Hyaluronic Acid (800 kDa) Supplementation of University of Wisconsin Solution Improves Viability of Osteochondral Grafts and Reduces Matrix Metalloproteinase Expression during Cold... by Takuya Yamada, Kentaro Uchida, Kenji Onuma, Gen Inoue, Jun Aikawa, Shotaro Takano, Hiroyuki Sekiguchi, Hisako Fujimaki, Masayuki Miyagi, Masashi Takaso

“…In contrast, UW solution supplemented with either 1900 or 6000 kDa HA did not markedly improve the cell viability of the OCT. Real-time PCR analysis revealed that the levels of matrix metalloproteinases 2, 3, and 9 were significantly decreased in OCT stored in UW solution supplemented with 800 kDa HA. …”
Get full text

Effect of Parent-based Autism Intervention in Autism Spectrum Disorder Children by Praveen Suman, Sonika Pal, Jyoti Prajapati, Ashima Mehta

“…This assessment revealed a marked improvement in the child’s development and reduced autism characteristics.…”
Get full text

Feminism and androgyny: Gender politics in contemporary classical Chinese opera by Lisha Xu

“…It investigates how translation and performance as representational forms interrogate entrenched gender norms, and engage with themes of marked relevance today, such as domestic violence and the commodification of women’s bodies. …”
Get full text

Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides by Beus Maja, Fontinha Diana, Held Jana, Rajić Zrinka, Prudêncio Miguel, Zorc Branka

“…Title compounds showed marked, dose dependent activity in vitro against hepatic stages of Plasmodium berghei. …”
Get full text

Sintesis dan Karakterisasi Katalis Bentonit Termodifikasi TiO2 dan Terinpregnasi Logam Ni by Mohamad Mirzan, Nining Austi Duda, Khairuddin, Nurakhirawati, Ruslan

“…The success of nickel metal impregnation into the TiO2/bentonite support was obtained from XRD data, which was marked by the appearance of a typical Ni peak at 2θ = 37.70° d = 2.38 Å, 2θ = 39.39° d = 2.28 Å, 2θ = 43.02° d = 2.10 Å, 2θ = 51.38°d = 1.77 Å.…”
Get full text

The Relevance of HLA Sequencing in Population Genetics Studies by Alicia Sanchez-Mazas, Diogo Meyer

“…In this review, we first explain how HLA sequencing allows a better assessment of the HLA diversity in human populations, taking also into account the methodological difficulties it introduces at the statistical level; secondly, we show how analyzing HLA sequence variation may improve our comprehension of population genetic relationships by facilitating the identification of demographic events that marked human evolution; finally, we discuss the interest of both HLA and genome-wide sequencing and genotyping in detecting functionally significant SNPs in the MHC region, the latter having also contributed to the makeup of the HLA molecular diversity observed today.…”
Get full text

Unveiling degenerative bone changes in the condyle: a texture analysis approach using cone-beam computed tomography by Michelle Bianchi-de Moraes, Natália Caroline Queiroz Costa, Gabriella Yasmim Santos da Silva, Fernanda Calvo Costa, Fernando Vagner Raldi, Sérgio Lúcio Pereira de Castro Lopes

“…The scans were exported to MaZda software, in which the ROIs were delimited following previously marked contours, and the co-occurrence matrix values were calculated for selected texture analysis parameters. …”
Get full text

The Gender of the Neuronovel: Joyce Carol Oates and the Double Brain by Stephen J. Burn

“…For less clear reasons, the canon of neuronovels (primarily bequeathed by Marco Roth) has tended to pivot on a homogeneously white-male axis, dominated by Mark Haddon, Jonathan Lethem, Ian McEwan, and Richard Powers. …”
Get full text

Acupuncture in the Treatment of a Female Patient Suffering from Chronic Schizophrenia and Sleep Disorders by Peggy Bosch, Sabina Lim, Sujung Yeo, Sook-Hyun Lee, Heike Staudte, Maurits van den Noort

“…Acupuncture treatment led to a decrease in general psychopathology, less severe sleep problems, and markedly improved cognitive functioning (working memory) in the patient; however, the positive and the negative symptoms remained stable. …”
Get full text

Conversions to Catholicism among Fin de Siècle Writers: A Spiritual and Literary Genealogy by Claire Masurel-Murray

“…The Decadent converts were also marked by another major, but less obvious, imprint, that left by John Henry Newman. …”
Get full text

Recent Intensified Winter Coldness in the Mid-High Latitudes of Eurasia and Its Relationship with Daily Extreme Low Temperature Variability by Chuhan Lu, Shaoqing Xie, Yujing Qin, Jiewen Zhou

“…The results show that a sign-consistent mode dominates the CI variation in MEA, with a marked intensification during the last decade via empirical orthogonal function (EOF) analysis. …”
Get full text

Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides by Bing Wei, Ran Zhang, Jingbo Zhai, Junfeng Zhu, Fangli Yang, Dan Yue, Xiaoyi Liu, Changlong Lu, Xun Sun

“…GLP significantly improved survival rates, colon length shortening, body weight loss, histopathological score, and DAI scores in mice with DSS-induced colitis. GLP markedly suppressed the secretions of TNF-α, IL-1β, IL-6, IL-17A, and IL-4 and significantly affected populations of Th17 cells, B cells, NK cells, and NKT cells in the lamina propria lymphocytes. …”
Get full text

The Role of Imaging in Patient Selection, Preoperative Planning, and Postoperative Monitoring in Human Upper Extremity Allotransplantation by Eira S. Roth, David G. Buck, Vijay S. Gorantla, Joseph E. Losee, Daniel E. Foust, Cynthia A. Britton

“…Within the screening phase, musculoskeletal exclusion criterion included severe shoulder arthropathy, poor native bone integrity, and marked muscular atrophy. Vascular exclusion criterion included loss of sufficient arterial or venous supply and significant distortion of the native vascular architecture. …”
Get full text

Transcriptomic Analysis Reveals Molecular Mechanisms Underpinning Mycovirus-Mediated Hypervirulence in <i>Beauveria bassiana</i> Infecting <i>Tenebrio molitor</i> by Charalampos Filippou, Robert H. A. Coutts, Ioly Kotta-Loizou, Sam El-Kamand, Alexie Papanicolaou

“…Mycoviral infection can either be asymptomatic or have marked effects on fungal hosts, influencing them either positively or negatively. …”
Get full text

Readymade–Human: Principles of Artistic and Theoretical Work of Robert Cyprich by Ján KRALOVIČ

“…Cyprich made a significant mark on the Czechoslovak art scene through his samizdat texts and by disseminating and translating works within the Pro Arte Nova series.…”
Get full text

Epidural Dexamethasone for Postoperative Analgesia in Patients Undergoing Unilateral Inguinal Herniorrhaphy: A Comparative Study by M. R. Razavizadeh, MR. Fazel, N. Heydarian, F. Atoof

“…Duration of analgesia was markedly prolonged in the dexamethasone group than in the control group (P<0.001). …”
Get full text

Cicatricial Organizing Pneumonia with Dendriform Pulmonary Ossification: An Unusual Cause for a Recurrent Pneumothorax by Mnahi Bin Saeedan, Carol Farver, Atul C. Mehta, Ruchi Yadav

“…Video-assisted thoracoscopic biopsy of the lung demonstrated cicatricial organizing pneumonia with areas of marked diffuse DPO. The case highlights that dendriform pulmonary ossification arising from cicatricial organizing pneumonia should be considered in the differential diagnosis of recurrent pneumonias among patients with lower lobe sub-pleural reticular opacities. …”
Get full text

Omniphobic Photoresist‐Assisted Patterning of Porous Polymethacrylate Films by Dmitrii D. Kartsev, Ilia M. Lukianov, Eduard G. Sharapenkov, Artur Yu. Prilepskii, Pavel A. Levkin

“…Abstract Patterning of various surface properties, including roughness, wettability, adhesiveness, and mechanical properties, can markedly enhance the functionality of test systems. …”
Get full text

BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation by Jialu Xu, Chunyu Li, Rongping Fan, Jiaxin Yin, Lei Xie, Xuemin Peng, Jing Tao, Weijie Xu, Shujun Zhang, Xiaoli Shi, Kun Dong, Xuefeng Yu, Xi Chen, Yan Yang

“…Herein, we discussed the role of Bmal1, a core circadian rhythm-regulating gene, in the process of T2DM-associated cognitive dysfunction. We identified a marked decrease in BMAL1 levels in the hippocampus of db/db mice, followed by gain- and loss-of-function studies to explore the impact of BMAL1 on cognitive function. …”
Get full text

Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans by Hugues Allard-Chamard, Kirsty Hillier, Michelle L. Ramseier, Alice Bertocchi, Naoki Kaneko, Katherine Premo, Grace Yuen, Marshall Karpel, Vinay S. Mahajan, Christina Tsekeri, Joseph S. Hong, Jean Vencic, Rory Crotty, Anish V. Sharda, Sara Barmettler, Emma Westermann-Clark, Jolan E. Walter, Musie Ghebremichael, Alex K. Shalek, Jocelyn R. Farmer, Shiv Pillai

“…Abstract: Patients with cytotoxic T-lymphocyte–associated protein 4 (CTLA4) deficiency exhibit profound humoral immune dysfunction, yet the basis for the B-cell defect is not known. We observed a marked reduction in transitional-to-follicular (FO) B-cell development in patients with CTLA4 deficiency, correlating with decreased CTLA4 function in regulatory T cells, increased CD40L levels in effector CD4+ T cells, and increased mammalian target of rapamycin complex 1 (mTORC1) signaling in transitional B cells (TrBs). …”
Get full text