Foreign Policy Preferences of Kazakhstan after 2022 by M. Y. Kucherov, I. V. Vokhmintsev, I. D. Kravchuk, V. Y. Andriukhin, M. A. Fedotov, A. A. Tokarev

“…This research investigates the focal states and international organizations prioritized by Kazakhstan during Kassym-Jomart Tokayev's presidency, spanning from March 20, 2019, when Tokayev assumed office, to December 31, 2022, marking the end of data collection. Employing content analysis and discourse analysis as primary methods, this study examines data from diverse sources, including the official website of Kazakhstan's President, his social media profiles, and relevant media outlets. …”
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Removing Land Subsidence Impact from GPS Horizontal Motion in Tianjin, China by Zhao Peng, Wenbing Liu, Lei Zhang

“…The results demonstrate that following the removal of the impact of land subsidence, the dispersion of GPS horizontal motion within the Tianjin subsidence area is markedly diminished, and the horizontal motion trend exhibits greater consistency with that observed at neighboring stations in non-subsidence regions. …”
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Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy by Hassan Tariq, Syeda Zunaira Bukhari, Ruibing An, Jian Dong, Ayesha Ihsan, Muhammad Rizwan Younis

“…As a chronic inflammatory disease with a complicated pathophysiology marked by abnormal lipid metabolism and arterial plaque formation, atherosclerosis is a major contributor to CVDs and can induce abrupt cardiac events. …”
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Administration of FTY720 during Tourniquet-Induced Limb Ischemia Reperfusion Injury Attenuates Systemic Inflammation by Anthony D. Foster, Diego Vicente, Jonathan J. Sexton, Luke Johnston, Nick Clark, Crystal Leonhardt, Eric A. Elster, Thomas A. Davis, Matthew J. Bradley

“…Peripheral blood as well as lung, liver, kidney, and ischemic muscle tissue was analyzed and compared between groups. FTY720 treatment markedly decreased the number of peripheral blood T cells (p<0.05) resulting in a decreased systemic inflammatory response and lower serum creatinine levels and had a modest but significant effect in decreasing the transcription of injury-associated target genes in multiple end organs. …”
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Analysis of Conduction and Charging Mechanisms in Atomic Layer Deposited Multilayered HfO2/Al2O3 Stacks for Use in Charge Trapping Flash Memories by Nenad Novkovski, Albena Paskaleva, Aleksandar Skeparovski, Dencho Spassov

“…By applying our previously developed comprehensive model for MOS structures containing high-κ dielectrics on the J-V characteristics measured in the voltage range without marked degradation and charge trapping (from −3 V to +3 V), several parameters of the structure connected to the interfacial layer and the conduction mechanisms have been extracted. …”
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IL-33 Acts to Express Schaffer Collateral/CA1 LTP and Regulate Learning and Memory by Targeting MyD88 by Tomoyuki Nishizaki

“…Moreover, the retention latency in MyD88-deficient mice was markedly prolonged. In contrast, the acquisition and retention latencies in ST2-deficient mice were not affected. …”
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Successful treatment of etanercept- and adalimumab-resistant pyoderma gangrenosum with spesolimab, moderate-dose corticosteroids, and minocycline by Hanlin Zhang, Chao Wu, Hongzhong Jin

“…After reviewing the screening results and discussing treatment options, the patient received two doses of spesolimab (900 mg intravenously) administered two weeks apart.Results Marked clinical improvement was observed after spesolimab initiation. …”
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Subtilases: a major prospect to the genome editing in horticultural crops by Umashankar Chandrasekaran, Umashankar Chandrasekaran, Woo Jong Hong, Hyeran Kim, Hyeran Kim

“…Over the past five years, research on proteolytic enzymes, especially SBTs, has increased markedly, yet reports involving loss- or gain-of function analyses aimed at improving crop yield and quality are still limited. …”
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Nuclear Magnetic Resonance Fingerprinting and Principal Component Analysis Strategies Lead to Anti-Tuberculosis Natural Product Discovery from Actinomycetes by Jianying Han, Xueting Liu, Lixin Zhang, Ronald J. Quinn, Miaomiao Liu

“…Additionally, elaiophylin and polycyclic tetramate macrolactams (PTMs) displayed significant bactericidal effects, with elaiophylin achieving complete BCG inhibition at 72 h and PTMs marking their first reported anti-TB activity. The study also identified bafilomycins as potent scaffolds for anti-TB drug development, showcasing rapid bactericidal activity at low MIC values. …”
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Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD by Fabrizio Termite, Sebastiano Archilei, Francesca D’Ambrosio, Lucrezia Petrucci, Nicholas Viceconti, Roberta Iaccarino, Antonio Liguori, Antonio Gasbarrini, Luca Miele

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition marked by excessive lipid accumulation in hepatic tissue. …”
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GIS and remote sensing based analysis for monitoring urban growth dynamics in Western Himalayan city of Dharamshala, India by Nishant Mehra, Janaki Ballav Swain

“…Integrating remote sensing and GIS has markedly helped frame intervention strategies in the fragile Himalayan regions. …”
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Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity by A. Rodriguez-Barbero, E. Bosque, L. Rivas-Cabaero, M. Arévalo, J. M. López-Novoa

“…Histological examination revealed a massive cortical tubular necrosis in rats treated with gentamicin, whereas in BN-52021 injected animals tubular damage was markedly attenuated. The present results suggest a role for PAF in the gentamicininduced nephro-toxicity.…”
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Herbal remedies as a potential alternative therapy for arthritis by Disha Trivedi, Riya Jayapal Roja, Eva Künnemann

“…Arthritis forms a vicious cycle, where upon overuse of a joint or an autoimmune reaction inflammation and pain occur. These are marked by specific molecular patterns and immunological pathways that lead to chondrolysis and destruction of cartilage. …”
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Advancing energy efficiency: thermomechanical characterization of plastic-infused concrete for sustainable building solutions by Siddique, Mohammed Javeed, Akhas, Punitha Kumar

“…This modification leads to the highest annual savings, calculated at 0.9946 $/m2 in Muscat and 0.9928 $/m2 in New Delhi, along with a marked reduction in carbon emissions—19 kg/kWh in Oman and 18.2 kg/kWh in New Delhi. …”
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Translocator Protein (18 kDa) Mapping with [I]-CLINDE in the Quinolinic Acid Rat Model of Excitotoxicity: A Longitudinal Comparison with Microglial Activation, Astrogliosis, and Ne... by Nicolas Arlicot, Claire Tronel, Sylvie Bodard, Lucette Garreau, Brice de la Crompe, Inge Vandevelde, Denis Guilloteau, Daniel Antier, Sylvie Chalon

“…Combined immunohistochemical studies showed a marked increase in microglial expression in the lesion, peaking at 14 dpl, and astrocytic reactivity enhanced at 7 and 14 dpl, whereas a prominent neuronal cell loss was observed. …”
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Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEK/Erk Signaling Pathway by Yuqin Ye, Zhenyu Zhao, Hongyu Xu, Xin Zhang, Xinhong Su, Yongxiang Yang, Xinguang Yu, Xiaosheng He

“…The results showed that a marked upregulation of S1PR1 occurred with a peak at 7 days after trauma, revealing an enhancement of proliferation and neuronal differentiation of NSCs in hippocampus due to S1PR1 activation. …”
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Association between overt hepatic encephalopathy and liver pathology after transjugular intrahepatic portosystemic shunt creation in cirrhotic patients by Chaoyang Wang, Yuyang Gu, Guofeng Zhou, Pengfei Chen, Guorui Zhao, Jianzhuang Ren, Wenguang Zhang, Huanzhang Niu

“…Liver pathology by H&E staining showed typical features of liver cirrhosis (including disordered structure and pseudolobule formation) in all the patients. No marked difference was observed in extracellular matrix (ECM) deposition between the OHE and non-OHE groups. …”
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Modeling Mastitis Risk Management Effects on Dairy Milk Yield and Global Warming Potential by Giulia Ferronato, Anna Simonetto, Gianni Gilioli, Alfonso Zecconi

“…The occurrence of overcrowding and a lack of adequate cleanliness in resting areas were found to have a markedly detrimental impact on both productivity and the environmental performance of cows. …”
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Medical foods in Alzheimer’s disease by Klaus W. Lange, Jianjun Guo, Shigehiko Kanaya, Katharina M. Lange, Yukiko Nakamura, Shiming Li

“…Treatments achieving a marked improvement in symptoms or preventing or delaying the progression of the disease are not available. …”
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Diverse behaviors of marine ice sheets in response to temporal variability of the atmospheric and basal conditions by Olga Sergienko, Duncan John Wingham

“…Our results show that numerical simulations with a parameterization of the ice flux through the grounding line used in large-scale ice-sheet models produce markedly different results from simulations without the parameterization. …”
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