Pharmacological and non-pharmacological interventions in patients undergoing nasal surgeries for prevention of emergence agitation: a systematic review and network meta-analysis by Gustavo R.M. Wegner, Bruno F.M. Wegner, Henrik G. Oliveira, Luis A. Costa, Luigi W. Spagnol, Valentine W. Spagnol, Gilberto T.F. de Oliveira Filho

“…Background: Emergence agitation is a common complication after nasal surgeries, marked by increased agitation and a heightened risk of injuries. …”
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Calponin 3 Regulates Myoblast Proliferation and Differentiation Through Actin Cytoskeleton Remodeling and YAP1-Mediated Signaling in Myoblasts by Mai Thi Nguyen, Quoc Kiet Ly, Thanh Huu Phan Ngo, Wan Lee

“…CNN3 knockdown led to a marked increase in filamentous actin, which promoted the nuclear localization of Yes-associated protein 1 (YAP1), a mechanosensitive transcriptional coactivator required for response to the mechanical cues that drive cell proliferation. …”
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Physical, Microbial, and Chemical Quality of Hot-Air-Dried Persimmon (Diospyros kaki) Chips during Storage by Rebecca R. Milczarek, Ana M. Vilches, Carl W. Olsen, Andrew P. Breksa, Bruce E. Mackey, Maria T. Brandl

“…It was found that–with the exception of a marked decrease in ascorbic acid (vitamin C)—all 4 Preparation/Packaging combinations yielded products that maintained acceptable color, microbial, nutritional, and textural quality throughout the entire study. …”
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Fatigue and Mental Status of Caregivers of Severely Chronically Ill Patients by Sung-Goo Kang, Sang-Wook Song, Se-Hong Kim, Yi-Jin Kang, Young-Rye Kim, Youngmi Eun

“…Caregivers of patients with severe illnesses who require long-term treatment often experience marked physical and mental fatigue. This study investigated the factors affecting fatigue among caregivers of patients with severe chronic diseases. …”
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SwinClustering: a new paradigm for landscape character assessment through visual segmentation by Tingting Huang, Tingting Huang, Bo Huang, Bo Huang, Sha Li, Haiyue Zhao, Xin Yang, Jianning Zhu

“…Furthermore, its strong generalization capabilities enable its seamless application to LCA tasks at arbitrary scales, marking a sustainable development in the field of LCA.…”
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Copy Number Variations in Short Tandem Repeats Modulate Growth Traits in Penaeid Shrimp Through Neighboring Gene Regulation by Hao Zhou, Guangfeng Qiang, Yan Xia, Jian Tan, Qiang Fu, Kun Luo, Xianhong Meng, Baolong Chen, Meijia Chen, Juan Sui, Ping Dai, Xupeng Li, Mianyu Liu, Qun Xing, Jie Kong, Sheng Luan

“…In this study, we systematically identified and compared STRs across multiple species, confirming a significantly higher prevalence of STRs (26–32%) in penaeid shrimp, which is markedly higher than that observed in other species, such as mammals (1.3–2.1%) and plants (0.21–0.73%). …”
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Effects of fluconazole and amphotericin B in the control of cryptococcal pneumonia in vivo by Zhao Yu, Zhihao Liu, Jiaojiao Qian, Yuanyuan Qian

“…Results demonstrated marked improvements in pulmonary function within the observation group, with significantly higher FEV1, FVC, and FEV1/FVC values than those in the control group (P < 0.05). …”
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Efficacy and Safety of Sacubitril/Valsartan Versus Amlodipine in Japanese Patients With Essential Hypertension: A Randomized, Multicenter, Open‐Label, Noninferiority Study (PARASOL... by Koichi Yamamoto, Daisuke Yarimizu, Ayano Shimanishi, Shunsuke Eguchi, Kazuma Iekushi, Yoichi Takami, Yoichi Nozato, Kazuomi Kario, Hiromi Rakugi

“…These results suggested that the blood pressure‐lowering effect of sacubitril/valsartan is comparable to that of amlodipine, with no marked differences in tolerability between the two groups. …”
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Mechanical properties and damage characterization of cracked granite after cyclic temperature action by Xiankai Bao, Lingyu Wang, Guangqin Cui, Jianlong Qiao, Baolong Tian, Shunjia Huang, Lizhi Wang

“…At the same fracture inclination, peak stress, elastic modulus, and σci/σm slightly increased at 70 °C, while AE ring counts and total energy were lower, indicating the degree of internal thermal damage in the specimen has significantly decreased, and the development of internal microcracks in the specimen has shown a marked reduction in orderliness. These findings provide theoretical insight into the meso-damage and failure mechanisms of granite influenced by different cyclic temperatures and fracture inclinations.…”
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Detection of Insertion/Deletions (InDel) Within Five Clock Genes and Their Associations with Growth Traits in Four Chinese Sheep Breeds by Ziteng Wang, Xiaohua Yi, Mengzhe Yang, Xiuzhu Sun, Shuhui Wang

“…Numerous studies have demonstrated a marked association between these genes and various growth traits of sheep. …”
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Reduction in Surgical Wound Infection Rates Associated with Reporting Data to Surgeons by GD Taylor, M Buchanan-Chell, T Kirkland, M McKenzie, B Sutherland, R Wiens

“…In clean orthopedic surgery the ssi rate remained stable from 1987 through 1992. In 1993 a marked increase was experienced. Reasons for this are being explored. …”
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The Impact of Electrophysiological Diversity on Pattern Completion in Lithium Nonresponsive Bipolar Disorder: A Computational Modeling Approach by Abraham Nunes, Selena Singh, Anouar Khayachi, Shani Stern, Thomas Trappenberg, Martin Alda

“…Induced pluripotent stem cell–derived CA3 pyramidal cell–like neurons show significant hyperexcitability in lithium‐responsive BD patients, while lithium nonresponders show marked variance in hyperexcitability. We hypothesize that this variable excitability will impair episodic memory recall, as assessed by cued retrieval (pattern completion) within a computational model of the hippocampal CA3. …”
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The evolutionary journey to a new normal for learning and capacity building of healthcare workers to prepare and respond to health emergencies across Africa by Boukaré Bonkoungou, Fausta Mosha, Amarachi Abianuru, Joseph Okeibunor, Heini Utunen, Giselle Balaciano, Ana C. Barbosa de Lima, Lauren Burke, Shannon McKenna, Sukriti Nag, Abdou Salam Gueye, Bruce Struminger

“…This paper aims to present the lessons learned.ResultsFrom April 2020 to February 2024, 287 virtual learning sessions were conducted with over 125,816 attendances from 173 countries and regions. This marked a significant increase compared to pre-pandemic face-to-face training, which targeted fewer than 2,000 participants annually. …”
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Tanshinone IIA Sodium Sulfonate Attenuates LPS-Induced Intestinal Injury in Mice by Xin-Jing Yang, Jin-Xian Qian, Yao Wei, Qiang Guo, Jun Jin, Xue Sun, Sheng-Lan Liu, Chun-Fang Xu, Guo-Xing Zhang

“…LPS-induced release of inflammatory mediators, including TNF-α, IL-1β, and IL-6, were markedly inhibited by TSS. Furthermore, TSS treatment could effectively upregulate LPS-induced decrease of autophagy levels, as evidenced by the increased expression of LC3 and Beclin-1, and more autophagosomes. …”
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Ecosystem health assessment based on the V-O-R-S framework for the Upper Ganga Riverine Wetland in India by Alka Yadav, Mitthan Lal Kansal, Aparajita Singh

“…Consequently, the WEHI declined from 0.75 in 2000 to 0.58 in 2020, marking a 23% decrease over the period. All V-O-R-S indicators showed a downward trend, with ecosystem organization (O) showing the steepest decline of 45%, followed by ecosystem services (S) at 18%, ecosystem resilience (R) at 14%, and ecosystem vigor (V) at 8%. …”
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Implications of a Narrow Automated Vehicle-Exclusive Lane on Interstate 15 Express Lanes by Sahar Ghanipoor Machiani, Alidad Ahmadi, Walter Musial, Anagha Katthe, Benjamin Melendez, Arash Jahangiri

“…AVs’ automated longitudinal and lateral control systems could potentially reduce these types of collisions on an AV-exclusive lane with proper infrastructure features for AV sensor operation (e.g., distinct lane marking). Microsimulation findings indicated an AV-exclusive lane may increase traffic flow and density by up to 14% and 24%, respectively. …”
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Turning to friends in preference to parents for support in early adolescence: does this contribute to the gender difference in depressive symptoms? by Nicky Wright, Helen Sharp, Jessica Gay, Andrew Pickles, Jonathan Hill

“…The association between preferentially turning to friends and depressive symptoms was stronger for girls than for boys (p = .004).ConclusionsIn young adolescents, preferentially turning to friends over parents when distressed is common, and the association between preferentially turning and depressive symptoms is markedly higher in girls than in boys. This reflects either a gender difference in social vulnerability to depression or a greater impact of depression on the reliance on friends instead of parents in girls. …”
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Downregulation of TNF-α/TNF-R1 Signals by AT-Lipoxin A4 May Be a Significant Mechanism of Attenuation in SAP-Associated Lung Injury by Suhui Yu, Jianming Xie, Yukai Xiang, Shengjie Dai, Dinglai Yu, Hongwei Sun, Bicheng Chen, Mengtao Zhou

“…In vitro, we found that AT-Lipoxin A4 markedly suppressed protein expression in TNF-α signals in human pulmonary microvascular endothelial cell, such as tumor necrosis factor receptor-associated factor 2 (TRAF2), TNF-R1-associated death domain (TRADD), receptor-interacting protein (RIP), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. …”
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Adaptive Autophagy Offers Cardiorenal Protection in Rats with Acute Myocardial Infarction by Zhendong Feng, Han Xue Jiang, Huiyang Chen, Yu Ning Liu, Yahui Wang, Rui Bing Yang, Xueting Han, Chen Hui Xia, Ze Bing Zhu, Hongcai Shang, Aiming Wu, Wei Jing Liu

“…At week 4, LC3-II did not significantly increase and p62 levels significantly increased. In addition, 3-MA markedly increased KIM1, NGAL, and the activity of caspase-3 in the hypoxic HK-2 and AC16 cell. …”
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Spinal cord injury enhances lung inflammation and exacerbates immune response following exposure to LPS by Bradford C. Berk, Bradford C. Berk, Amanda Pereira, Velia Sofia Vizcarra, Christoph Pröschel, Chia George Hsu, Chia George Hsu, Chia George Hsu

“…Twenty-four hours post-LPS exposure, lung tissues and bronchoalveolar lavage (BAL) fluid were analyzed. ResultsLPS markedly induced proinflammatory gene expression (SAA3, IRG1, NLRP3, IL-1beta, MCP-1) and cytokine release (IL-1beta, IL-6, MCP-1) in SCI mice compared to controls, indicating an exaggerated inflammatory response. …”
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