Exploring the antiviral potential of shikimic acid against Chikungunya virus through network pharmacology, molecular docking, and in vitro experiments by Jialiang Xin, Xingxing Song, Haohong Zheng, Wenjing Li, Yuyang Qin, Wei Wang, Wei Wang, He Zhang, Guangneng Peng

“…Additionally, SA was found to markedly downregulate the expression of CHIKV-related attachment factors ACTG1, TSPAN9, and TIM-1 in 293T cells infected with CHIKV. …”
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Pearls on a String: Dark and Bright Galaxies on a Strikingly Straight and Narrow Filament by M. Arabsalmani, S. Roychowdhury, B. Schneider, V. Springel, E. Le Floc’h, F. Bournaud, A. Burkert, J.-C. Cuillandre, P.-A. Duc, E. Emsellem, D. Galárraga-Espinosa, E. Pian, F. Renaud, M. A. Zwaan

“…These clouds must be marking the peaks of the dark matter and H i distributions over large scales within the filament. …”
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GH inhibits ALV-J replication and restricts cell cycle by activating PI3K/Akt signaling pathway by Junliang Xia, Ling Lin, Rongyang Ju, Chengxun Xu, Guodong Mo, Xiquan Zhang

“…In this study, we observed a significant upregulation of GH protein expression in the plasma of ALV infected chickens, and a marked increase in GH mRNA in ALV-J infected cells. …”
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TLR7/8/9 agonists and low-dose cisplatin synergistically promotes tertiary lymphatic structure formation and antitumor immunity by Shuting Wu, Rong Xiang, Yiwei Zhong, Shushu Zhao, Zhiyu Zhang, Zhihua Kou, Shijie Zhang, Yi Zhao, Cheng Zu, Gan Zhao, Yanling Xiao, Sulin Ren, Xiaoming Gao, Bin Wang

“…The synergistic antitumor effects of cisplatin and CR108 were accompanied by markedly increased tumor tertiary lymphatic structures (TLS) formation, higher levels of type I and III interferons and TNF-α in serum, augmented T and B lymphocyte infiltration, antigen-presenting cell activation, as well as reduced functionally of exhausted T cells. …”
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Basic research for ultrasound-guided injection into skeletal muscle lesions in an experimental animal model by KiyomitsuFujimoto, TakashiKanamoto, ShunyaOtani, RyoMiyazaki, KosukeEbina, KenNakata

“…It also showed that ultrasound-guided injections allowed for highly accurate distribution of solution and cells in abnormal muscle tissue, but the patterns of solution and cell distribution were markedly different. Although future studies using a more clinically relevant model are necessary, these results are important findings when considering biological therapies for skeletal muscle injuries and disorders. …”
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The use of triptans as an effective form of migraine treatment – review by Agata Borkowska, Anna Kiełb, Anna Mich, Anna Kaźmierczak, Patrycja Sornek, Wiktoria Izdebska, Igor Pawlak, Radosław Ciesielski, Jakub Stanek, Klaudia Perkowska

“…These pharmaceuticals markedly alleviate pain and symptoms like nausea, photophobia, and phonophobia, providing substantial pain relief. …”
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Elevated Serum Extracellular Vesicle‐Packaged SPARC in Hypertension: A Cross‐Sectional Study in a Middle‐Aged and Elderly Population by Xueying Chen, Han Guo, Xinwei Li, Yang Liu, Xinxin Li, Zhengshuo Cui, Huijuan Ma, Jianxun He, Zhechun Zeng, Huina Zhang

“…Our findings revealed that the levels of SPARC derived from serum EVs were markedly elevated in individuals with hypertension, averaging 20.60 ng/mL (p < 0.01), when contrasted with the levels observed in normotensive subjects, which were 14.25 ng/mL (p < 0.01) in average. …”
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Highly pathogenic bovine viral diarrhea virus BJ-11 unveils genetic evolution related to virulence in calves by Yuanyuan Zhang, Yuanyuan Zhang, Jing Cheng, Yu Guo, Yu Guo, Yibin Hu, Yibin Hu, Zhuo Zhao, Wenxiao Liu, Linyi Zhou, Peize Wu, Chunjie Cheng, Chunjie Cheng, Chun Yang, Chun Yang, Jing Yang, Jing Yang, Enqi Du, Yongqing Li, Yongqing Li

“…Clinical signs included fever, diarrhea, bloody stools, anorexia, and death in some cases. A marked reduction in leukocyte and lymphocyte counts were observed, accompanied by an increase in neutrophil counts. …”
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Saponin content in medicinal plants in response to application of organic and inorganic fertilizers: a meta-analysis by Junyan Lv, Junyan Lv, Shouzan Liu, Shouzan Liu, Chunli Hu, Lan Ding, Hongzhen Wang, Hongzhen Wang, Xin Li, Feng Yang, Feng Yang, Qiong Shen, Qiong Shen, Hongbin Zhang, Hongbin Zhang, Guobiao Ma, Guobiao Ma, Shaobo Zhang, Yan Bai, Yan Bai

“…Moreover, the application of organic fertilizers was found to markedly elevate the concentrations of Notoginsenoside R1, Ginsenoside Rb1, Ginsenoside Rb2, Re, and Rg1, along with Lancemasid saponins and Quinoa saponins. …”
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Overwintering temperature affects lipid and fatty acid metabolism in hepatopancreas and ovary of female mud crab Scylla paramamosain by Kaijia Yu, Hanying Xu, Ce Shi, Chunlin Wang, Changkao Mu, Yangfang Ye, Shujian Chen, Ronghua Li, Qingyang Wu

“…Hemolymph biochemical indices demonstrated that the level of low-density lipoprotein cholesterol (LDL-C) increased markedly as temperature rose (P < 0.05). In addition, the fatty acid profile of hepatopancreas tissue did not change significantly at different overwintering temperatures (P > 0.05), however, the content of EPA in ovary tissue significantly increased with the temperature rise (P < 0.05). …”
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A VersaTile Approach to Reprogram the Specificity of the R2-Type Tailocin Towards Different Serotypes of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> by Dorien Dams, Célia Pas, Agnieszka Latka, Zuzanna Drulis-Kawa, Lars Fieseler, Yves Briers

“…<b>Conclusions:</b> This work lays the groundwork for a scalable platform for the development of engineered tailocins, marking an important step towards making R2 tailocins a practical therapeutic tool for targeted bacterial infections.…”
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Research progress of femoral head necrosis in HIV-infected patients by Youhan Yang, Futao Ke, Zhengqi Pan, Liaobin Chen

“…The postoperative quality of life of patients is markedly enhanced, and there are no reports of surgical complications. …”
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Biocontrol yeast Kurtzmaniella quercitrusa BS-AY-S1 controls postharvest green mold of citrus fruit by producing metabolites with antifungal activity by Bi Liao, Ou Chen, Hongyan Zhang, Wenjun Wang, Lanhua Yi, Honghai Li, Kaifang Zeng

“…Additionally, the volatile organic compounds (VOCs) from BS-AY-S1 markedly reduced the spore germination, spore production and mycelial growth of P. digitatum, and slowing down the progression of green mold in citrus fruit. …”
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The Burden of Severe Periodontitis in China From 1990 to 2021, With Projections to 2050: A Comprehensive Analysis From The Global Burden of Disease Study 2021 by Yuyang Wang, Yinbao Wang, Lu Fan, Yueyuan Yu

“…The burden was higher in males than in females, with a marked increase observed in middle-aged and elderly populations. …”
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Iodine/Chlorine Multi‐Electron Conversion Realizes High Energy Density Zinc‐Iodine Batteries by Jiajin Zhao, Yan Chen, Mengyan Zhang, Ziqi An, Binbin Nian, Wenfeng Wang, Hao Wu, Shumin Han, Yuan Li, Lu Zhang

“…Consequently, the aqueous Zn‐I2 cell achieves an exceptional capacity of 987 mAh gI2−1 with an energy density of 1278 Wh kgI2−1, marking an enhancement of ≈300 mAh g−1 compared to electrolyte devoid of EG, and enhancing the Coulombic efficiency (CE) from 68.2% to 98.7%. …”
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Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet by Xiaojuan Li, Luming Qiao, Wei Wang, Ying Shi, Lei Yuan, Zhiwei Zhai

“…Elevated levels of plasma glucose, serum insulin, and glycated haemoglobin in obese rats were significantly reduced by SG. Markedly increased levels of alanine transaminase, aspartate transaminase, alkaline phosphatase albumin, total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, elevated values of heart rate, left ventricular end-systolic pressure, left ventricular end-diastolic pressure, systolic pressure, and end diastolic pressure, and decreased value of stroke volume were observed in obese rats, which were sharply reversed by SG. …”
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The Protective Effects of Maresin 1 in the OVA-Induced Asthma Mouse Model by Guochun Ou, Qin Liu, Chengxiu Yu, Xiaoju Chen, Wenbo Zhang, Yong Chen, Tao Wang, Yongqiang Luo, Guolu Jiang, Mingmei Zhu, Hongmei Li, Mei Zeng

“…Furthermore, high-dose MaR1 treatment markedly suppressed the activation of the NF-κB signaling pathway, the degradation of IκBα, and the expression of inflammatory genes downstream of NF-κB, such as COX-2 and ICAM-1, in the OVA-induced asthma mouse model. …”
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Enhanced Lung Cancer Prediction via Integrated Multi‐Space Feature Adaptation, Collaborative Alignment and Disentanglement Learning by Abigail Kawama, Ronald Waweru Mwangi, Lawrence Nderu

“…ABSTRACT Lung cancer, marked by the rapid and uncontrolled proliferation of abnormal cells in the lungs, continues to be one of the leading causes of cancer‐related deaths globally. …”
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Diversity of Rhizophydiales (Chytridiomycota) in Thailand: unveiling the hidden gems of the Kingdom by Vedprakash G. Hurdeal, Joyce E. Longcore, E. B. Gareth Jones, Kevin D. Hyde, Eleni Gentekaki

“…The identification and characterization of these eight novel species mark a noteworthy stride towards a more comprehensive comprehension of fungal ecosystems and their vital role.…”
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Strain rebound and inhomogeneity in glass-to-metal seals: Radial vs axial strain evolution by Keqian Gong, Zheng Liu, Zifeng Song, Chao Zhou, Zhangjing Shi, Siyue Nie, Weisong Zhou, He Yan, Zhichun Fan, Yong Zhang

“…Moreover, the mismatch in thermal expansion coefficients between the glass and the metal housing significantly amplified radial strain, resulting in marked directional differences in strain behavior. …”
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