COMBINED TREATMENT OF LOCALLY-ADVANCED BLADDER CANCER by I. V. Chernyshev, Y. V. Samsonov, D. V. Perepechin, A. M. Ulbashev

“…In the group of NACT 21% of patients survived for more than 4 years, but did not survive the 5‑year mark. In the group of CE + ACT the indicator achieved only 3‑year survival rate, which amounted to 43%. …”
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Phytochemical analysis, antioxidant, anti-inflammatory and enzyme inhibitory activities of bean pear (Pyrus calleryana fruit) by Huan Zhao, Huan Zhao, Qinqin Wang, Lanlan Yang, Lanlan Yang, Yuanquan Ran, Qiong Hu, Yi Hong, Minyi Tian, Minyi Tian, Minyi Tian

“…In the antioxidant activity, WE and EE showed marked free radical scavenging effects on both ABTS (2.33 ± 0.15 μg/mL and 2.23 ± 0.15 μg/mL, respectively) and DPPH (5.93 ± 0.55 μg/mL and 7.07 ± 0.23 μg/mL, respectively), especially, their scavenging effects on DPPH free radicals were superior or equivalent to that of BHT (7.47 ± 0.47 μg/mL). …”
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Evaluating H2BC9 as a potential diagnostic and prognostic biomarker in head and neck squamous cell carcinoma by Lanhua Wu, Liang Li, Mingjing Zhu, Ziyan Zhou, Xuejin Su, Yueming Jiang, Min Kang, Li Jiang

“…The impact of H2BC9 on HNSCC cells was further investigated through in vitro experiments. Results H2BC9 was markedly upregulated in HNSCC cell lines and tissues. …”
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An animal model of severe acute respiratory distress syndrome for translational research by Kuo-An Chu, Chia-Yu Lai, Yu-Hui Chen, Fu-Hsien Kuo, I.-Yuan Chen, You-Cheng Jiang, Ya-Ling Liu, Tsui-Ling Ko, Yu-Show Fu

“…Within seven days after the injury, we found that arterial blood oxygen saturation (SpO2) significantly decreased to 83.7%, partial pressure of arterial oxygen (PaO2) markedly reduced to 65.3 mmHg, partial pressure of arterial carbon dioxide (PaCO2) amplified to 49.2 mmHg, and the respiratory rate increased over time. …”
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Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Our Galaxy [version 2; peer review: 2 approved] by Pamela Klaassen, Maria Beltrán, Alessio Traficante, Mark Booth, Kate Pattle, Jonathan Marshall, Joshua Lovell, Brandt Gaches, Alvaro Hacar, Nicolas Peretto, Caroline Bot, Doris Arzoumanian, Thomas Stanke, Gaspard Duchêne, Ana Duarte Cabral, Antonio Hales, David Eden, Patricia Luppe, Jens Kauffmann, Elena Redaelli, Sebastian Marino, Álvaro Sánchez-Monge, Andrew Rigby, Dmitry Semenov, Eugenio Schisano, Mark Thompson, Silvia Spezzano, Claudia Cicone, Friedrich Wyrowski, Martin Cordiner, Tony Mroczkowski, Doug Johnstone, Luca Di Mascolo, Minju Lee, Eelco van Kampen, Thomas Maccarone, Daizhong Liu, Matthew Smith, Amélie Saintonge, Sven Wedemeyer, Alexander Thelen

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Effectiveness of an electronic clinical decision support system in improving the management of childhood illness in primary care in rural Nigeria: an observational study by Marek Kwiatkowski, Rodolfo Rossi, Torsten Schmitz, Fenella Beynon, Capucine Musard, Marco Landi, Daniel Ishaya, Jeremiah Zira, Muazu Muazu, Camille Renner, Edwin Emmanuel, Solomon Gideon Bulus

“…We observed higher parenteral and lower oral antimicrobial prescription rates (adjusted OR=2·42 (1·00 to 5·85) and adjusted OR=0·40 (0·22 to 0·73), respectively) in ALMANACH facilities as well as markedly higher rates for referral, communication of diagnosis, and follow-up advice.Conclusion Implementation of digital CDSS with training, mentorship and feedback in primary care can improve quality of care and recovery of sick children in resource-constrained settings, likely mediated by better guideline adherence. …”
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Varying circumstances surrounding opioid toxicity deaths across ethno-racial groups in Ontario, Canada: a population-based descriptive cross-sectional study by Tara Gomes, Mina Tadrous, Sophie A Kitchen, Frank Crichlow, Tonya J Campbell, Cynthia Damba, Colin H Johnson, Ashley Smoke

“…Racialised people had a lower prevalence of opioid agonist treatment in the 5 years preceding death (black people: 27.9%, SD: 0.73; Asian people: 51.1%, SD: 0.22; white people: 61.9%).Conclusions There are marked differences in the risk factors, context and patterns of drug involvement in opioid toxicity deaths across ethno-racial groups, and substantial disparities exist in access to harm reduction and treatment services. …”
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A Case Study on Multi-Real-Option-Integrated STO-PF Models for Strengthening Capital Structures in Real Estate Development by Jung Kyu Park, Jun Bok Lee, Young Mee Ahn, Ga Young Yoo

“…Consequently, the STO-PF model is determined to yield a project value (E) of USD 7.34 million and a real-options value (ROV) of USD 3.69 million. This is markedly higher than the net present value (NPV) of USD 3.65 million derived from the traditional project finance (PF) model. …”
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Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and h... by Yidan Wang, Pengxiao Liu, Zihao Li, Shiya Wu, Meijuan Long, Yang Li, Juan Jiao, Zheng Xie

“…Abstract Background Fibromyalgia is a chronic condition marked by widespread pain and various accompanying symptoms. …”
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Assessment of upper respiratory and gut bacterial microbiomes during COVID-19 infection in adults: potential aerodigestive transmission by Hafez Al-Momani, Andrew Nelson, Hadeel Al Balawi, Dua’a Al Balawi, Iman Aolymat, Ashraf I. Khasawneh, Hala Tabl, Ayman Alsheikh, AbdelRahman M. Zueter, Jeffrey Pearson, Christopher Ward

“…The data indicates that COVID-19 is associated with a dysregulation of both the gut and lung microbiome with a more marked perturbation in the lung, particularly among COVID-19 patients who had been admitted to the ICU. …”
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A genogeographic study of the Kyrgyz mountain merino via microsatellite markers by A. В. Bekturov, Zh. T. Isakova, V. N. Kipen, T. Dzh. Chortonbaev, S. B. Mukeeva, S. K. Osmonaliev, К. A. Aitbaev

“…Considering the ETH152 locus, 186 allele prevalence in the TALAS group was 51.1 %, but allele 190 was also markedly prevalent in the ISSYK-KUL and OSH groups, 34.5 and 34.3 %, respectively. …”
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Low apolipoprotein A1 and high apolipoprotein B levels indicate specific lipid changes in treatment naïve early psoriatic arthritis by Kurt de Vlam, Rik Lories, M Van Mechelen, Sofia Pazmino, P Verschueren, Barbara Neerinckx, Lies Storms, Alla Ishchenko

“…ApoB was higher in PsA than in RA patients but lower than in controls (df2, χ243.8; p<0.001). ApoA1 was markedly lower in PsA patients compared with both RA and controls (df2, χ2118.9; p<0.001). …”
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sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings by Xiaochen Du, Yan Chen, Jie Zhu, Zhenjiang Bai, Jun Hua, Ying Li, Haitao Lv, Guangbo Zhang

“…In addition, sB7H3 was found as the only marker in children with AA, which was markedly associated with the degree of histological findings of the appendix. …”
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The Antiobesity Effect of GLP-1 Receptor Agonists Alone or in Combination with Metformin in Overweight /Obese Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Ana... by Xiaorui Lyu, Taibiao Lyu, Xue Wang, Huijuan Zhu, Hui Pan, Linjie Wang, Hongbo Yang, Fengying Gong

“…Both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and metformin (MET) have markedly antiobesity effects in overweight/obese polycystic ovary syndrome (PCOS) patients. …”
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Breaking the biofilm barrier: Juglone derivatives as dual-action inhibitors and anti-quorum sensing agents by Muhammad Abdullah Bhatti, Atif Ali Khan Khalil, Sayed Muhammad Ata Ullah Shah Bukhari, Faisal Hanif, Mi-Jeong Ahn, Sumra Wajid Abbasi, Nazir Ahmed Lone, Wen-Jun Li, Wasim Sajjad

“…In the spectrophotometric assay, we confirmed that juglone derivatives inhibit biofilm formation. All the compounds markedly inhibited the coagulase, β-hemolytic and proteolytic activity of MRSA. …”
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Global, regional, and national burden of heart failure and its underlying causes, 1990–2021: results from the global burden of disease study 2021 by Jun Ran, Ping Zhou, Jinxi Wang, Xuemei Zhao, Yan Huang, Qiong Zhou, Mei Zhai, Yuhui Zhang

“…Conclusion Global burden of HF increased significantly over recent decades, with a potential turning point in 2019 and marked regional disparities. It is essential to prioritize regions with heavy burdens or rapid growth rates, strengthen the management of major causes, and monitor HF burden trends in the post-COVID era.…”
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Effects of prolonged NaHCO3 exposure on the serum immune function, antioxidant capacity, intestinal tight junctions, microbiota, mitochondria, and autophagy in crucian carp (Carass... by Jia Liu, Faye Zhang, Zihao Yan, Zhengyao Guo, Yuqian Lu, Baolan Yao, Yuehong Li, Wenfa Lv

“…The results showed that compared to the control group, NaHCO3 stress significantly decreased the levels of the serum immunity indices (AKP, ACP, C3, C4, IgM, LZM) and the antioxidant capacity indices (CAT, GSH-PX, SOD, T-AOC), while markedly increasing the content of MDA. Additionally, NaHCO3 influenced the mRNA expression of HSP90, Nrf2, Keap1, and HO-1. …”
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Circular economy and inclusion as effective tools to prevent ecological threats in rural areas during military operations by V.G. Shcherbak, Y.I. Danko, S. Tereshchenko, O. Nifatova, N. Dehtiar, O. Stepanova, V. Yatsenko

“…Direct positive impact of circular economy practices and inclusivity on environmental health, marking a 30 percent ecological improvement, was discovered. …”
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Hepatoprotective Effects of a Novel Trihoney against Nonalcoholic Fatty Liver Disease: A Comparative Study with Atorvastatin by Hamad Abdulsalam Hamad Alfarisi, Muhammad Bin Ibrahim, Zenab B. Hamad Mohamed, Nuraniza Azahari, Asmah Hanim Bt. Hamdan, Che Anuar Che Mohamad

“…Trihoney and atorvastatin showed marked (p<0.001) reduction of hepatic lipid peroxidation. …”
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The ground beneath our feet: A critical reflection on 135 years of landscape evolution models for southern Africa by Rivoningo Khosa, Vela Mbele, Kelly Kirsten, Robyn Pickering

“…We also note that the key narratives that have driven research on landscape evolution have been largely shaped by selected prominent Western-based scientists. As we mark the centenary of the Taung discovery, we look toward a new era of landscape evolution research: one characterised by technological advancements and more diverse, local teams that will produce more quantitative, nuanced models for southern Africa and create richer, more dynamic backdrops for our own human evolution. …”
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