Carboplatin-resistance-related DNA damage repair prognostic gene signature and its association with immune infiltration in breast cancer by Shuwen Dong, Anqi Li, Ruixin Pan, Jin Hong, Zheng Wang, Kunwei Shen

“…Compared to the control group, TONSL-knockdown cell lines exhibited a diminished response to DNA-damaging agents, marked by a notable increase in DNA damage levels and enhanced drug sensitivity. …”
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Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice by Yunsheng Liu, Lan Cao, Xiaoxu Zhang, Yan Liang, Yuxia Xu, Cuiqing Zhu

“…Additionally, MEM reduced CRS-induced upregulation of NMDA receptor subunit levels (GluN2A, GluN2B) in the frontal cortex. However, MEM markedly enhanced tau phosphorylation in the frontal cortex and other cerebral cortical regions following 28 days of CRS. …”
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YWHAG promotes bladder cancer metastasis by regulating TMOD3 to activate ERK1/2 and JNK phosphorylation in the MAPK pathway by Tai Tian, Shiming He, Han Hao, Bao Guan, Yanqing Gong, Jian Fan, Zhenpeng Zhu, Wenzhi Gao, Yucai Wu, Ninghan Feng, Aixiang Wang, Yuexian Guo, Xuesong Li

“…Transcriptome analysis revealed that YWHAG knockdown markedly inhibited the phosphorylation of ERK1/2 (extracellular signal-related kinases 1 and 2) and JNK (JUN N-terminal kinases), key components of the MAPK (mitogen-activated protein kinase) signaling pathway. …”
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Transformer-Based Person Detection in Paired RGB-T Aerial Images With VTSaR Dataset by Xiangqing Zhang, Yan Feng, Nan Wang, Guohua Lu, Shaohui Mei

“…This article presents the visible-thermal from SaR scenarios for person detection network (VTSaRNet) to address the challenge of detecting persons situated sparsely in SaR scenes marked by intricate illumination conditions and restricted accessibility. …”
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Feasibility and safety evaluation of ultra-remote robot-assisted laparoscopic hysterectomy by Juyuan Huang, Li'an Li, Jing Cheng, Jing Liao, Yurou Chen, Yi Peng, Sha Wang, Qiongyan Zou, Guoyan Zhao, Wei Zhao, Mengya You, Jingying Yang, Yan Xiong, Kunxian Zhang, Chang Chen, Jiaqiang Xiong, Haotong Guan, Renjie Liu, Peng Zhou, Wuyi Zhao, Yangyang Dong, Xiuli Sun, Sichen Liang, Wei Zhang, Jianliu Wang, Yuanguang Meng

“…This surgery represents the first globally broadcast remote procedure in the field of gynecology, marking a new milestone in the stability and safety of China's remote medical technology. …”
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High-resolution Cryo-EM Structure Determination of a-Synuclein—A Prototypical Amyloid Fibril by Juan Sanchez, Joshua Pierson, Collin Borcik, Chad Rienstra, Elizabeth Wright

“…We detail how sample quality is assessed by negative stain transmission electron microscopy (NS-TEM) analysis and followed by sample vitrification using the Vitrobot Mark IV vitrification robot. We provide a detailed step-by-step protocol for high-resolution cryo-EM structure determination of a-syn fibrils using RELION and a series of specialized helical reconstruction tools that can be run within RELION. …”
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Functional analysis of heterozygous variants in the SALL1 gene in 2 children with Townes-Brocks syndrome with FSGS by Rong Liang, Bixia Zheng, Chunli Wang, Sanlong Zhao, Wei Zhou, Ying Chen, Ruochen Che

“…The expression level of variant c.3175 C > T(p.Q1059X) in podocytes showed a significant decrease compared to that of the wild-type (P < 0.05), whereas variant c.694 C > T(p.Q232X) was markedly upregulated (P < 0.01). Immunofluorescence analysis revealed aberrant localization patterns for both SALL1 variants within podocytes. …”
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Assessing clenbuterol’s modulation of metabolic and inflammatory pathways in Nile tilapia (Oreochromas niloticous) fed high fat diet by Aya G. Rashwan, Doaa H. Assar, Abdallah S. Salah, Muyassar H. Abualreesh, Shimaa M. R. Salem, Norah Althobaiti, Zizy I. Elbialy

“…The results revealed that compared to the control group, HFD exhibited a marked reduction in FBW, BWG, PER, and body protein percent but significantly increased the FCR, IPF, liver fat percent, and body ash percent with altered hematological parameters, raised serum biomarkers of hepatic and renal injury. …”
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A Voting-Based Star Identification Algorithm Using a Partitioned Star Catalog by Xu He, Lei Zhang, Jiawei He, Zhiya Mu, Zhuang Lv, Jun Wang

“…Compared to conventional methods, the proposed algorithm significantly simplifies the navigation feature library and narrows the retrieval region during star identification, markedly enhancing identification speed while effectively reducing the probability of redundant and false matching. …”
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Impact of COVID-19 on the Air Quality over China and India Using Long-term (2009–2020) Multi-satellite Data by Manish Soni, Sunita Verma, Hiren Jethava, Swagata Payra, Lok Lamsal, Priyanshu Gupta, Janhavi Singh

“…Abstract We have examined the air quality over China, India and demonstrated marked differences in levels of air pollution resulted from the COVID-19 restrictions during December–April, 2019–20 to that of 11 years mean of 2009–19. …”
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Bisphenol A attenuates testosterone synthesis via increasing apolipoprotein A1-mediated reverse cholesterol transport in mice by Tong Zhao, Tong Zhao, Wenzhe Yang, Wenzhe Yang, Feilong Pan, Feilong Pan, Jinhao Wang, Jinhao Wang, Wenqi Shao, Wenqi Shao, Fangfang Chen, Fangfang Chen, Kexiang Liu, Kexiang Liu, Shuchen Zhao, Shuchen Zhao, Lijia Zhao, Lijia Zhao

“…Conversely, testicular high-density lipoprotein (HDL) content was partially elevated. Furthermore, BPA markedly enhanced Apoa1 mRNA and protein expression in the mouse model. …”
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Dietary Fiber-Rich <i>Spartina anglica</i> Improves Intestinal Health and Antioxidant Capacity of Zhedong White Geese by Xiao Zhou, Li Wang, Jiuli Dai, Huiyan Jia, Kai Shi, Jian Zhao, Shufang Chen

“…Notably, SA supplementation markedly improved intestinal morphology, although excessive levels appeared to compromise these benefits. …”
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Impact of Silent Cerebral Embolism during and after Left Atrial Appendage Occlusion on Long‐Term Cognitive Function by Kexin Wang, Zhe Wang, Caiyi Jin, Mingjia Xu, Mingfang Li, Hailei Liu, Zidun Wang, Hongwu Chen, Weizhu Ju, Minglong Chen

“…Conclusions LAAO‐related SCE is associated with a marked impairment in cognitive function immediately after the procedure and is irreversible over a 1‐year follow‐up. …”
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Comparative efficacy of different drugs in acute heart failure with renal dysfunction: a systematic review and network meta-analysis by Qianyu Lv, Qian Wu, Yingtian Yang, Lanlan Li, Xuejiao Ye, Shihan Wang, Yanfei Lv, Manshi Wang, Yushan Li

“…No significant difference was found in 60-day all-cause mortality and cardiovascular mortality across drugs.ConclusionHDD showed the best efficacy in reducing NT-proBNP levels compared with dopamine and nesiritide, and levosimendan could significantly improve GFR levels, with no marked difference in the effect of various drugs on 60-day all-cause mortality. …”
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Understanding and measuring workplace violence in healthcare: a Canadian systematic framework to address a global healthcare phenomenon by Christian Schulz-Quach, Brendan Lyver, Charlene Reynolds, Trevor Hanagan, Jennifer Haines, John Shannon, Laura Danielle Pozzobon, Yasemin Sarraf, Sam Sabbah, Sahand Ensafi, Natasha Bloomberg, Jaswanth Gorla, Brendan Singh, Lucas B. Chartier, Marnie Escaf, Diana Elder, Marc Toppings, Brian Hodges, Rickinder Sethi

“…Abstract Background Globally, healthcare institutions have seen a marked rise in workplace violence (WPV), especially since the Covid-19 pandemic began, affecting primarily acute care and emergency departments (EDs). …”
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Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation by Kabita Pradhan, Balram Neupane, Paul Niehues, Martin Kirschner, Fabian Beier, Chao‐Chung Kuo, Erika Anneliese Hilbold, Christian Bär, Oana‐Maria Thoma, Maximilian Waldner, Margherita Vieri, Tim H. Brümmendorf, Vithurithra Tharmapalan, Wolfgang Wagner, Michael Kleines, Mahdi Emrani, Matthias Daniel Zink, Andreas Napp, Nikolaus Marx, Michael Gramlich

“…Finally, atrial tissue of mouse models with shortened telomeres showed marked left atrial fibrosis and over‐expression of fibrosis‐related genes. …”
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Characterisation of internal tremors and vibration symptoms by Harlan M Krumholz, Mitsuaki Sawano, Richa Sharma, Tianna Zhou, Dorothy Massey, Anna D Baker, Diana Berrent Güthe, Nick Güthe, Suzanne Pincus Shidlovsky, Liza Fisher, Connor B Grady, Cesar Caraballo

“…Among the responses, many described symptoms that varied in location, timing and triggers, occurred soon after their COVID-19 infection, and were markedly debilitating. There were often frustrating experiences with the healthcare system.Conclusions This study describes key themes and experiences among a group of people reporting long COVID and having a prolonged and debilitating symptom complex that prominently features internal tremors and vibrations.…”
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Development of HfO₂-Based Solar-Blind SAW UV-C Sensor for Corona Discharge Detection Application by Hyunho Lee, Faisal Nawaz, Eeunsun Shim, Jinjae Lee, Cheol Choi, Keekeun Lee

“…This study presents a novel surface acoustic wave (SAW)-based solar-blind ultraviolet-C (UV-C) corona sensor, marking the first reported use of HfO₂ as a sensing material for UV-C corona sensing. …”
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Evaluation of the antidiabetic and antinephritic effects of Pueraria tuberosa and Pterocarpus santalinus extracts co-encapsulated in nanostructured lipid carriers in streptozotocin... by Gyamcho Tshering Bhutia, Asit Kumar De, Manas Bhowmik, Pavia Bera, Tanmoy Bera

“…The bioactive compounds in these extracts play a crucial role in their antidiabetic and antinephritic effects, marking significant progress in the field.…”
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C1q/TNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components by Feiyu Jiang, Min Yang, Xili Zhao, Rui Liu, Gangyi Yang, Dongfang Liu, Hua Liu, Hongting Zheng, Zhiming Zhu, Ling Li

“…Circulating CTRP5 concentrations were markedly decreased in MetS individuals relative to normal adults. …”
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