Adipose tissue may not be a major player in the inflammatory pathogenesis of Autism Spectrum Disorder by Baojiang Wang, Yueyuan Qin, Yong Chen, Xiujie Zheng, Yanjuan Chen, Juan Zhao, Feng Zhang, Shan Duan

“…Plasma analysis showed no significant difference in adipokines levels, including adiponectin, leptin, resistin, adipsin, and lipocalin-2, between the ASD and control groups. However, markedly elevated levels of IL-6, IL-8, and tumor necrosis factor (TNF-α) were detected in children with ASD, suggesting that the inflammatory state is independent of adipokines. …”
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Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism by Lin Li, Senjie Zhong, Jiahao Ye, Siyuan Hu, Xiajun Xiong, Guangyu Chen, Zhixi Hu

“…Abstract Heart failure (HF) is a complex syndrome marked by considerable expenditures and elevated mortality and morbidity rates globally. …”
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Mechanistic study on the mitigation of cadmium accumulation in Ligusticum sinense cv. Chuanxiong through plant growth-promoting rhizobacteria Arthrobacter sp. CX-2 by Shu-qi Niu, Ting Li, Lin Liu, Xiu-wen Bao, Xing-mao Yang, Hao-ran Song, Yang Li, Jing Bai, Li-ying He, Qing-he Wang, Si-jing Liu, Jin-lin Guo

“…Specifically, CX-2 could markedly reduce Cd transportation capacity of L. Chuanxiong, such as the translocation factor (TF) Leaf/root (30.66 %) and TF rhizome/root (41.66 %). …”
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Mesenchymal Stem Cells Carrying Viral Fusogenic Protein p14 to Treat Solid Tumors by Inducing Cell–Cell Fusion and Immune Activation by Yao Wang, Xunlei Pang, Ruirui Li, Jiuzhou Chen, Chen Wen, Huihuang Zhu, Tingyu Long, Jianjie Li, Lijun Zheng, Youcai Deng, Junnian Zheng, Bo Xu

“…In mouse tumor models, mMSCs-p14 treatment markedly suppressed tumor growth and also enhanced the activity of natural killer cells and macrophages. …”
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Amebicidal and Antiadhesion Activities of Knema retusa Extract Against Acanthamoeba triangularis T4 Genotype on Contact Lenses and Modeling Simulation of Its Main Compound, E2N, Ag... by Watcharapong Mitsuwan, Imran Sama-ae, Suthinee Sangkanu, Dhrubo Ahmed Khan, Partha Biswas, Md. Nazmul Hasan, Julalak Chuprom, Tajudeen O. Jimoh, Christophe Wiart, Masyitah Binti Zulkipli, Nor Hayati Abdullah, Maria de Lourdes Pereira, Sonia M. Rodrigues Oliveira, Shanmuga Sundar Saravanabhavan, Polrat Wilairatana, Tooba Mahboob, Veeranoot Nissapatorn

“…Treated cysts exhibited wall disruption and dramatically showed forms of marked retraction. Treatment of Kre at 1/2 × MIC showed about 87% reduction in the trophozoite adhesion, while treatment at 2 × MIC exhibited a 59% reduction in the trophozoite adhesion to the plastic surface, compared with the control. …”
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Carboplatin-resistance-related DNA damage repair prognostic gene signature and its association with immune infiltration in breast cancer by Shuwen Dong, Anqi Li, Ruixin Pan, Jin Hong, Zheng Wang, Kunwei Shen

“…Compared to the control group, TONSL-knockdown cell lines exhibited a diminished response to DNA-damaging agents, marked by a notable increase in DNA damage levels and enhanced drug sensitivity. …”
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Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice by Yunsheng Liu, Lan Cao, Xiaoxu Zhang, Yan Liang, Yuxia Xu, Cuiqing Zhu

“…Additionally, MEM reduced CRS-induced upregulation of NMDA receptor subunit levels (GluN2A, GluN2B) in the frontal cortex. However, MEM markedly enhanced tau phosphorylation in the frontal cortex and other cerebral cortical regions following 28 days of CRS. …”
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Transformer-Based Person Detection in Paired RGB-T Aerial Images With VTSaR Dataset by Xiangqing Zhang, Yan Feng, Nan Wang, Guohua Lu, Shaohui Mei

“…This article presents the visible-thermal from SaR scenarios for person detection network (VTSaRNet) to address the challenge of detecting persons situated sparsely in SaR scenes marked by intricate illumination conditions and restricted accessibility. …”
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Feasibility and safety evaluation of ultra-remote robot-assisted laparoscopic hysterectomy by Juyuan Huang, Li'an Li, Jing Cheng, Jing Liao, Yurou Chen, Yi Peng, Sha Wang, Qiongyan Zou, Guoyan Zhao, Wei Zhao, Mengya You, Jingying Yang, Yan Xiong, Kunxian Zhang, Chang Chen, Jiaqiang Xiong, Haotong Guan, Renjie Liu, Peng Zhou, Wuyi Zhao, Yangyang Dong, Xiuli Sun, Sichen Liang, Wei Zhang, Jianliu Wang, Yuanguang Meng

“…This surgery represents the first globally broadcast remote procedure in the field of gynecology, marking a new milestone in the stability and safety of China's remote medical technology. …”
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High-resolution Cryo-EM Structure Determination of a-Synuclein—A Prototypical Amyloid Fibril by Juan Sanchez, Joshua Pierson, Collin Borcik, Chad Rienstra, Elizabeth Wright

“…We detail how sample quality is assessed by negative stain transmission electron microscopy (NS-TEM) analysis and followed by sample vitrification using the Vitrobot Mark IV vitrification robot. We provide a detailed step-by-step protocol for high-resolution cryo-EM structure determination of a-syn fibrils using RELION and a series of specialized helical reconstruction tools that can be run within RELION. …”
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Functional analysis of heterozygous variants in the SALL1 gene in 2 children with Townes-Brocks syndrome with FSGS by Rong Liang, Bixia Zheng, Chunli Wang, Sanlong Zhao, Wei Zhou, Ying Chen, Ruochen Che

“…The expression level of variant c.3175 C > T(p.Q1059X) in podocytes showed a significant decrease compared to that of the wild-type (P < 0.05), whereas variant c.694 C > T(p.Q232X) was markedly upregulated (P < 0.01). Immunofluorescence analysis revealed aberrant localization patterns for both SALL1 variants within podocytes. …”
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Impact of COVID-19 on the Air Quality over China and India Using Long-term (2009–2020) Multi-satellite Data by Manish Soni, Sunita Verma, Hiren Jethava, Swagata Payra, Lok Lamsal, Priyanshu Gupta, Janhavi Singh

“…Abstract We have examined the air quality over China, India and demonstrated marked differences in levels of air pollution resulted from the COVID-19 restrictions during December–April, 2019–20 to that of 11 years mean of 2009–19. …”
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Bisphenol A attenuates testosterone synthesis via increasing apolipoprotein A1-mediated reverse cholesterol transport in mice by Tong Zhao, Tong Zhao, Wenzhe Yang, Wenzhe Yang, Feilong Pan, Feilong Pan, Jinhao Wang, Jinhao Wang, Wenqi Shao, Wenqi Shao, Fangfang Chen, Fangfang Chen, Kexiang Liu, Kexiang Liu, Shuchen Zhao, Shuchen Zhao, Lijia Zhao, Lijia Zhao

“…Conversely, testicular high-density lipoprotein (HDL) content was partially elevated. Furthermore, BPA markedly enhanced Apoa1 mRNA and protein expression in the mouse model. …”
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Dietary Fiber-Rich <i>Spartina anglica</i> Improves Intestinal Health and Antioxidant Capacity of Zhedong White Geese by Xiao Zhou, Li Wang, Jiuli Dai, Huiyan Jia, Kai Shi, Jian Zhao, Shufang Chen

“…Notably, SA supplementation markedly improved intestinal morphology, although excessive levels appeared to compromise these benefits. …”
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Impact of Silent Cerebral Embolism during and after Left Atrial Appendage Occlusion on Long‐Term Cognitive Function by Kexin Wang, Zhe Wang, Caiyi Jin, Mingjia Xu, Mingfang Li, Hailei Liu, Zidun Wang, Hongwu Chen, Weizhu Ju, Minglong Chen

“…Conclusions LAAO‐related SCE is associated with a marked impairment in cognitive function immediately after the procedure and is irreversible over a 1‐year follow‐up. …”
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Understanding and measuring workplace violence in healthcare: a Canadian systematic framework to address a global healthcare phenomenon by Christian Schulz-Quach, Brendan Lyver, Charlene Reynolds, Trevor Hanagan, Jennifer Haines, John Shannon, Laura Danielle Pozzobon, Yasemin Sarraf, Sam Sabbah, Sahand Ensafi, Natasha Bloomberg, Jaswanth Gorla, Brendan Singh, Lucas B. Chartier, Marnie Escaf, Diana Elder, Marc Toppings, Brian Hodges, Rickinder Sethi

“…Abstract Background Globally, healthcare institutions have seen a marked rise in workplace violence (WPV), especially since the Covid-19 pandemic began, affecting primarily acute care and emergency departments (EDs). …”
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Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation by Kabita Pradhan, Balram Neupane, Paul Niehues, Martin Kirschner, Fabian Beier, Chao‐Chung Kuo, Erika Anneliese Hilbold, Christian Bär, Oana‐Maria Thoma, Maximilian Waldner, Margherita Vieri, Tim H. Brümmendorf, Vithurithra Tharmapalan, Wolfgang Wagner, Michael Kleines, Mahdi Emrani, Matthias Daniel Zink, Andreas Napp, Nikolaus Marx, Michael Gramlich

“…Finally, atrial tissue of mouse models with shortened telomeres showed marked left atrial fibrosis and over‐expression of fibrosis‐related genes. …”
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Characterisation of internal tremors and vibration symptoms by Harlan M Krumholz, Mitsuaki Sawano, Richa Sharma, Tianna Zhou, Dorothy Massey, Anna D Baker, Diana Berrent Güthe, Nick Güthe, Suzanne Pincus Shidlovsky, Liza Fisher, Connor B Grady, Cesar Caraballo

“…Among the responses, many described symptoms that varied in location, timing and triggers, occurred soon after their COVID-19 infection, and were markedly debilitating. There were often frustrating experiences with the healthcare system.Conclusions This study describes key themes and experiences among a group of people reporting long COVID and having a prolonged and debilitating symptom complex that prominently features internal tremors and vibrations.…”
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Evaluation of the antidiabetic and antinephritic effects of Pueraria tuberosa and Pterocarpus santalinus extracts co-encapsulated in nanostructured lipid carriers in streptozotocin... by Gyamcho Tshering Bhutia, Asit Kumar De, Manas Bhowmik, Pavia Bera, Tanmoy Bera

“…The bioactive compounds in these extracts play a crucial role in their antidiabetic and antinephritic effects, marking significant progress in the field.…”
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C1q/TNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components by Feiyu Jiang, Min Yang, Xili Zhao, Rui Liu, Gangyi Yang, Dongfang Liu, Hua Liu, Hongting Zheng, Zhiming Zhu, Ling Li

“…Circulating CTRP5 concentrations were markedly decreased in MetS individuals relative to normal adults. …”
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