Evaluating the antifibrotic potential of naringenin, asiatic acid, and icariin using murine and human precision‐cut liver slices by Ke Luo, Yana Geng, Dorenda Oosterhuis, Vincent E. deMeijer, Peter Olinga

“…Our findings indicate that NRG reduced collagen type 1 (COL1A1) expression in a concentration‐dependent manner in both mPCLS and chPCLS, decreased fibrosis‐related gene expression, and significantly lowered pro‐collagen type 1 (PCOL1A1) levels in the culture medium by 54 ± 21% (mPCLS) and 78 ± 35% (chPCLS). …”
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Role of lipid binding protein, Niemann pick type C-2, in enhancing shrimp sperm physiological function by Thitiporn Khongkha, Alyssa Rattanadechakul, Piyaporn Surinlert, Orawan Thongsum, Supawich Boonkua, Kessiri Kongmanas, Monsicha Somrit, Wattana Weerachatyanukul, Somluk Asuvapongpatana

“…Finally, the enhanced levels of protein tyrosine phosphorylation and ionophore-induced AR levels in the MrNPC2 treated Tsp significantly increased in a concentration-dependent manner, similar to that of the Vsp sperm. Altogether, our results indicated the importance of MrNPC2 as CHO moderator in sperm membrane, leading to an enhancement in sperm fertilizing ability.…”
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Synthesis and characterization of nano dicalcium phosphate dihydrate from biogenic sources by Md. Kawcher Alam, Md. Sahadat Hossain, Mofassel Hossen Akash, Muhammad Shahriar Bashar, Newaz Mohammed Bahadur, Samina Ahmed

“…In the present study, calcium-enriched marine sources (Turritella, Cardium, and Conch shells) were used to prepare dicalcium phosphate dihydrate (DCPD) in an easy, affordable, and sustainable manner. To produce DCPD, orthophosphoric acid was subjected to a reaction with each type of shell powdered substance, resulting in DCPD in a sheet-like or irregular-type shape. …”
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Anti-Inflammatory and Antioxidant Effects of Carpesium cernuum L. Methanolic Extract in LPS-Stimulated RAW 264.7 Macrophages by Yea-Jin Park, Se-Yun Cheon, Dong-Sung Lee, Divina C. Cominguez, Zhiyun Zhang, Sangwoo Lee, Hyo-Jin An

“…CLME treatment also reduced reactive oxygen species (ROS) generation and enhanced the expression of heme oxygenase-1 (HO-1) protein in a dose-dependent manner in the LPS-stimulated RAW 264.7 cells. Moreover, CLME treatment abolished the nuclear translocation of nuclear factor-κB (NF-κB), enhanced the activation of nuclear factor-erythroid 2 p45-related factor 2 (Nrf2), and reduced the expression of extracellular signal-related kinase (ERK) and ERK kinase (MEK) phosphorylation in LPS-stimulated RAW 264.7 cells. …”
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Versatility of the Anterolateral Thigh Flap for Abdominal Wall Reconstruction by Nadine E. Pedrazzi, MD, Riccardo Schweizer, MD, Holger J. Klein, MD, Stephan Steiner, MD, René Vonlanthen, MD, Thomas Hermanns, MD, Didier Schneiter, MD, Pietro Giovanoli, MD, Jan A. Plock, MD

“…Depending on the localization of the defect, this flap can be used in a pedicled or free microsurgical manner. The fascial component of the ALT fasciocutaneous flap and of the extended iliotibial tract provides stable fascia for reinforcement or fascial reconstruction of the abdominal wall. …”
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A novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative inhibits cell proliferation by suppressing the MEK/ERK signaling pathway in colorectal cancer by Li Weiwei, Yang Zhifu, Ding Likun, Wang Ying, Zhao Xian, Chu Jian Jie, Ji Qing, Yao Minna, Wang Jingwen

“…Compound 4 also inhibited colony formation, migration, and invasion of HCT116 cells in a dose-dependent manner, as well as inducing cell apoptosis and arresting the cell cycle in the G2/M phase. …”
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Comparison of chicoric acid, and its metabolites caffeic acid and caftaric acid: In vitro protection of biological macromolecules and inflammatory responses in BV2 microglial cells by Qian Liu, Fan Liu, Liling Zhang, Yajie Niu, Zhigang Liu, Xuebo Liu

“…Moreover, CA, CTA and CFA all exerted remarkable inhibition capacities on linoleic acid and soybean lecithin liposomes peroxidation in a dose-dependent manner, and restrained the oxidation of herring sperm DNA, as well as the breakage of pBR322 plasmid DNA. …”
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Methyl Canthin-6-one-2-carboxylate Inhibits the Activation of the NLRP3 Inflammasome in Synovial Macrophages by Upregulating Nrf2 Expression by Yuanyuan Chen, Zongying Zhang, Yuan Yao, Xiaorong Zhou, Yong Ling, Liming Mao, Zhifeng Gu

“…Our data reveal that exposure to Cant significantly suppressed the transcription and secretion of multiple pro-inflammatory mediators, including IL-1β, IL-6, IL-18, TNF-α, NO, and COX2, in a dose-dependent manner. These alterations were associated with changes in the activation of various signaling pathways, including NF-kB, MAPK, and PI3K-AKT pathways. …”
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Identification of new reference genes with stable expression patterns for cell cycle experiments in human leukemia cell lines by Otília Tóth, Gergely Attila Rácz, Eszter Oláh, Máté Tóth, Edit Szabó, György Várady, Beáta G. Vértessy, Nikolett Nagy

“…Here we show that for cell cycle-dependent gene expression analysis the commonly used TBP is suitable, while the recently recognized reference genes SNW1 and CNOT4 are applicable in a cell line-dependent manner. We also suggest that proper selection of reference genes for each experimental condition is crucial for reliable normalization as these aspects can severely compromise conclusions.…”
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AM966, an Antagonist of Lysophosphatidic Acid Receptor 1, Increases Lung Microvascular Endothelial Permeability through Activation of Rho Signaling Pathway and Phosphorylation of V... by Junting Cai, Jianxin Wei, Shuang Li, Tomeka Suber, Jing Zhao

“…AM966 decreased the transendothelial electrical resistance (TEER) value immediately in a dose-dependent manner. VE-cadherin and f-actin double immunostaining reveals that AM966 increases stress fibers and gap formation between endothelial cells. …”
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Atomic Energy Optimization: A Novel Meta-Heuristic Inspired by Energy Dynamics and Dissipation by Mohammed Omari, Mohammed Kaddi, Khouloud Salameh, Ali Alnoman, Mohammed Benhadji

“…Solutions interact, exchanging and dissipating energy in a manner analogous to static electricity buildup and release—such as when a plastic rod is rubbed to accumulate charge, then gradually neutralized upon contact with another surface. …”
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Study of Corrosion Behavior of Mg–Gd-Based Soluble Magnesium Alloys by Qinghua Wang, Zhiquan Huang, Yanchun Zhu, Ling Qin, Jingfeng Zou, Lifeng Ma

“…The results demonstrated that corrosion rates increased with higher Cl⁻ concentrations and elevated temperatures, albeit in a nonlinear manner. Notably, significant effects on corrosion rates were observed in the Cl⁻concentration range of 1% to 3% and at temperatures between 75 °C and 100 °C. …”
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A lectin produced by a Streptomyces species targets mammalian pancreatic acinar cells in mice and humans by Janine C. Quijano, Honoka Natsuyama, Alonso Tapia, Karine Bagramyan, Jose A. Ortiz, Jacob Mares, Markus Kalkum, Yoko Fujita-Yamaguchi, Hsun Teresa Ku

“…Abstract Lectins are produced in almost all life forms, can interact with targets (glycans) in a cross-kingdom manner and have served as valuable tools for studying glycobiology. …”
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MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma by Camille Niveau, Mélanie Cettour-Cave, Stéphane Mouret, Eleonora Sosa Cuevas, Mylene Pezet, Benoît Roubinet, Hugo Gil, Florence De Fraipont, Ludovic Landemarre, Julie Charles, Philippe Saas, Caroline Aspord

“…Notably, melanoma tumor cells directly remodel the metabolic profile of DC subsets, in a glycan-dependent manner. Strikingly, modulation of the mTOR/AMPK-dependent metabolic pathways and/or the MCT1 lactate transporter rescue cDC2s and cDC1s from skewing by tumor-derived glycans, Sialyl-Tn antigen and Fucose, and restore anti-tumor T-cell fitness. …”
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Creating interventions to transition long-lasting insecticide net distribution in Ghana by Philip Adongo, Phyllis Dako-Gyeke, Nana Yaw Peprah, Emmanuel Asampong, Philip Teg-Nefaah Tabong, Franklin Glozah, Adanna Nwameme, Ruby Hornuvo, Margaret Chandi

“…Cocreation involved participatory learning in action technique which is a practical, adaptive research strategy which enabled diverse groups and individuals to learn, work and act together in a cooperative manner.Results The results suggest the establishment of a Community Health Advocacy Team (CHAT). …”
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Evaluation of the Operational Simplified Surface Energy Balance Model for Pastureland Evapotranspiration Mapping and Drought Monitoring in North Central Kentucky by Maheteme Gebremedhin, Ian Ries, Gabriel B. Senay, Martin Matisoff, Ibukun Amusan, Jeremy Sandifer, Buddhi Gyawali

“…Flux and SSEBop ET track each other in a consistent manner in response to seasonal changes. The mean bias error (MBE), root mean squared error (RMSE), mean absolute percentage error (MAPE), and coefficient of determination (R2) were 5.47, 21.49 mm mon−1, 30.94%, and 0.87, respectively. …”
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Expression of VEGF-A, Otx Homeobox and p53 Family Genes in Proliferative Vitreoretinopathy by Claudio Azzolini, Ilaria Stefania Pagani, Cristina Pirrone, Davide Borroni, Simone Donati, Muna Al Oum, Diana Pigni, Anna Maria Chiaravalli, Riccardo Vinciguerra, Francesca Simonelli, Giovanni Porta

“…We individuated two possible pathways (VEGF-A, Otx2, p53, p63 and Otx1 and Otx3) involved in PVR progression that could influence in different manners the course of the pathology. Individuating the genetic pathways of PVR represents a novel approach to PVR therapies.…”
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Poly-L-Arginine Induces Apoptosis of NCI-H292 Cells via ERK1/2 Signaling Pathway by Ya-Ni Wang, Ling-Ling Zhang, Xiao-Yun Fan, Sha-Sha Wu, Sheng-Quan Zhang

“…PLA can induce apoptosis in NCI-H292 cells in a concentration-dependent manner. Moreover, the phosphorylation of the ERK1/2 and the unbalance of Bcl2/Bax, as well as the activation of caspase-3, were involved in the PLA-induced apoptosis. …”
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How to implement pairing assistance during fighting COVID-19 in China: collaborative governance between local governments under the authoritative regulation by Changwei Wei, Jiaxi Xu, Zhixiang Wang, Huangyue Wu, Juan Wang

“…The three stages of co-operative governance based on authoritative regulation work together in a step-by-step manner to enhance the effectiveness of crisis response.ConclusionThe results of the study indicate that collaborative governance under the authoritative regulation is the main reason why provincial counterpart support mechanism plays a great role in COVID-19. …”
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Phylogenetic analysis and protective effects of thymol and its chromatographic fractions from a novel wild mushroom in combating oxidative stress by M. Subbulakshmi, Sugapriya Dhanasekaran, S. Abirami, M. Kannan, R. Palaniappan, Divya Venugopal

“…Also, the phenolic and flavonoid fractions of SMK-1 expressed cytotoxic effects in HeLa cells with IC50 values ranging from 5 μg/mL to 80 μg/mL in a dose-dependent manner. This present research highlights the presence of high thymol concentration in a novel wild mushroom that has antioxidant and anti-poliferative potential with therapeutic benefits. …”
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