Adjuvant endocrine therapy with cyclin-dependent kinase 4/6 inhibitor, ribociclib, for localized hormone receptor-positive/HER2– breast cancer (LEADER) by Laura M. Spring, Lauren Scarpetti, Arielle J. Medford, Andrzej Niemierko, Amy Comander, Therese Mulvey, Lowell Schnipper, Steven J. Isakoff, Beverly Moy, Seth A. Wander, Jennifer Shin, Zanta Ephrem, Anneke R. Laposta, Elyssa Denault, Elizabeth Abraham, Gayle Calistro, Ekaterina Kalashnikova, Angel Rodriguez, Minetta C. Liu, Alexey Aleshin, Jeffrey Peppercorn, Leif W. Ellisen, Aditya Bardia

Get full text

Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma by Douglas A Lauffenburger, Khloe S Gordon, Caleb R Perez, Andrea Garmilla, Maxine S Y Lam, Joey J Y Aw, Anisha Datta, Andrea Pavesi, Michael E Birnbaum

Get full text

Anti-VEGF therapy improves EGFR-vIII-CAR-T cell delivery and efficacy in syngeneic glioblastoma models in mice by Dai Fukumura, Rakesh K Jain, Jun Ren, Xinyue Dong, Zohreh Amoozgar, Somin Lee, Meenal Datta, Sylvie Roberge, Mark Duquette

Get full text

Randomised, pragmatic, waitlist controlled trial of cannabis added to prescription opioid support on opioid dose reduction and pain in adults with chronic non-cancer pain: study pr... by A Eden Evins, Ellie Grossman, Julia Jashinski, Aurora Quaye, Corinne Cather, Kevin Potter, David A Schoenfeld, Jodi M Gilman

“…We will record adverse events.Ethics and dissemination This study has ethical approval by the Massachusetts General Brigham Institutional Review Board (#2021P000871). …”
Get full text

Effective and Engaging Active Learning in the Medical School Classroom: Lessons from Case-Based Collaborative Learning by Henrike C. Besche, Randall W. King, Keri M. Shafer, Sarah E. Fleet, Julia F. Charles, Tamara B. Kaplan, Katie A. Greenzang, Melanie P. Hoenig, Richard M. Schwartzstein, Barbara A. Cockrill, Krisztina Fischer

Get full text

Impetus of US hospital leaders to invest in patient-reported outcome measures (PROMs): a qualitative study by Andrea L Pusic, Marilyn Heng, Danny Mou, Rachel C Sisodia, Meredith B Rosenthal, Barbara Bokhour, Christer Mjåset, Claire M Sokas, Azan Virji

Get full text

Utilizing multidisciplinary mobile outreach clinics to provide comprehensive diabetic foot care to patients experiencing homelessness by Kris M. Boelitz, MD, Jaeyoung Lee, BS, Michael D. Pepin, BS, Yiming Zhang, MS, Mallory Gibbons, MSN, NP, Frances J. Lagana, DPM, Shahida Balaparya, EdD, MBA, RVT, Lindsey Carr, Jessin Varghese, BS, NP, Caitlin Sorensen, MD, Jessica P. Simons, MD, MPH, Douglas Jones, MS, MD, Andres Schanzer, MD, Tammy T. Nguyen, MD, PhD

Get full text

Advancing tritium self-sufficiency in fusion power plants: insights from the BABY experiment by Rémi Delaporte-Mathurin, Nikola Goles, John Ball, Collin Dunn, Emily Edwards, Sara Ferry, Edward Lamere, Andrew Lanzrath, Rick Leccacorvi, Samuele Meschini, Ethan Peterson, Stefano Segantin, Rui Vieira, Dennis Whyte, Weiyue Zhou, Kevin Woller

Get full text

Self-Cleaning Textiles for Publicly Shared Soft Surfaces: An Accessible and Scalable Photocatalytic Polyester System with Embedded Light-Emitting Diodes by Aditi Maheshwari, Fiona Bell, Eric Gallo, Mihai Ibanescu, Emily Robertson, Charlotte Fairless, Francis Logan, Mary Jane Schmuhl, Henry Cheung, Michael Rein, Andreea Danielescu, Mirela Alistar

Get full text

Racial Disparities of Alcohol-Associated Liver Disease and Its Complications in Hospitalized Patients With Alcohol Use Disorder by Soo Young Hwang, Elina Stoffel, David Sooik Kim, Elizabeth Verna, Wei Zhang

Get full text

Temperature-Dependent Water Oxidation Kinetics: Implications and Insights by Tianying Liu, Pan Wang, Wei Li, David Z. Wang, Damith D. Lekamge, Boqiang Chen, Frances A. Houle, Matthias M. Waegele, Dunwei Wang

Get full text

A multiresolution approach with method-informed statistical analysis for quantifying lymphatic pumping dynamics by Mohammad S. Razavi, Katarina J. Ruscic, Elizabeth G. Korn, Marla Marquez, Timothy T. Houle, Dhruv Singhal, Lance L. Munn, Timothy P. Padera

Get full text

Mesenchymal Hippo signaling regulates intestinal homeostasis in adult mice by Kyvan Dang, Alka Singh, Xin Chen, Jennifer L. Cotton, Susu Guo, Xiaodi Hu, Zhipeng Tao, Haibo Liu, Lihua J. Zhu, Y. Tony Ip, Xu Wu, Junhao Mao

Get full text

Immunostimulatory/Immunodynamic model of mRNA‐1273 to guide pediatric vaccine dose selection by Vijay Ivaturi, Husain Attarwala, Weiping Deng, Baoyu Ding, Sabine Schnyder Ghamloush, Bethany Girard, Javid Iqbal, Saugandhika Minnikanti, Honghong Zhou, Jacqueline Miller, Rituparna Das

Get full text

UW supplementation with AP39 improves liver viability following static cold storage by McLean Taggart, Saige Holkup, Alexandra Tchir, Mohammadreza Mojoudi, Arnaud Lyon, Madeeha Hassan, Christopher Taveras, Ozge Sila Ozgur, James F. Markmann, Heidi Yeh, Korkut Uygun, Alban Longchamp

Get full text

Geometric squeezing of rotating quantum gases into the lowest Landau level by Crépel, Valentin, Yao, Ruixiao, Mukherjee, Biswaroop, Fletcher, Richard, Zwierlein, Martin

Get full text

Equitable artificial intelligence for glaucoma screening with fair identity normalization by Min Shi, Yan Luo, Yu Tian, Lucy Q. Shen, Nazlee Zebardast, Mohammad Eslami, Saber Kazeminasab, Michael V. Boland, David S. Friedman, Louis R. Pasquale, Mengyu Wang

Get full text

Probing aspects of extracellular vesicle associated AAV allows increased vector yield and insight into its transduction and immune-evasive properties by Ming Cheng, Demitri de la Cruz, Adam V. Crain, Paula Espinoza, Carrie Ng, Zachary C. Elmore, Aravind Asokan, Casey A. Maguire

Get full text

Uptake of HIV pre-exposure prophylaxis and contraception in South African hair salons: a study protocol for a pilot cluster randomised controlled trial by Christina Psaros, Ingrid Bassett, Sabina Medal Govere, Jana Jarolimova, Joyce Yan, Sthabile Shezi, Lungile M Ngcobo, Shruti Sagar, Dani Zionts, Nduduzo Dube, RA Parker

“…We will assess feasibility by collecting process measures and evaluate retention as continued use of PrEP and contraception separately, defined as one additional visit within 6 months with continued use of PrEP and/or contraception.Ethics and dissemination The study has been approved by the University of KwaZulu-Natal Biomedical Research Ethics Committee and the Massachusetts General Brigham Institutional Review Board. …”
Get full text

Enhancing social functioning using multi-user, immersive virtual reality by D. J. Holt, N. R. DeTore, B. Aideyan, L. Utter, L. Vinke, D. S. Johnson, J. Zimmerman, K. N. Dokholyan, A. Burke

Get full text