Curcumin and α/β-Adrenergic Antagonists Cotreatment Reverse Liver Cirrhosis in Hamsters: Participation of Nrf-2 and NF-κB by José Roberto Macías-Pérez, Bruno Jesús Vázquez-López, Martin Humberto Muñoz-Ortega, Liseth Rubí Aldaba-Muruato, Sandra Luz Martínez-Hernández, Esperanza Sánchez-Alemán, Javier Ventura-Juárez

“…In addition, carvedilol treatment and the combination of doxazosin with curcumin increased Nrf-2/NF-κB mRNA ratio and its protein expression in the inflammatory cells in the livers, possibly as another mechanism of hepatoprotection. Therefore, these results suggest for the first time that α/β adrenergic blockers with curcumin completely reverse hepatic damage, possibly as a result of adrenergic antagonism on HSC and conceivably by the increase of Nrf-2/NF-κB mRNA ratio.…”
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Effects of weed management on soil metagenomic composition in cultivated chickpea fields by Hammami Imran, Ferchichi Nouha, Toukebri Wael, Wissal M’sehli, Ben Hammouda Thouraya, Ajengui Arwa, Guiga Cyrine, Trabelsi Darine

“…Non-chemical methods, including mechanical and manual weed management are important for improving crop yields and preserving soil microbial diversity. …”
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CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT... by Yongbo Zhang, Sheng Yang, Xuan You, Zhengguang Li, Liuyang chen, Rui Dai, Hua Sun, Liang Zhang

“…The purpose of this study was to investigate the competitive endogenous RNA mechanism involved in the senescence of NPMSCs induced by tert-butyl hydroperoxide (TBHP). …”
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The Effects of Gender Based Violence on Academic Performance of Learners in Selected Primary Schools in Buyanja Sub-County, Rukungiri District. by Katushabe, Aster

“…The study revealed the impact of gender-based violence on the well-being of people in Buyanja Sub-county, Rukungiri District, which included low self-esteem and lack of confidence (21.6%), physical health consequences (16.6%), negative coping mechanisms, social isolation, gender stereotypes, and discrimination (13.3% each). …”
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Neuroprotective Effect of Crocin on Rats with Focal Cerebral Ischemia-Reperfusion Injury Based on TLR4/NF-κB Pathway by LI Xiaolei, ZHU Haisheng, MA Ruijuan, HU Ke, FENG Lina, WANG Xudong

“…ObjectiveTo observe the protective effect of crocin on neurons of rats with focal cerebral ischemia-reperfusion (FCIR) injury based on the toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) pathway, and to explore the possible mechanism of crocin in the prevention and treatment on FCIR injury.MethodsA total of 128 SD rats were divided randomly into sham operation group, model group, crocin group, crocin + lipopolysaccharide group, with 32 rats in each group. …”
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Prevención de eventos trombóticos en pacientes sometidos a cirugía de artrodesis lumbar por vía posterior: experiencia en nuestro centro. Estudio retrospectivo de casos by M. Desviat Ruiz, P. Jordà Gómez, K. Ramón López, J.M. Romero Martínez, J.J. Valls Vilalta, N. Fernández Fernández, Á. Chulvi Gimeno, L. Cuñat Navarro, J. Poyatos Campos

“…All four patients who suffered thrombotic events were receiving anticoagulant drugs, in addition to mechanical compression stockings, because of the presence of risk factors for thrombosis. …”
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Multiomics analysis reveals the involvement of NET1 in tumour immune regulation and malignant progression by Jian Pang, Xiaoyan Huang, Ya Gao, Xinyu Guan, Lejia Xiong, Lun Li, Nana Yin, Mei Dai, Tong Han, Wenjun Yi

“…A deeper understanding of the role of NET1 may provide new insights into the molecular mechanisms of cancer progression and metastasis. This study aims to fill this knowledge gap and provide a more comprehensive understanding of the role of NET1 in cancer biology. …”
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Opposing trends in the peak and low ozone concentrations in eastern China: anthropogenic and meteorological influences by Z. Wang, Z. Wang, C. Shi, C. Shi, H. Zhang, H. Zhang, X. Ji, Y. Zhu, C. Xia, X. Sun, X. Sun, X. Lin, S. Yan, S. Wang, Y. Zhou, Y. Zhou, C. Xing, Y. Chen, Y. Chen, C. Liu, C. Liu, C. Liu, C. Liu

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[Translated article] Thrombotic event prevention in patients undergoing posterior lumbar arthrodesis: Our experience. A retrospective case series study by M. Desviat Ruiz, P. Jordà Gómez, K. Ramón López, J.M. Romero Martínez, J.J. Valls Vilalta, N. Fernández Fernández, Á. Chulvi Gimeno, L. Cuñat Navarro, J. Poyatos Campos

“…All four patients who suffered thrombotic events were receiving anticoagulant drugs, in addition to mechanical compression stockings, because of the presence of risk factors for thrombosis. …”
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Computational Modeling and Experimental Investigation of CO₂-Hydrocarbon System Within Cross-Scale Porous Media by Feiyu Chen, Linghui Sun, Bowen Li, Xiuxiu Pan, Boyu Jiang, Xu Huo, Zhirong Zhang, Chun Feng

“…The phase behavior of CO₂ and hydrocarbons at different scales significantly affects oil recovery efficiency, yet its underlying mechanisms remain insufficiently understood. This study improves existing thermodynamic models by introducing Helmholtz free energy as a convergence criterion and incorporating adsorption effects in micro- and nano-scale pores. …”
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The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP by Zigmunds Orlovskis, Archana Singh, Adi Kliot, Weijie Huang, Saskia A Hogenhout

“…Obligate parasites often trigger significant changes in their hosts to facilitate transmission to new hosts. The molecular mechanisms behind these extended phenotypes - where genetic information of one organism is manifested as traits in another - remain largely unclear. …”
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Preliminary investigation on the establishment of a new meibomian gland obstruction model and gene expression by Ming Sun, Huanmin Cheng, Zheng Yang, Jiangqin Tang, Shengshu Sun, Zhanglin Liu, Shaozhen Zhao, Lijie Dong, Yue Huang

“…Abstract Meibomian gland dysfunction is a chronic ocular surface disease with a complex pathogenesis, whose main clinical manifestations are meibomian gland obstruction or/and lipid abnormalities. To explore the mechanism of MGD due to meibomian gland obstruction (MGO), we established a rat model of MGO by cauterizing the meibomian gland orifice. …”
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Two-dimensional cell membrane chromatography guided screening of myocardial protective compounds from Yindan Xinnaotong soft capsule by Si-Min Shao, Xuan Ji, Xing Wang, Run-Zhou Liu, Yu-Ru Cai, Xiaobing Lin, Ze-Jie Zeng, Ling Chen, Liu Yang, Hua Yang, Wen Gao

“…Additionally, an RNA-seq approach was employed to predict the targets and mechanisms of YD and the active compounds for myocardial protection. …”
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Integrating machine learning with mendelian randomization for unveiling causal gene networks in glioblastoma multiforme by Lixin Du, Pan Wang, Xiaoting Qiu, Zhigang Li, Jianlan Ma, Pengfei Chen

“…Despite advances in understanding its molecular mechanisms, effective therapeutic strategies remain elusive due to the tumor’s genetic complexity and heterogeneity. …”
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Metabolic profile of blood serum in experimental arterial hypertension by A. A. Seryapina, A. A. Malyavko, Yu. K. Polityko, L. V. Yanshole, Yu. P. Tsentalovich, A. L. Markel

“…The etiology of essential hypertension is intricate, since it employs simultaneously various body systems related to the regulation of blood pressure in one way or another: the sympathetic nervous system, renin-angiotensin-aldosterone and hypothalamic-pituitary-adrenal systems, renal and endothelial mechanisms. The pathogenesis of hypertension is influenced by a variety of both genetic and environmental factors, which determines the heterogeneity of the disease in human population. …”
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Severe primary graft failure: Are there lasting impacts? Analysis from the PHTS Database by Jennifer Conway, MD, Tara Pidborochynski, MSc, James K. Kirklin, MD, Ryan Cantor, PhD, Hong Zhao, PhD, Aryaz Sheybani, MD, Jacqueline Lamour, MD, Lakshmi Gokanapudy Hahn, MD, Leslie Collins, MD, Jessica Laks, MD, Darren H. Freed, MD, PhD

“…PGF was defined as death, retransplantation, or need for mechanical circulatory support within 72 hours of HTx. …”
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Association of blood inflammatory phenotypes and asthma burden in children with moderate-to-severe asthma by Amir Hossein Alizadeh Bahmani, Susanne J.H. Vijverberg, Simone Hashimoto, Christine Wolff, Catarina Almqvist, Lizan D. Bloemsma, Susanne Brandstetter, Paula Corcuera-Elosegui, Mario Gorenjak, Susanne Harner, Anna M. Hedman, Michael Kabesch, Leyre López-Fernández, Aletta D. Kraneveld, Anne H. Neerincx, Maria Pino-Yanes, Uroš Potočnik, Olaia Sardón-Prado, Barbara S. Dierdorp, Tamara Dekker, Nariman K.A. Metwally, Jan Willem Duitman, René Lutter, Paul Brinkman, Mahmoud I. Abdel-Aziz, Anke H. Maitland-van der Zee

“…Background Underlying immunological mechanisms in children with moderate-to-severe asthma are complex and unclear. …”
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Iron-oxidizing microorganisms affect the iron-bound organic carbon in the subsoil of alpine grassland during the thawing of seasonal frozen soil by Yuxin Tian, Maidinuer Abulaizi, Zailei Yang, Tianle Kou, Yuanbin Jia, Yunpeng Hu, Mo Chen, Mo Chen, Mo Chen, Hongtao Jia, Hongtao Jia, Hongtao Jia

“…We characterized changes in the Fe phase, Fe-OC, Fe-oxidizing bacteria (FeOB), and Fe-reducing bacteria (FeRB) in the subsoil and analyzed the microbial mechanism underlying Fe-OC changes in alpine grassland by constructing a composite structural equation model (SEM). …”
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Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction by Lijiang Wei, Naifu Wan, Wentong Zhu, Chenchen Liu, Zeyu Chen, Wuwei Rong, Lujun Zhang, Meifeng Xie, Yueqi Qin, Ting Sun, Qing Jing, Ankang Lyu

“…Although existing reports indicating that mixed lineage kinase domain-like protein (MLKL) is involved in macrophage necroptosis and inflammasome activation, the downstream mechanism of MLKL in necroptosis remain poorly characterized in AMI. …”
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Endometrial Cancer Cells Promote M2-Like Macrophage Polarization by Delivering Exosomal miRNA-21 under Hypoxia Condition by Li Xiao, Yumin He, Fan Peng, Jianlin Yang, Chengfu Yuan

“…In summary, we found that endometrial cancer KEL cells in hypoxic condition promoted monocyte THP-1 cell transformation to M2-like polarization macrophages through delivering exosomal miRNA-21, which may be a potential mechanism of the formation of the immune microenvironment in EC progression.…”
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