ANALYSIS OF HIGH RISK FACTORS FOR NON-COMMUNICABLE DISEASE, STROKE IN THE SIDOARJO DISTRICT HEALTH SERVICE by Luluk Widarti, Muhammad Afif Hilmi Masyfahani, Dony Sulystiono, Kusmini Suprihatin, Hotmaida Siagian, Siti Maemonah

“…The results of the analysis of stroke risk factors are still high, so it is necessary to optimize advocacy and integrated partnerships in stroke prevention and control through promotive, preventive, curative, and rehabilitative activities in an integrated and sustainable manner.…”
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Computationally-efficient rendering of diffuse reflections for geometrical acoustics based room simulation by Ewert Stephan D., Gößling Nico, Buttler Oliver, van de Par Steven, Hu Hongmei

“…Effects of scattering and multiple (inter-) reflections caused by larger geometric structures at walls, and by objects in the room are accounted for in a highly simplified manner. A single parameter is used to quantify deviations from an empty shoebox room. …”
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METTL3 inhibition promotes radiosensitivity in hepatocellular carcinoma through regulation of SLC7A11 expression by Chen Zhang, Tianpeng Yang, Hanbin Chen, Xiaofeng Ding, Huajian Chen, Zhenzhen Liang, Yinlong Zhao, Shumei Ma, Xiaodong Liu

“…In conclusion, our study suggests that METTL3 regulates the stability of SLC7A11 mRNA in an m6A/IGF2BP2-dependent manner and the ubiquitination of SLC7A11 protein through the m6A/YTHDF2/SOCS2 pathway, both of which require the m6A methyltransferase activity of METTL3. …”
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Fine-tuning a local LLaMA-3 large language model for automated privacy-preserving physician letter generation in radiation oncology by Yihao Hou, Yihao Hou, Christoph Bert, Christoph Bert, Christoph Bert, Ahmed Gomaa, Ahmed Gomaa, Ahmed Gomaa, Godehard Lahmer, Godehard Lahmer, Godehard Lahmer, Daniel Höfler, Daniel Höfler, Daniel Höfler, Thomas Weissmann, Thomas Weissmann, Thomas Weissmann, Raphaela Voigt, Raphaela Voigt, Raphaela Voigt, Philipp Schubert, Philipp Schubert, Philipp Schubert, Charlotte Schmitter, Charlotte Schmitter, Charlotte Schmitter, Alina Depardon, Alina Depardon, Alina Depardon, Sabine Semrau, Sabine Semrau, Sabine Semrau, Andreas Maier, Rainer Fietkau, Rainer Fietkau, Rainer Fietkau, Yixing Huang, Yixing Huang, Florian Putz, Florian Putz, Florian Putz

“…IntroductionGenerating physician letters is a time-consuming task in daily clinical practice.MethodsThis study investigates local fine-tuning of large language models (LLMs), specifically LLaMA models, for physician letter generation in a privacy-preserving manner within the field of radiation oncology.ResultsOur findings demonstrate that base LLaMA models, without fine-tuning, are inadequate for effectively generating physician letters. …”
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Transcriptomics and Physiological Analyses of Soybean Stay-Green Syndrome by Dagang Wang, Yanan Wang, Ruidong Sun, Yong Yang, Wei Zhao, Guoyi Yu, Yueying Wang, Feng Wang, Lin Zhou, Zhiping Huang

“…Transcriptomic analyses were performed in a tissue-specific manner to investigate differentially expressed genes (DEGs) in soybeans impacted by SGS and in those without SGS. …”
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Investigating the Effectiveness of the Interest Rate Monetary Policy Tool on Inflation Management in the Condition of the Banking System Imbalance and Analyzing the Imbalance Based... by Mohammad Shirijian, Mohammad Reza Farzin, Manijeh Hadinejad, Marjan Daman Keshideh

“…To answer this, first of all, the mechanisms of monetary policy transmission channels are elaborated in the condition of the banking system  soundness, and then by examining and explaining the reasons for creating imbalances in the banking system from the operational aspect and from the perspective of Islamic banking, the manner of disrupting the transmission channel mechanism of the monetary policy of the interest rate to the inflation rate when there is an imbalance in the banking network, and the final result of the quality of the application of this policy to the inflation variable in the mentioned conditions are theoretically analyzed.…”
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NaP-TRAP reveals the regulatory grammar in 5’UTR-mediated translation regulation during zebrafish development by Ethan C. Strayer, Srikar Krishna, Haejeong Lee, Charles Vejnar, Nils Neuenkirchen, Amit Gupta, Jean-Denis Beaudoin, Antonio J. Giraldez

“…NaP-TRAP measures translation in a frame-specific manner through the immunocapture of epitope tagged nascent peptides of reporter mRNAs. …”
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Upcycling supercritical-CO2-defatted tiger nut milk Co-products into pork burgers: A sustainable fat replacer with enhanced quality properties by Raquel Lucas-González, Carmen Botella-Martínez, Manuel Salgado-Ramos, Noelia Pallarés, Pedro V. Martínez-Culebras, Francisco J. Barba, Juana Fernández-López

“…DTNC are rich in fiber and minerals, and their addition to pork burgers resulted in reduced fat content while increasing fiber, magnesium, and potassium in a concentration-dependent manner. The DTNC improved the cooking properties of the burgers and significantly affected their color and texture. …”
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Functional Involvement of Melatonin and Its Receptors in Reproductive Regulation of the Marine Teleost, Large Yellow Croaker (<i>Larimichthys crocea</i>) by Xudong Liang, Jixiu Wang, Baoyi Huang, Haojie Yuan, Yucheng Ren, Chenqian Wu, Tianming Wang, Jingwen Yang

“…Enzyme- linked immunosorbent assay (ELISA) results further demonstrated that in vitro melatonin incubation in the brain of <i>L. crocea</i> influenced gonadotropin-releasing hormone (GnRH) and testosterone secretion in a dose-dependent manner, suggesting actions beyond the classical hypothalamic–pituitary–gonadal (HPG) axis. …”
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Protective activity of propofol, Diprivan® and intralipid against active oxygen species by M. Mathy-Hartert, G. Deby-Dupont, P. Hans, C. Deby, M. Lamy

“…IL acted in the same manner, but was a less powerful antioxidant.…”
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A Modified Surgical Technique of Fovea-Sparing Internal Limiting Membrane Peeling: Continuous Arc-Shaped Foldback Peeling by Zheng-Gao Xie, Qing-Yi He, Jun Zhu, Wei Du, Jun Tong, Fang Chen

“…Next, an ILM forceps was used to grasp the outer side of the ILM flap, and it was moved forward slowly from the outside to the paracentral fovea, followed by folding ILM back in an arc-shaped manner and then removing it. The above operations were repeated, and all ILM flaps were removed from the outside to paracentral fovea until a narrow strip of ILM remained. …”
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Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body by Luis Leon-Mercado, Ivan Menendez-Montes, Jonathan Tao, Bandy Chen, David P. Olson, C. Mackaaij, C.G.J. Cleypool, Laurent Gautron

“…In vitro luciferase assays reveal that hypoxia stimulates the human and mouse Agrp promoters in a Hypoxia Inducible Factor (HIF1/2)-dependent manner. Our in vivo experiments further demonstrate that exposure to environmental hypoxia (10%) robustly induces Agrp expression in type I glomus cells of mice. …”
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Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma by Haihua Wang, Songqing Fan, Yuting Zhan, Yue Xu, Yao Du, Jiadi Luo, Hongjing Zang, Shuping Peng, Weiyuan Wang

“…We discovered that EGFR, operating in a kinase-independent manner, played a role in stabilizing the expression of SLC7A11, which subsequently inhibited MHC-I antigen presentation. …”
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Gene Expression Profiling of IL-17A-Treated Synovial Fibroblasts from the Human Temporomandibular Joint by Toshio Hattori, Naomi Ogura, Miwa Akutsu, Mutsumi Kawashima, Suguru Watanabe, Ko Ito, Toshirou Kondoh

“…IL-6 protein production was increased by IL-17A in a time- and a dose-dependent manner. Additionally, IL-17A simulated IL-6 protein production in synovial fibroblasts samples isolated from three patients. …”
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Blockchain-Assisted Hierarchical Attribute-Based Encryption Scheme for Secure Information Sharing in Industrial Internet of Things by A. Sasikumar, Logesh Ravi, Malathi Devarajan, A. Selvalakshmi, Abdulaziz Turki Almaktoom, Abdulaziz S. Almazyad, Guojiang Xiong, Ali Wagdy Mohamed

“…In particular, an IoT device incorporates an encryption-based authentication system to verify users&#x2019; access rights at the network&#x2019;s periphery in a decentralized manner. Using HABE, we provide a blockchain-integrated architecture for the IoT that protects user privacy. …”
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SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration by Zhen-Zhen Guo, Qun-An Cao, Zong-Zhuang Li, Li-Ping Liu, Zhi Zhang, Ya-Juan Zhu, Guang Chu, Qiu-Yan Dai

“…In vitro, nicotine induced the expression of MCP-1 and RANTES in both RAW264.7 (mouse macrophage) and MOVAS (mouse vascular smooth muscle) cells in a dose-dependent manner; expression was upregulated by 0.5 ng/mL nicotine but strongly downregulated by 500 ng/mL nicotine. …”
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Modulation of stress-related behaviour by preproglucagon neurons and hypothalamic projections to the nucleus of the solitary tract by Marie K. Holt, Natalia Valderrama, Maria J. Polanco, Imogen Hayter, Ellena G. Badenoch, Stefan Trapp, Linda Rinaman

“…Through chemogenetic manipulations we reveal that cNTS PPG neurons have the ability to moderately increase anxiety-like behaviours in mice in a sex-dependent manner. Using an intersectional approach, we show that input from the paraventricular nucleus of the hypothalamus (PVN) drives activation of both the cNTS as a whole and PPG neurons in particular in response to acute restraint stress, but that while this input is rich in corticotropin-releasing hormone (CRH), PPG neurons do not express significant levels of receptors for CRH and are not activated following lateral ventricle delivery of CRH. …”
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Norcantharidin induces G2/M arrest and apoptosis via activation of ERK and JNK, but not p38 signaling in human renal cell carcinoma ACHN cells by Huang Shuaishuai, Tuergong Gulimire, Zhu Hangjie, Wang Xue, Weng Guobin, Ren Yu

“…It had also markedly induced apoptosis and G2/M phase cell cycle arrest in a dose-dependent manner by decreasing the expressions of pro-caspase-3, pro-caspase-9, cyclin B1, and pCDC25C while increasing active caspase-3, cleaved-PARP, P21, and pCDC2 levels. …”
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Flow stress-strain curves and dynamic recrystallization behavior of high carbon low alloy steels during hot deformation by D.Z. Li, X.M. Zhao, H.L. Zhang, J. Li

“…Conversely, at low strain rates, both serrated and bulged grain boundaries can simultaneously be the nucleation sites of DRX grains in a uniform manner. In the DRX type curve, when the strain rate reduced from 0.1 s−1 to 0.01 s−1, the inoculation temperature for the rapid growth of DRX grains in HCLA steel was reduced from 1050 °C to 1000 °C. …”
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DyCeModel: a tool for 1D simulation for distribution of plant hormones controlling tissue patterning by D. S. Azarova, N. A. Omelyanchuk, V. V. Mironova, E. V. Zemlyanskaya, V. V. Lavrekha

“…Plant hormones are the main regulators of the cell dynamics in plant tissues; they form gradients and maxima and control molecular processes in a concentration-dependent manner. Here, we present DyCeModel, a software tool implemented in MATLAB for one-dimensional simulation of tissue with a dynamic cellular ensemble, where changes in hormone (or other active substance) concentration in the cells are described by ordinary differential equations (ODEs). …”
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