Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis by Meng Wang, Xing Huang, Tingbo Liang, Tianyu Tang, Gang Zhang, Minghao Lu, Zhengtao Hong, Junming Huang, Xiao Zhi

“…As regards the mechanism, ATP11B interacted with PD-L1 in a CKLF-like MARVEL transmembrane domain containing 6 (CMTM6)-dependent manner. The depletion of ATP11B promoted CMTM6-mediated lysosomal degradation of PD-L1, thus reactivating the immune microenvironment and inducing an antitumor immune response. …”
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A Phase I/II Study of Ultra-Hypofractionated Carbon-ion Radiation therapy for Low- and Intermediate-Risk Localized Prostate Cancer by Noriyuki Okonogi, MD, PhD, Hiroshi Tsuji, MD, PhD, Kana Kobayashi, MD, PhD, Mio Nakajima, MD, PhD, Shuri Aoki, MD, PhD, Takanobu Utsumi, MD, PhD, Hiroyoshi Suzuki, MD, PhD, Koichiro Akakura, MD, PhD, Tomohiko Ichikawa, MD, PhD, Hitoshi Ishikawa, MD, PhD

“…Ten patients were enrolled in each group, and the CIRT dose was increased in a stepwise manner if there were fewer than 4 cases of DLT. The initial CIRT dose was 36 Gy, followed by 40 Gy or 44 Gy. …”
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Quinazolinone Derivative MR2938 Protects DSS-Induced Barrier Dysfunction in Mice Through Regulating Gut Microbiota by Ling Lv, Mireguli Maimaitiming, Jichen Yang, Shuli Xia, Xin Li, Pingyuan Wang, Zhiqing Liu, Chang-Yun Wang

“…MR2938, a quinazolin-4(3H)-one derivative derived from the marine natural product penipanoid C, alleviated DSS-induced colitis in a dose-dependent manner. Herein, we aimed to investigate the impact of MR2938 on the gut microbiota in dextran sodium sulfate (DSS)-induced colitis in mice and to elucidate the role of the gut microbiota in the therapeutic mechanism of MR2938 for alleviating colitis. …”
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Aerodynamic energy consumption analysis of divided evacuated tube transportation system by Ziwei Zhang, Yingxue Wang, Guanqing Wang, Feilong Li, Dengke Wang, Jianjun Luo

“…Theoretical discussions into reasonable parameter range including tube design and HST operation manners were conducted and then formed system-designing strategy. …”
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Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice by Yunsheng Liu, Lan Cao, Xiaoxu Zhang, Yan Liang, Yuxia Xu, Cuiqing Zhu

“…MEM treatment suppressed the elevation of phosphorylated tau (P-tau) levels induced by 16-day CRS in a dose-dependent manner. P-tau reduction was accompanied by the attenuation of the upregulation of GSK3β and CDK5 expression and the downregulation of PP2A activity induced by CRS. …”
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PPARα suppresses growth of hepatocellular carcinoma in a high-fat diet context by reducing neutrophil extracellular trap release by Banglun Pan, Zhu Zhang, Dongjie Ye, Xiaoxia Zhang, Yuxin Yao, Yue Luo, Haijie Hong, Xinran Cai, Yanling Chen, Nanhong Tang

“…Consequently, this activation triggered the release of NETs containing Ox-mtDNA through the enhancement of NLRP3-GSDMD-N in a NF-κB-dependent manner. Moreover, the release of NETs within HCC tissues effectively isolated cytotoxic leukocytes in the outer regions of HCC. …”
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An EEG-based framework for automated discrimination of conversion to Alzheimer’s disease in patients with amnestic mild cognitive impairment: an 18-month longitudinal study by Yingfeng Ge, Jianan Yin, Caie Chen, Shuo Yang, Yuduan Han, Chonglong Ding, Jiaming Zheng, Yifan Zheng, Jinxin Zhang

“…Early prediction of whether aMCI will progress to AD is of paramount importance, as it can provide pivotal guidance for subsequent clinical interventions in an early and effective manner.MethodsA total of 107 aMCI cases were enrolled and their electroencephalogram (EEG) data were collected at the time of the initial diagnosis. …”
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A clean energy Korea by 2035: Transitioning to 80% carbon-free electricity generation by Won Young Park, Yong Hyun Song, Nikit Abhyankar, Hee Seung Moon, Umed Paliwal, Eunsung Kim, Nina Khanna, Sanghyun Hong, James Hyungkwan Kim, Kenji Shiraishi, Jiang Lin, Seung Wan Kim, Amol Phadke

“…We find that accelerated renewable energy deployment by 2035 is achievable in a cost-effective and reliable manner, offering substantial economic, environmental, and energy security benefits. …”
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Quantitative proteomics and targeted metabolomics reveal the role of Cassia siamea L. extract in the response to high-fat diet-induced obesity in Drosophila by Ananya Dechakhamphu, Nattapong Wongchum, Theeraphan Chumroenphat, Alongklod Tanomtong, Sirithon Siriamornpun

“…In vitro, CSE significantly inhibited pancreatic lipase activity (IC50 = 67.73±3.24 µg/mL) in a noncompetitive manner. In a high-fat diet-fed Drosophila model, CSE supplementation (10 mg/mL) reduced lipase activity and triglyceride levels and improved body weight, suggesting antiobesity and potential antidiabetic effects. …”
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Effects of soil water on fungal community composition along elevational gradients on the northern slope of the Central Kunlun Mountains by Yongguang Zhang, Yongguang Zhang, Chaonan Li, Zhihao Zhang, Chenhong Li, Bo Zhang, Hongchen Jiang, Waqar Islam, Xiangzhen Li, Fanjiang Zeng

“…Variations in ecological processes may be linked to changes in key environmental factors that influence soil fungal communities in an elevation-dependent manner. These findings can enhance our ability to predict soil fungal diversity patterns and their responses to climate change in the ecosystems of the northern slope of the Central Kunlun Mountain.…”
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Enhancement of CD8+T cell cytotoxicity activity by IFN-α implies alternative pathologic role in systemic lupus erythematosus by Chen-xing Zhang, You-ying Mao, Yu-pin Tan, Mei-yu Zhang, Kang Shao, Shu-jun Wang, Ping Ji, Jia-yuan Wang, Lei Yin, Ying Wang

“…PI3K inhibitor reversed increased granzyme B synthesis upon IFN-α costimulation in a dose-dependent manner. Conclusion: In summary, elevated serum level of IFN-α was responsible for increased secretion of granzyme B and enhanced cytotoxicity of CD8+T cells in SLE and this process may be related to PI3K pathway. …”
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Ruxolitinib synergizes with regulatory T cells to improve inflammation but has no added benefits in decreasing albuminuria in SLE by Mi-Ae Lyu, Ximing Tang, Maria Gabriela Raso, Meixian Huang, Ke Zeng, Tara Sadeghi, Christopher R. Flowers, Simrit Parmar

“…A xenogeneic SLE model was utilized to study their in vivo combination.ResultsIn a dose-dependent manner, ruxolitinib addition synergizes with UCB-Tregs to suppress SLE-PBMC proliferation, inhibit CD8+ T cells, and reduce phosphorylation of STAT3/STAT5/AKT in CD8+ T cells. …”
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Platinum drugs upregulate CXCR4 and PD‐L1 expression via ROS‐dependent pathways, with implications for novel combined treatment in gastric cancer by Xiaoyu Kang, Lin Zhang, Shushang Liu, Fei Wang, Haiming Liu, Fenli Zhou, Fei Wu, Haohao Zhang, Daiming Fan, Yongzhan Nie, Zhangqian Chen

“…Increased levels of CXCR4 and PD‐L1 expression, in a dose‐ and time‐dependent manner upon cisplatin treatment, were observed in GC cells (p < 0.05). …”
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Hypermethylation in Calca Promoter Inhibited ASC Osteogenic Differentiation in Rats with Type 2 Diabetic Mellitus by Lei Wang, Feng Ding, Shaojie Shi, Xingxing Wang, Sijia Zhang, Yingliang Song

“…Meanwhile, it could significantly enhance the formation of ALP and calcium nodules in ASCs-T2DM, increase the expression of osteogenesis-related genes in vitro, and promote the healing of calvarial defects of T2DM rat in a concentration-dependent manner. 5-az intervention indicated that the reduction of the methylation level in Calca target fragment of ASCs-T2DM indeed escalated the gene expression, which may be related to DNMT1. …”
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Triglyceride-independent associations between circulating levels of apolipoprotein C-III and biomarkers of inflammation by Dídac Llop, Pere Rehues, Silvia Paredes, Montse Guardiola, Josefa Girona, Roser Rosales, Yaiza Esteban, Lluís Masana, Daiana Ibarretxe, Joan-Carles Vallvé, Josep Ribalta

“…Conclusion In patients with MD and RA, circulating apoCIII levels were positively associated with glycoproteins and negatively with hsCRP, in a TG-independent manner. Our results suggest that apoCIII is associated with the low-grade inflammatory profile represented by glycoproteins, independent of triglyceride levels. …”
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PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer by Jiacheng Li, Jia Liu, Shifeng Yang, Yu Xia, Qingzhe Meng, Biying Sun, Yansong Liu, Bin Zhao, Jiaqi Jin, Hui Xu, Lihong Wang, Pengxia Zhang, Zhuoxin Cheng

“…Animal experiments revealed that antiplatelet pharmacological agents and genetic knockout of platelets potentiated the antitumour effect of the PD-L1 mAb treatment in a CD8 + T cell dependent manner. Conclusions Our data suggest that PD-L1 positive platelets suppress CD8 + T cell immunity. …”
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Combining In Vitro, In Vivo, and In Silico Approaches to Explore the Effect of <i>Ceratonia siliqua</i> and <i>Ocimum basilicum</i> Rich Phenolic Formula on Lipid Metabolism and Pl... by Mohammadine Moumou, Amani Tayebi, Abderrahmane Hadini, Omar M. Noman, Abdulsalam Alhalmi, Hamza Ahmoda, Souliman Amrani, Hicham Harnafi

“…Accordingly, the CBF prevented LRP oxidation in a concentration-dependent manner. This formula is not toxic in mice (LD₅₀ > 2000 mg/kg body weight). …”
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Targeting CXCL8 signaling sensitizes HNSCC to anlotinib by reducing tumor-associated macrophage-derived CLU by Xin Hu, Yikang Ji, Mi Zhang, Zhihui Li, Xinhua Pan, Zhen Zhang, Xu Wang

“…The levels of both CXCL8 mRNA and its protein IL-8 in cancer cells under conditions of glucose deficiency were increased in an NF-κB-dependent manner. Supplementary IL-8 stimulated TAMs to synthesize CLU, and CLU counteracted oxidative stress in HNSCC cells under conditions of glucose deficiency. …”
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Curcumin-Loaded Lipid Nanoparticles: A Promising Antimicrobial Strategy Against <i>Enterococcus faecalis</i> in Endodontic Infections by Sónia Ferreira, Liliana Grenho, Maria Helena Fernandes, Sofia A. Costa Lima

“…CURs were released from SLNs in a controlled and sustained manner over 100 h. The nanoparticles remained stable for at least two months when stored at 4 °C or 25 °C, making them suitable for clinical use. …”
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Biofabrication of copper oxide nanoparticles using Dalbergia sisso leaf extract for antibacterial, antibiofilm and antioxidant activities by Muhammad Hussnain Siddique, Maimona Sadia, Saima Muzammil, Muhammad Saqalein, Asma Ashraf, Sumreen Hayat, Saba Saba, Arif Muhammad Khan, Abeer Hashem, Graciela Dolores Avila-Qezada, Elsayed Fathi Abd-Allah

“…In vitro antioxidant activity of fabricated nanoparticles revealed significant antioxidant potential (p < 0.05) by quenching free radicals such as DPPH (73.6%), ABTS (68%) and H2O2 (63%) in a dose-dependent manner.…”
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