The neural activity of auditory conscious perception by Kate L. Christison-Lagay, Aya Khalaf, Noah C. Freedman, Christopher Micek, Sharif I. Kronemer, Mariana M. Gusso, Lauren Kim, Sarit Forman, Julia Ding, Mark Aksen, Ahmad Abdel-Aty, Hunki Kwon, Noah Markowitz, Erin Yeagle, Elizabeth Espinal, Jose Herrero, Stephan Bickel, James Young, Ashesh Mehta, Kun Wu, Jason Gerrard, Eyiyemisi Damisah, Dennis Spencer, Hal Blumenfeld

Get full text

Antenatal pelvic floor muscle exercise intervention led by midwives in England to reduce postnatal urinary incontinence: APPEAL feasibility and pilot randomised controlled cluster... by Karla Hemming, Jonathan Bishop, Sarah Dean, Jean Hay-Smith, Tim Coleman, Elizabeth Edwards, Christine MacArthur, Debra Bick, Mark Pearson, Rohini Terry, Eivor Oborn, Sara Webb, Eleni Gkini, Victoria Salmon, Ellie Jones, Helena Frawley

Get full text

Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology by Anand E. Rajesh, Abraham Olvera-Barrios, Alasdair N. Warwick, Yue Wu, Kelsey V. Stuart, Mahantesh I. Biradar, Chuin Ying Ung, Anthony P. Khawaja, Robert Luben, Paul J. Foster, Charles R. Cleland, William U. Makupa, Alastair K. Denniston, Matthew J. Burton, Andrew Bastawrous, Pearse A. Keane, Mark A. Chia, Angus W. Turner, Cecilia S. Lee, Adnan Tufail, Aaron Y. Lee, Catherine Egan, UK Biobank Eye and Vision Consortium

Get full text

Human Factors Studies to Assess the Usability of the Faricimab Prefilled Syringe by Barakat MR, Kwong Jr HM, Marcon G, O'Leary OE, Paris LP, Schneider P, Tang Y, Graff JM

“…Mark R Barakat,1,2 Henry M Kwong Jr,2,3 Gelson Marcon,4 Olivia E O’Leary,4 Liliana P Paris,5 Petrick Schneider,4 Yannan Tang,5 Jordan M Graff2,6,7 1Retina Macula Institute of Arizona, Scottsdale, AZ, USA; 2Department of Ophthalmology, University of Arizona College of Medicine – Phoenix, Phoenix, AZ, USA; 3Associated Retina Consultants, Phoenix, AZ, USA; 4F. …”
Get full text

Identification of SLC35A1 as an essential host factor for the transduction of multi-serotype recombinant adeno-associated virus (AAV) vectors by Xiujuan Zhang, Siyuan Hao, Zehua Feng, Kang Ning, Cagla Aksu Kuz, Shane McFarlin, Donovan Richart, Fang Cheng, Ander Zhang-Chen, Richenda McFarlane, Ziying Yan, Jianming Qiu

“…Notably, the SLC35A1 KO markedly increased transduction of rAAV9 and rAAV11, which primarily attach to cells via binding to galactose. …”
Get full text

A c-type lectin HcLec1 with dual function of immunology and mineralization from the freshwater oyster (Hyriopsis cumingii Lea) by Xiaofeng Chen, Xiaoya Shen, Shijun Liu, Wenjuan Li, Wenjuan Li, He Wang, Jiale Li, Jiale Li, Zhiyi Bai, Zhiyi Bai

“…In animal models for shell damage and nucleus insertion in pearl cultivation, HcLec1 showed a consistent expression pattern, with an initial significant decrease followed by a marked increase, peaking at day 14 (P < 0.05). …”
Get full text

Therapeutic effects of composite probiotics derived from fermented camel milk on metabolic dysregulation and intestinal barrier integrity in type 2 diabetes rats by Tabusi Manaer, Tabusi Manaer, Tabusi Manaer, Tabusi Manaer, Jialehasibieke Sailike, Xin Sun, Baheban Yeerjiang, Baheban Yeerjiang, Baheban Yeerjiang, Baheban Yeerjiang, Xinhua Nabi, Xinhua Nabi, Xinhua Nabi, Xinhua Nabi

“…CPCM lowered serum DAO, D-lactate, and LPS levels (all p < 0.001). mRNA levels of TGR5 and CYP7A1 in the liver, and TGR5 and FXR in the colon, were markedly elevated (all p < 0.001). Histological examinations revealed reduced pancreatic inflammation and hepatic steatosis, with restored colonic structure.ConclusionCPCM treatment significantly improved metabolic dysregulation in the T2DM rat model, reducing blood glucose and lipid levels, enhancing intestinal barrier function, and increasing insulin secretion. …”
Get full text

Specifically blocking αvβ8-mediated TGF-β signaling to reverse immunosuppression by modulating macrophage polarization by Cuicui Guo, Hui Sun, Yulei Du, Xiaodong Dai, Yu Pang, Zhen Han, Xinhui Xiong, Shaowei Li, Junhua Zhang, Qingbing Zheng, Xun Gui

“…Combining αvβ8 targeting with PD-1 treatment markedly increases the sensitivity of immune-excluded tumors. …”
Get full text

THE ORGANIZATION WORKS TO IMPROVE THE CLINICAL AND ECONOMIC OUTCOMES OF CARE FOR PROSTATE CANCER by O. I. Apolikhin, A. V. Sivkov, I. V. Chernishov, M. I. Katibov, O. V. Zolotukhin, I. A. Shaderkin, S. A. Leonov, D. A. Vojtko, M. Y. Prosyannikov

“…From 2009 to 2013 an improvement of a number of indicators was marked: increase in the absolute number of patients with newly diagnosed prostate cancer from 451 to 603 cases, a localized increase in the share stages with 60.3% to 71.2 %, a decrease of deaths within one year from the date of diagnosis for prostate cancer from 14.6% to 6.5% and deaths among all registered patients with prostate cancer from 10.4% to 5.5%, reducing the proportion of clinically insignificant PCA from 36.4 to 14.1%.Conclusions. …”
Get full text

Targeting PCSK9, through an innovative cVLP-based vaccine, enhanced the therapeutic activity of a cVLP-HER2 vaccine in a preclinical model of HER2-positive mammary carcinoma by Laura Scalambra, Francesca Ruzzi, Olga Maria Pittino, Maria Sofia Semprini, Chiara Cappello, Stefania Angelicola, Arianna Palladini, Patrizia Nanni, Louise Goksøyr, Cyrielle Fougeroux, Manuel L. Penichet, Adam Frederik Sander, Pier-Luigi Lollini

“…The combined vaccine approach elicited strong anti-human HER2 antibody responses (reaching 1–2 mg/ml range) comprising multiple immunoglobulins isotypes. cVLP-PCSK9 vaccine elicited anti-PCSK9 antibody responses, resulting in a marked reduction in PCSK9 serum levels. Although the anti-PCSK9 response was reduced when co-administered with cVLP-HER2, it remained significant. …”
Get full text

A pulsed carbon dioxide laser-induced breakdown analysis for chemical profile of tsunami-affected soil by R. Mitaphonna, N. Idris, M. Ramli, N. Ismail, K. Kurihara, K. Lahna

“…BACKGROUND AND OBJECTIVES: The catastrophic 2004 Indian Ocean tsunami left a profound mark, triggering significant contamination of organic and inorganic chemical components in the water and soil of affected regions. …”
Get full text

Efficacy and safety of PD-1 inhibitors as second-line treatment for advanced squamous esophageal cancer: a systematic review and network meta-analysis with a focus on PD-L1 express... by Fei Yang, Min Dan, Jindan Shi, Ling Fan, Haoluo Zhang, Tiantian Jian, Kelu Lei, Yue Wang, Juan Xin, Zhigang Yu, Wei Chen

“…Moreover, Nivolumab (OR = 0.13, 95% CI: 0.08-0.20) was associated with a markedly lower risk of Grade ≥ 3 AEs compared to chemotherapy. …”
Get full text

Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial by André Luiz Schuh Teixeira da Rosa, Marina Ribeiro Barreto da Costa, Gabriela Bezerra Sorato, Felipe de Moura Manjabosco, Érica Bonganhi de Bem, Lucas Dellazari, Arthur Bezerra Falcão, Lucas de Oliveira Cia, Olivia Sorato Bezerra, Rogério Boff Borges, Luis Augusto Rohde, Ana Soledade Graeff-Martins

“…Our study represents the first open-label trial to explore the anti-aggressive effects of clozapine in this specific demographic, marking a pioneering step in clinical investigation. …”
Get full text

Lentivirus‐mediated gene therapy for Fabry disease: 5‐year End‐of‐Study results from the Canadian FACTs trial by Aneal Khan, Dwayne L. Barber, William M. McKillop, C. Anthony Rupar, Christiane Auray‐Blais, Graeme Fraser, Daniel H. Fowler, Alexandra Berger, Ronan Foley, Armand Keating, Michael L. West, Jeffrey A. Medin

“…Circulating α‐gal A activity was observed at Day 6–8 in each patient following infusion and has remained durable for 5+ years. LV marking of peripheral blood cells has remained durable and polyclonal. …”
Get full text

Probiotic Supplementation Alleviates Corticosterone-Induced Fatty Liver Disease by Regulating Hepatic Lipogenesis and Increasing Gut Microbiota Diversity in Broilers by Yuyan Feng, Wenqing Mei, Qu Chen, Xiaojing Chen, Yingdong Ni, Mingming Lei, Jie Liu

“…However, probiotic supplementation markedly decreased the intrahepatic lipid accumulation and steatosis histological score, which was associated with the downregulation of sterol regulatory element-binding protein-1 (<i>SREBP1</i>) and acetyl-CoA carboxylase (<i>ACC</i>) mRNA (<i>p</i> < 0.05) and the expression of its protein (<i>p</i> = 0.06). …”
Get full text

Efficacy of the internet-based intervention “Cultivating our resilience” (CORE) for improving resilience and coping strategies in university students: A randomized controlled trial... by Rocio Herrero, Marvin Franke, Dennis Görlich, Azucena Garcia-Palacios, Rosa Baños, Corinna Jacobi, Thomas Berger, Michael P. Schaub, Tobias Krieger, David D. Ebert, Cristina Botella

“…The college stage is marked by high prevalence of mental disorders, particularly anxiety, low mood, and substance abuse. …”
Get full text

USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer by Fang Yuan, Juan Xu, Lingmei Xuan, Chan Deng, Wei Wang, Rong Yang

“…We found that DGS had marked antiproliferative effects in radiosensitive ESCA cell lines. …”
Get full text

Surgeon Preference and Clinical Outcome of 3D Vision Compared to 2D Vision in Laparoscopic Surgery: Systematic Review and Meta-Analysis of Randomized Trials by Rawin Amiri, BSc, Maurice J. W. Zwart, PhD, Leia R. Jones, BSc, Mohammad Abu Hilal, PhD, FRCS, Harrie P. Beerlage, PhD, FEBU, Mark I. van Berge Henegouwen, PhD, Wytze W. Lameris, PhD, Willem A. Bemelman, PhD, Marc G. Besselink, MD, MSc, PhD

Get full text

The role of nutrient availability and resorption efficiency and their impact on nutrient conservation in mangroves by M.E.B. Gerona-Daga, R.A. MacKenzie, L.G. Sumabat-Dacones, C.F.P. Naputo, S.G. Salmo III

“…The calculations were performed to determine the leaf nitrogen to phosphorus ratio, nitrogen resorption efficiency, phosphorus resorption efficiency, and the ratio of nitrogen resorption efficiency to phosphorus resorption efficiency based on the nutrient concentrations.FINDINGS: While there was a marked difference in the nutrient composition of soil and leaves across various stand types, the data did not indicate any clear age-related patterns in the restored and recolonized stands. …”
Get full text

Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel by Kate Halsby, Gerhard Dobler, Ava Easton, Guntis Karelis, Lenka Krbková, Jan Kyncl, Johann Sellner, Franc Strle, Malin Veje, Joanna Zajkowska, Dace Zavadska, Frederick J. Angulo, Andreas Pilz, Wilhelm Erber, Meghan Gabriel, Jon Russo, Mark Price, Harish Madhava, Uta Katharina Meyding-Lamadé

Get full text