Development of a cell-penetrating peptide-based nanocomplex for long-term delivery of intact mitochondrial DNA into epithelial cells by Kyrie Wilson, Charles Holjencin, Hwaran Lee, Balasubramaniam Annamalai, Masaaki Ishii, Jeremy L. Gilbert, Andrew Jakymiw, Bärbel Rohrer

“…Gene therapy approaches for mitochondrial DNA (mtDNA)-associated damage/diseases have thus far been limited, and despite advancements in single gene therapy for mtDNA mutations and progress in mitochondrial transplantation, no method exists for restoring the entire mtDNA molecule in a clinically translatable manner. Here, we present for the first time a strategy to deliver an exogenous, fully intact, and healthy mtDNA template into cells to correct endogenous mtDNA mutations and deletions, with the potential to be developed into an efficient pan-therapy for inherited and/or acquired mtDNA disorders. …”
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G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration by Liana C. Boraas, Mengwei Hu, Pieter Martino, Lauren Thornton, Charles E. Vejnar, Gang Zhen, Longhui Zeng, Dylan M. Parker, Andy L. Cox, Antonio J. Giraldez, Xiaolei Su, Christine Mayr, Siyuan Wang, Stefania Nicoli

“…Mechanistically, G3BP1 binds to FA proteins in an RNA-dependent manner, and its RNA-binding and dimerization domains, essential for G3BP1 to form RNPs in SG, are required for FA localization and cell migration. …”
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Design of a Digital-Based, Multicomponent Nutrition Guidance System for Prevention of Early Childhood Obesity by Keriann H. Uesugi, Anne M. Dattilo, Maureen M. Black, Jose M. Saavedra

“…The multicomponent system consists of scientifically substantiated content, tools, and telephone-based professional support delivered in an anticipatory and sequential manner via the internet, email, and text messages, focusing on educational modules addressing the modifiable factors associated with childhood obesity. …”
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VGDD: A Virtual Grid Based Data Dissemination Scheme for Wireless Sensor Networks with Mobile Sink by Abdul Waheed Khan, Abdul Hanan Abdullah, Mohammad Abdur Razzaque, Javed Iqbal Bangash, Ayman Altameem

“…Using the virtual structure, the proposed VGDD scheme follows a set of rules to disseminate sink's mobility updates in an energy efficient manner thereby maintaining nearly optimal routes. …”
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Meningococcal Antigen Typing System Development and Application to the Evaluation of Effectiveness of Meningococcal B Vaccine and Possible Use for Other Purposes by Alexander Domnich, Roberto Gasparini, Daniela Amicizia, Giuseppe Boccadifuoco, Marzia Monica Giuliani, Donatella Panatto

“…To date, MATS has proved advantageous for several reasons, including its ability to assess both qualitative and quantitative aspects of surface antigens of single strains in a highly reproducible, rapid, and resource-saving manner, while its shortcomings include a possible underestimation of 4CMenB coverage and the use of pooled sera to calculate the positive bactericidal threshold. …”
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Induction of MAP Kinase Homologues during Growth and Morphogenetic Development of Karnal Bunt (Tilletia indica) under the Influence of Host Factor(s) from Wheat Spikes by Atul K. Gupta, J. M. Seneviratne, G. K. Joshi, Anil Kumar

“…Such treatment induced the expression of MAPks in time dependent manner compared to the absence of host factors. These results suggest that host factor(s) provide certain signal(s) which activate TiFus3 and TiPmk1 during morphogenetic development of T. indica. …”
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Generalised fracture mechanics approach to the interfacial failure analysis of a bonded steel-concrete joint by Wouter De Corte, Peter Helincks, Veerle Boel, Jan Klusak, Stanislav Seitl, Geert De Schutter

“…In the tests, specimens made with various manners of preparation of the epoxy interlayer are tested experimentally. …”
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Partitioned Strong Coupling of Discrete Elements with Large Deformation Structural Finite Elements to Model Impact on Highly Flexible Tension Structures by Klaus Bernd Sautter, Tobias Teschemacher, Miguel Ángel Celigueta, Philipp Bucher, Kai-Uwe Bletzinger, Roland Wüchner

“…Thus, the strong coupling approach is presented here, where the convergence is achieved in an iterative manner within each time step. This approach helps increase the time step size significantly, decreases the overall computational costs, and improves the numerical stability. …”
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A Real-Time Safe Navigation Proposal for Mobile Robots in Unknown Environments Using Meta-Heuristics by Micael Balza, Mateus A. Goldbarg, Sergio N. Silva, Lucileide M. D. Silva, Marcelo A. C. Fernandes

“…Comparisons with other approaches in the literature showed that MHRTSN generated paths of equivalent length to those of the literature, but in a safer manner. Thus, the proposed approach offers an efficient and safe solution for autonomous navigation in mobile robots, contributing to the advancement of this field in real-world applications. …”
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Greener and facile synthesis of binary zinc oxide/nickel oxide heterojunction nanocomposite for potential solar energy conversion, environmental remediation and energy storage appl... by Muthusamy Kandasamy, Ahmad Husain, S. Alex Pandian, Manickam Selvaraj, Santhanakrishnan Suresh, Prem Gunnasegaran, Nalandhiran Pugazhenthiran, Sekar Thambidurai, Devakumar Balaji

“…Herein, we demonstrate preparation of binary ZnO/NiO NC through a greener manner using extract of Syzygium cumini leaves in view of its multifunctional application potential in DSSC, photocatalysis and energy storage. …”
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A Machine Learning Approach to Predicting SEP Events Using Properties of Coronal Mass Ejections by Jesse Torres, Lulu Zhao, Philip K. Chan, Ming Zhang

“…Therefore, in order to provide an advance warning for astronauts to seek shelter in a timely manner, we apply neural networks to forecast the occurrence of SEP events. …”
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Efficacy of Larimichthys crocea TASOR protein-derived peptide FAM286 against Staphylococcus aureus by Ritian Jin, Guanglei Wei, Rong Lin, Wenfeng Lin, Jude Juventus Aweya, Duo Liang, Wuyin Weng, Shen Yang

“…FAM286 could also bind the bacterial DNA in an embedded manner, disrupting the structure of DNA and leading to the death of bacteria. …”
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Cultured Human Airway Epithelial Cells (Calu-3): A Model of Human Respiratory Function, Structure, and Inflammatory Responses by Yan Zhu, Aaron Chidekel, Thomas H. Shaffer

“…Calu-3 cells exposed to graded oxygen concentrations demonstrate cell dysfunction and inflammation in a dose-dependent manner. Modeling positive airway pressure reveals that pressure may exert a greater injurious effect and cytokine response than oxygen. …”
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Asymmetric representation of symmetric semantic information in the human brain by Jiaxin Wang, Kiichi Kawahata, Antoine Blanc, Naoya Maeda, Shinji Nishimoto, Satoshi Nishida

“…We addressed this question in a data-driven manner by using the voxelwise modeling of movie-evoked cortical response measured by functional magnetic resonance imaging. …”
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Antimicrobial membranes based on polycaprolactone:pectin blends reinforced with zeolite faujasite for cloxacillin-controlled release by Bárbara Bernardi, João Otávio Donizette Malafatti, Ailton José Moreira, Andressa Cristina de Almeida Nascimento, Juliana Bruzaca Lima, Lilian Aparecida Fiorini Vermeersch, Elaine Cristina Paris

“…These results prove that obtaining a hybrid fiber (polymer-zeolite) to incorporate drugs to be released in a controlled manner was successfully achieved. The bactericidal activity of this material shows that its use for measured applications could be an alternative to conventional methods. …”
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Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice by Takefumi Kimura, Takero Nakajima, Yuji Kamijo, Naoki Tanaka, Lixuan Wang, Atsushi Hara, Eiko Sugiyama, Eiji Tanaka, Frank J. Gonzalez, Toshifumi Aoyama

“…Fenofibrate treatment increased serum and hepatic sulfatides in Ppara (+/+) and (+/−) mice through a marked induction of hepatic cerebroside sulfotransferase (CST), a key enzyme in sulfatide synthesis, in a PPARα-dependent manner. Furthermore, increases in CST mRNA levels were correlated with mRNA elevations of several known PPARα target genes, and such changes were not observed for other sulfatide-metabolism enzymes in the liver. …”
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Small Extracellular Vesicles Promote Axon Outgrowth by Engaging the Wnt-Planar Cell Polarity Pathway by Samar Ahmad, Tania Christova, Melanie Pye, Masahiro Narimatsu, Siyuan Song, Jeffrey L. Wrana, Liliana Attisano

“…Thus, our data reveal that fibroblast-derived sEVs promote axon elongation through the Wnt-PCP pathway in a manner that is dependent on endogenous Wnts.…”
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The Polymorphism of the ACE Gene Affects Left Ventricular Hypertrophy and Causes Disturbances in Left Ventricular Systolic/Diastolic Function in Patients with Autosomal Dominant Po... by Maria Wanic-Kossowska, Bartlomiej Posnik, Mikolaj Kobelski, Elzbieta Pawliczak, Krzysztof Pawlaczyk, Krzysztof Hoppe, Krzysztof Schwermer, Dorota Sikorska

“…Autosomal dominant polycystic kidney disease (ADPKD) is one of the most frequently occurring autosomal diseases inherited in the dominant manner. Due to this, lesions in the cardiovascular system of ADPKD patients have caught the attention of clinical investigators worldwide. …”
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Analysis of the Influencing Factors on the Well Performance in Shale Gas Reservoir by Cheng Dai, Liang Xue, Weihong Wang, Xiang Li

“…Due to the ultralow permeability of shale gas reservoirs, stimulating the reservoir formation by using hydraulic fracturing technique and horizontal well is required to create the pathway of gas flow so that the shale gas can be recovered in an economically viable manner. The hydraulic fractured formations can be divided into two regions, stimulated reservoir volume (SRV) region and non-SRV region, and the produced shale gas may exist as free gas or adsorbed gas under the initial formation condition. …”
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Developing an On‐Resin Synthesis of α‐Galactosylceramide‐Peptide Conjugate Vaccines by Dr. Michael A. Meijlink, Dr. Susanna T. S. Chan, Kathryn J. Farrand, Sarah L. Draper, Dr. Oliva K. Burn, Jasmine M. Seifert‐Simpson, Ngarangi C. Mason, Dr. Lisa M. Connor, Prof. Ian F. Hermans, Prof. Gavin F. Painter, Dr. Benjamin J. Compton

“…In vivo testing showed that vaccines incorporating peptide antigen attached via the galactosyl head group induced strong antigen specific CD8+ T cell responses compared to those with antigen attached via the lipid tail and control vaccine manufactured in a stepwise manner.…”
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