Durable responders in advanced NSCLC with elevated TMB and treated with 1L immune checkpoint inhibitor: a real-world outcomes analysis by David P Carbone, David Spigel, Jeffrey S Ross, Karthikeyan Murugesan, Gerald Li, Richard S P Huang, Ryon P Graf, Geoffrey R Oxnard, Alexa Schrock, Liangliang Zhang, Khaled Tolba, Jacob Sands

“…Here, we examined the complementary roles of tumor mutational burden (TMB) and programmed death ligand-1 (PD-L1) immunohistochemistry (IHC) to inform first-line therapy using a large real-world (rw) data set.Materials and methods The study included patients with NSCLC from an rw de-identified clinico-genomic database. …”
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The Policy and Governance Observatory as a Facilitator of Smart and Evidence-based Governance by Atiye Yousefi, Mahdi Abdolhamid

“…Case study This study examines the structure of policy and governance observatories through a survey of 32 observatories around the world.Materials and Methods In this research, the purposive sampling and content analysis method has been used. …”
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Actitudes sobre la gestación subrogada en alumnas de Trabajo Social en México by Luis Manuel Rodríguez Otero

“…La subrogación es el proceso por el cual una mujer gesta un feto con material genético de otras personas y establece un contrato, mediante el que cede la filiación a uno tercero/s. …”
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Comparison of Functioning, Quality of Life, and Cognition between Lithium and Sodium Valproate Combination Therapy and Sodium Valproate Monotherapy in Euthymic Bipolar Patients: A... by M Ashwini, R Jhamuna, V Jaikumar

“…Aim: To compare the functioning, quality of life and cognitive functioning of euthymic bipolar patients on lithium and sodium valproate combination therapy with those on sodium valproate monotherapy. Materials and Methods: The present hospital-based cross-sectional study was conducted in the Outpatient Department, Institute of Mental Health, Madras Medical College, Chennai, Tamil Nadu, India, from March 2017 to July 2017. …”
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Control of the ratio of monovalent and bivalent ions in drinking water treatment by nanofiltration method by D. V. Spitsov, A. G. Pervov, I. A. Abrosimova

“…Operational costs are evaluated and compared with conventionally used approach to produce drinking quality water from ground water.Materials and methods. A series of experiments were conducted to remove lithium from ground water and to demonstrate the efficiency of the new developed method of ion separation. …”
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Fruit Quality and Production Parameters of Some Bitter Cherry Cultivars by Ionel Perju, Iulia Mineață, Sorina Sîrbu, Iuliana Elena Golache, Ionuț Vasile Ungureanu, Carmen Doina Jităreanu

“…<i>sylvestris</i> Ser.) represent a valuable raw material in the traditional Eastern European food industry with high potential within the horticultural chain and circular economy in the context of global food security due to exceptional nutritional properties. …”
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Electrical and Viscoelastic Parameters of Erythrocytes as a Part of Diagnostic Models for Differentiating Fatty Liver Disease of Mixed Genesis from Non-Alcoholic and Alcohol-Relate... by M. V. Kruchinina, M. F. Osipenko, M. V. Parulikova, A. A. Gromov

“…Aim: creation of diagnostic models including electrical, viscoelastic parameters of erythrocytes to distinguish fatty liver disease of mixed etiology (metabolic + alcoholic) from non-alcoholic and alcoholic fatty liver disease.Materials and methods. We examined 46 men with non-alcoholic fatty liver disease (NAFLD), 43 men with alcoholic fatty liver disease (AFLD), as well as 54 men with fatty liver disease (FLD) of mixed genesis (metabolic + alcohol-related); average age of the patients included in the study made 48.4 ± 9.6 years. …”
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Remimazolam Suppresses Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury by Regulating AKT/GSK-3&beta;/NRF2 Pathway by Duan M, Yu N, Liu J, Zhao Y, Zhang J, Song S, Wang S

“…Therefore, we explored whether remimazolam activates protein kinase B (AKT)/glycogen synthase kinase-3β (GSK-3β)/nuclear factor erythroid 2-related factor 2 (NRF2) to attenuate brain I/R injury in transcerebral I/R-injured rats and transoxygenic glucose deprivation/reperfusion (OGD/R)-injured SY5Y cells.Material and Methods: Remimazolam was added at the beginning of cell and rat reperfusion, and the PI3K/AKT inhibitor LY294002 was added to inhibit the AKT/GSK-3β/NRF2 pathway 24 h before cellular OGD/R treatment and 30 min before rat brain I/R treatment. …”
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Artificial intelligence analysis of thermal energy for convectively heated ternary nanofluid flow in radiated channel considering viscous dissipations aspects by Hamid Qureshi, Amjad Ali Pasha, Muhammad Asif Zahoor Raja, Zahoor Shah, Salem Algarni, Talal Alqahtani, Waqar Azeem Khan, Moinul Haq

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The Model of Disengagement of Talent with Meta-synthesis Method by Ali Asghar Mobasheri, Ali Nasr Isfahani, Hadi Teimouri

“…After an extensive search and review of available sources, the selection of appropriate materials was conducted by evaluating the titles, abstracts, and content of the identified sources. …”
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A PEDAGOGIA DA ALTERNÂNCIA COMO PROPOSTA DE EDUCAÇÃO NO CAMPO: UM ESTUDO NA ESCOLA FAMÍLIA AGRÍCOLA ITAPIREMA EM RONDÔNIA, BRASIL by Claudineia Ferreira dos Santos, Charles Carminati de Lima, Yanet Reimondo Barrios, Daniete Fernandes Rocha

“…The research identified a lack of investments in infrastructure and teaching materials in the school. However, it is noteworthy in the study that the totality of the former students is satisfied with the school. …”
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Interleukin 15‐Presenting Nanovesicles with Doxorubicin‐Loaded Ferritin Cores for Cancer Immunochemotherapy by Yihui Zhai, Wen Zhang, Jinming Wang, Ying Kong, Rong Rong, Tianqun Lang, Chao Zheng, Yanke Wang, Yang Yu, Helen He Zhu, Ying Cai, Pengcheng Zhang, Yaping Li

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Network Pharmacology, Molecular Docking, and Molecular Dynamics Analysis of Honokiol against Triple-negative Breast Cancer by Hassan H. Alhassan

“…Settings and Design: The study employed a multidisciplinary approach, combining network pharmacology analysis, molecular docking simulations, and molecular dynamics simulations to elucidate the molecular mechanisms of honokiol against TNBC. Materials and Methods: Network pharmacology analysis was used to identify potential protein targets and signaling pathways associated with honokiol’s activity. …”
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Prevalence of Japanese encephalitis in pigs in Mainland China during 2000–2024: a systemic review and meta-analysis by Xue-Tong Liu, Li-Dong Jiang, Yu-Ting Lin, Ran Zhao, Qi Wang, Shu-Ying Zhang, Shu-Ying Zhang, Shu-Ying Zhang, Emad Beshir Ata, Xin Liu, Yuan Wang, Zi-Xuan Liu, Cui Xu, Ying Xiao, Yi-Fan Wang, Xue Leng, Qing-Long Gong, Rui Du, Rui Du, Rui Du

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Synthesis of Fe3O4@MIL-101-OH/Chitosan for adsorption and release of doxorubicin by Iman Najafipour, Nafiseh Emami, Pegah Sadeh, Adonis Amoli, Sareh Mosleh-Shirazi, Ali Mohammad Amani, Hesam Kamyab, Shreeshivadasan Chelliapan, Seyed Reza Kasaee, Ehsan Vafa

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Trends, challenges and solutions of digital information security in Central and Eastern Europe by Serhii Lubenets, Igor Harchenko, Tetiana Shediakova

“…The problems and directions of ensuring effective international digital information security in Central and Eastern Europe (CEE) are considered, which are based on the analysis of the current state, key trends and challenges of information security in this region, using current reporting materials of international companies specializing in information security issues and development of appropriate complex tools for its provision. …”
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Comparison of Proximal Tibiofibular Joint Detachment with Tibial-Sided Osteotomy for Fibular Untethering in Lateral Closing-Wedge High Tibial Osteotomy: A Cadaveric Study by Ryu Kyoung Cho, Keun Young Choi, Dai-Soon Kwak, Man Soo Kim, Yong In

“…The aim of this study was to compare the degree of completion and safety of PTFJD versus tibial-sided osteotomy (TSO); this latter procedure is our novel technique for fibular untethering during LCWHTO. <i>Materials and Methods:</i> Sixteen fresh frozen cadaver knees from eight cadavers were included in the study. …”
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Evaluation and Management of Patients with Seizures in the Emergency Department: A One-Year Analysis by K. Puteikis, K. Zdanytė, R. Mameniškienė

“…The study aims to determine the prevalences of causes of TLoC in the ED, analyse the characteristics of patients with seizures or established epilepsy in particular and estimate the level of evaluation and management they receive in respect to available international guidelines. Materials and methods. The data was cross-sectional and was retrieved from the local database of Vilnius University Hospital Santaros Klinikos from January 1st to December 31st, 2016. …”
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COMPETENZE CHIAVE PER IL CURRICOLO VERTICALE: L’OPINIONE DEGLI INSEGNANTI E I MATERIALI DIDATTICI by Matteo La Grassa, Monica Barni

“…Key competences for the vertical curriculum: teachers’ opinions and teaching materials In this contribution we present the first results of a qualitative survey, carried out in schools in Tuscany, which aimed to verify what knowledge and importance is given in the educational sphere to the Key Competences for Lifelong Learningdescribed by the 2006 European Recommendation and updated by the 2018 Recommendation, and whether there is systematic planning on these competences within schools and whether the conditions are in place for their effective development from a vertical and transversal perspective across the various disciplines. …”
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S’approprier, c’est résister. Appropriations spatiales et mobilisation infra-politique des femmes en immobilité résidentielle et sociale dans les bidonvilles de Salé (Maroc)... by Myriame Ali-Oualla

“…Sub-political mobilisation through the material consolidation of living space, and the refusal to leave it, sometimes makes it possible to obtain “in situ resettlement”, i.e. the official allocation by the state of plots of land to be built on the shantytown site, at subsidised cost. …”
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