The emergence of DNAM-1 as the facilitator of NK cell-mediated killing in ovarian cancer by Rachel Pounds, Rachel Pounds, Wayne Croft, Hayden Pearce, Tasnia Hossain, Kavita Singh, Janos Balega, David N. Jeevan, Sudha Sundar, Sudha Sundar, Sean Kehoe, Jason Yap, Jason Yap, Paul Moss, Jianmin Zuo

“…The cell type contexture of metastatic OC tissue was explored utilising scRNAseq analysis, with a focus on portraying an immunogenic tumour microenvironment and determining the characteristics of a dysfunctional NK cell population.ResultsThe proportion of peripheral NK cells was markedly elevated with a highly activated profile and increased cytotoxicity. …”
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Women empowerment, efficiency and food security nexus in rural Ethiopia: A generalized structural equation modeling by Fentahun Tesafa, Messay Mulugeta, Solomon Tsehay

“…Women are disempowered in two major domains including heavy workload and lack of voice in production decisions, which contributed to a marked level of disempowerment at 48 and 22 % respectively. …”
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Incidence and temporal patterns of true recurrences and second primaries in women with breast cancer: A 10-year competing risk-adjusted analysis by Silvia Mancini, Lauro Bucchi, Annibale Biggeri, Orietta Giuliani, Flavia Baldacchini, Alessandra Ravaioli, Federica Zamagni, Fabio Falcini, Rosa Vattiato

“…The subhazard of SBCs fluctuated for five years, had a drop between the 6th and the 7th year and a marked peak between the 8th and the 9th year. Prognostic factors for TRs (tumour stage and grade, lymph node status and residual disease) and SBCs (patient age and –inverse association– hormone therapy) were different. …”
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High interstitial fluid pressure enhances USP1-dependent KIF11 protein stability to promote hepatocellular carcinoma progression by Zhengyi Wu, Chao Li, Shouhua Zhang, Liang Sun, Junwen Hu, Bingbing Qiu, Shuiqiu Liu, Yiran Hong, Tianxiang Chen, Kai Wang, Xiangbao Yin, Jinlong Yan

“…Omics analysis and subsequent molecular validation revealed that KIF11 protein levels were markedly upregulated under HIFP, despite no significant change in mRNA levels. …”
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Intelligent model for forecasting fluctuations in the gold price by Mahdieh Tavassoli, Mahnaz Rabeei, Kiamars Fathi Hafshejani

“…It was concluded that global interest rates had the most significant impact on fluctuations in the gold price, with the Pivot Point DeMark's Index making the greatest contribution.Originality/Value: The gold market is known for its volatility, and accurate predictions about its future can significantly impact decision-making. …”
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Rockfish abundance, recruitment, and community structure trends in the western Strait of Juan de Fuca, Washington, 2005-2023 by Shawn E. Larson, Katie Shelledy, Daniela Escontrela Dieguez, Jeff Christiansen, Amy Y. Olsen, Zachary Randell, Megan H. Williams, Chris VanDamme, Dayv Lowry, William Jasper

“…Strip transects were conducted annually in August from 2005 through 2023 at five permanently marked index sites. Species-specific relative abundance data for bottomfish were later extracted by biologists from archived video. …”
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Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail by Lorena V. Cortés-Medina, Herminia Pasantes-Morales, Alejandro Aguilera-Castrejon, Arturo Picones, Cesar O. Lara-Figueroa, Enoch Luis, Juan Jose Montesinos, Victor A. Cortés-Morales, M. P. De la Rosa Ruiz, Erika Hernández-Estévez, Laura C. Bonifaz, Marco Antonio Alvarez-Perez, Gerardo Ramos-Mandujano

“…The present study showed marked differences between the MSCs from different sources in response to the transdifferentiation protocol used here. …”
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Exploration of techno-functional properties and metabolomic profile of Scleroderma texense (Phutuki Mushroom): a comparative study with Agaricus bisporus (white button mushroom) by Arun Kumar Gupta, Avinash Kumar Jha, Bindu Naik, Vijay Kumar, Sarvesh Rustagi, Milad Tavassoli

“…The levels of K, Ca, Fe, P, and Mg were significantly higher in ST than in AB, marking the first study to report the elemental composition of ST as revealed by EDX. …”
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Composite Primary Outcomes Reported in Studies of Critical Care: A Scoping Review by Prashanti Marella, MD, Sansuka De Silva, Antony G. Attokaran, Kevin B. Laupland, PhD, Lars Eriksson, BA, Mahesh Ramanan, MMed

“…Ventilator-free days were the most commonly reported CPO (29/71, 40.8%) with marked variability in the definition used and death handling (0 d in 33 studies and –1 d in 7 studies). …”
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Antibiotic-induced changes in the human gut microbiota for the most commonly prescribed antibiotics in primary care in the UK: a systematic review by Alastair D Hay, Alyson L Huntley, Karen T Elvers, Esther T van der Werf, Victoria J Wilson, Ashley Hammond, Lorna Duncan

“…Doxycycline was associated with a marked short-term decrease in Bifidobacterium diversity. …”
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Evidence that transverse variability of critical current density can greatly mitigate screening current stress in high field REBCO magnets by Jeseok Bang, Jonathan Lee, Griffin Bradford, Kwangmin Kim, Xinbo Hu, Dmytro Abraimov, Jan Jaroszynski, Anatolii Polyanskii, So Noguchi, Seungyong Hahn, David C. Larbalestier

“…Our computed screening current stresses were markedly lowered by this $$J_c$$ gradient. This paper shows the importance of considering such transverse $$J_c$$ variability, which has not previously been considered, in the precise stress analysis of ultra-high-field REBCO magnets.…”
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Effects of replacing fishmeal with soybean meal on growth performance, liver antioxidant capacity and intestinal health in juvenile Asian red-tailed catfish (Hemibagrus wyckioides) by Weijia Cai, Xinping Li, Minglang Cai, Zhe Tang, Bo Zhu, Mengxi Yang, Yi Hu, Jihong Dai

“…Besides, hepatic antioxidant enzyme activities and nrf2 gene expression levels were markedly upregulated in the SBM45 and SBM60 groups (P < 0.05). …”
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Therapeutic potential of the neutralizing monoclonal antibody 45G3 against encephalomyocarditis virus by Yanfang Zhang, Zhiying Wang, Yaohui Fang, Qiong Zhu, Jie Fu, Sijing Hu, Jiayin Jin, Min Zhou, Xijia Liu, Danna Zhang, Shouwei Huang, Yali Deng, Lingling Xie, Shu Shen, Jing Ye, Fei Deng, Shengbo Cao

“…Additionally, posttreatment analysis revealed reduced tissue damage and a markedly decreased inflammatory response in the brain, indicating that the 45G3 antibody effectively blocked viral infection, thereby mitigating tissue damage and enhancing survival. …”
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TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner by Arun Chhetri, Channy Park, Hyunsoo Kim, Laxman Manandhar, Chagtsalmaa Chuluunbaatar, Jaetaek Hwang, Xiaofan Wei, Gyuho Jang, Batching Chinbold, Hyug Moo Kwon, Sang-wook Lee, Raekil Park

“…CD36 expression was markedly induced by HFD or FFA, which was reduced by TMEM135 depletion. …”
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Reduced p63 expression is linked to unfavourable prognosis in muscle‐invasive urothelial carcinoma of the bladder by Kira Furlano, Henning Plage, Sebastian Hofbauer, Sarah Weinberger, Bernhard Ralla, Annika Fendler, Florian Roßner, Simon Schallenberg, Sefer Elezkurtaj, Martina Kluth, Maximilian Lennartz, Niclas C. Blessin, Andreas H. Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Stefan Koch, Nico Adamini, Sarah Minner, Ronald Simon, Guido Sauter, Joachim Weischenfeldt, Tobias Klatte, Thorsten Schlomm, David Horst, Henrik Zecha

“…The rate of p63 positive cases and the staining intensity was lower in pTaG3 tumours (93.2%, p < 0.0001 for pTaG3 vs. pTaG2) and markedly lower in pT2‐4 carcinomas (83.5%, p = 0.0120 for pT2‐4 vs. pTaG3). …”
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Lateralized differences in power spectra across different frequency bands during NREM sleep in patients with primary insomnia by Jiao Huang, Jiao Huang, Jing Ye, Mingjie Gao, Wentao Gao, Weijia Chen, Yifeng Zhu, Yongbo Wang, Daijin Huang, Yunhui Lv, Hong Shi

“…The Beta1 power was positively correlated the number of awakenings (r = 0.3291, p = 0.02) in primary insomnias on the right side.ConclusionThis study marked the first specialized comparison of power spectral analysis during non-rapid eye movement sleep in different areas and across different frequency bands. …”
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A new multi-grid bathymetric dataset of the Gulf of Naples (Italy) from complementary multi-beam echo sounders by F. Foglini, M. Rovere, R. Tonielli, G. Castellan, G. Castellan, M. Prampolini, M. Prampolini, F. Budillon, M. Cuffaro, G. Di Martino, V. Grande, S. Innangi, M. F. Loreto, L. Langone, F. Madricardo, A. Mercorella, P. Montagna, C. Palmiotto, C. Pellegrini, A. Petrizzo, L. Petracchini, A. Remia, M. Sacchi, D. Sanchez Galvez, A. N. Tassetti, F. Trincardi

“…The digital bathymetric data previously available are restricted to the shallow highly dynamic area of the Gulf of Naples and appear fragmented as they were acquired in successive years, with different goals thereby using a variety of devices, with markedly different spatial resolutions. In this paper, we present bathymetric maps of the Gulf of Naples and adjacent slope basins at unprecedented resolution using three state-of-the-art multi-beam echo sounders. …”
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The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment by Fan Chen, Na Wang, Xinyan Tian, Juan Su, Yan Qin, Rongqiao He, Xiaping He

“…It was further found that these protective effects were achieved by attenuating FA-induced endoplasmic reticulum stress (ERS), as indicated by the inhibition of the ERS markers, GRP78 and CHOP, and downstream Tau-associated kinases (GSK-3β and CaMKII) expression. In addition, MGF markedly inhibited FA-induced oxidative damage, including Ca²⁺ overload, ROS generation, and mitochondrial dysfunction, all of which are associated with ERS. …”
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Overcoming breast cancer cell treatment resistance by optimizing sonodynamic therapy and radiation sensitizers on lncRNA PVT1 and miR-1204 expression by Ali Neshastehriz, Zeinab Hormozi-Moghaddam, Zahra Abedi Kichi, Seyedeh Mona Taheri, Seyed Mohammad Amini, Amir Aghaei

“…This was associated with a marked increase in ROS with a mean fluorescence intensity of 20,576.2 ± 4.6 (>4.5 times). …”
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The association of systemic immune-inflammation index with incident breast cancer and all-cause mortality: evidence from a large population-based study by Yu Li, Yu Li, Meng Yu, Ming Yang, Jingqi Yang

“…The optimal inflection point for SII/100 in this context was 5.22, and above this threshold, there was a marked escalation in all-cause mortality (HR=1.09, 95% CI: 1.04-1.14).ConclusionThe SII, as a novel inflammatory composite index, is significantly associated with the risk of breast cancer incidence and all-cause mortality in breast cancer patients. …”
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