Targeting the IKZF1/BCL-2 axis as a novel therapeutic strategy for treating acute T-cell lymphoblastic leukemia by Juan Li, Chunmei Ye, Hui Li, Jun Li

“…Functional assays demonstrated that IKZF1 overexpression reduced BCL-2 mRNA levels and increased repressive histone marks at the BCL-2 promoter, while IKZF1 knockdown led to elevated BCL-2 expression. …”
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Advanced sleep disorder detection using multi-layered ensemble learning and advanced data balancing techniques by Muhammad Mostafa Monowar, S. M. Nuruzzaman Nobel, Maharin Afroj, Md Abdul Hamid, Md Zia Uddin, Md Mohsin Kabir, M. F. Mridha

“…The combination of models not only enhanced accuracy but also improved the system's ability to handle unbalanced data, a common limitation in traditional methods. This study marks a significant advancement in sleep disorder detection through the integration of innovative ensemble techniques. …”
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New epigenome players in the regulation of PCSK9-H3K4me3 and H3K9ac alterations by statin in hypercholesterolemia by Sushmitha Duddu, Yash T. Katakia, Rituparna Chakrabarti, Pooja Sharma, Praphulla Chandra Shukla

“…Together, these findings suggest that statin induces the colocalization of H3K4me3 and H3K9ac to transcribe PCSK9 actively and that inhibiting these marks reduces PCSK9 expression and ultimately increases hepatocyte LDL uptake. …”
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A comparative analysis of methods of preinduction cervical ripening and induction of labor in Poland and in Germany (Part II): maternal and neonatal outcomes by Agnieszka K. Kleszcz, Dorota Ćwiek, Olimpia Sipak-Szmigiel

“…The average change in evaluation of the cervix marked on the Bishop Score was higher in Germany, and it was 2.7 points, whereas in Poland, it was 1.6 points. …”
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Research on Innovative Apple Grading Technology Driven by Intelligent Vision and Machine Learning by Bo Han, Jingjing Zhang, Rolla Almodfer, Yingchao Wang, Wei Sun, Tao Bai, Luan Dong, Wenjing Hou

“…Currently, apple grading predominantly relies on manual methods, which present challenges such as low production efficiency and high subjectivity. This study marks the first integration of advanced computer vision, image processing, and machine learning technologies to design an innovative automated apple grading system. …”
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Reduction in thermal plasticity of life history traits in response to cold selection: an experimental evolution study using Drosophila melanogaster by Rishav Roy, Rishav Roy, Aradhya Chattopadhyay, Sreebes Deb Sharma, Aharna Mondal, Payel Biswas, Payel Biswas, Shampa M. Ghosh

“…Sustained fecundity levels across cold and warm conditions are potential marks of adaptation to a broader thermal range. While phenotypic plasticity may aid in adaptation to new environments, for traits such as fecundity, consistent levels across environments, that is, low plasticity, may be more adaptive. …”
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Wpływ prawa rzymskiego na kształtowanie się wybranych instytucji prawa ukraińskiego — uwagi na marginesie art. 291 k.p.k. by Wojciech J. Kosior

“…The article analyses Roman influences on Ukrainian criminal proceedings focusing on the institution of an indictment, which marks the conclusion of the initial stage of the proceedings by accumulating evidence of a person’s perpetration and guilt. …”
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Three-Dimensional Printable Magnetic Hydrogels with Adjustable Stiffness and Adhesion for Magnetic Actuation and Magnetic Hyperthermia Applications by Xueting Xuan, Yi Li, Xing Xu, Zhouyi Pan, Yu Li, Yonghao Luo, Li Sun

“…Compared to existing magnetic hydrogels, our 3D-printable platform uniquely combines adjustable mechanical properties, strong adhesion, and multifunctionality, offering enhanced capabilities for use in magnetic actuation and hyperthermia in biomedical applications. This advancement marks a significant step toward the scalable production of next-generation intelligent hydrogels for precision medicine and bioengineering.…”
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Lightning-induced vulnerability assessment in Bangladesh using machine learning and GIS-based approach by Tanmoy Mazumder, Md. Mustafa Saroar

“…This comprehensive, data-driven approach marks a significant advancement in our understanding of lightening vulnerability and offrrs valuable insight for strategy developed to combat the fatalities of lightning in Bangladesh.…”
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Ichthyoarchaeological perspectives on roles of fish and red meat during Indus Civilization in Gujarat, India by G. S. Abhayan, Pramod P. Joglekar, Pramod P. Joglekar, P. Ajithprasad, S. V. Rajesh, Pankaj Goyal, Brad Chase, Jeevan Kharakwal, Prabodh Shirvalkar

“…Evidence of anthropogenic activities such as cut marks, charring, and chewing on the bones suggests various aspects of fish consumption. …”
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Insights into incompatible plasmids in multidrug-resistant Raoultella superbugs by Jiao Feng, Changxin Wu, Dongsheng Zhou, Lingfei Hu, Kai Mu, Zhe Yin

“…Furthermore, this research marks the first report of four Inc groups of plasmids within Raoultella, namely IncFIIp23141−CTXM plasmid, IncFIIpKPC2_EC14653 plasmid, IncX8 plasmid, and IncFIIpCP020359: IncFIB-7.1 dual-replicon plasmid. …”
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Characterization of the Cannabis sativa glandular trichome epigenome by Lee J. Conneely, Bhavna Hurgobin, Sophia Ng, Muluneh Tamiru-Oli, Mathew G. Lewsey

“…We identified putative trichome-specific enhancer elements by identifying intergenic regions of H3K56ac enrichment, a histone mark that maintains enhancer accessibility, then associated these to putative target genes using the tissue specific gene transcriptomic data. …”
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Acute effect of technique modification training on 180° change of direction performance and kinematics in adolescent male soccer players by Hayato Nakamura, Daichi Yamashita, Daichi Nishiumi, Naoto Nakaichi, Norikazu Hirose

“…Each section of the Pro-Agility test was divided into acceleration and deceleration phases based on the COM velocity; Stop marks the moment of direction change. Two-way (group and time) mixed ANOVA was conducted with Bonferroni corrections for post-hoc comparisons.ResultsNo significant interactions were observed in the total time of the Pro-Agility test, CODD, 20-m sprint time, or average acceleration and deceleration in each phase (p > 0.05). …”
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Algorithm of Behaviour of Virtual Avatars During Public Speaking Training in a VR Environment by Karol Jędrasiak, Robert Robert Wolański, Damian Bereska

“…The development of the algorithm marks a pivotal advancement in educational technology, providing a platform that surpasses traditional training methods. …”
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Aberrant heterochromatin silences immune response genes in chronic lymphocytic leukemia by Olivia M. Depies, Qianqian Guo, Yuan Gao, Sutapa Sinha, Zhenqing Ye, Weiguo Han, Kari G. Rabe, Mingma S. Hoel, Heather C. Darby, Chuanhe Yu, Esteban Braggio, Sameer A. Parikh, Susan L. Slager, Neil E. Kay, Zhiquan Wang

“…Importantly, these lost enhancers exhibit an increased level of heterochromatin marks, including H3K9me3 and H3K27me3. Using the EBF1 gene locus as an example, we demonstrated that acquired H3K9me3 contributes to enhancer silencing and associated gene suppression. …”
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IUENNA – openIng the soUthErn jauNtal as a micro-regioN for future Archaeology: A «para-description» by Hagmann, Dominik, Reiner, Franziska

“…IUENNA is a collaborative effort in digital archaeology and digital humanities: It involves a diverse set of stakeholders, including the State Museum for Carinthia (kärnten.museum), the Austrian Archaeological Institute (ÖAI) at the Austrian Academy of Sciences (ÖAW), the Austrian Centre for Digital Humanities and Cultural Heritage (ACDH-CH) at the ÖAW, the Austrian Federal Monuments Authority (BDA), and the archaeological service company ARDIG. The project marks a novel initiative in Austrian Classical studies by providing a robust model for the active and sustainable long-term archiving of digital archaeological data. …”
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Effect of phycocyanin and phycoerythrin on antioxidant and antimicrobial activity of refrigerated low-fat yogurt and cream cheese by Azadeh Ahmadi, Seyed Amir Ali Anvar, Bahareh Nowruzi, Leila Golestan

“…Therefore, low-fat yogurt and cream cheese containing cyanobacterial PE and PC can be considered an innovative dairy product for the food industry. This study marks the initial effort to employ PE and PC derived from Nostoc sp. and Spirulina sp. as antioxidant and antimicrobial agents in the food industry.…”
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Patients' perspectives on buprenorphine subcutaneous implant: a case series by Claudio Pierlorenzi, Marco Nunzi, Sabino Cirulli, Giovanni Francesco Maria Direnzo, Lucia Curatella, Sandra Liberatori, Annalisa Pascucci, Edoardo Petrone, Generoso Ventre, Concettina Varango, Maria Luisa Pulito, Antonella Varango, Cosimo Dandolo, Brunella Occupati, Roberta Marenzi, Claudio Leonardi

“…Case presentation This article marks the pioneering use of OAT through buprenorphine implant in Europe and delves into the experience of six patients diagnosed with OUD at a relatively young age. …”
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Academician V. H. Serheiev – Control System Designer, Founder of the Scientific and Design School, Honored Citizen of Kharkiv (on His 110th Birthday) by Elena Tverytnykova, Olena Voitiuk

“… March 5, 2024 marks the 110th birthday of Volodymyr Hryhorovych Serheiev, an outstanding scientist, chief designer of control systems for strategic combat missiles, launch vehicles, spacecraft and transport modules of orbital complexes, Academician of the National Academy of Sciences of  Ukraine and an Honored Citizen of Kharkiv. …”
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The effect of clinician-expressed empathy and nocebo-alleviating information on breast-cancer-patients' anxiety and side effects during active chemotherapy: A clinical feasibility... by Lara C. Gröschel, Fiona T. Brosig, Marcel Soesan, Katherina T. Vourtsis, Mirte van der Spek, Elise Sluiter, Liesbeth M. van Vliet

“…Innovation: This study marks an innovative approach in utilizing digital interventions to enhance cancer patient outcomes within clinical settings.…”
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