S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasis by Panpan Lian, Li Li, Renwei Lu, Bin Zhang, Junaid Wazir, Chaode Gu, Bojie Ma, Wenyuan Pu, Wangsen Cao, Zhiqiang Huang, Zhonglan Su, Hongwei Wang

“…S1PR3 expression is markedly elevated in psoriatic lesions and correlates with disease severity. …”
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YTHDF1 Regulates RELA m6A Modification and Activates the NF‐Kappa B Signaling Pathway to Promote the Mechanism of Gastric Cancer by Yangyuan Huang, Shihao Liang, Liping Li, Qingyu Zeng, Bin Li

“…Results Online data and clinical samples analysis showed that the expression of YTHDF1 in GC was markedly elevated compared to surrounding tissues. …”
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Liraglutide Promotes Osteoblastic Differentiation in MC3T3-E1 Cells by ERK5 Pathway by Yue Sun, Yuzhen Liang, Zhengming Li, Ning Xia

“…The mRNA and protein levels of Col-1, OPG, and OCN in MC3T3-E1 cells were also markedly increased following 100 nM liraglutide treatment compared with those of the control group. …”
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Restoration of Sestrin 3 Expression Mitigates Cardiac Oxidative Damage in Ischemia–Reperfusion Injury Model by Mina Park, Sunghye Cho, Dongtak Jeong

“…We found that miR-25 was markedly upregulated under hypoxic conditions in both in vitro and in vivo models. …”
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Upregulation of TCPTP in Macrophages Is Involved in IL-35 Mediated Attenuation of Experimental Colitis by Baoren Zhang, Chenglu Sun, Yanglin Zhu, Hong Qin, Dejun Kong, Jingyi Zhang, Bo Shao, Xiang Li, Shaohua Ren, Hongda Wang, Jingpeng Hao, Hao Wang

“…With Pichia/IL-35 treatment, the proportion of M1 macrophages, Th17, and Th1 cells in mouse MLNs were markedly decreased, while Tregs were significantly increased. …”
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Abnormal insulin metabolism and decreased levels of mindfulness in type 2 diabetes mellitus by Xue Zhang, Rui Huang, Jiaxin Li, Mingyue Yang, Daowen Zhang, Cancan Liu, Kuanlu Fan

“…Compared to the control group (low HOMA-IR/high HOMA-β), the high HOMA-IR/low HOMA-β group exhibited markedly lower scores in “Non-judging of Inner Experience” (P = 0.02) and “Acting with Awareness” (P < 0.001). …”
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Impact of 21 June 2020 Annular Solar Eclipse on Meteorological Parameters, O3 and CO at a High Mountain Site in Taiwan by Saginela Ravindra Babu, Shantanu Kumar Pani, Chang-Feng Ou-Yang, Neng-Huei Lin

“…We also noticed a steady decline in WS just after the onset of the eclipse at LABS. Interestingly, a marked decline in ozone and carbon monoxide was seen during the eclipse day at LABS. …”
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Investigating the influence of urban green spaces on urban heat island mitigation – taking four districts in Shijiazhuang as an example by Nan Zhang, Qiuning Ding, Haitao Wang

“…Furthermore, augmentation of green space configurations is recommended in vicinities characterized by building densities falling within the range of 0.2 to 0.3. Notably, in locales marked by high building density, park layouts should adhere to a more regularized design during the renovation process. …”
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Gross soil N transformations and microbial communities in Luxembourg beech forest (Fagus sylvatica L.) soils along a pH gradient by Mengru Jia, Annemieke Kooijman, Roland Bol, Wim W. Wessel, Kathrin Hassler, Albert Tietema

“…Our results demonstrate that soil N supply mechanisms differ markedly along the pH gradient, from low immobilization at low pH to high nitrification at high pH, driven by shifts in fungal versus bacterial dominance and their distinct N demands. …”
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The case of Kinsburn’s Encephalopathy in a child with neuroblastoma of posterior mediastinum by T.I. Stetsenko, H.M. Fedushka, S.O. Rebenkov, T.P. Ivanova

“…On the background of the received therapy, the child was marked with positive dynamics, she began to walk by herself, the atactic syndrome diminished, opsoclonus remained unchanged. …”
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Presenting a multi-objective decision-making model for cost-time trade-off considering the time value of money and solving it using particle swarm optimization by Mohammadreza Shahriari

“…This approach allows for scheduling decisions that account for the time value, reducing delay-related costs and enhancing overall project efficiency.Originality/Value:  This research presents a novel approach by introducing a bi-objective decision-making model that integrates the time value of money in project scheduling, marking a new step in optimizing the cost-time tradeoff. …”
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Histopathological Finding of Microdamage Accumulation in Atypical Subtrochanteric Femoral Fracture by Yo Watanabe, Naoki Kondo, Tomomi Fukuhara, Norio Imai, Masahiko Yamada, Naoto Endo

“…In the cortex of fracture site, the lacunar density was markedly lower than the osteocyte density, and microcracks were detected, suggesting impaired osteocyte function and a low potential for fracture healing. …”
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Assessment of economic burden due to COVID-19 pandemic during institutional childbirth in Nepal: before-and-after design by Ashish KC, Rejina Gurung, Prajwal Paudel, Honey Malla, Avinash K Sunny, Mats Målqvist, Omkar Basnet, Pratiksha Bhattarai

“…OOPE increased in all wealth quintile with marked rise in richer wealth quintile group. Mitigation efforts to secure affordable maternal healthcare services are required during pandemic.…”
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Effect on Physical and Mechanical Properties of Conventional Glass Ionomer Luting Cements by Incorporation of All-Ceramic Additives: An In Vitro Study by Runki Saran, Nagraj P. Upadhya, Kishore Ginjupalli, Arul Amalan, Bharath Rao, Saurabh Kumar

“…The experimental GICs with 5% all-ceramic powders showed no improvement in strength, whereas those containing 15% all-ceramic powders exhibited a marked decrease in strength. Setting time of all experimental GICs progressively increased with increasing concentration of all-ceramic powders. …”
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Procedural Sedation with Dexmedetomidine for Anterior Mediastinotomy in a High-Risk Patient by Miguel Pratas, Jorge Aires, Nuno Pereira da Silva, Tiago Oliveira, Cristovão Pinto, Jiele Li, Ana Filipa Ribeiro

“…In this case, we report our anesthetic management of a 22-year-old male scheduled for anterior mediastinotomy, with a large anterior mediastinal mass, with 50% distal tracheal compression and marked collapse of the superior vena cava and brachiocephalic trunk. …”
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Sigmoid Volvulus in Pregnancy Assessed by Contrast-Enhanced Computed Tomography Scanning by Toshiaki Watanabe, Tadatsugu Kinjo, Yoshino Kinjyo, Hayase Nitta, Hitoshi Masamoto, Keiko Mekaru, Yoichi Aoki

“…The proximal end of the transverse to sigmoid colon was markedly dilated, and the distal end was collapsed. …”
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Effect of Biofloc Culture on the Daily Rhythmicity of the Activity and Expression of Digestive Enzymes in Tilapia, Oreochromis niloticus by María del Carmen Monroy-Dosta, Daniel Becerril-Cortés, Juan Pablo Lazo, Arturo Mena-López, Pilar Negrete-Redondo, Eliasid Nogueda-Torres, Carmen Navarro-Guillén, José Antonio Mata-Sotres

“…The maximum expression levels of digestive gene enzymes between treatments show a marked effect dependent on the presence of light and dark phases. …”
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Potential Use of C60/2-Hydroxypropyl-β-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer by Abdulmalik Altaf, Hibah Aldawsari, Zainy M. Banjar, Daisuke Iohara, Makoto Anraku, Kaneto Uekama, Fumitoshi Hirayama

“…Treatment with C60/HP-β-CyD nanoparticles at a C60 dose of 2.0 mg/kg under visible light irradiation at 350 mW/cm2 (63 J/cm2) markedly suppressed tumor growth, whereas that at 30 J/cm2 was less effective. …”
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Drugs and Constipation in Elderly in Nursing Homes: What Is the Relation? by Gunvor S. Fosnes, Stian Lydersen, Per G. Farup

“…Reduced activity of daily living (OR = 0.71, 95% CI : 0.60–0.84, P<0.001), other antidepressants (N06AX) (OR 3.08, 95% CI : 1.09–8.68, P=0.03), and benzodiazepine derivatives (N05BA) (OR = 2.80, 95% CI : 1.12–7.04, P=0.03) were significantly associated with constipation; drugs with markedly anticholinergic effect (OR = 3.7, 95% CI : 0.78–17.53, P=0.10), natural opium alkaloid (N02AA) (OR = 5.01, 95% CI : 0.95–25.94, P=0.06), and propionic acid derivatives (M01AE) (OR = 7.00, 95% CI : 0.75–65.08, P=0.09) showed a trend. …”
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Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation by Ren-Shi Shyu, Themmila Khamrang, Joen-Rong Sheu, Chih-Wei Hsia, Marappan Velusamy, Chih-Hsuan Hsia, Duen-Suey Chou, Chao-Chien Chang

“…Moreover, Ir-6 did not considerably diminish OH radical signals in collagen-activated platelets or Fenton reaction solution. At 2 mg/kg, Ir-6 markedly prolonged the bleeding time in experimental mice. …”
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