Therapeutic potential of the neutralizing monoclonal antibody 45G3 against encephalomyocarditis virus by Yanfang Zhang, Zhiying Wang, Yaohui Fang, Qiong Zhu, Jie Fu, Sijing Hu, Jiayin Jin, Min Zhou, Xijia Liu, Danna Zhang, Shouwei Huang, Yali Deng, Lingling Xie, Shu Shen, Jing Ye, Fei Deng, Shengbo Cao

“…Additionally, posttreatment analysis revealed reduced tissue damage and a markedly decreased inflammatory response in the brain, indicating that the 45G3 antibody effectively blocked viral infection, thereby mitigating tissue damage and enhancing survival. …”
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TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner by Arun Chhetri, Channy Park, Hyunsoo Kim, Laxman Manandhar, Chagtsalmaa Chuluunbaatar, Jaetaek Hwang, Xiaofan Wei, Gyuho Jang, Batching Chinbold, Hyug Moo Kwon, Sang-wook Lee, Raekil Park

“…CD36 expression was markedly induced by HFD or FFA, which was reduced by TMEM135 depletion. …”
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Reduced p63 expression is linked to unfavourable prognosis in muscle‐invasive urothelial carcinoma of the bladder by Kira Furlano, Henning Plage, Sebastian Hofbauer, Sarah Weinberger, Bernhard Ralla, Annika Fendler, Florian Roßner, Simon Schallenberg, Sefer Elezkurtaj, Martina Kluth, Maximilian Lennartz, Niclas C. Blessin, Andreas H. Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Stefan Koch, Nico Adamini, Sarah Minner, Ronald Simon, Guido Sauter, Joachim Weischenfeldt, Tobias Klatte, Thorsten Schlomm, David Horst, Henrik Zecha

“…The rate of p63 positive cases and the staining intensity was lower in pTaG3 tumours (93.2%, p < 0.0001 for pTaG3 vs. pTaG2) and markedly lower in pT2‐4 carcinomas (83.5%, p = 0.0120 for pT2‐4 vs. pTaG3). …”
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Lateralized differences in power spectra across different frequency bands during NREM sleep in patients with primary insomnia by Jiao Huang, Jiao Huang, Jing Ye, Mingjie Gao, Wentao Gao, Weijia Chen, Yifeng Zhu, Yongbo Wang, Daijin Huang, Yunhui Lv, Hong Shi

“…The Beta1 power was positively correlated the number of awakenings (r = 0.3291, p = 0.02) in primary insomnias on the right side.ConclusionThis study marked the first specialized comparison of power spectral analysis during non-rapid eye movement sleep in different areas and across different frequency bands. …”
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A new multi-grid bathymetric dataset of the Gulf of Naples (Italy) from complementary multi-beam echo sounders by F. Foglini, M. Rovere, R. Tonielli, G. Castellan, G. Castellan, M. Prampolini, M. Prampolini, F. Budillon, M. Cuffaro, G. Di Martino, V. Grande, S. Innangi, M. F. Loreto, L. Langone, F. Madricardo, A. Mercorella, P. Montagna, C. Palmiotto, C. Pellegrini, A. Petrizzo, L. Petracchini, A. Remia, M. Sacchi, D. Sanchez Galvez, A. N. Tassetti, F. Trincardi

“…The digital bathymetric data previously available are restricted to the shallow highly dynamic area of the Gulf of Naples and appear fragmented as they were acquired in successive years, with different goals thereby using a variety of devices, with markedly different spatial resolutions. In this paper, we present bathymetric maps of the Gulf of Naples and adjacent slope basins at unprecedented resolution using three state-of-the-art multi-beam echo sounders. …”
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The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment by Fan Chen, Na Wang, Xinyan Tian, Juan Su, Yan Qin, Rongqiao He, Xiaping He

“…It was further found that these protective effects were achieved by attenuating FA-induced endoplasmic reticulum stress (ERS), as indicated by the inhibition of the ERS markers, GRP78 and CHOP, and downstream Tau-associated kinases (GSK-3β and CaMKII) expression. In addition, MGF markedly inhibited FA-induced oxidative damage, including Ca²⁺ overload, ROS generation, and mitochondrial dysfunction, all of which are associated with ERS. …”
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Overcoming breast cancer cell treatment resistance by optimizing sonodynamic therapy and radiation sensitizers on lncRNA PVT1 and miR-1204 expression by Ali Neshastehriz, Zeinab Hormozi-Moghaddam, Zahra Abedi Kichi, Seyedeh Mona Taheri, Seyed Mohammad Amini, Amir Aghaei

“…This was associated with a marked increase in ROS with a mean fluorescence intensity of 20,576.2 ± 4.6 (>4.5 times). …”
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The association of systemic immune-inflammation index with incident breast cancer and all-cause mortality: evidence from a large population-based study by Yu Li, Yu Li, Meng Yu, Ming Yang, Jingqi Yang

“…The optimal inflection point for SII/100 in this context was 5.22, and above this threshold, there was a marked escalation in all-cause mortality (HR=1.09, 95% CI: 1.04-1.14).ConclusionThe SII, as a novel inflammatory composite index, is significantly associated with the risk of breast cancer incidence and all-cause mortality in breast cancer patients. …”
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Novel green synthesis of silver nanoparticles from empty fruit bunch waste: Biomedical applications and mechanistic insights by Bashirat Olamide Yusuf-Salihu, Shakirat Afodun Abdulmumini, Toheeb Taiye Bajepade, Halimah Adekunbi Durosinmi, Muinat Olanike Kazeem, Victoria Atinuke Ajayi, Agbaje Lateef

“…This study addresses this issue by innovatively transforming EFB biomass into high-value silver nanoparticles (AgNPs) via a green synthesis approach, marking the first successful biosynthesis of AgNPs from EFB. …”
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Evaluation of Hepatoprotective Potential of Polyherbal Preparations in CCl4-Induced Hepatotoxicity in Mice by Rayhana Begum, Sonia Akther Papia, Mst Marium Begum, Hongbin Wang, Rubaba Karim, Rebeka Sultana, Priyanka Rani Das, Taslima Begum, Md. Ragibul Islam, Nargis Manwar, Md. Sohanur Rahman

“…CCl4 administration caused significant hepatotoxicity as evidenced by marked elevation in AST, ALT, ALP, and total bilirubin. …”
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Case report: Monitoring consciousness with fNIRS in a patient with prolonged reduced consciousness following hemorrhagic stroke undergoing adjunct taVNS therapy by Fei Gao, Likai Wang, Likai Wang, Zhan Wang, Yaru Tian, Jingyi Wu, Mengchun Wang, Litong Wang

“…Behavioral improvements were evidenced by an increase in CRS-R scores from 2 to 14, marking the patient's transition from UWS to minimally conscious state plus (MCS+). …”
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The MyFlex-&#x03B6; Foot: A Variable Stiffness ESR Ankle-Foot Prosthesis by Johnnidel Tabucol, Vera G. M. Kooiman, Marco Leopaldi, Ruud Leijendekkers, Giacomo Selleri, Marcello Mellini, Nico Verdonschot, Magnus Oddsson, Raffaella Carloni, Andrea Zucchelli, Tommaso M. Brugo

“…With further actuation and control system development, MyFlex-<inline-formula> <tex-math notation="LaTeX">$\zeta $ </tex-math></inline-formula> could mark significant progress in prosthesis technology.…”
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Enhancing athlete performance under pressure: the role of attribution training in mitigating choking by Dan Huang, Dan Huang, Huilin Wang, Yiwei Tang, Hanyue Lei, Denise Koh

“…IntroductionChoking in athletes describes a marked reduction in their skill level, falling below the normal level, when under stress. …”
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Comparative Analysis of the Safety and Functional Outcomes of Anterior versus Retropupillary Iris-Claw IOL Fixation by Paolo Mora, Giacomo Calzetti, Stefania Favilla, Matteo Forlini, Salvatore Tedesco, Purva Date, Viola Tagliavini, Arturo Carta, Rino Frisina, Emilio Pedrotti, Stefano Gandolfi

“…Both groups experienced similarly marked ECD loss and showed similar incidence of postoperative complications, with cystoid macular edema being the most common complication. …”
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Changes in movement patterns in relation to sun conditions and spatial scales in wild western gorillas by B. Robira, S. Benhamou, E. Obeki Bayanga, T. Breuer, S. Masi

“…By contrast, movement straightness was not markedly different when the sun elevation was low (the sun azimuth then being potentially usable as a compass) or high (so providing no directional information) and the sky was clear or overcast. …”
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Chiari malformation with concurrent papilledema: a patient-level meta-analysis of case reports and case series by Alejandro Pando, Daniel J. Valdivia, Daniel A. Brenner, Mohammed Ali Alvi, Hai Sun, James K. Liu, Ira Goldstein

“…Historically, papilledema marked IIH, but there are reports of papilledema in patients with Chiari I/1.5, leading to uncertainty about the most effective treatment strategies. …”
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Glucose‐induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma by Yanfang Liu, Junjiao Song, Qili Shi, Bing Chen, Wenying Qiu, Yizhe Liu, Shenglin Huang, Xianghuo He

“…Notably, administration of an N‐acetylgalactosamine (GalNAc)‐conjugated siRNA specifically targeting LINC01419 markedly retarded the growth of orthotopic xenograft tumours. …”
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The Ediacaran-Cambrian Radiation of Animals within the Villuercas-Ibores-Jara UNESCO Global Geopark, Spain by Iván Cortijo, Teodoro Palacios, Sören Jensen, José María Barrera

“…Geosites, geological itineraries and interpretation centres in the geopark show the visitors these exceptional fossils, including the holotype of Cloudina carinata, which provide vivid evidence of time that marked the beginning of life on our planet as we know it today.…”
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Long-chain chlorinated paraffins (LCCPs) exposure induces apoptosis in primary chicken embryo hepatocytes through oxidative stress by Haochu Deng, Yezi Taishi, Guoxia Wang, Yuebing Kong, Ruoting Zhang, Xin Zheng

“…Additionally, we observed that LCCPs exposure markedly decreased the autophagy levels in primary chicken embryo hepatocytes while significantly increase the levels of apoptosis. …”
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Transcriptome analysis of muscle atrophy in Leizhou black goats: identification of key genes and insights into limb-girdle muscular dystrophy by Ke Wang, Mengning Xu, Xiaotao Han, Hu Liu, Jiancheng Han, Wei Sun, Hanlin Zhou

“…Results Differential expression analysis revealed 536 mRNAs with significant differences across three muscle groups. Marked variations in mRNA expression patterns were observed between leg and back muscles versus abdominal muscles, reflecting characteristics similar to those found in limb-girdle muscular dystrophy. …”
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