Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition by Jonathan W. Nyce

“…The autoinflammatory reaction observed closely resembles mevalonate kinase deficiency (MKD), a rare autosomal recessive disease in humans characterized by recurrent febrile attacks, arthralgia, skin rash, and aphthous ulcers of mucocutaneous tissues. In a manner comparable to animal models of MKD, the reconstitution of protein geranylgeranylation blocked the autoinflammatory reaction caused by systemic G6PD inhibition. …”
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Chaperone Hsp70 helps Salmonella survive infection-relevant stress by reducing protein synthesis. by Carissa Chan, Eduardo A Groisman

“…DnaK-dependent reduction in protein synthesis is critical for survival against Mg2+ starvation because inhibiting protein synthesis in a dnaK-independent manner overcame the 10,000-fold loss in viability resulting from DnaK truncation. …”
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Pituitary adenoma: important genetic factors and clinical diagnostic issues by G. Juknytė, E. Karinauskė, R. Liutkevičienė

“…PA can be inherited in an autosomal dominant manner. Recently, many new genetic alterations have been identified that make people predisposed to pituitary adenomas. …”
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Effects of Pyrrhotite on the Combustion Behavior and the Kinetic Mechanism of Pyrite-Pyrrhotite Mixture Powders in the Air by Changshun Tian, Yunzhang Rao, Gang Su, Tao Huang

“…The calculated kinetic parameters and phase analysis results suggested that pyrite combustion is consistent with the shrinking core mechanism, and in the combustion process, the irregular pyrite particle shrank into a spherical particle; the combustion products of pyrrhotite grew in a layer-by-layer manner. Pyrrhotite combustion corresponded to the three-dimensional diffusion mechanism, and mixed mineral combustion was dominated by the shrinking core mechanism and supplemented by the three-dimensional diffusion mechanism. …”
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IL-33 Acts to Express Schaffer Collateral/CA1 LTP and Regulate Learning and Memory by Targeting MyD88 by Tomoyuki Nishizaki

“…Taken together, these results show that IL-33 acts to express Schaffer collateral/CA1 LTP relevant to spatial learning and memory in a MyD88-dependent manner and that the LTP might be expressed through an IL-1R1/IL-1RAcP-MyD88 pathway in the absence of ST2.…”
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Cosmological constant as an integration constant by Justin C. Feng, Pisin Chen

“…We also propose a full variational principle (full in the sense that variations in all variables are considered) for each of the aforementioned theories that can incorporate the matter sector; in this manner, we can obtain the trace-free Einstein equations without a unimodular constraint. …”
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Reputation Detection for Information Diffusion in Social Network Systems by Yifeng Zhou, Fang Yu

“…., Twitter), the characteristic of the unidirectional relationship between agents and the decay property of diffusion will result in lacking direct interactions; therefore, interaction reputations will be difficult to be obtained by agents in a distributed manner. To solve this problem, a novel distributed reputation detection model following the pattern “from path to individual” (FPTI) is proposed, which can provide a new reputation factor as an alternative to interaction reputation in such environments. …”
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Drawing the Map: Siting Architecture by Anne Bordeleau, Liana Bresler

“…If maps can successfully represent sets of complex interactions in an effective manner, they also have an objectifying tendency and are often criticized for being tools of domination as well for their propensity to stabilize space-time. …”
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Continuous Motion Modeling and Analysis of a New 2UPR-PRS Mechanism with Variable Rotation Axis by Feiyang Shen, Xueting Hu, Hanyan Wang, Shuofei Yang

“…Finally, the mobility of the mechanism is analyzed by a newly developed method through a parameterizing twist in a continuous motion manner, and its kinematic model is thus formulated, revealing the rotational characteristics of the mechanism with the variable axis.…”
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Xanthoxyletin blocks the RANK/RANKL signaling pathway to suppress the growth of human pancreatic cancer cells by Zhang Xin, Li Luming, Wu Yan

“…The administration of pancreatic cancer cells with xanthoxyletin diminished the viability of Capan-2 cells in a concentration-dependent manner and led to a significant decline in RANK, RANKL, and OPG expression. …”
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Chlorogenic acid complex (CGA7), standardized extract from green coffee beans exerts anticancer effects against cultured human colon cancer HCT-116 cells by K. Gouthamchandra, H.V. Sudeep, B.J. Venkatesh, K. Shyam Prasad

“…From our results we found CGA7 treatment induces cell death in a dose and time dependent manner in different cancer cell lines. Further, CGA7 induced apoptosis was characterized by DNA fragmentation, PARP-1 cleavage, caspase-9 activation, and down regulation of Bcl-2, an anti-apoptotic protein and up regulation of pro-apoptotic protein BAX. …”
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Function approximation method based on weights gradient descent in reinforcement learning by Xiaoyan QIN, Yuhan LIU, Yunlong XU, Bin LI

“…Function approximation has gained significant attention in reinforcement learning research as it effectively addresses problems with large-scale, continuous state, and action space.Although the function approximation algorithm based on gradient descent method is one of the most widely used methods in reinforcement learning, it requires careful tuning of the step size parameter as an inappropriate value can lead to slow convergence, unstable convergence, or even divergence.To address these issues, an improvement was made around the temporal-difference (TD) algorithm based on function approximation.The weight update method was enhanced using both the least squares method and gradient descent, resulting in the proposed weights gradient descent (WGD) method.The least squares were used to calculate the weights, combining the ideas of TD and gradient descent to find the error between the weights.And this error was used to directly update the weights.By this method, the weights were updated in a new manner, effectively reducing the consumption of computing resources by the algorithm enhancing other gradient descent-based function approximation algorithms.The WGD method is widely applicable in various gradient descent-based reinforcement learning algorithms.The results show that WGD method can adjust parameters within a wider space, effectively reducing the possibility of algorithm divergence.Additionally, it achieves better performance while improving the convergence speed of the algorithm.…”
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Examining the Frequency of Clinical and Paraclinical Symptoms in Opium Addicts Hospitalized Due to Lead Poisoning in Isfahan Province by Hamid Kalantari, Farzad Gheshlaghi, Marzieh Etezadi

“…Information related to the age and sex of the patients, duration and manner of opium consumption, clinical symptoms, and laboratory findings of patients were extracted from their files. …”
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THE CHORAL OUTLINE IN THE OPERA “ALEXANDRU LĂPUŞNEANU” BY GHEORGHE MUSTEA by Luminiţa GUŢANU

“… The music of Gheorghe Mustea displays a heterogeneous style, richly inspired by the compositional manner of the great composers of this genre (M. Mussorgsky, George Enescu), with elements of folk origin, of a special charm and richness. …”
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Refleksi sosial dalam antologi cerpen Kita Susah Tidur sejak Dilahirkan karya Aksan Taqwin Embe by Nurkalina Pratiwi Suganda, Tedi Permadi, Yostiani Noor Asmi Harini

“…Twelve stories are delivered in a light and simple manner, and the topics discussed in each story reflect the circumstances that occur in the real world. …”
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Single-cell bilayer design of a terahertz six-channel metasurface for simultaneous holographic and grayscale images by Zhiqiang Du, Chunhui Zhu, Zhengyong Song

“…However, some of these designs are implemented in a manner of interleaved subarrays that complicates the design and makes them difficult to achieve integration. …”
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Optimalisasi Strategi Idarah: Studi Kasus Pengelolaan Masjid Agung Kauman di Kota Semarang by Miftahul Fadilah, Bima Fandi Asy'arie, Abdul Latif

“…The data obtained are: First, the blood of the Great Mosque of Kauman Semarang can be said to be good, because from the data collected with the daily mosque secretary there are security guards and marbots who handle mosque security and administration runs in an orderly manner. Second, the supporting factor of the Great Kauman Semarang mosque is its very strategic location, the management always considers that the mosque building is always in good condition, funding is obtained from other sources, and the mosque function is used for positive activities. …”
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Delay/Disruption Tolerant Networking Performance Characterization in Cislunar Relay Communication Architecture by Ding Wang, Ethan Wang, Ruhai Wang

“…We present a performance characterization of the concatenations of different CLAs and the associated data transport protocols in an experimental manner. The performance of different concatenations is compared over a typical primary and secondary cislunar relay architecture. …”
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Surely not!Between certainty and disbelief by Graham Ranger

“…The marker surely possesses at least three different functions: as an intrapredicative adverb of manner, an extrapredicative epistemic adverb and a discourse adverb. …”
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Kwestia ochrony życia ludzkiego - czyli konieczność uznania miłości do człowieka za podstawę szacunku do naturalnego środowiska by Stanisław Biały

“…Because of this, the author comes to the conclusions that among the fundamental tasks that are before the world of today, one must also include the equiping of man with an ecological knowledge (that is: with a determined set of information connected in a causal-consecutive system on the subject of the functioning of the natural environment and the dependences between it and civilization), but above all: with a system of values and their normative equivalents. Only in such a manner can people be instilled with an adequate attitude, understood as a developed feeling of a link with the world of nature and its parts. …”
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