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  1. 21901

    Novel, low-cost bioreactor for in vitro electrical stimulation of cardiac cells by Joseph P. Licata, Jonathan A. Gerstenhaber, Peter I. Lelkes

    Published 2025-02-01
    “…Finite element analysis and mathematical modeling were used to model the fluid dynamics and to characterize in detail the delivery of pulsatile electrical signals, providing precise control over stimulation parameters such as voltage, current, and charge.ResultsThe bioreactor developed here provides an easy-to-use, inexpensive platform for culturing hiPSC-CMs under the influence of ES and low-shear fluid flow for enhanced nutrient availability, while its “drop-in” design facilitates real-time observation of cultured cells. …”
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