N6-methyladenosine-modification of USP15 regulates chemotherapy resistance by inhibiting LGALS3 ubiquitin-mediated degradation via AKT/mTOR signaling activation pathway in hepatoce... by Ronghuan Fang, Zhigang Jia, Yuhang Xin, Kai Zhao, Wei Qin, Haoran Lu, Yi Zhou, Yongsheng Yang, He Fang

“…Functional analyses of immortalized human liver and HCC cell lines were conducted, including quantitative real-time PCR; western blot; plasmid, lentivirus, and siRNA transfection; co-immunoprecipitation; mass spectrometry; MeRIP-qPCR; and ubiquitination, cell growth, colony formation, and spheroid formation assays. …”
Get full text

Chemical Comparison of White Ginseng before and after Extrusion by UHPLC-Q-Orbitrap-MS/MS and Multivariate Statistical Analysis by Yun-Long Guo, Yang Wang, Yi-Lin Zhao, Xiu-Ying Xu, Hao Zhang, Cheng-Bin Zhao, Ming-Zhu Zheng, Shu-Ying Liu, Yu-Zhu Wu, Jing-Sheng Liu

“…Ultrahigh-performance liquid chromatography Quadrupole-Orbitrap tandem mass spectrometry (UHPLC-Q-Orbitrap-MS/MS) was used to compare the composition of ginsenosides in white ginseng (WG) and extruded white ginseng (EWG). …”
Get full text

Extraction of Saponins from Xanthoceras sorbifolium Bunge Leaves Using Deep Eutectic Solvents and Their Inhibitory Activity against Postharvest Pathogenic Fungi by Xue LI, Xinyu CHU, Erzheng SU, Jiahong WANG

“…The extracts were characterized using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The mechanism of XLs saponins extraction by DES was investigated by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). …”
Get full text

Antiviral Activity of the Marine Haptophyta <i>Diacronema lutheri</i> by Eleonora Montuori, Annalisa Ambrosino, Gerardo Della Sala, Costanza Ragozzino, Gianluigi Franci, Carla Zannella, Anna De Filippis, Donatella de Pascale, Massimiliano Galdiero, Chiara Lauritano

“…Liquid chromatography coupled with untargeted high-resolution tandem mass spectrometry (LC-HRMS²) were employed to chart the metabolite distribution in all SPE fractions and pinpoint molecular families unique (or almost unique) to the bioactive fraction. …”
Get full text

Comparison of Extracellular Metabolites and Antioxidant Activity of Different Strains of Wolfiporia hoelen (Fr.) Y.C. Dai &amp;V. Papp by TAN Yun, SHEN Airong, SHEN Baoming, YU Jinxiu, LIU Lina, LI Sainan, TAN Zhuming

“…Totally 55 flavonoids and 33 phenolic compounds were qualitatively detected using ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS). The relative content of each component varied among different W. hoelen strains; the most abundant flavonoid was malonyldaidzin and the most abundant phenolic component was 3-formylsalicylic acid in W. hoelen strains FLA, FGD, FGZ, FHB, GTR1, XJ28 and F5.78. …”
Get full text

Corrosion inhibition effects of eco-friendly clarithromycin molecules on aluminium in hydrochloric acid solution via experimental, theoretical and optimization approach by O.D. Onukwuli, I.A. Nnanwube, F.O. Ochili, M. Omotioma, J.I. Obibuenyi

“…Characterization of the inhibitor was executed with gas chromatography mass spectrometry (GC–MS) and Fourier transform infrared (FTIR) spectroscopy, while optimization of the process was executed with response surface methodology (RSM). …”
Get full text

Recovery of Phenolic Compounds with Antioxidant Capacity Through Solid-State Fermentation of Pistachio Green Hull by Andrés Javier Ordoñez-Cano, Ulises Ramírez-Esparza, Fernando Méndez-González, Mónica Alvarado-González, Ramiro Baeza-Jiménez, Leonardo Sepúlveda-Torre, Lilia Arely Prado-Barragán, José Juan Buenrostro-Figueroa

“…Gallic acid 4-<i>O</i>-glucoside and geranine were identified in the PGH extracts using high-performance liquid chromatography coupled with mass spectrometry. The SSF provides eco-friendly alternatives for releasing bioactive compounds from PGH, adding value to this waste.…”
Get full text

In Vitro and In Vivo Antifungal Activity of Clove (Eugenia caryophyllata) and Pepper (Piper nigrum L.) Essential Oils and Functional Extracts Against Fusarium oxysporum and Aspergi... by Laila Muñoz Castellanos, Nubia Amaya Olivas, Juan Ayala-Soto, Carmen Miriam De La O Contreras, Miriam Zermeño Ortega, Fabiola Sandoval Salas, Leon Hernández-Ochoa

“…Gas chromatography-mass spectrometry (GC-MS) was used to identify eugenol as the principal compound in clove oil and limonene, sabinene, and β-caryophyllene in pepper oil.…”
Get full text

Pharmacokinetics of Eight Flavonoids in Rats Assayed by UPLC-MS/MS after Oral Administration of Drynariae rhizoma Extract by Zhan-Ling Xu, Ming-Yue Xu, Hai-Tao Wang, Qing-Xuan Xu, Ming-Yang Liu, Chun-Peng Jia, Fang Geng, Ning Zhang

“…In order to make good and rational use of Drynariae rhizoma in future, a rapid, sensitive, and selective ultraperformance liquid chromatography-mass spectrometry (UPLC-MS/MS) method was developed to investigate the pharmacokinetics of eight main flavonoids in rat plasma after oral administration of the Drynariae rhizoma extract, including neoeriocitrin, luteolin-7-O-β-D-glucoside, astragalin, naringin, eriodictyol, luteolin, naringenin, and kaempferol. …”
Get full text

Hair Mercury Levels Detection in Fishermen from Sicily (Italy) by ICP-MS Method after Microwave-Assisted Digestion by Giuseppe Giangrosso, Gaetano Cammilleri, Andrea Macaluso, Antonio Vella, Nicolantonio D’Orazio, Stefania Graci, Gianluigi Maria Lo Dico, Fabio Galvano, Margherita Giangrosso, Vincenzo Ferrantelli

“…A number of ninety-six hair samples from Sicilian fishermen were examined for total mercury detection by an Inductively Coupled Plasma Mass Spectrometry (ICP-MS) method. The mercury levels obtained were compared with mercury levels of 96 hair samples from a control group, in order to assess potential exposure to heavy metals of Sicilian fishermen due to fish consumption and closeness to industrial activities. …”
Get full text

Precision fetal cardiology detects cyanotic congenital heart disease using maternal saliva metabolome and artificial intelligence by Ray Bahado-Singh, Nadia Ashrafi, Amin Ibrahim, Buket Aydas, Ali Yilmaz, Perry Friedman, Stewart F. Graham, Onur Turkoglu

“…Metabolomic analyses using Ultra-High Performance Liquid Chromatography/Mass Spectrometry identified 468 metabolites in the saliva. …”
Get full text

Cell-free supernatants from plant growth-promoting rhizobacteria Bacillus albus strains control Aspergillus flavus disease in peanut and maize seedlings by Lai Loi Trinh, Kim Ngoc Le, Hoang Anh Le Lam, Hoai Huong Nguyen

“…These were characterized using rapid chemical assays and ultra-high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight/mass spectrometry (UHPLC-ESI-QTOF/MS), combined with bioinformatic tools such as Global Natural Product Social Molecular Networking (GNPS) and Natural Products Atlas (NPAtlas). …”
Get full text

Intestinal flora composition and fecal metabolic phenotype in elderly patients with sleep disorders combined with type 2 diabetes by Zhuohao Yin, Huaze Xie, Fuyuan Liu, Xue Kong, Wei Chen, Yangfan Gong, Wei Ge

“…The composition feature of intestinal flora and metabolomics in the ESdD group was described through high‐throughput 16S rDNA sequencing and nontargeted analysis based on liquid chromatography–mass spectrometry. Results Gender, body mass index (BMI), T2D, intestinal discomfort, and anxiety depression were independent risk factors for sleep disorders in the elderly. …”
Get full text

Assessment of the Chemical Diversity and Functional Properties of Secondary Metabolites from the Marine Fungus <i>Asteromyces cruciatus</i> by María Paz González-Troncoso, Catalina Landeta-Salgado, Javiera Munizaga, Ruth Hornedo-Ortega, María del Carmen García-Parrilla, María Elena Lienqueo

“…Crude extracts of fungal biomass were analyzed for total phenolic content (TPC), antioxidant capacity (TAC), toxicity, and phenolic compound identification using ultra-high-performance liquid chromatography coupled with high-resolution electrospray ionization mass spectrometry (UHPLC-MS/MS). The analysis revealed the presence of anthraquinone compounds, including emodin (0.36 ± 0.08 mg/g DW biomass) and citrereosein in glucose medium and citrereosein and endocrocin in <i>M. pyrifera</i> medium. …”
Get full text

Evaluation of Antibiotic Resistance and Biofilm Production among Clinical Strain Isolated from Medical Devices by Veronica Folliero, Gianluigi Franci, Federica Dell’Annunziata, Rosa Giugliano, Francesco Foglia, Rossella Sperlongano, Anna De Filippis, Emiliana Finamore, Massimiliano Galdiero

“…Identification of isolates and antibiotic susceptibility testing were performed using Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) and Phoenix Becton Dickinson, respectively. …”
Get full text

Malaria exposure remodels the plasma proteome of Ghanaian children by Aisha M. Mohammed, Charles Ochieng’ Olwal, Andrea Fossati, Nancy K. Nyakoe, Jacqueline M. Fabius, Martin Gordon, Benjamin J. Polacco, Danielle L. Swaney, Gordon A. Awandare, Nevan J. Krogan, Mehdi Bouhaddou, Yaw Bediako

“…The plasma proteome of these children was profiled using a mass spectrometry-based approach and putative protein-based biomarkers and predictors of immune tolerance to malaria were identified. …”
Get full text

Aqueous humor metabolomic profiling identifies a distinct signature in pseudoexfoliation syndrome by Arturs Zemitis, Arturs Zemitis, Juris Vanags, Juris Vanags, Theresa Schiemer, Theresa Schiemer, Kristaps Klavins, Kristaps Klavins, Guna Laganovska, Guna Laganovska

“…Intraocular fluid samples from these patients were analyzed using targeted metabolite analysis, performed through HILIC liquid chromatography coupled with mass spectrometry detection.ResultsThe aqueous humor of PEXS patients contains statistically significant higher levels of cystine (p &lt; 0.001), citrulline (p &lt; 0.001), phenylalanine (p = 0.041), tyrosine (p = 0.025), serine (p = 0.030), arginine (p = 0.017), lactic acid (p = 0.055), tryptophan (p = 0.055), and creatinine (p = 0.022). …”
Get full text

Synthesis of Novel Benzothiazole–Profen Hybrid Amides as Potential NSAID Candidates by Iliyan Ivanov, Stanimir Manolov, Dimitar Bojilov, Yordan Stremski, Gabriel Marc, Stela Statkova-Abeghe, Smaranda Oniga, Ovidiu Oniga, Paraskev Nedialkov

“…The compounds were characterized using techniques such as ¹H- and ¹³C-NMR, FT-IR spectrometry, and high-resolution mass spectrometry (HRMS), with detailed HRMS analysis conducted for each molecule. …”
Get full text

Investigation of <i>Atraphaxis virgata</i>, an Unexplored Medicinal Plant Rich in Flavonoids, as a Functional Material by Soeun Shin, Seunghee Kim, Jeongho Lee, Hyerim Son, Jin-Hyub Paik, Nadezhda Gennadievna Gemejiyeva, Zhanat Zhumabekovna Karzhaubekova, Taek Lee, Hah Young Yoo

“…In this study, phytochemical compounds of <i>A. virgata</i> extracts were identified using high-performance liquid chromatography (HPLC) and gas chromatography–mass spectrometry (GC-MS) and their antioxidant activity was evaluated. …”
Get full text

Thiosemicarbazone-Based Compounds: A Promising Scaffold for Developing Antibacterial, Antioxidant, and Anticancer Therapeutics by Agnieszka Czylkowska, Monika Pitucha, Anita Raducka, Ewelina Fornal, Edyta Kordialik-Bogacka, Sylwia Ścieszka, Marek Smoluch, Franciszek Burdan, Mateusz Jędrzejec, Paweł Szymański

“…The structures of the obtained compounds were confirmed using mass spectrometry, infrared spectroscopy, and NMR spectroscopy. …”
Get full text