The global RNA-binding protein RbpB is a regulator of polysaccharide utilization in Bacteroides thetaiotaomicron by Ann-Sophie Rüttiger, Daniel Ryan, Luisella Spiga, Vanessa Lamm-Schmidt, Gianluca Prezza, Sarah Reichardt, Madison Langford, Lars Barquist, Franziska Faber, Wenhan Zhu, Alexander J. Westermann

“…Ablation of RbpB in Bacteroides thetaiotaomicron compromises colonization in the mouse gut in a diet-dependent manner. Together, this study adds to our understanding of RNA-coordinated metabolic control as an important factor contributing to the in-vivo fitness of predominant microbiota species in dynamic nutrient landscapes.…”
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Impact of Likelihood Ratios of Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibody in Clinical Diagnosis of Rheumatoid Arthritis by Two Available Platforms by Juan Irure-Ventura, María Díaz-Toledo, Noelia Palazuelos-Cayón, Marcos López-Hoyos

“…In addition, the use of test result interval-specific LR allows better clinical interpretation for RF and ACPA assays compared to the traditional idea of interpreting antibody results in a dichotomous manner, such as negative or positive.…”
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Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells by Jie-Jen Lee, Yi-Chiung Hsu, Ying-Syuan Li, Shih-Ping Cheng

“…Both inhibitors decreased migratory and invasive abilities in a dose-dependent manner. Furthermore, GB1107 and TD139 treatment attenuated AKT phosphorylation and decreased the expression of β-catenin and MMP2. …”
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Rapamycin inhibits tamoxifen-induced endometrial proliferation in vitro as a pilot approach for endometrial protection in breast cancer by Akiko Nakamura, Yuji Tanaka, Tsukuru Amano, Akie Takebayashi, Akimasa Takahashi, Tetsuro Hanada, Yutaka Yoneoka, Shunichiro Tsuji, Takashi Murakami

“…Tamoxifen significantly increased endometrial cell proliferation in a dose-dependent manner. Rapamycin effectively inhibited this proliferation, even at concentrations lower than those typically observed in clinical settings. …”
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Sulforaphane ameliorates non-alcoholic steatohepatitis by KLF4-mediated macrophage M2 polarization by Xianghui Huang, Jia Xu, Ye Xu, Bingxin Huangfu, Feng Zhang, Yanzhou Hu, Ruxin Gao, Xinxin Ren, Boyang Zhang, Kunlun Huang, Xiaoyun He

“…Further analysis demonstrated that this SFN-induced macrophage M2-type polarization occurs in a Krüppel-like factor 4 (KLF4)-dependent manner. In summary, we uncovered a new mechanism of action underlying SFN activity and provide evidence that dietary intervention with SFN might be protective against NASH.…”
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TREMSUCS-TCGA – an integrated workflow for the identification of biomarkers for treatment success by Balogh Gabor, Jorge Natasha, Dupain Célia, Kamal Maud, Servant Nicolas, Le Tourneau Christophe, Stadler Peter F., Bernhart Stephan H.

“…TREMSUCS-TCGA produces a comprehensive single report file which holds all relevant results in descriptive and tabular form that can be explored in an interactive manner. As a showcase application we describe a comprehensive analysis of the available data for the combination of patients with squamous cell carcinomas of head and neck, cervix and lung treated with cisplatin, carboplatin and the combination of carboplatin and paclitaxel. …”
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Tailoring Bimetallic Pt/Pd Cryogels for Efficient Ethanol Electro‐Oxidation by Hadir Borg, Dániel Zámbó, Patrick Bessel, Daniel Kranz, Marina Rosebrock, Franziska Lübkemann‐Warwas, Nadja C. Bigall, Dirk Dorfs

“…Scanning electron microscopy (SEM) images of the different prepared cryogel films show a cellular to dendritic superstructure regardless of the Pt and/or Pd composition in a highly reproducible manner. Elemental analysis shows homogenous distribution of Pt and Pd NPs at the microscale for all samples. …”
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Dynamic Full-Duplex Cellular System for Wide Area IoT Network Backbone by Keiichi Mizutani, Kazuki Nishikori, Kyoya Teramae, Hiroto Kuriki, Takeshi Matsumura, Hiroshi Harada

“…This study proposes a dynamic full-duplex cellular (DDC) system by introducing an in-band full-duplex in a phased manner into a conventional time-division duplex (TDD)-based cellular system. …”
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Evaluation of the Oxidative Effect of Long-Term Repetitive Hyperbaric Oxygen Exposures on Different Brain Regions of Rats by Kemal Simsek, Mehmet Ozler, Ali Osman Yildirim, Serdar Sadir, Seref Demirbas, Muzaffer Oztosun, Ahmet Korkmaz, Hakan Ay, Sukru Oter, Senol Yildiz

“…The present study aims enlightening the relation of HBO2 with oxidative/antioxidant systems when administered in a prolonged and repetitive manner in brain tissues of rats. Sixty rats were divided into 6 study (n=8 for each) and 1 control (n=12) group. …”
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Online Monitoring Oxidative Products and Metabolites of Nicotine by Free Radicals Generation with Fenton Reaction in Tandem Mass Spectrometry by Shih-Shin Liang, Yow-Ling Shiue, Chao-Jen Kuo, Su-Er Guo, Wei-Ting Liao, Eing-Mei Tsai

“…In the EEO method, the oxidative products of nicotine including cotinine, cotinine-N-oxide, trans-3′-hydroxycotinine, nornicotine, norcotinine, 4-oxo-4-(3-pyridyl)-butanoic acid, 4-hydroxy-4-(3-pyridyl)-butanoic acid, and nicotine-N′-oxide were detected by tandem mass spectrometer to simulate the changes of nicotine and its derivatives in a time-dependent manner.…”
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AMPK Activation Mediated by Hinokitiol Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells through Autophagy Flux by Ju-Hee Lee, Jae-Kyo Jeong, Sang-Youel Park

“…Hinokitiol treatment of MSCs decreased their differentiation to mature adipocytes and increased AMPK phosphorylation in a concentration-dependent manner. Moreover, we confirmed that the antiadipogenic effect of hinokitiol was associated with autophagy. …”
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Novel target and cofactor repertoire for the transcriptional regulator JTY_0672 from Mycobacterium bovis BCG by Hui Wang, Xiaotian Li, Shuxian Wang, Ren Fang, Jiayin Xing, Ruiying Wu, Chunhui Zhang, Zhaoli Li, Ningning Song

“…Intracellular survival plays a central role in the pathogenesis of Mtb in a manner that is dependent on an array of transcriptional regulators for Mtb. …”
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Modelling Shallow Water Wakes Using a Hybrid Turbulence Model by Clemente Rodriguez-Cuevas, Carlos Couder-Castañeda, Esteban Flores-Mendez, Israel Enrique Herrera-Díaz, Rodolfo Cisneros-Almazan

“…The experimental results show that a k-ϵ with ml turbulence model makes it possible to approach the experimental results in a more qualitative manner. We found that when using only a k-ϵ model in the vertical and horizontal direction, the numerical results overestimate the experimental data. …”
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Natural and anthropogenic noise shape bat activity and sonar behavior by Ryan Vosbigian, Ryan Wardle, Hannah S. Rempel, Ellie Brauer, Michael Huggins, Samantha West, Joshua S. Willems, Clinton D. Francis

“…We also observed that T. brasiliensis modified call duration and frequency in response to river playbacks in a manner consistent with a behavioral switch from foraging to navigating. …”
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Natural products against resistant bacterial infections: A systematic literature review by Harshit Kaushik, Ruchika Sharma, Anoop Kumar

“…The results have indicated the antibacterial potential of natural products in concentration/dose/dosage manner under in-vitro, in-vivo, and clinical conditions via different mechanisms of action Conclusion: Overall, available evidence has indicated the potential of natural products against various types of resistant bacterial strains under in-vitro, in-vivo, and clinical conditions.…”
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Measuring the Cytochrome c Nitrite Reductase Activity—Practical Considerations on the Enzyme Assays by Célia M. Silveira, Stéphane Besson, Isabel Moura, José J. G. Moura, M. Gabriela Almeida

“…In this work the kinetic behaviour of ccNiR has been evaluated in a systematic manner using two different spectrophotometric assays carried out in the presence of different redox mediators and a direct electrochemical approach. …”
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Emerging roles of circular RNAs on the regulation of production traits in chicken by Guishuang You, Hong Long, Xiaoxu Shen, Huadong Yin, Shibin Zhang

“…In society today, enhancing the productive performance of chickens in a safe and efficient manner has become a central focus of research. This performance is determined by various production traits that are primarily influenced by multiple factors, including epigenetics—a critical aspect of gene regulation. …”
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Local Administration of (−)-Epigallocatechin-3-Gallate as a Local Anesthetic Agent Inhibits the Excitability of Rat Nociceptive Primary Sensory Neurons by Syogo Utugi, Risako Chida, Sana Yamaguchi, Yukito Sashide, Mamoru Takeda

“…Following the administration of EGCG, the mean firing rate of TG neurons to both non-noxious and noxious mechanical stimuli significantly decreased in a dose-dependent manner (1–10 mM), and both the non-noxious and nociceptive mechanical stimuli experienced the maximum suppression of discharge frequency within 5 min. …”
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VibrioBase: A Model for Next-Generation Genome and Annotation Database Development by Siew Woh Choo, Hamed Heydari, Tze King Tan, Cheuk Chuen Siow, Ching Yew Beh, Wei Yee Wee, Naresh V. R. Mutha, Guat Jah Wong, Mia Yang Ang, Amir Hessam Yazdi

“…VibrioBase currently houses a total of 252 Vibrio genomes developed in a user-friendly manner and useful to enable the analysis of these genomic data, particularly in the field of comparative genomics. …”
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MBCdeg4: A modified clustering-based method for identifying differentially expressed genes from RNA-seq data by Chiharu Ichikawa, Koji Kadota

“…The sole distinction between them is the manner of data normalization. MBCdeg4 employs normalization factors derived from a robust normalization algorithm, designated as DEGES. …”
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