Imaging cell spheroid clusters: An MRI protocol for non-invasive standardized characterization by Rebecca Wißmann, Petros Martirosian, Marina Danalache, Gerd Grözinger, Fritz Schick, Stefanie Elser

“…Despite its limited spatial resolution, this method adeptly reveals information about the composition and vitality of stem cell and cancer spheroids and their micro-environment in a non-invasive manner. This work reports on the development of an MRI-compatible setup for culturing cell spheroids, tailored for use with standard 3 T whole-body MRI systems. …”
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Wnt5a Signaling in Normal and Cancer Stem Cells by Yan Zhou, Thomas J. Kipps, Suping Zhang

“…Wnt5a is involved in activating several noncanonical Wnt signaling pathways, which can inhibit or activate canonical Wnt/β-catenin signaling pathway in a receptor context-dependent manner. Wnt5a signaling is critical for regulating normal developmental processes, including stem cell self-renewal, proliferation, differentiation, migration, adhesion, and polarity. …”
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Sepsis: An emergency medical condition and out-of-hospital diagnostic challenge by Vukićević Verica, Ilić Andrijana, Obradović Aleksandra, Milivojčević-Bevc Ivana

“…As such, sepsis is an emergency medical condition that must be treated in an appropriate and timely manner. Early recognition and treatment improve outcomes. …”
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Deep empirical neural network for optical phase retrieval over a scattering medium by Huaisheng Tu, Haotian Liu, Tuqiang Pan, Wuping Xie, Zihao Ma, Fan Zhang, Pengbai Xu, Leiming Wu, Ou Xu, Yi Xu, Yuwen Qin

“…Herein, we propose a concept of deep empirical neural network (DENN) that is a hybridization of a deep neural network and an empirical model, which enables seeing through an opaque scattering medium in an untrained manner. The DENN does not rely on labeled data, all while delivering as high as 58% improvement in fidelity compared with the supervised learning using 30000 data pairs for achieving the same goal of optical phase retrieval. …”
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Protective effects of tilapia (Oreochromis niloticus) skin gelatin hydrolysates on osteoporosis rats induced by retinoic acid by Bingtong Liu, Liping Sun, Yongliang Zhuang

“…The bone length, dry weight index, maximum load, and Ca content of OP rats significantly increased by treatment TSGH in a dose-dependent manner. Micro-CT images of the femurs and tibias of the rats indicated that the bone mineral density, cortical bone thickness, and cortical/trabecular bone area ratios were recovered and that OP symptoms were improved. …”
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Antimony production by carbothermic reduction of stibnite in the presence of lime by Padilla R., Chambi L.C., Ruiz M.C.

“…Experimental work on the carbothermic reduction of Sb2S3 in the presence of lime was carried out in the temperature range of 973 to 1123 K to produce antimony in an environmentally friendly manner. The results demonstrated the technical feasibility of producing antimony by this method without producing SO2 gas. …”
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Human Antibodies Can Cross Guinea Pig Placenta and Bind Its Neonatal Fc Receptor: Implications for Studying Immune Prophylaxis and Therapy during Pregnancy by Evi Budo Struble, Li Ma, Lilin Zhong, A. Lesher, Joel Beren, Pei Zhang

“…We also observe that human IgG binds to an engineered soluble variant of the guinea pig neonatal Fc receptor in vitro in a manner similar to that demonstrated for the human variant, suggesting that this transplacental transport mirrors the receptor-based mechanism seen in humans. …”
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Prmt5 is essential for intestinal stem cell maintenance and homeostasis by Li Yang, Xuewen Li, Chenyi Shi, Bing Zhao

“…Mechanistically, Prmt5 sustains a high level of H3K27ac accumulation by inhibiting Hdac9 expression in the intestinal epithelium, and maintains the stemness of ISCs in a cell-autonomous manner. Notably, inhibition of histone deacetylases can rescue both self‐renewal and differentiation capacities of Prmt5‐depleted ISCs. …”
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Effects of Ginkgo biloba Extract on Inflammatory Mediators (SOD, MDA, TNF-α, NF-κBp65, IL-6) in TNBS-Induced Colitis in Rats by Yan-Hong Zhou, Jie-Ping Yu, Yi-Fei Liu, Xiao-Jun Teng, Mei Ming, Peng Lv, Ping An, Shi-Quan Liu, Hong-Gang Yu

“…The results showed that EGB could significantly ameliorate macroscopic and histological damage, evidently elevate the activities of SOD and reduce the contents of MDA, inhibit the protein and mRNA expressions of TNF-α, NF-κBp65, and IL-6 in the colon tissues of experimental colitis in a dose-dependent manner compared with the model group. We concluded that the probable mechanisms of EGB ameliorated inflammatory injury in TNBS-induced colitis in rats by its modulation of inflammatory mediators and antioxidation.…”
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Disposable and flexible smart electronic tapes for long-term biopotential monitoring by Jiuwei Gao, Mingwei Hu, Hao Sun, Yuanyuan Wang, Yuan Wei, Weiwei Li, Lu Zheng, Manzhang Xu, Qianbo Lu, Zhiyuan Liu, Hui Yang, Yongtian Wang, Weitao Song, Xuewen Wang, Wei Huang

“…The strong adhesive behavior of the tape as well as the low-cost manufacturing process allow convenient and long-term wearing in a disposable manner. We anticipate the SET will pioneer next-gen wearable electronics for applications like disease prevention, health monitoring, and human–computer interaction.…”
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Road Traffic Accident Traumatic Vehicle Seat Belt Abdominal Wall Hernia by Mahmoud R. Manasra, Roua E. Farah, Arein A. Abufara, Bara M. AbuIrayyeh, Rahaf E. Farah, Mohammed A. Maraqa

“…This condition is often not present as an isolated case, as 30% to 60% of the cases are accompanied by other intra-abdominal injuries. The typical manner of presentation is a tender subcutaneous swelling across the abdomen wall with overlaying bruising and ecchymosis. …”
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Involvement of serotonin and eicosanoids in the rat paw oedema response to the essential oil of Pilocarpus spicatus by J. C. R. Silva, V. S. N. Rao

“…Subplantar injection of Pilocarpus spicatus essential oil (PSEO), induced rat hindpaw oedema in a dose-dependent manner. The time course study revealed that when compared to carrageenan-induced oedema, the oedema response to PSEO was greater at 1 h post-injection, and thereafter remained relatively constant until 5 h post-injection. …”
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Hereditary Angioedema and Gastrointestinal Complications: An Extensive Review of the Literature by Napoleon Patel, Lisbet D. Suarez, Sakshi Kapur, Leonard Bielory

“…Very few cases have been reported in the literature of HAE presentation in this manner, and there are no reports of any nonsurgical management of these cases.…”
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Enhanced 12-Lead ECG Reconstruction from Single-Lead Data Using WaveNet by Et-Tousy Jamal, Et-Tousy Said, Ait El Aouad Soufiane, Zyane Abdellah

“…Recent advancements in wearable technology, such as smartwatches, allow for the collection of ECG signals in a more convenient manner, but typically only provide a single lead. …”
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Linking Research Data with Physically Preserved Research Materials in Chemistry by Chia-Lin Lin, Pei-Chi Huang, Simone Gräßle, Christoph Grathwol, Pierre Tremouilhac, Sylvia Vanderheiden, Patrick Hodapp, Sonja Herres-Pawlis, Alexander Hoffmann, Fabian Fink, Georg Manolikakes, Till Opatz, Andreas Link, M. Manuel B. Marques, Lena J. Daumann, Manuel Tsotsalas, Frank Biedermann, Hatice Mutlu, Eric Täuscher, Felix Bach, Tim Drees, Steffen Neumann, Shashank S. Harivyasi, Nicole Jung, Stefan Bräse

“…A big step towards transparency and reproducibility of the scientific work can be gained if scientists publish their data in research data repositories in a FAIR manner. Nevertheless, in order to make chemistry a sustainable discipline, obtaining FAIR data is insufficient and a comprehensive concept that includes preservation of materials is needed. …”
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Pompe Disease Could Mimic Exam Findings of Amyloidosis: Two Rare Diagnoses Bona Fide by Jithma P. Abeykoon, Narjust Duma, Jennifer A. Tracy, Margherita Milone, Ronald Go

“…Since the wild-type transthyretin amyloidosis could not entirely explain her clinical presentation and evaluation, further studies were conducted in a sequential manner, thus leading to a diagnosis of Pompe disease explaining her presenting signs and symptoms including her macroglossia. …”
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Collecting facts and burden of proof in administrative procedure by Milkov Dragan L., Radošević Ratko S.

“…The process of collecting facts and means of proof in administrative procedure is determined by the principle of investigation, but not in an absolute manner, without any exceptions. This is the context in which the burden of proof in administrative procedure is examined, having in mind its two basic aspects. …”
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Challenges in “probing spectroscopic probes” for noninvasive simultaneous disease diagnosis by Lopamudra Roy, Shweta Paul, Amrita Banerjee, Ria Ghosh, Susmita Mondal, Monojit Das, Monojit Das, Nivedita Pan, Ishitri Das, Soumendra Singh, Debasish Bhattacharya, Asim Kumar Mallick, Samir Kumar Pal

“…Noninvasive diagnosis of human diseases relies on the detection of molecular markers (probes) in a painless manner. Although extrinsic and intrinsic molecular markers are often used, intrinsic disease probes (molecular markers) are preferable because they are naturally present in our body, and deviation in their concentration from normal levels clearly indicates anomalies in human bodies, that is, diseases. …”
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Scalable preparation of furanosteroidal viridin, β-viridin and viridiol from Trichoderma virens by Wen Zhang, Kazu Sunami, Shuo Liu, Desita Triana, Zetryana Puteri Tachrim, Rikuto Kikuchi, Tohru Taniguchi, Kenji Monde, Tsunayoshi Takehara, Da-Yang Zhou, Takeyuki Suzuki, Yasuyuki Hashidoko, Makoto Hashimoto, Yuta Murai

“…In this study, we generated an efficient method to produce both viridin and viridiol by using a unique pH regulated T. virens culture manner. Besides, we successfully obtained β-viridin (epimer of viridin) crystal and X-ray structure, of which the CAS number was registered without stereochemistry. …”
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Sedoanalgesia Strategies and their Potential Benefits in the Intensive Care Unit: Narrative Review of the Literature by Arango-Martínez, Alejandro, Penagos-Sanchez, Sebastian, Restrepo-Arismendy, Simón, Arias-Correa, Ruber Hernando

“…The information was extracted and synthesized in a structured manner according to the recommendations of the SANRA guidelines. …”
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