Altered Viral Replication and Cell Responses by Inserting MicroRNA Recognition Element into PB1 in Pandemic Influenza A Virus (H1N1) 2009 by Xiaoyue Shen, Wenkui Sun, Yi Shi, Zheng Xing, Xin Su

“…MicroRNAs (miRNAs) are endogenous noncoding RNAs that spatiotemporally modulate mRNAs in a posttranscriptional manner. Engineering mutant viruses by inserting cell-specific miRNA recognition element (MRE) into viral genome may alter viral infectivity and host responses in vital tissues and organs infected with pandemic influenza A virus (H1N1) 2009 (H1N1pdm). …”
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Application of complexity theory in health and social care research: a scoping review by Áine Carroll, Claire Collins, Andrew Darley, Diarmuid Stokes, Jane McKenzie

“…Despite its potential value, many empirical investigations apply the theory in a tokenistic manner without engaging with its underlying concepts and underpinnings.Objectives The aim of this scoping review is to synthesise the literature on empirical studies that have centred on the application of complexity theory to understand health and social care provision.Methods This scoping review considered primary research using complexity theory-informed approaches, published in English between 2012 and 2021. …”
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Urban versus rural older adults: occupational balance and quality of life comparison by Emel Pekçetin, Serkan Pekçetin, Emine Sağlamoğlu, Gamze Ekici

“…In contrast, rural residents had lower scores on these items, potentially reflecting fewer perceived opportunities for engaging in activities in a balanced manner. Older adults daily residing in urban areas had higher scores in the WHOQOL-OLD total score, WHOQOL-OLD Sensory Abilities Subtest, and WHOQOL-OLD Autonomy Subtest (p < .05). …”
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Application Effect of Transparent Supervision Based on Informatization in Prevention and Control of Carbapenem-Resistant Klebsiella pneumoniae Nosocomial Infection by Xiaoqin Wu, Quansheng Lu, Guo Feng, Hongxia Kan, Liran Shi

“…Transparent supervision of CRKP-infected patients was conducted daily from January to December 2020, which resulted in the following: (a) the infection rate of CRKP decreased in a fluctuating manner, and the actual value of hydrocarbon alkene use rate was basically the same as the predicted value with an overall decreasing trend; (b) after the intervention, hand hygiene compliance rate increased from 53.30% to 70.24% (P<0.001) and the ATP qualified rate increased from 53.77% to 92.24% (P<0.001); (c) the fitted value of the ARIMA model was in good agreement with the actual value. …”
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Therapeutic effects of mirodenafil, a phosphodiesterase 5 inhibitor, on stroke models in rats by Fred Kim, Padmanabh Singh, Hyunji Jo, Tianyang Xi, Dong-Keun Song, Sae Kwang Ku, Jai Jun Choung

“…Effects were seen in a dose-dependent manner up to 1 ​mg/kg mirodenafil. The benefits of mirodenafil treatment increased with longer treatment duration, and the largest improvements over control were typically observed on the last assessment day. …”
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C-POS: A Context-Aware Adaptive Part-of-Speech Language Learning Framework by Shazia Maqsood, Abdul Shahid, Fakhra Nazar, Muhammad Asif, Muhammad Ahmad, Manuel Mazzara

“…Further, the need for learning an additional language has increased due to globalization in an unprecedented manner. Therefore, English is being taught as an additional language at various levels of education. …”
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Improved Antibacterial Activity of Water-Soluble Nanoformulated Kaempferol and Combretastatin Polyphenolic Compounds by Y. Santhosh Kumar, Langeswaran Kulanthaivel, G. S. Hikku, R. Saravanan, Thangavelu Lakshmi, C. Kirubhanand, Murugesan Karthikeyan, P. Vijayalakshmi, Gowtham Kumar Subbaraj

“…Owing to the size effect, the NF-k and NF-c release up to 50% of the drug in a sustained manner till 50 h showing twofold higher concentration than the control where it released 25%. …”
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Putative evolution of Myxococcus fulvus 124B02 plasmid pMF1 from a chromosomal segment in another Myxococcus species by Shruti Jain, Gaurav Sharma

“…We further reported that all pMF1 plasmid genes depict homology with Myxococcus stipitatus CYD1 draft genome (contig 28) and a chromosomal segment of M. stipitatus DSM14675 in a syntenic manner, implying the presence of plasmid-like structure in M. stipitatus CYD1, integrated into its chromosome. …”
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Rare Presentation of Neonatal Necrotizing Fasciitis: Case Series and Review of Literature by Kruti N Shah, Shwetal Bhatt, Dipal Zanzrukriya, Salesh K Soni

“…It becomes essential to diagnose in a timely manner and culminate in a multidisciplinary approach with antimicrobial treatments and surgical aid to prevent its fulminating course. …”
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STAT3 Genotypic Variant rs744166 and Increased Tyrosine Phosphorylation of STAT3 in IL-23 Responsive Innate Lymphoid Cells during Pathogenesis of Crohn’s Disease by Ying Tang, Sanda A. Tan, Atif Iqbal, Jian Li, Sarah C. Glover

“…Signal transducer and activator of transcription 3 (STAT3) regulates gene expression in a cell-specific, cytokine-dependent manner, involving multiple immune responses. This study proposes the positive correlation between the prevalence of STAT3 rs744166 risky allele “A” with the severity of disease in a cohort of 94 CD patients. …”
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Intratumor microbiome-derived butyrate promotes chemo-resistance in colorectal cancer by Linsheng Xu, Linsheng Xu, Bingde Hu, Jingli He, Xin Fu, Na Liu

“…Experimental assays, including CCK8 and wound-healing, demonstrated that intratumor microbiome-derived butyrate enhances the proliferation and migration of HCT15 cells in a time- and concentration-dependent manner. Cell survival analysis further indicated that butyrate treatment significantly increased the IC50 value, suggesting heightened drug resistance in HCT15 cells. …”
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A contentious intervention to support the medical workforce: a case study of the policy of introducing physician associates in the United Kingdom by Martin McKee, Louella K. Vaughan, Giuliano Russo

“…The name soon changed, to physician associate, and the range of roles and responsibilities expanded greatly, although in a largely unregulated manner; by 2024, some were undertaking complex procedures or managing undifferentiated patients in primary care. …”
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Preparation and Protective Performance of High-Reflection and High-Thermal Insulation Laser Protection Coatings by LI Shuwen, WU Lingfeng, YANG Guanjun, CHEN Lin

“…Laser weapons have entered the actual combat application stage， and the research on anti-laser protection for air and space weapons is becoming increasingly urgent.Prolonged high-energy laser irradiation leads to problems such as reduced metal reflectance，mass loss of ablated layer of the ablative layer and insufficient heat insulation toughness.Based on this，a composite laser protection strategy based on the principles of reflection and heat insulation was proposed.In this study， by adjusting spraying power， spraying distance and other parameters， supersonic flame spraying technology and plasma spraying technology were used to prepare NiCoCrAlTaY bond coating and yttria-stabilized zirconia(YSZ) top coating double-layer coatings， to explore the influence of surface roughness and porosity on reflectivity， and to investigate the laser protection performance of the coatings.Results showed that the larger the spraying power or spraying distance， the more obvious the layer effect， and the more cross-sectional pores were observed in the coating.The surface roughness of the coating decreased first and then increased with the increase in spraying distance.When the secondary reflection structure was removed， the coating surface had&#x00A0;Ra＝1.8 μm.When&#x00A0;Ra＝0.5 μm， the wedge-shaped structure of the coating increased the reflectivity by about 2.4%compared to that of the coating when&#x00A0;Ra＝1.8 μm.It was pointed out that the layered pores were key to the high-reflection wedge structure， the spherical voids were the laser absorption points，and the process parameter of 14.7%porosity (39 kW，100 mm) was the best.In the laser ablation experiment，with the increase in laser power density， the cracks in the coating gradually increased until holes were ablated.The line ablation rate increased approximately in a parabolic manner.With low laser power density (&lt;3 800 W/cm2)， the surface structure changed slightly； as the power increased， the surface cracks increased and deepened， and the petal-like structure in the recondensing zone increased.With high laser power density (&gt;8 050 W/cm2)， partial peeling and ablation of the coating surface caused the coating to fail.…”
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Ellagic Acid Alleviates Rheumatoid Arthritis in Rats through Inhibiting MTA1/HDAC1-Mediated Nur77 Deacetylation by Huanjin Song, Hao Wu, Jun Dong, Sihua Huang, Jintao Ye, Ruoxi Liu

“…Western blot analysis showed that EA reduced MTA1 expression in a dose-dependent manner in MH7A cells. Then, TNF-α-treated MH7A cells were incubated with EA alone or together with MTA1 overexpression plasmid (pcDNA-MTA1), and we found that EA inhibited proliferation, inflammation cytokine levels, and oxidative stress marker protein levels and promoted apoptosis in MH7A cells, while MTA1 overexpression abolished these effects. …”
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Grouting Design of Rich Water Tunnels and the Calculation of Distance between Annular Blind Pipes by Helin Fu, Pengtao An, Kai Li, Guowen Cheng, Jie Li, Xiaohui Yu

“…The results show that (1) grouting reinforcement is an important means to reduce water seepage, and tunnel water seepage can be adjusted by changing the thickness and permeability coefficient of the grouting reinforcement circle, in which the thickness of the reinforcement circle should not be too large, and the permeability coefficient should not be less than 1/80 of the surrounding rock permeability coefficient; (2) according to the derived formula, the water pressure of the secondary lining structure decreases in a parabolic manner from the middle of the two rows of annular blind pipes to the place where the annular blind pipes are set; (3) the allowable water seepage of the tunnel and the design value of the water pressure resistance of the lining structure should be considered when determining the distance between annular blind pipes; and (4) based on the derived formula, the distance between the annular blind pipes in the test section of the Hongtu extra-long tunnel is determined to be 8 m.…”
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Charakter prawny rady społecznej w samodzielnym publicznym zakładzie opieki zdrowotnej by Michał Gornowicz

“…De lege lata, the current manner of legal shaping of social councils makes it a facade, deprived of any authority enabling effective implementation of statutory objectives accompanying their establishment within the broadly understood social control of independent public healthcare institutions. …”
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Antibacterial, Antifungal, and Antidiabetic Effects of Leaf Extracts from Persea americana Mill. (Lauraceae) by Mercy Makopa, Benjamin Mangiza, Benjamin Banda, Winnie Mozirandi, Molly Mombeshora, Stanley Mukanganyama

“…Out of all the tested extracts, the methanolic extract showed the best inhibitory activity on α-glucosidase enzyme in a time-dependent and dose-dependent manner. Ki and Kinact values were found to be 1.4 mg/mL and 2.4 U/min, respectively, after incubation for 1 hour. …”
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Assessment of a new protocol strategy to control the ectoparasitic infestation in Nile tilapia (Oreochromis niloticus) using efficient natural products by Magdy I. Hanna, Aya T. EL Sayed, Ola Hasan Abd El Megeed, Marwa A. Ibrahim, Reda M. S. Korany, Marwa M. Attia

“…The treatment and prophylaxis significantly downregulated both genes in the studied organ in a dose-dependent manner. Recorded lesions which were scored according to their severity. …”
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Comparison of Statistical, Graphical, and Wavelet Transform Analyses for Rainfall Trends and Patterns in Badulu Oya Catchment, Sri Lanka by Ashika M. Ruwangika, Anushka Perera, Upaka Rathnayake

“…The results reveal that the nonparametric Mann–Kendall test is powerful to produce the statistically significant rainfall trends in qualitative and quantitative manner. Mann–Kendall analysis shows a positive trend to Ledgerwatte Estate in monthly (3.7 mm in February and 7.4 mm in October), seasonal (6.9 mm in the 2ndintermonsoon), and annual (3 mm annually) scales. …”
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Time Course of Acute Hip Adduction Range of Motion Changes Following Foam Rolling by Anthony D’Amico, Kevin Silva, Joseph Gallo

“…# Background With the increased popularity of foam rolling (FR), it is important to establish the exact manner in which the practice is useful. # Purpose The purpose of this study was to examine the impact of FR the iliotibial (IT) band on hip adduction range of motion (ROM) and the short-term time course of any ROM changes that may occur…”
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