Jing Huang, Xuan Zhou, Dima Chen

“…However, the potential mechanisms that regulate soil biota (microbes and fauna) attributes (biomass, activity, and abundance) to plant mixtures over experimental time are still unclear. …”
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Galectin-3 secreted by triple-negative breast cancer cells regulates T cell function by Annat Raiter, Yael Barhum, Julia Lipovetsky, Chen Menachem, Sharona Elgavish, Shmuel Ruppo, Yehudit Birger, Shai Izraeli, Orna Steinberg-Shemer, Rinat Yerushalmi

“…Consequently, T exhausted cells (CD8/PD1/Tim3/Lag3+) significantly increased in PBMC co-cultured with Gal-3pos TNBCs.To conclude, we revealed a novel TNBC-related Gal-3 suppressor mechanism that involved upregulation of CD4 T regulatory and of CD8 T exhausted cells.…”
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Teacher competency and work engagement among secondary school physical education teachers: the multiple mediating roles of occupational stress, emotional exhaustion, and profession... by Weisong Chen, Zhen Huang, Bo Peng, Lin Li, Jingsong Chen

“…Structural invariance analysis confirmed that the model was consistent across genders, demonstrating robust applicability across male and female teacher populations.ConclusionTeacher competency is a key driver of work engagement, operating through both direct and indirect mechanisms, particularly by alleviating occupational stress and enhancing professional achievement. …”
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Role of hypothalamic-pituitary-adrenal axis and catecholamine factors in independent and primary multiple types of tumor growth by E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, Yu. A. Pogorelova, N. D. Cheryarina, L. K. Trepitaki, I. V. Neskubina, A. A. Vereskunova, I. M. Kotieva, K. A. Shumarin, A. I. Shikhlyarova, I. V. Goroshinskaya

“…At independent and primary multiple types of tumor growth, the sex-specific features of the functioning of the adrenal axis at the central and peripheral levels are observed, which determines a more pronounced stressful state of the body with B16+LLC combination growth, realized by various mechanisms.…”
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Parameter Sensitivity Analysis of the Hydraulic Fracture Growth Geometry in a Deep Shale Oil Formation: An Experimental Study by Shanzhi Shi, Yushi Zou, Lihua Hao, Beibei Chen, Shicheng Zhang, Xinfang Ma, Shipeng Zhang

“…In order to fully understand the law of hydraulic fracture propagation in the formation during fracturing construction, the anisotropy characteristics and basic reservoir physical parameters (mineral composition and rock strength parameters) of rock were obtained through mineral composition test and indoor rock mechanics test (Brazil splitting test), and it was found that the heterogeneity was strong. …”
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High-Density Genetic Map Construction and QTL Detection for Cotyledon Color in Faba Bean Based on Double Digest Restriction-Site Associated DNA Sequencing (ddRAD-Seq) by Changcai Teng, Hongyan Zhang, Wanwei Hou, Ping Li, Xianli Zhou, Yujiao Liu

“…Therefore, an in-depth study of the genetic mechanism of cotyledon color is vital for promoting faba bean industry development. …”
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Human_SNP_TATAdb: a database of SNPs that statistically significantly change the affinity of the TATA-binding protein to human gene promoters: genome-wide analysis and use cases by S. V. Filonov, N. L. Podkolodnyy, O. A. Podkolodnaya, N. N. Tverdokhleb, P. M. Ponomarenko, D. A. Rasskazov, A. G. Bogomolov, M. P. Ponomarenko

“…The Institute of Cytology and Genetics SB RAS (ICG) has developed a method for predicting TBP affinity for gene promoters based on a three-step binding mechanism: (1) TBP slides along DNA, (2) TBP stops at the binding site, and (3) the TBP-promoter complex is fixed due to DNA helix bending. …”
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Chlamydia trachomatis Growth and Cytokine mRNA Response in a Prostate Cancer Cell Line by Ivan M. Petyaev, Naylia A. Zigangirova, Elena Y. Morgunova, Nigel H. Kyle, Elena D. Fedina, Yuriy K. Bashmakov

“…Furthermore, propagation of C. trachomatis in CWR-R1 cells leads to enhanced transcription of interleukin-6 and fibroblast growth factor-2, genes encoding two important proinflammatory cytokines implicated in the molecular mechanisms of chemoresistance of prostate cancer and its ability to metastasize. …”
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Phytoplankton growth and succession driven by topography and hydrodynamics in seasonal ice-covered lakes by Ziyue Zhao, Yanfeng Wu, Y. Jun Xu, Yexiang Yu, Guangxin Zhang, Dehua Mao, Xuemei Liu, Changlei Dai

“…However, there is a lack of in-depth research that accurately depicts underwater topography and coupleing hydrodynamics to establish the reproduction and migration mechanisms of phytoplankton, especially in seasonal ice-covered lakes. …”
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Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice by Mengjie Liu, Zhenlin Li, Jie Li, Guorong Yan, Chaoqi Liu, Qingqiang Yin, Yeqiang Liu, Xiaoxiang Xu

“…Deoxynivalenol (DON) is a prevalent mycotoxin, causing extreme liver damage. However, the mechanism whereby COS alleviates DON-induced liver injury remains unclear. …”
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Modified Xiao-Qing-Long-decoction prevents inflammation and promotes Nur77 expression in mice with acute respiratory distress syndrome by inhibiting HDAC7 expression by Qing Zhang, Yafen Liu, Lu Jiang, Dongdong Yang

“…Context Modified Xiao-Qing-Long-decoction (MXQLD) is believed to have the potential to alleviate lung diseases.Objective We explored the effects and mechanisms of MXQLD in acute respiratory distress syndrome (ARDS).Materials and methods Thirty male C57BL/6 mice were randomized into sham (distilled water), model (distilled water), MXQLD (1 g/kg MXQLD), DEX (distilled water + 0.7 mg/kg dexamethasone), MXQLD + oe-HDAC7 (HDAC7 over-expression + 1 g/kg MXQLD) groups. …”
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Pt@ZnCo₂O₄ Microspheres as Peroxidase Mimics: Enhanced Catalytic Activity and Application for L-Cysteine Detection by Shuqi Liao, Weisen Deng, Feng Yang, Jutao Zhou, Ling Wu, Donghong Yu, Zhong Cao

“…Using fluorescent probes and electrochemical methods, the peroxidase-like catalytic mechanism has been explored that Pt@ZnCo₂O₄ microspheres can accelerate the electron transfer between H₂O₂ and 3,3′,5,5′-tetramethylbenzidine (TMB). …”
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Screening Southeast Asian medicinal plants: Clausena lansium, Leea indica, Strobilanthes crispa, Vitex trifolia for anti-platelet aggregation and blood coagulation effects by Sogand Zareisedehizadeh, Fu-Xun Heng, Chay-Hoon Tan, Paul Chi-Lui Ho, Hwee-Ling Koh

“…These compounds, particularly kaempferol, quercetin, epigallocatechin-3-O-gallate, and β-sitosterol, contribute to Leea indica's potent antiplatelet and anticoagulant effects through multiple mechanisms, including inhibition of platelet activation and various coagulation factors. …”
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Synergistic photothermal conversion and visible-light photodegradation of antibiotic in S-type TiO2 derived Ti3C2-MXene loaded on NaYF4: Tm3+, Er3+, Yb3+ @BiOI by Seyyedeh Fatemeh Hosseini, Mir Saeed Seyed Dorraji, Shiva Mohajer, Seyedeh Narges Saeedi, Masoumeh Kianfar, Alexandr V. Koshelev, Nataliya A. Arkharova, Denis N. Karimov

“…Excellent catalytic activity is explained by the S-scheme mechanism, which produces holes at the valence band and superoxide radicals at the conductive band in the BiOI and Ti3C2, respectively. …”
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Screening and Functional Pathway Analysis of Pulmonary Genes Associated with Suppression of Allergic Airway Inflammation by Adipose Stem Cell-Derived Extracellular Vesicles by Sung-Dong Kim, Shin Ae Kang, Yong-Wan Kim, Hak Sun Yu, Kyu-Sup Cho, Hwan-Jung Roh

“…Although mesenchymal stem cell- (MSC-) derived extracellular vesicles (EVs) are as effective as MSCs in the suppression of allergic airway inflammation, few studies have explored the molecular mechanisms of MSC-derived EVs in allergic airway diseases. …”
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NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway by Alexander J. Gill, Matthew D. Smith, Danny Galleguillos, Thomas Garton, Jackson W. Mace, Sachin P. Gadani, Swati Kumar, Aayush Pokharel, Krista Solem, Saahith Potluri, Omar Hussein, Giuliana Sardi Rogines, Arihant Singh, Annatje Clark, Peter A. Calabresi, Marjan Gharagozloo

“…Further studies are needed to better understand the cell-specific mechanisms underlying the neuroprotective role of NLRX1 in response to inflammation in the CNS.…”
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