AozC, a zn(II)2Cys6 transcription factor, negatively regulates salt tolerance in Aspergillus oryzae by controlling fatty acid biosynthesis by Wenbin Yu, Zeying Zhao, Yufei Zhang, Yayi Tu, Bin He

“…Conversely, the knockdown of AozC via RNA interference significantly enhanced spore density and dry biomass, particularly under 15% salt stress, where these parameters were markedly improved over the wild type strain. Moreover, the overexpression of AozC led to a downregulation of the FAD2 gene, a pivotal enzyme in the biosynthesis of unsaturated fatty acids (UFAs), which are essential for preserving cell membrane fluidity and integrity under saline conditions. …”
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Global survey of limestone used in poultry diets: calcium content, particle size and solubility by S. Gilani, A. Mereu, W. Li, P.W. Plumstead, R. Angel, G. Wilks, Y. Dersjant-Li

“…Mean Ca content of fine limestone (GMD<1000 μm, n=566) was 37.8% (range 33.3-39.7%) and for coarse limestone (GMD>1000 μm, n=75) was 38.0% (range 34.7-40.0%). There was marked variation among and within regions in the concentration of other macro minerals and microminerals. …”
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Genomic data suggest parallel dental vestigialization within the xenarthran radiation by Emerling, Christopher A, Gibb, Gillian C, Tilak, Marie-Ka, Hughes, Jonathan J, Kuch, Melanie, Duggan, Ana T, Poinar, Hendrik N, Nachman, Michael W, Delsuc, Frédéric

“…Echoes of this event are recorded in the genomes of all living anteaters, being marked by a 2-bp deletion in a gene critical for dentinogenesis (DSPP) and a putative shared 1-bp insertion in a gene linked to tooth retention (ODAPH). …”
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EU-TIRADS-Based Omission of Fine-Needle Aspiration and Cytology from Thyroid Nodules Overlooks a Substantial Number of Follicular Thyroid Cancers by Tamas Solymosi, Laszlo Hegedüs, Miklos Bodor, Endre V. Nagy

“…In such nodules (n = 118), the number of suspicious features (marked hypoechogenicity, microcalcifications, irregular shape, and irregular border) per lesion was lower in FTC (0.7 ± 0.6) than in PTC (1.7 ± 1.0) or MTC (1.8 ± 0.7; p<0.02), resulting in EU-TIRADS scores of 4.1 ± 0.6, 4.8 ± 0.3, and 4.9 ± 0.2, respectively (p<0.01). …”
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Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity by Eman Aly Khalifa, Ahmed Nabil Ahmed, Khalid Shaaban Hashem, Ahmad Gad Allah

“…MDA level was significantly lower when combination therapy was used. Marked renal damage was histologically detected in the cisplatin group, whereas the least renal damage was noticed in the combination group. …”
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Collecting duct NCOR1 controls blood pressure by regulating mineralocorticoid receptor by Ke Sun, Yong-Li Wang, Chen-Chen Hou, Da Shang, Lin-Juan Du, Lan Bai, Xing-Yu Zhang, Chuan-Ming Hao, Sheng-Zhong Duan

“…Among the sodium transporter in the collecting duct, the expression of the three epithelial sodium channel (ENaC) subunits was markedly increased in the renal medulla of KO mice. …”
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Cobalt oxide nanoparticles induce cytotoxicity and excessive ROS mediated mitochondrial dysfunction and p53-independent apoptosis in melanoma cells by Hanan R. H. Mohamed, Basma A. Mohamed, George M. Hakeem, Shahd H. Elnawasani, Maria Nagy, Rawan Essam, Ayman Diab, Gehan Safwat

“…Results of qRT-PCR analysis demonstrated remarkable dysregulation of apoptotic and mitochondrial genes, including a significant downregulation of apoptotic p53 and mitochondrial ND3 genes and marked upregulation of the anti-apoptotic gene Bcl2. …”
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Adulthood trajectories of resilience and vulnerability: exploring gender differences in disadvantage after experience of out-of-home care by Lisa Bornscheuer, Evelina Landstedt, Karl Gauffin, Ylva B. Almquist

“…Higher level of education was associated with reduced likelihood of membership in the group marked by disabling health disadvantage (OR = 0.55, p = 0.002) and complex disadvantage (OR = 0.37, p = 0.001). …”
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ICD-11 posttraumatic stress disorder and complex PTSD: prevalence, predictors, and construct validity in Swiss older adults by Myriam V. Thoma, Enya Redican, Nathanael Adank, Valerie B. Schneemann, Mark Shevlin, Andreas Maercker, Shauna L. Rohner

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Dietary Tryptophan Requirement of Juvenile Hybrid Grouper (<i>Epinephelus fuscoguttatus</i>♀ <i>× E. lanceolatus</i>♂) by Jiaxian Chen, Xiaohui Dong, Qihui Yang, Shuyan Chi, Shuang Zhang, Beiping Tan, Junming Deng

“…Furthermore, the activities of Trp metabolism-related enzymes in the liver were markedly elevated by this Trp level, including indoleamine 2,3-dioxygenase, 5-hydroxytryptophan decarboxylase, and tryptophan-2,3-dioxygenase. …”
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Mechanical and microstructural characterization of graphene reinforced Alumina Ceramic matrix composite by Madhankumar Anbazhagan, Anthony Xavior Michael

“…The results demonstrate that a graphene content of 0.5 wt% is best for enhancing the mechanical performance of alumina composites. Graphene markedly enhanced the tribological performance of alumina composites, in addition to mechanical property improvements. …”
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Synthesis and performance analysis of novel SiO2 Janus nanoparticles for enhancing gas foam injection in oil reservoirs by Amir Hossein Saeedi Dehaghani, Reza Gharibshahi, Mohammad Mohammadi

“…Two variations of SiO2 JNPs were synthesized via a masking procedure, employing oleic acid and ascorbic acid within a Pickering emulsion, marking a pioneering approach. These nanoparticles underwent comprehensive analysis for a deeper understanding. …”
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Decision Support Systems adoption in pesticide management [version 2; peer review: 1 approved, 2 approved with reservations] by Efi Vasileiou, Aurora García-Gallego, Jotham Jea Akaka, Mark Ramsden, Jean-Christian Tisserand, Nikolaos Georgantzis

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Endometrial Cancer Cells Promote M2-Like Macrophage Polarization by Delivering Exosomal miRNA-21 under Hypoxia Condition by Li Xiao, Yumin He, Fan Peng, Jianlin Yang, Chengfu Yuan

“…In addition, hypoxia markedly stimulated the increase in miRNA-21 expression in the exosomes. …”
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Review—Recent Progress in Materials Development for Electrochemical Gas Sensors by Kening Lang, Tianyi Liu, Rishi J. Patel, Mark L. Ballentine, Alan J. Kennedy, Wu-Sheng Shih, Adam Scotch, Jiadeng Zhu

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Gelatin/Poly (Lactic-Co-Glycolic Acid)/Attapulgite Composite Scaffold Equipped with Teriparatide Microspheres for Osteogenesis in vitro and in vivo by Zhao Z, Feng X, Zhao Y, Song Z, Zhang R, Zhang K, He Y, Chen G, Zhang J, Wang W

“…Markers of osteoblast activity, including COL1, RUNX2, OCN, and OPN, were markedly up-regulated. Further, micro-CT, histological, and immunohistochemical analyses revealed extensive new bone formation on the scaffold.Conclusion: The GEL/PLGA/ATP composite scaffold, equipped with TPTD microspheres, demonstrates significant potential for use in bone tissue engineering, providing an effective option for bone regeneration and repair in clinical applications. …”
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The potential of the serum uric acid to high-density lipoprotein cholesterol ratio as a predictive biomarker of diabetes risk: a study based on NHANES 2005–2018 by Jianming Yin, Chuanjie Zheng, Xiaoqian Lin, Chaoqiang Huang, Zhanhui Hu, Shuyuan Lin, Yiqian Qu

“…The occurrence of diabetes showed a marked increase across ascending UHR quartiles (6.63%, 10.88%, 14.15%, 18.02%; p &lt; 0.001). …”
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Thrombin Induces COX-2 and PGE2 Expression via PAR1/PKCalpha/MAPK-Dependent NF-kappaB Activation in Human Tracheal Smooth Muscle Cells by Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Chih-Kai Hsu, Chia-Yu Hu, Chuen-Mao Yang

“…Our results verified that thrombin markedly triggered PGE2 secretion via COX-2 upregulation which were diminished by the inhibitor of thrombin (PPACK), PAR1 (SCH79797), Gi/o protein (GPA2), Gq protein (GPA2A), PKCα (Gö6976), p38 MAPK (SB202190), JNK1/2 (SP600125), MEK1/2 (U0126), or NF-κB (helenalin) and transfection with siRNA of PAR1, Gqα, Giα, PKCα, JNK2, p38, p42, or p65. …”
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The Short-Term Effects of Transcranial Direct Current Stimulation on Electroencephalography in Children with Autism: A Randomized Crossover Controlled Trial by Anuwat Amatachaya, Mark P. Jensen, Niramol Patjanasoontorn, Narong Auvichayapat, Chanyut Suphakunpinyo, Suparerk Janjarasjitt, Niran Ngernyam, Benchaporn Aree-uea, Paradee Auvichayapat

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