High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells by Hong Feng, Junling Gu, Fang Gou, Wei Huang, Chenlin Gao, Guo Chen, Yang Long, Xueqin Zhou, Maojun Yang, Shuang Liu, Shishi Lü, Qiaoyan Luo, Yong Xu

“…Simultaneously, the mRNA and protein levels of TXNIP, NLRP3, procaspase-1, and IL-1β were significantly induced by high glucose concentration and lipopolysaccharide in a dose-dependent and time-dependent manner in vitro. This induction by both high glucose and lipopolysaccharide was significantly inhibited by N-acetyl-L-cysteine. …”
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Understanding Hip Contact Stress Based on Types of Physical Activity: A Systematic Review by Arief Indra Perdana Prasetya, Muhammad Imam Ammarullah, Tri Indah Winarni, Adriyan Pramono, Jamari Jamari, Tunku Kamarul, Ardiyansyah Syahrom

“…Conclusion Types of physical activity (n = 21) have correlation with high hip joint contact stress in various manner. Based on the research findings obtained from various inclusion papers, it can be broadly concluded that the more intense the physical activity, such as running and stair climbing, the greater the impact on the increase in hip contact stress values. …”
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Symptom-based depression subtypes: brain dynamic specificity and its association with gene expression profiles by Qunjun Liang, Zhifeng Zhou, Shengli Chen, Shiwei Lin, Xiaoshan Lin, Ying Li, Yingli Zhang, Bo Peng, Gangqiang Hou, Yingwei Qiu

“…However, in clinical practice, patients consistently present symptoms in a regular rather than random manner, and the neural basis underlying the MDD subtypes remains unclear. …”
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C5a-C5aR1 axis mediates lung inflammation and fibrosis induced by single-walled carbon nanotubes via promoting neutrophils recruitment by Jiaojiao Zhu, Xiang Zhang, Lanlan Li, Hongxu Yang, Hang Liu, Danyang Wu, Zikai Liu, Bin Liu, Tong Shen

“…C5a-C5aR1 signaling activation and neutrophils recruitment were subsequently decreased in a time-dependent manner. Furthermore, inhibition of C5a-C5aR1 axis with C5aR1 antagonist PMX205 treatment not only dramatically reduced neutrophils recruitment and inflammatory cytokines secretion at early phase, but also effectively alleviated early lung inflammation and late pulmonary fibrosis induced by SWCNT exposure. …”
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<i>Artemisia herba</i>-<i>alba</i> Essential Oil: Chemical Composition, Phytotoxic Activity and Environmental Safety by Beáta Baranová, Daniela Gruľová, Flavio Polito, Vincent Sedlák, Mária Konečná, Marta Mydlárová Blaščáková, Ismail Amri, Vincenzo De Feo, Janka Poráčová

“…The EO demonstrated variable phytotoxic effects with a dose-dependent manner, inhibiting both the germination and the radical elongation of the tested seeds, and was also found to be environmentally safe for the selected organisms. …”
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Real-world outcomes of maintenance therapy post-autologous stem cell transplantation in newly diagnosed multiple myeloma by Ka-Won Kang, Dae Sik Kim, Se Ryeon Lee, Mi Hwa Heo, Hyeon-Seok Eom, Jongheon Jung, Ji Hyun Lee, Sung-Hyun Kim, Youngil Koh, Chang-Ki Min, Seung Shin Lee, Sung-Nam Lim, Ho-Young Yhim, Myung-won Lee, Je-Jung Lee, Sung-Hoon Jung, Soo-Mee Bang, Kihyun Kim, the Korean Multiple Myeloma Working party [KMMWP]

“…Therefore, it may be prudent to consider implementing maintenance therapy in a feasible manner.…”
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Investigating the Allelopathic and Bioherbicidal Potential of <i>Solidago altissima</i> with a Focus on Chemical Signaling in <i>Trifolium repens</i> by Ho-Jun Gam, Arjun Adhikari, Yosep Kang, Md. Injamum-Ul-Hoque, Shifa Shaffique, Ji-In Woo, Jin Ryeol Jeon, Byeong-Kwan An, Min Young Back, Ki-Yong Kim, Sang-Mo Kang, In-Jung Lee

“…Moreover, SRE treatment significantly inhibited the seed germination of all tested weed species in a concentration-dependent manner. Gas chromatography-mass spectrometry analysis of <i>S. altissima</i> root extract identified a high concentration of methyl kolavenate, a clerodane diterpene predicted to act as a phytotoxic agent. …”
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Formation mechanism of multiple spallation and its penetration induced by shear localization in NiTi alloy under implosion loading by Xianye Wu, Xiaoyang Pei, Xiang Chen, Hao Zhang, Jin Wang, Xin Yang, Meizhen Xiang, Shang Gao, Fang Wang

“…For larger grain sizes, void nucleation at the first spallation occurs in a coexisting intergranular/transgranular manner, whereas with decreasing grain size, voids tend to nucleate along the grain boundaries. …”
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On the Use of SuperDARN Ground Backscatter Measurements for Ionospheric Propagation Model Validation by Joshua J. Ruck, David R. Themens, Pasha Ponomarenko, Angeline G. Burrell, Bharat Kunduri, J. Michael Ruohoniemi, Sean Elvidge

“…Abstract Prior to use in operational systems, it is essential to validate ionospheric models in a manner relevant to their intended application to ensure satisfactory performance. …”
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A division-dependent compartmental model for computing cell numbers in CFSE-based lymphocyte proliferation assays by H. Thomas Banks, W. Clayton Thompson, Cristina Peligero, Sandra Giest, Jordi Argilaguet, Andreas Meyerhans

“…Some key features of a mathematical description of an immune response are an estimate of the number of responding cells and the manner in which those cells divide, differentiate, and die. …”
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Molecular aspects of cell-penetrating peptides: key amino acids, membrane partners, and non-covalent interactions by Walrant, Astrid, Tazi, Farah, Khemaissa, Sonia, Sagan, Sandrine

“…It separates the external environment from the cell interior and is composed of thousands of different lipids, proteins, and sulfated carbohydrates, all arranged in a complex and dynamic manner and at various length scales. Floating above the lipid bilayer, negatively charged proteoglycans and other polysaccharides form a viscous, anionic matrix layer surrounding animal cells, which CPPs have to go through to reach the lipid bilayer. …”
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β-Glucan induced plasma B cells differentiation to enhance antitumor immune responses by Dectin-1 by Yu Bai, Jun Ding, Liuyang He, Zhichao Zhu, Jie Pan, Chunjian Qi

“…Conclusions These findings reveal that β-glucan can serve as a potent adjuvant to modulate B cell immune responses in a Dectin-1 dependent manner and improve immune checkpoint blockade (ICB) therapy in antitumor. …”
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Electrical Stimulation Promotes Cardiac Differentiation of Human Induced Pluripotent Stem Cells by Damián Hernández, Rodney Millard, Priyadharshini Sivakumaran, Raymond C. B. Wong, Duncan E. Crombie, Alex W. Hewitt, Helena Liang, Sandy S. C. Hung, Alice Pébay, Robert K. Shepherd, Gregory J. Dusting, Shiang Y. Lim

“…Beating EBs were also shown to cycle calcium and were responsive to the chronotropic agents, isoproterenol and carbamylcholine, in a concentration-dependent manner. Conclusions. Our results demonstrate that brief electrical stimulation can promote cardiac differentiation of human iPS cells. …”
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Taguchi Grey relational analysis (GRA) based multi response optimization of flammability, comfort and mechanical properties in station suits by Hafsa Jamshaid, Awais Ahmad Khan, Rajesh Kumar Mishra, Naseer Ahmad, Vijay Chandan, Viktor Kolář, Miroslav Müller

“…Therefore, it is essential to balance these multi responses in a scientific manner. This study explores the multi-response optimization of fiber blend composition and knitted structures on the responses like flammability, comfort, and serviceability/mechanical properties, for the development of fire-resistant fabrics. …”
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A distinct double-ring LH1–LH2 photocomplex from an extremophilic phototroph by Kazutoshi Tani, Kenji V. P. Nagashima, Risa Kojima, Masaharu Kondo, Ryo Kanno, Issei Satoh, Mai Kawakami, Naho Hiwatashi, Kazuna Nakata, Sakiko Nagashima, Kazuhito Inoue, Yugo Isawa, Ryoga Morishita, Shinichi Takaichi, Endang R. Purba, Malgorzata Hall, Long-Jiang Yu, Michael T. Madigan, Akira Mizoguchi, Bruno M. Humbel, Yukihiro Kimura, Yutaka Nagasawa, Takehisa Dewa, Zheng-Yu Wang-Otomo

“…The additional LH1-B797 BChls a are located in such a manner that they facilitate exciton transfer from monomeric BChls in LH2 to the dimeric BChls in LH1. …”
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Hyperglycemia Does Not Affect Iron Mediated Toxicity of Cultured Endothelial and Renal Tubular Epithelial Cells: Influence of L-Carnosine by Shiqi Zhang, Emmanouil Ntasis, Sarah Kabtni, Jaap van den Born, Gerjan Navis, Stephan J. L. Bakker, Bernhard K. Krämer, Benito A. Yard, Sibylle J. Hauske

“…Irrespective of glucose concentrations L-carnosine prevented toxicity in a dose-dependent manner, only if it was present during the FeCl3 challenge. …”
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Analysis of the Impact of Big Data on E-Commerce in Cloud Computing Environment by Rongrui Yu, Chunqiong Wu, Bingwen Yan, Baoqin Yu, Xiukao Zhou, Yanliang Yu, Na Chen

“…This method can avoid the disadvantages of the traditional e-commerce, where large-scale data cannot be processed in a timely manner, realize the value of mining data behind, and realize the precision marketing of e-commerce enterprises.…”
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Sulforaphane as a promising anti-caries agents: inhibitory effects on Streptococcus mutans and caries control in a rat model by Meijiao Yu, Meijiao Yu, Yu Chen, Yu Chen, Sishi Dong, Sishi Dong, Zhongxin Chen, Zhongxin Chen, Xuelian Jiang, Xuelian Jiang, Yufei Wang, Yufei Wang, Linglin Zhang, Linglin Zhang

“…The growth of S. mutans and the biofilm formation were inhibited by SFN in a dose-dependent manner through suppressing the synthesis of extracellular polysaccharide (EPS) and acid production, as well as decreasing the acid tolerance. …”
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Cadmium Uptake and Distribution in Fragrant Rice Genotypes and Related Consequences on Yield and Grain Quality Traits by Adam Sheka Kanu, Umair Ashraf, Zhaowen Mo, Issaka Fuseini, Lamin R. Mansaray, Meiyang Duan, Shenggan Pan, Xiangru Tang

“…The results showed that, with increased levels of soil Cd toxicity, Cd uptake in roots and distribution to other organs increased in dose dependent manner. Uptake and accumulation were higher in roots than in shoots with the highest uptake in both roots and shoots observed in Meixiangzhan 2, followed by Nongxiang 18, Basmati, Xiangyaxiangzhan, and Guixiangzhan cultivars. …”
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TRIM8 inhibits porcine epidemic diarrhoea virus replication by targeting and ubiquitinately degrading the nucleocapsid protein by Zhenbin Bi, Wei Wang, Shanshen Gu, Yajing Zhou, Zhengchang Wu, Wenbin Bao, Haifei Wang

“…Furthermore, TRIM8 was shown to reduce the expression of the PEDV N protein in a dose-dependent manner. Mechanistically, TRIM8 inhibits the expression of PEDV N through K48-linked ubiquitin proteasome degradation. …”
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