Efficacy and safety of Janus kinase inhibitors in the treatment of psoriasis and psoriatic arthritis: An analysis of evidence from 2014 to 2022 by Jiao Wang, Tian Ma, Xiaoying Sun, Liu Liu, Seokgyeong Hong, Huijung Cha, Miao Zhang, Jiale Chen, Naixuan Lin, Bin Li, Xin Li

“…Filgotinib, a JAK1 inhibitor, markedly enhanced the response rate and improved ACR scores in patients with PsA, and the best effect was achieved with 16-week oral administration.…”
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The Impact of COVID-19 on Hospitalised COPD Exacerbations in Malta by Yvette Farrugia, Bernard Paul Spiteri Meilak, Neil Grech, Rachelle Asciak, Liberato Camilleri, Stephen Montefort, Christopher Zammit

“…Results. There was a marked decrease in AECOPD admissions in 2020, with a 54.2% drop in admissions (n=119 in 2020 vs. n=259 in 2019). …”
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LncRNA-ANRIL regulates CDKN2A to promote malignant proliferation of Kasumi-1 cells by Jianxia Xu, Jingxin Zhang, Chengsi Zhang, Huali Hu, Siqi Wang, Fahua Deng, Wu Zhou, Yuancheng Liu, Chenlong Hu, Hai Huang, Sixi Wei

“…Results ANRIL and CDKN2A were markedly overexpressed in AML patient samples. Knockdown of ANRIL and CDKN2A led to G1 phase arrest accompanied by reduced CDK2/4/6 and cyclin D1 protein levels, while ANRIL upregulation induced the opposite effect. …”
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A Review on Blockchain Applications in Operational Technology for Food and Agriculture Critical Infrastructure by Chengliang Zheng, Xiangzhen Peng, Ziyue Wang, Tianyu Ma, Jiajia Lu, Leiyang Chen, Liang Dong, Long Wang, Xiaohui Cui, Zhidong Shen

“…The findings are meticulously organized through tables, charts, and graphs. The year 2018 marked a surge in research within this domain, with the IEEE Internet of Things Journal and IEEE ACESS emerging as the most prolific journals, each boasting nine publications. …”
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Evaluation of Office and Ambulatory Central Blood Pressure and Augmentation Index by Two Methods and Their Changes After Lifestyle or Medical Interventions in Hypertension by Helga Gyöngyösi, Dóra Batta, Andrea László, Péter Torzsa, Beáta Kőrösi, Zsófia Nemcsik-Bencze, Orsolya Cseprekál, András Tislér, János Nemcsik

“…When examining the effect of antihypertensive treatment, the more marked changes in office tonometric cSBP suggests its higher variability compared with 24 h oscillometric central SBP. …”
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Superior Mesenteric Artery Syndrome: Clinical, Endoscopic, and Radiological Findings by Emanuele Sinagra, Dario Raimondo, Domenico Albano, Valentina Guarnotta, Melania Blasco, Sergio Testai, Marta Marasà, Vincenzo Mastrella, Valerio Alaimo, Valentina Bova, Giovanni Albano, Dario Sorrentino, Giovanni Tomasello, Francesco Cappello, Angelo Leone, Francesca Rossi, Massimo Galia, Roberto Lagalla, Federico Midiri, Gaetano Cristian Morreale, Georgios Amvrosiadis, Guido Martorana, Marcello Giuseppe Spampinato, Vittorio Virgilio, Massimo Midiri

“…All patients improved on conservative treatment. In our series, a marked (>5 kg) weight loss (p=0.006) and a long-standing presentation (more than six months in 80% of patients) (p=0.002) are significantly related to a diagnosis of confirmed SMA syndrome at CECT after an endoscopic suspicion. …”
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Variations in Sources, Composition, and Exposure Risks of PM2.5 in both Pre-Heating and Heating Seasons by Dingyuan Yang, Zhiyong Li, Ziyuan Yue, Jixiang Liu, Zhen Zhai, Zelin Li, Minglei Gao, Ailian Hu, Wenjia Zhu, Ning Ding, Zhenxin Li, Songtao Guo, Xiangxue Wang, Lei Wang, Jihong Wei

“…On average, SO42− and NO3− (in µg m−3) were found to be markedly enhanced from 3.54 and 11.1 in the PHS to 13.1 and 23.2 in the HS, especially in the case of SO42−, reflecting the increased usage of coal/natural gas. …”
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Do you think medicines can be prescribed in a more eco-directed, greener way? A qualitative study based on public and prescriber focus groups on the impact of pharmaceuticals in Sc... by Claire Anderson, Lydia Niemi, Naoko Arakawa, Mark Taggart, Stuart Gibb, Sharon Pfleger

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The <i>Meq</i> Genes of Nigerian Marek’s Disease Virus (MDV) Field Isolates Contain Mutations Common to Both European and US High Virulence Strains by Joseph N. Patria, Luka Jwander, Ifeoma Mbachu, Levi Parcells, Brian Ladman, Jakob Trimpert, Benedikt B. Kaufer, Phaedra Tavlarides-Hontz, Mark S. Parcells

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The impact of the objective state and self-esteem of health on academic performance in senior students of medical and humanitarian specialties, taking into account various environm... by V. V. Kuznetsov, K. V. Kosilov

“…Academic performance was higher among students of both directions, marking their learning conditions as satisfactory and good (r = 0.034; r = 0.048 / r = 0.045; r = 0.065). …”
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Orally administered prednisolone decreases plasma arginine vasopressin and serum copeptin concentrations in healthy dogs by Mathieu Victor Paulin, Dorsa Mehrabanpour, Suraj Unniappan, Elisabeth C. R. Snead

“…Conclusions and Clinical Importance Orally administered prednisolone led to markedly decreased plasma AVP and serum CoP concentrations despite increased calculated plasma osmolality and stable systolic blood pressure.…”
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A supervised model to identify wolf behavior from tri-axial acceleration by Charlotte Lorand, Léa Bouet, Olivier Devineau, Marianna Chimienti, Alina L. Evans, Peggy Callahan, Mark Beckel, Timothy G. Laske, Ane Eriksen

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Accelerated expansion of NATO into the Balkans as a consequence of Euro-Atlantic Discord by S. Gajić, E. G. Ponomareva

“…Bush, in which there is “no substitute for American leadership”.The year of 2008 marked the start of profound changes. The changes we are witnessing today are of the magnitude described by Paul Kennedy’s classic The Rise and Fall of the Great Powers. …”
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Impact of Order Set on Exocrine Pancreatic Insufficiency in Chronic Pancreatitis, Pancreatic Cancer, and Pancreatic Resection by Michael Ladna, Ishaan Madhok, Adnan Bhat, Nicole Ruiz, Jackson Brown, Jake Wilson, Peter Jiang, Robert Taylor, Mark Radetic, John George, Christopher Forsmark

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Manière de dire et manière d’exercer la parenté en Kabylie. Pour une approche renouvelée du croisement genre et fait matrimonial by Mohand Anaris

“…The Kabyle’s kinship terminology reveals results that dissociate kinship from a system described as "patrilineal" and "patriarchal". The vocabulary is marked by a matripolarity attested and generalizable to all languages in the Berber area. …”
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Forecast for the zone of viticulture in European Russia under climate change by L. Yu. Novikova, P. V. Ozerski

“…The QGIS program was applied to plot the points on the European Russia map and mark the terminal latitude. Versions with Tmin &gt; –26 °C and Tmin &gt; –35 °C were considered. …”
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Relative Fat Mass and Physical Indices as Predictors of Gallstone Formation: Insights From Machine Learning and Logistic Regression by Deng L, Wang S, Wan D, Zhang Q, Shen W, Liu X, Zhang Y

“…Laifu Deng,1,&ast; Shuting Wang,1,&ast; Daiwei Wan,1,&ast; Qi Zhang,2 Wei Shen,1 Xiao Liu,1,&ast; Yu Zhang1,&ast; 1Department of General Surgery, Wuxi Medical Center of Nanjing Medical University, Wuxi, People’s Republic of China; 2Department of Oncology, Tengzhou Central People’s Hospital, Jining Medical College, Shandong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiao Liu; Yu Zhang, Department of General Surgery, Wuxi Medical Center of Nanjing Medical University, Wuxi, People’s Republic of China, Tel +8613561164619 ; +8613793706777, Email ningzhouwxrmyy@163.com; yuzhangjs@yeah.netPurpose: Gallstones (GS), a prevalent disorder of the biliary tract, markedly impair patients’ quality of life. This study aims to construct predictive models employing diverse machine learning algorithms to elucidate risk factors linked to gallstone formation.Patients and Methods: This study integrated data from the National Health and Nutrition Examination Survey (NHANES) with a cohort of 7868 participants from Wuxi People’s Hospital and Wuxi Second People’s Hospital, including 830 individuals diagnosed with gallstones. …”
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Performance of HPV E4 and p16INK4a biomarkers in predicting regression of cervical intraepithelial neoplasia grade 2 (CIN2): protocol for a historical cohort study by David Jenkins, Mark H Stoler, Anne Hammer, Torben Steiniche, Lone Kjeld Petersen, Patti E Gravitt, Rikke Kamp Damgaard, Maurits NC de Koning, Wim GV Quint, John Doorbar, Johnny Kahlert

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Impact of Prenatal Stress on Neuroendocrine Programming by Odile Viltart, Christel C. A. Vanbesien-Mailliot

“…Potential threats to homeostasis might occur as early as during in utero life, potentially leaving a lasting mark on the developing organism. Indeed, environmental factors exert early-life influences on the structural and functional development of individuals, giving rise to changes that can persist throughout life. …”
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The proneural transcription factor Atoh1 promotes odontogenic differentiation in human dental pulp stem cells (DPSCs) by Camila Sabatini, Huey-Jiun Lin, Galib Ovik, Richard Hall, Techung Lee

“…The odontogenic phenotype is associated with metabolic remodeling marked by enhanced glycolytic flux and attenuated mitochondrial metabolic enzyme activities. …”
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