RNA m6A-mediated post-transcriptional repression of glucocorticoid receptor in LPS-activated Kupffer cells on broilers by Yulan Zhao, Yidan Jiang, Yue Feng, Ruqian Zhao

“…Mechanistically, m6A methylation on the transcripts of GR impairs its mRNA stability in a YTHDF2-dependent manner, which leads to the decrease of its protein. …”
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Prevalence of thyroid diffuse goiter and its association with body mass index and the presence of cysts and nodules in children and adolescents: the Fukushima Health Management Sur... by Nana Nakahata, Mahiro Asano, Norikazu Abe, Haruka Ejiri, Hisashi Ota, Satoshi Suzuki, Ayako Sato, Rina Tazaki, Natsuki Nagamine, Chisato Takahashi, Yukie Yamaya, Manabu Iwadate, Takashi Matsuzuka, Tetsuya Ohira, Seiji Yasumura, Satoru Suzuki, Fumihiko Furuya, Hiroki Shimura, Shinichi Suzuki, Susumu Yokoya, Hitoshi Ohto, Kenji Kamiya

“…The prevalence of diffuse goiter increased in a female-dominant manner with aging. Compared with the absence of diffuse goiter, the age- and sex-adjusted odds ratios (95% confidence intervals) for BMI-SDS (1 SD), BWTAR-SDS (1 SD), cysts, and nodules were 1.24 (1.21–1.27), 3.21 (3.13–3.29), 0.53 (0.50–0.58), and 1.38 (1.17–1.64), respectively. …”
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Strengthening identification and characterization of causes of perinatal deaths in Kaski district of Nepal (Perinatal MITS Nepal) by Nuwadatta Subedi, Sunita Ranabhat, Sanjib Mani Regmi, Mukesh Mallik, Dela Singh, Shree Krishna Shrestha, Bandana Gurung, Arjun Bhattarai, Madan Prasad Baral, Sudhir Raman Parajuli, Ramchandra Bastola, Junu Shrestha, Sahisnuta Basnet, Eva Gauchan, Sabita Paudel

“…Discussion The mechanism of counting and accounting for deaths in a systematic manner is important and it can provide evidence to determine changes in clinical practice and to develop guidelines and training packages for preventive measures. …”
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Automatic Segmentation of Asphalt Cracks on Highways After Large-Scale and Severe Earthquakes Using Deep Learning-Based Approaches by Mehmet Yilmaz, Erkut Yalcin, Fatih Demir, Ahmet Munir Ozdemir, Muhammed Atar, Aysegul Gunes, Beyza Furtana Yalcin, Ertugrul Cambay

“…This study aims to present the performance results of popular deep learning-based segmentation models in an unbiased manner, providing a feasible infrastructure for future real-time applications. …”
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The role of Latin America medicinal plants in wound healing by Mariana Sánchez-Ramos, Andrea Ruiz-Betancourt, Stephany Abigail Tadeo-Cuenca, Angélica Román-Guerrero, María Crystal Columba-Palomares, Araceli Guerrero-Alonso, Antonio Bernabé-Antonio, Deyanira Ojeda-Ramírez, Francisco Cruz-Sosa

“…At a biological level, wound healing involves a complex mechanism in which the immune system and cellular biochemical cascades intervene in a coordinated manner, whose development occurs in stages such as inflammation, proliferation, and remodeling. …”
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SCUBADive. I. JWST+ALMA Analysis of 289 Submillimeter Galaxies in COSMOS-web by Jed McKinney, Caitlin M. Casey, Arianna S. Long, Olivia R. Cooper, Sinclaire M. Manning, Maximilien Franco, Hollis Akins, Erini Lambrides, Elaine Gammon, Camila Silva, Fabrizio Gentile, Jorge A. Zavala, Aristeidis Amvrosiadis, Irham Andika, Malte Brinch, Jaclyn B. Champagne, Nima Chartab, Nicole E. Drakos, Andreas L. Faisst, Seiji Fujimoto, Steven Gillman, Ghassem Gozaliasl, Thomas R. Greve, Santosh Harish, Christopher C. Hayward, Michaela Hirschmann, Olivier Ilbert, Boris S. Kalita, Jeyhan S. Kartaltepe, Anton M. Koekemoer, Vasily Kokorev, Daizhong Liu, Georgios Magdis, Henry Joy McCracken, Jason Rhodes, Brant E. Robertson, Margherita Talia, Francesco Valentino, Aswin P. Vijayan

“…We extract multiwavelength photometry in a manner that leverages the unprecedented near-infrared (NIR) spatial resolution of JWST, and we fit the data with spectral energy distribution models to derive photometric redshifts, stellar masses, star formation rates, and optical attenuation. …”
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Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells by Chu-An Wang, Ya-Chin Hou, Yi-Kai Hong, Yu-Jing Tai, Chieh Shen, Pei-Chi Hou, Jhao-Lin Fu, Cheng-Lin Wu, Siao Muk Cheng, Daw-Yang Hwang, Yung-Yeh Su, Yan-Shen Shan, Shaw-Jenq Tsai

“…In vitro and in vivo studies reveal that early infiltrating macrophage-derived tissue inhibitor of metallopeptidase 1 (TIMP-1) is the key factor in maintaining the ERKactiveDUSP2low cell population in a CD63-dependent manner. The ERKactiveDUSP2low cancer cells further exacerbate macrophage-mediated cancer malignancy, including loss of epithelial trait, increased lymphangiogenesis, and immune escape. …”
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Enhancing Digital Identity and Access Control in Event Management Systems Using Sui Blockchain by Suthir Sriram, P. R. Tharaniesh, Priyanka Saraf, Nivethitha Vijayaraj, Thangavel Murugan

“…It also ensures the validity of tickets and at the same time ensures that the ticket is transferable back and forth while the ownership of the ticket is wholly and clearly disclosed. zkLogin for Seamless User Authentication: zkLogin is then implemented in the platform to ensure users can be authenticated in a Privacy-Preserving manner while at the same time having High Security. …”
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Immuno-PET Imaging of the Programmed Cell Death-1 Ligand (PD-L1) Using a Zirconium-89 Labeled Therapeutic Antibody, Avelumab by Elaine M. Jagoda PhD, Olga Vasalatiy PhD, Falguni Basuli PhD, Ana Christina L. Opina PhD, Mark R. Williams BS, Karen Wong MS, Kelly C. Lane BS, Steve Adler PhD, Anita Thein Ton MS, Lawrence P. Szajek PhD, Biying Xu PhD, Donna Butcher BS, Elijah F. Edmondson DVM, PhD, Rolf E. Swenson PhD, John Greiner PhD, James Gulley MD, PhD, Janet Eary MD, Peter L. Choyke MD

“…In the unlabeled avelumab dose escalation studies, spleen tissue–muscle ratios decreased in a dose-dependent manner indicating specific [ 89 Zr]Zr-DFO-PD-L1 mAb binding to PD-L1. …”
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Normalization of tumor vasculature by imiquimod: proposal for a new anticancer therapeutic indication for a TLR7 agonist by Jarosz-Biej Magdalena, Czapla Justyna, Ciepła Joanna, Smolarczyk Ryszard, Drzyzga Alina, Sprus-Lipka Dorota, Pilny Ewelina, Matuszczak Sybilla, Cichoń Tomasz

“…Imiquimod normalized tumor vasculature both structurally (by reducing vessel tortuosity and increasing pericyte coverage) and functionally (by improving tumor perfusion) in a dose-dependent manner. Hypoxia regions in tumors of treated mice were significantly reduced after IMQ administration. …”
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Beyond Dermatological Findings: Multisystem Involvement in Prolidase Deficiency by Ezgi Yalcin Gungoren, Zeynep Meric, Asena Pinar Sefer, Asuman Deveci Ozkan, Salim Can, Royala Babayeva, Nurhan Kasap, Ercan Nain, Esra Ozek Yucel, Ayca Kiykim, Sevgi Bilgic-Eltan, Ayse Deniz Yucelten, Elif Karakoc-Aydiner, Ahmet Ozen, Safa Baris

“…Objective: Prolidase deficiency is a metabolic and immunological disorder that is inherited in an autosomal recessive manner. In prolidase deficiency, a broad spectrum of differences is observed in patients, ranging from asymptomatic to multisystem involvement. …”
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Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease by Jingyun Wu, Irene Santos-Garcia, Ivan Eiriz, Thomas Brüning, Aleš Kvasnička, David Friedecký, Tuula A. Nyman, Jens Pahnke

“…Different motor behavior and physiological parameters were assessed throughout the study.The findings revealed that FTY rescued disease-related body weight loss in a sex-dependent manner, indicating its potential to regulate metabolic disturbances and to counteract neurodegenerative processes in HD. …”
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Toxicological Effects of Commonly Used Mosquito Coil Smoke on Liver and Lung Function in Rats by Hadiza Abubakar, Yahuza Gimba Muhammed, Alhassan Muhammad Wudil, Dayyabu Shehu, Murtala Yaú

“…A questionnaire was used to make inquiries regarding the prevalent types and brands of mosquito coils employed, the manner in which they are used, the durations for which they are utilized. …”
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Sandpiper Optimization Algorithm With Region Growing Based Robust Retinal Blood Vessel Segmentation Approach by Ibrahim AlMohimeed, Mohamed Yacin Sikkandar, A. Mohanarathinam, Velmurugan Subbiah Parvathy, Mohamad Khairi Ishak, Faten Khalid Karim, Samih M. Mostafa

“…This method has been specifically designed to improve the generalization capabilities and accuracy of retinal vessel segmentation manners, vital for the precise detection of retinal diseases like vein occlusion and DR. …”
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Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of <i>Ganoderma lucidum</i> by Xiaolan Xu, Chunxia Li, Fangjing Wu, Shuangshuang Zhao, Tiqiang Chen, Haihong You, Yijie Lin, Xiaoxing Zou

“…These compounds have various pharmacological functions, including anti-tumor, antioxidant, anti-inflammatory, liver-protective, and immune-regulating effects. However, the manner in which they accumulate, and their biosynthesis mechanisms remain unclear. …”
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Effect of carbon quantum dots on the anticorrosive action of the tin coatings by Taiane Fíngolo Duarte, Victor Magno Paiva, Braulio Soares Archanjo, Clara Muniz da Silva de Almeida, Natasha Midori Suguihiro, Rodrigo José Corrêa, Emerson Schwingel Ribeiro, Eliane D'Elia

“…The SEM and XDR show that this concentration favored the growth of the film in a more uniform manner, providing a more homogeneous barrier when compared to the pure Sn film. …”
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MicroRNA-122 protects against interferon-α-induced hepatic inflammatory response via the Janus kinase–signal transducer and activator of transcription pathway by Fanwei Liu, Bowen Liu, Shanshan Xu, Yinhua Ni, Xiaoli Liu

“…Furthermore, silencing IFIT1 via an siRNA elicited an inflammatory response, whereas IFIT1 overexpression ameliorated hepatic inflammation and fibrosis in a manner comparable to that induced by IFN-α treatment. …”
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Altered circadian rhythmicity of the QT interval predicts mortality in a large real-world academic hospital population by Rutger R. van de Leur, Bastiaan C. du Pré, Markella I. Printezi, Rutger J. Hassink, Pieter A. Doevendans, René van Es, Linda W. van Laake

“…The QT interval was corrected for age, sex and ventricular rate in a personalized manner. Subsequently, the added value of a 24-h sinusoid of time-of-day was evaluated. …”
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Rosiglitazone, a Ligand to PPARγ, Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo Del Valle-Mondragón, María Esther Rubio-Ruiz, Alicia G. Aguilar-Navarro, Absalom Zamorano-Carrillo, Margarita del Carmen Ramírez-Ortega, Gustavo Pastelín-Hernández, Alicia Sánchez-Mendoza

“…We conclude that RGZ lowers blood pressure values by increasing the expression of RAS axis proteins ACE2 and AT2R, decreasing the levels of AngII and increasing levels of Ang-(1-7) in a PPARγ-dependent manner. The in silico analysis is a valuable tool to predict the interaction between PPARγ and RAS.…”
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Comprehensive safety and toxicity analysis of 2,2’-Bipyridine derivatives in combating MRSA biofilm formation and persistence by Priyanka, Priyanka, Mohini Sharma, Bhavna Vaid, Bhavna Vaid, Ram Bharti, Ram Bharti, Sachin Raut, Sachin Raut, R. S. Jolly, Neeraj Khatri, Neeraj Khatri

“…They inhibited biofilm formation and eradicated biofilms in a dose-dependent manner against MTCC 737 and MRSA 831, and they effectively eliminated MRSA persister cells, outperforming the reference antibiotic vancomycin. …”
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