High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis by Peng Zou, Tianjing Li, Zixuan Cao, Erwan Yang, Mingdong Bao, Haofuzi Zhang, Zhuoyuan Zhang, Dan Liu, Min Zhang, Xiangyu Gao, Junmiao Ge, Xiaofan Jiang, Zhicheng Tian, Peng Luo

“…Our study provides a theoretical foundation for further understanding of the mechanism of high-altitude hypoxic TBI and targeted intervention therapy.…”
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Helicobacter pylori infection promotes M1 macrophage polarization and gastric inflammation by activation of NLRP3 inflammasome via TNF/TNFR1 axis by Xiao Fei, Sihai Chen, Leyan Li, Xinbo Xu, Huan Wang, Huajing Ke, Cong He, Chuan Xie, Xidong Wu, Jianping Liu, Yong Xie, Nonghua Lu, Yin Zhu, Nianshuang Li

“…However, the molecular mechanism by which H. pylori infection drives NLRP3 inflammasome and macrophages activation remains unclear. …”
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The impact of weight change on suicide mortality: a nationwide population-based cohort study of 2 million Koreans by Kyuho Kim, Jin-Hyung Jung, Yoo Hyun Um, Yu-Bae Ahn, Seung-Hyun Ko, Kyungdo Han, Jae-Seung Yun

“…To better understand the mechanisms through which weight change affects suicide mortality, studies incorporating information on weight change intentions, medications, weight change-related medical conditions are needed.…”
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Saussurea costus alleviates ulcerative colitis by regulating the gut microbiota and improving intestinal barrier integrity by Wen-lin Pang, Wen-lin Pang, Tian-gang Li, Tian-gang Li, Yin-ying Wang, Yin-ying Wang, Li-yun Song, Li-yun Song, Li Li, Li Li, Xiao-ya Li, Xiao-ya Li, Yong Qiu, Yong Qiu, Zhong-shan Yang, Zhong-shan Yang

“…Nevertheless, its underlying mechanism remains elusive.MethodsFirstly, we identified the main active components of SC through UHPLC-QTOF-MS analysis. …”
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Boards' strategic involvement models: Past, present, and future by Bozhinovska Tihona, Eftimov Ljupcho

“…Background: The research on boards' strategic involvement has increased dramatically in the last few decades due to the need for improving boards' strategic effectiveness as a mechanism for improving organizational performance. …”
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A computational time integrator for heat and mass transfer modeling of boundary layer flow using fuzzy parameters by Muhammad Shoaib Arif, Wasfi Shatanawi, Yasir Nawaz

“…It is imperative to comprehend the mechanics of heat and mass transfer to enhance aeronautical technology, forecast weather, and design thermal systems that are more efficient. …”
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Prevalence, risk factors and clinical features of sensory A-V pattern exotropia by Bin-Bin Zhu, Shi-Yu Tang, Xiang-Jun Wang, Li-Cheng Fu, Jian-Hua Yan

“…AIM: To investigate the potential mechanisms of A-V pattern and evaluate the surgical outcomes used in the treatment of sensory exotropia. …”
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Integrating microplastic research in sustainable agriculture: Challenges and future directions for food production by Marcelo Illanes, María-Trinidad Toro, Mauricio Schoebitz, Nelson Zapata, Diego A. Moreno, María Dolores López-Belchí

“…Currently, the application of omics technologies, including genomics, transcriptomics, and metabolomics, offers novel insights into molecular mechanisms that enable the identification of specific biomarkers associated with MP exposure. …”
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Effect of Mining Thickness on Overburden Movement and Underground Pressure Characteristics for Extrathick Coal Seam by Sublevel Caving with High Bottom Cutting Height by Yongkang Yang, Yanrong Ma, Chunxu Ji, Tianhe Kang, Xingyun Guo

“…Some conclusions can be drawn as follows: (i) under the “beam-hinged cantilever beam rocks” structure theory, the rock pillar thickness which needs to be controlled increases linearly as a function of mining thickness is achieved, and the reason of increased of support resistance in full-mechanized caving mining in extremely thick seams is explained in the theory; (ii) based on the results of the theoretical analysis and the lab simulation tests, the law of the abutment pressure peak is inverse to the full-seam mining thickness, and the distance between abutment peak and working face is proportional to the full-seam mining thickness, that is to say that the damage range of overlying strata increased; (iii) there are three working states of loading support in extrathick coal seams, such as normal circumstance, lower main roof pressure, and higher main roof pressure, meanwhile these states keep changing; (iv) under the guarantee of stope safety conditions, due to lower support strength, it will benefit the special thick seam top-coal caving under normal circumstance; (v) increasing the supporting strength can balance the impact loading under the lower main roof pressure, guaranteeing valid support for roof strata; (vi) by releasing high pressure, due to lower production, lower recovery rate of coal and other measures guarantee the stability of the stope support in the case of the higher main roof pressure.…”
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Infectious Aortitis with Abdominal Aortic Aneurysm in a 47-Year-Old Female with Systemic Lupus Erythematosus by Valerie R. Ramiro, Carmegie C. Saliba, John Anthony D. Tindoc, Marinette R. Jambaro, Enrique M. Chua, Donna Ricca M. Hornilla, Maria Teresa B. Abola

“…Abdominal imaging revealed a saccular infrarenal aneurysm with dissection. An atherosclerotic mechanism was primarily considered, but a vasculitic process was likewise considered due to elevated acute phase reactants. …”
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Transcriptomics-based analysis of neurotoxic and reproductive effects in turbot (Scophthalmus maximus) after exposure to tris (2-chloroethyl) phosphate (TCEP) by Xiaoqian Zhou, Weifeng Liu, Bailin Cong, Aifang Deng, Jing Lin, Linlin Zhao, Shenghao Liu

“…However, the specific mechanisms of TCEP-induced neurological and reproductive toxicity in fish are largely unknown. …”
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The impact of online education during the Covid-19 pandemic on the professional identity formation of medical students: A systematic scoping review. by Jonathan Zhen Liang, Donovan Kai Wei Ng, Vijayprasanth Raveendran, Mac Yu Kai Teo, Elaine Li Ying Quah, Keith Zi Yuan Chua, Jun Kiat Lua, Jasmine Lerk Juan Owyong, Andrew Vimal Vijayan, Nur Amira Binte Abdul Hamid, Ting Ting Yeoh, Eng Koon Ong, Gillian Li Gek Phua, Stephen Mason, Warren Fong, Crystal Lim, Natalie Woong, Simon Yew Kuang Ong, Lalit Kumar Radha Krishna

“…The Funnelling Process identified online programs (encapsulating the content, approach, structures and the support mechanisms); their effects; and PIF development that framed the domains guiding the discussion. …”
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PABPN1 functions as a downstream gene of CREB to inhibit the proliferation of preadipocytes by Xiao-Han Zhang, Jia-Xin Li, Xiao-Xu Wu, Qian Zhang, Ming Tian, Si-Qi Yang, Di Liu, Xiu-Qin Yang

“…These results suggest that the CREB/PABPN1 axis plays a role in the regulation of preadipocyte proliferation, which will contribute to further revealing the mechanism of fat accumulation.…”
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Relationship Between Soil Aggregate Stability and Associated Carbon and Nitrogen Changes Under Different Ecological Construction Measures in the Karst Region of Southwest China by Meiting Li, Keqin Wang, Xiaoyi Ma, Mingsi Fan, Biyu Li, Yali Song

“…This study aims to quantify the effects of various ecological construction measures on soil aggregate stability, including focusing on geometric mean diameter (GMD), mean weight diameter (MWD), and K values, as well as aggregate-related organic carbon (SOC) and total nitrogen (TN), soil mechanical composition, and aggregate content. The ecological construction measures examined include plantation forests (Y7th–rgl), restored forests (Y6th–zr), fruit forests (Y6th–jgl), and contour reverse slope terraces (Y1th–crt). …”
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Quantification of Rear-End Crash Risk and Analysis of Its Influencing Factors Based on a New Surrogate Safety Measure by Qiangqiang Shangguan, Ting Fu, Junhua Wang, Rui Jiang, Shou’en Fang

“…Traditional surrogate measures of safety (SMoS) cannot fully consider the crash mechanism or fail to reflect the crash probability and crash severity at the same time. …”
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Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis by Yijian Deng, Liying Zeng, Yigui Lai, Shuai Ji, Baizhao Peng, Hanqi Lu, Ming Wang, Hiu Yee Kwan, Qi Wang, Xiaoshan Zhao

“…Conclusion: The results of this analysis indicate a positive association between the circulating BCAA concentrations and the risk of ED, but their underlying mechanisms require further investigation.…”
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Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng, Can Lu, Qiuqiu Li

“…Background Clofarabine (Clo) is a Food and Drug Administration (FDA)-approved drug for the treatment of acute lymphoblastic leukemia; however, its effects on solid tumors remain largely unknown.Methods In vitro and in vivo experiments have demonstrated the cytotoxic effects of Clo on melanoma and lung cancer. The molecular mechanisms of Clo-induced tumor cell death were analyzed using western blotting, ELISA, reverse transcription-PCR, immunofluorescence, co-immunoprecipitation (CO-IP), short hairpin RNA, co-culture, chromatin immunoprecipitation, and flow cytometry. …”
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Bivalirudin exerts antiviral activity against respiratory syncytial virus-induced lung infections in neonatal mice by Zhuang Shihao, Tang Qiuyu, Chen Ping, Wang Chengyi, Liu Guanghua

“…Thus, the study shows that RSV infection induces specific changes in lung tissue and the clotting related signalling mechanism. Additionally, BR treatment significantly reduces bronchiolitis and prevents the severity of the infections suggesting that BR can possibly be used to reduce the viral-mediated infections in neonates.…”
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Liposomal Formulations: A Recent Update by Surendra S. Agrawal, Vrinda Baliga, Vaishali Y. Londhe

“…Innovative drug loading and release mechanisms highlighted in this review of next-generation liposomal formulations. …”
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Helicobacter mastomyrinus infection induces autoimmune hepatitis in mice by Liqi Zhu, Yuanyuan Liang, Linghan Yang, Qihui Yang, Jun Yin, Tao Wang, Xiangming Xu, Quan Zhang

“…Nevertheless, research on its role and mechanisms in causing liver disease is severely limited. …”
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