Lidocaine could promote the cuproptosis through up-regulating the long noncoding RNA DNMBP-AS1 in Hep-2 cells by Wei Liu, Yi Yu, Yi He, Meihong Lv

“…Conclusions lidocaine was cytotoxic to Hep-2 cells in a time- and dose-dependent manner, promoted the cuproptosis through up-regulating DNMBP-AS1. …”
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Fungal genomes: suffering with functional annotation errors by Tapan Kumar Mohanta, Ahmed Al-Harrasi

“…Conclusion The presence of functional annotation errors in fungal genome and proteome databases is of considerable concern and needs to be addressed in a timely manner.…”
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Alleviatory effect of isoquercetin on benign prostatic hyperplasia via IGF-1/PI3K/Akt/mTOR pathway by Young-Jin Choi, Meiqi Fan, Nishala Erandi Wedamulla, Yujiao Tang, Eun-Kyung Kim

“…IQ significantly reduced the prostate size in a concentration-dependent manner in a BPH rat model, and significantly decreased the expression of AR signaling factors in the rat prostate tissue and LNCaP cells in a concentration-dependent manner. …”
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Investigating the Concept of “Progressive Development of Law” In the System of International Human Rights Law and Comparing It with the General International Law by Amirhossein Mohebali

“…While in international law, progressive development brings to mind the concept of establishment and creation of rights.Examining keywords such as "progressive development of rights" and identifying and explaining their exact meaning in the subject area will have the benefit that human rights obligators, who are the governments in most cases, understand the nature and scope of their obligations correctly and implement them in a timely manner and in accordance with the protectionist goals of human rights.By explaining the characteristics of international law and international human rights law, The present study works on the semantic difference of the term "progressive development of rights" in international human rights law and in the field of general international law, and the alternatives to progressive development in international human rights law and what they mean.Examining keywords such as "progressive development of rights" and identifying and explaining their exact meaning in the subject area will have the benefit that human rights obligators, who are the governments in most cases, understand the nature and scope of their obligations correctly and implement them in a timely manner and in accordance with the protectionist goals of human rights.By explaining the characteristics of international law and international human rights law, The present study works on the semantic difference of the term "progressive development of rights" in international human rights law and in the field of general international law, and the alternatives to progressive development in international human rights law and what they mean.…”
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Main Directorate of the National Police in Kharkiv Region by D. V. Slynko, L. I. Kalenichenko

“…It required the parties to act per legis actiones, i.e. without resorting to violence, in a lawful manner, on legal grounds, in a lawful manner. Compliance with the legislative form of legal proceedings guaranteed the legality and formality of the claimant’s (plaintiff’s) claims and the absence of elements of analogy in the claim and provided for the occurrence of only the consequences specified in the law. …”
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American struggle for global leadership and the strategic options of Serbia by Lišanin Mladen

“…At the same time, the fact that the hegemon is usually a status quo power, seeking to maintain the basic global parameters of power distribution, does not mean that it will not behave in a revisionist manner in various subsystem (regional and sub-regional) frameworks. …”
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Anticancer Potential of Fruit Extracts from Vatica diospyroides Symington Type SS and Their Effect on Program Cell Death of Cervical Cancer Cell Lines by Atchara Chothiphirat, Kesara Nittayaboon, Kanyanatt Kanokwiroon, Theera Srisawat, Raphatphorn Navakanitworakul

“…MTT assay revealed that the extracts showed inhibition of cell survival in a dose-dependent manner and exhibited highly cytotoxic activity against both HeLa and SiHa cells with IC50 value less than 20 μg/mL along with less toxicity against L929 cells. …”
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Adenosine-Induced NLRP11 in B Lymphoblasts Suppresses Human CD4+ T Helper Cell Responses by Irem Ozel, Ilgin Akkaya, Ece Oylumlu, Goksu Uzel, Ceren Ciraci

“…Taken together, our data indicate that adenosine is a negative regulator of Th1 and Th17 responses via NLRP11 in an inflammasome-independent manner.…”
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N-Alkyl-Substituted Isatins Enhance P2X7 Receptor-Induced Interleukin-1β Release from Murine Macrophages by Ronald Sluyter, Kara L. Vine

“…ATP caused rapid IL-1β release in a concentration-dependent manner, and this process was completely impaired by the P2X7 antagonist, AZ10606120. …”
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A NUMERICAL STUDY REGARDING THE INFLUENCE OF THE LONGITUDINAL EXTENT OF A T-SHAPED CRACK ON THE EIGENFREQUENCY DECREASE OF CANTILEVER BEAMS by Cristian Tufisi, GILBERT-RAINER Gillich

“… The paper analyzes the effects of T-shaped cracks in beams regarding the manner in which the frequencies of the bending modes change. …”
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SYNTHESIS OF 5-(2-THIENYL)-4,5-DIHYDROFURA NS AND 7-(2-THIENYL)-2,8-DIOXABICYCLO[3.3.0]OCT-3-ENES USING MANGANESE(III)-BASED CYCLIZATION by Huỳnh Thanh Trúc, Nguyễn Văn Hạ

“…On the other hand, these ethenes react with 3-acetyl-1-phenylpentane-1,4-dione in a similar reaction leading to the formation of 7-(2-thienyl)-2,8-dioxabicyclo[3.3.0]oct-3-enes in high yields. The cis manner of fused bicyclic products is briefly discussed.…”
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Pesticide Options for Insect, Mite, and Mollusk Management in Commercial Strawberry Production in Florida by James F. Price, Curtis Nagle, Susan E. Webb

“…Effective management of arthropod and gastropod pests of strawberry is critical to the profitability of the industry and requires that pests be detected in a timely manner through systematic scouting. Appropriate control measures should be applied as conditions warrant. …”
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Novel Insights into the Role of Caveolin-2 in Cell- and Tissue-Specific Signaling and Function by Grzegorz Sowa

“…A new body of evidence suggests that caveolin-2 plays an important, and often more direct, role than caveolin-1 in regulating signaling and function in a cell- and tissue type-specific manner. The purpose of this paper is to primarily focus on discussing how these recent discoveries may help better understand the specific contribution of caveolin-2 to lipid raft- and caveolae-regulated cell/tissue-specific signaling and functions.…”
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Outbreaks of Foodborne Illness Associated with Melons by Clara Diekman, Matthew D. Krug, Ashley T. Myers, Rachel McEgan, Keith R. Schneider, Michelle D. Danyluk

“…Melons (specifically cantaloupe, honeydew, and watermelon) are popular commodities consumed around the world. Despite the manner in which they are prepared, melons are commonly consumed raw without a processing step which would eliminate pathogenic bacteria. …”
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La plaisance à voile, fenêtre sur le paysage marin by Philippe Bodénan, Sébastien Coupez

“…Establishing links with the seascape in the same manner as the landscape has been approached in terrestrial spaces is not self-evident, as the usual reference points are disrupted. …”
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Efficiency of internal controls in financial managament: A review from the audit perspective by Anačkov Darko

“…From an audit perspective, the internal control system is analyzed to determine whether it is designed and operated in a manner that reduces risk and helps achieve business objectives. …”
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Cholangiocellular carcinoma in a cat by M. Kemal Çiftçi, Mustafa Ortatatlı, Sırrı Avki

“…Microscopic examinations of the liver and lungs revealed that tumoral masses were originated from intrahepatic bile duct epithelial cells that orientated as commonly wide radial or rarely asinar manner. The case was classified as a cholangiocellular carcinoma.…”
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Dynamical credibility aware data forwarding mechanism for intermittently connected wireless networks by Da-peng WU, Hong-pei ZHANG, Ru-yan WANG, Qiao-shou LIU

“…A novel dynamic credibility aware packet forwarding mechanism for intermittently connected wireless networks is proposed.According to the network state information obtained locally by a moving node,the malicious degrees and collaboration degrees of nodes can be obtained in a distributed manner.Meanwhile,based on the node connectivity,the credibility of a node is estimated,furthermore,the relay node can be selected reasonably.Results show that the proposed mechanism can effectively enhance the reliability of data transmission while reducing the network load rate significantly.Thus,the utilization of network resources is improved.…”
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Key management scheme with private key self-healing ability in DTN by De-quan LI, Xi-yong ZHANG, Ting-ting ZHANG, Guan-jun GUO

“…Because of the large delay of DTN network,node cannot receive broadcast updating private key messages in a timely manner,thus unable to update the private key for a certain time period.Aiming at this problem,an allowing private key self-healing clustering key was management scheme.The scheme can not only accomplish the distribution of the private keys of node and update,but also can self-heal the old time private keys.Security and efficiency analysis show that the scheme is particularly suitable for large network latency,intermittent connection DTN network.…”
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Recommendations of Pope Francis on Rhetoric by Marian Šuráb

“…Several of them contain recommendations about the manner of preaching. Strong content is not enough for a good homily; the presentation must be appropriate. …”
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