Nootkatone inhibits the progression of glioblastoma by activating the ATF4-CHOP-CHAC1 pathway by Qian Wang, Xiumin Xue, Zhichao Chen, Wei Zhang, Yiming Qian, Danni Chen, Lin Lin, Yinfeng Yuan, Weiqiao Zhao, Zhihui Huang, Yongjie Wang

“…In this study, we found that NKT inhibited the growth of GBM cells in a dose-dependent manner in vitro. Subsequently, we observed that NKT suppressed the migration and arrested cell cycle at G2/M phase of GBM cells. …”
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Comparison of in vivo and in vitro preimplantation embryo development in OXYS and WAG rats by V. V. Kozhevnikova, T. N. Igonina, E. Yu.  Brusentsev, V. I. Mokrousova, E. A.  Kizilova, I. N. Rozhkova, V. A. Naprimerov, S. Ya. Amstislavsky

“…Thereafter the percentage of embryos at blastocyst stage and the cell numbers in these blastocysts were counted in the same manner as for the in vivo experiment. This study reports that in vivo derived blastocysts of OXYS rats contain fewer cells on day 5 of their development than in vivo derived blastocysts of WAG rats. …”
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The Effect of Culture Techniques of Hypoxic Stem Cell Secretome on The Number of Growth Factor TGF-β, BMP-2, VEGF by Mouli Edward, Ferdiansyah Mahyudin, Dionysius Bramta Putra Manyakori

“…Signaling molecules function in an orderly manner and are greatly influenced by the physiological environment. …”
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Opposing Roles of Leptin and Ghrelin in the Equine Corpus Luteum Regulation: An In Vitro Study by António Galvão, Angela Tramontano, Maria Rosa Rebordão, Ana Amaral, Pedro Pinto Bravo, Anna Szóstek, Dariusz Skarzynski, Antonio Mollo, Graça Ferreira-Dias

“…Conversely, LEP increased P4, PGE2, angiogenic activity, MIF, TNF and nitrite during early CL, in a dose-dependent manner. The in vitro effect of LEP on secretory activity was reverted by GHR, when both factors acted together. …”
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Consistent individual positions within roosts in Spix’s disc-winged bats by Giacomini, Giada, Chaves-Ramírez, Silvia, Hernández-Pinsón, H. Andrés, Barrantes, José Pablo, Chaverri, Gloriana

“…Individuals within both moving and stationary groups arrange themselves in a predictable manner; for example, some individuals are consistently found at the front of the group or in the periphery and others in the center. …”
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A multicenter study on TROP2 as a potential targeted therapy for extramammary Paget disease in Japan by Takamichi Ito, Yuka Tanaka, Dai Ogata, Haruto Nishida, Tatsushi Shiomi, Ryo Tanaka, Aya Kawaguchi, Azusa Miyashita, Satoshi Fukushima, Naoko Shojiguchi, Hiroyuki Goto, Yaei Togawa, Takahiro Kiyohara, Yoshinao Oda, Takeshi Nakahara

“…The KS-EMPD-1 cells were treated with a TROP2-targeted antibody–drug conjugate (ADC), sacituzumab govitecan, and it significantly reduced cell viability in a dose-dependent manner compared with that of the cells treated with sacituzumab alone. …”
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Ochratoxin A induces immunotoxicity by targeting Annexin A1 mediated neutrophil apoptosis in zebrafish by Yihong Zheng, Yinuo Liu, Jin Tian, Shuhong Liu, Gaowei Ma, Yupeng Xie, Chenhua Zheng, Zekai Wu

“…Additionally, the potential therapeutic effect of aesculetin was evaluated.ResultsOur results demonstrated that exposure to OTA inhibited embryonic development and induced malformations in a concentration-dependent manner. Additionally, OTA exposure led to a significant reduction in the number of neutrophils and macrophages, indicating compromised formation of innate immune cells. …”
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Systematic assessment of COVID-19 host genetics using whole genome sequencing data. by Axel Schmidt, Nicolas Casadei, Fabian Brand, German Demidov, Elaheh Vojgani, Ayda Abolhassani, Rana Aldisi, Guillaume Butler-Laporte, DeCOI host genetics group, T Madhusankha Alawathurage, Max Augustin, Robert Bals, Carla Bellinghausen, Marc Moritz Berger, Michael Bitzer, Christian Bode, Jannik Boos, Thorsten Brenner, Oliver A Cornely, Thomas Eggermann, Johanna Erber, Torsten Feldt, Christian Fuchsberger, Julien Gagneur, Siri Göpel, Tobias Haack, Helene Häberle, Frank Hanses, Julia Heggemann, Ute Hehr, Johannes C Hellmuth, Christian Herr, Anke Hinney, Per Hoffmann, Thomas Illig, Björn-Erik Ole Jensen, Verena Keitel, Sarah Kim-Hellmuth, Philipp Koehler, Ingo Kurth, Anna-Lisa Lanz, Eicke Latz, Clara Lehmann, Tom Luedde, Carlo Maj, Michael Mian, Abigail Miller, Maximilian Muenchhoff, Isabell Pink, Ulrike Protzer, Hana Rohn, Jan Rybniker, Federica Scaggiante, Anna Schaffeldt, Clemens Scherer, Maximilian Schieck, Susanne V Schmidt, Philipp Schommers, Christoph D Spinner, Maria J G T Vehreschild, Thirumalaisamy P Velavan, Sonja Volland, Sibylle Wilfling, Christof Winter, J Brent Richards, DeCOI, André Heimbach, Kerstin Becker, Stephan Ossowski, Joachim L Schultze, Peter Nürnberg, Markus M Nöthen, Susanne Motameny, Michael Nothnagel, Olaf Riess, Eva C Schulte, Kerstin U Ludwig

“…Polygenic scores accurately captured risk in an age-dependent manner. By enabling joint analyses of different types of variation across the entire frequency spectrum, this data will continue to contribute to the elucidation of COVID-19 etiology.…”
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The ERK1/2 Inhibitor U0126 Attenuates Diabetes-Induced Upregulation of MMP-9 and Biomarkers of Inflammation in the Retina by Ghulam Mohammad, Mohammad Mairaj Siddiquei, Mohammad Imtiaz Nawaz, Ahmed M. Abu El-Asrar

“…This study was conducted to determine the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in a time-dependent manner and the effect of extracellular-signal-regulated kinases-1/2 (ERK1/2) inhibition on the expressions of MMP-9, TIMP-1, and inflammatory biomarkers in the retinas of diabetic rats. …”
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Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines by Edismauro Garcia Freitas Filho, Elaine Zayas Marcelino da Silva, Camila Ziliotto Zanotto, Constance Oliver, Maria Célia Jamur

“…Cross-linking the gangliosides induced the phosphorylation of ERK1/2, JNK1/2, and p38 as well as activating both NFκB and NFAT in a Syk-dependent manner. Therefore, cross-linking the mast cell specific GD1b derived gangliosides results in the activation of signaling pathways that culminate with the release of newly formed and newly synthesized mediators.…”
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Calibration of ionization chamber in megavoltage x-ray field of medical linear accelerator by Pham Hong-Lam, Hoang Thanh-Phi-Hung, Sunjun Jin, Bui Duy-Linh, Nguyen Tuan-Khai, Bui Van-Loat, Le Tuan-Anh, Nguyen Huu-Quyet, Pham Duc-Khue, Phan Viet-Cuong, Phan Tien-Dung, Pham Quang-Trung, Tran Hoai-Nam, Le Ngoc-Thiem

“…Whereas, absorbed doses to water at a depth of 10 cm below the water surface were measured using the same ionization chamber (referred to as IC-1) in two different manners (i.e., applying the old beam quality correction factor kQ0 from the old IAEA/TRS-398 protocol, referred to as D1-old10 and using the new one, kQ from the updated protocol, referred to as D1-new10. …”
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Oncogenic PIK3CA corrupts growth factor signaling specificity by Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck

“…We conclude that oncogenic PIK3CA H1047R corrupts information transfer in a growth factor-dependent manner and suggest new opportunities for tuning of receptor-specific PI3K pathway outputs for therapeutic benefit.…”
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iNOS-Produced Nitric Oxide from Cancer Cells as an Intermediate of Stemness Regulation by PARP-1 in Colorectal Cancer by María del Moral-Martinez, Paula Sánchez-Uceta, Ruben Clemente-Gonzalez, Sara Moreno-SanJuan, Jose D. Puentes-Pardo, Huda Khaldy, David Lopez-Perez, Javier Arnedo, Jorge Casado, Luis Martínez-Heredia, Angel Carazo, Josefa León

“…We have recently reported that PARP-1 influences tumor progression in CRC through the regulation of CSCs in a p53-dependent manner. In this study, we propose that nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) could act as a mediator. …”
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Adipose Tissue-Derived Mesenchymal Stem Cells Exert In Vitro Immunomodulatory and Beta Cell Protective Functions in Streptozotocin-Induced Diabetic Mice Model by Hossein Rahavi, Seyed Mahmoud Hashemi, Masoud Soleimani, Jamal Mohammadi, Nader Tajik

“…AT-MSCs inhibited splenocytes proliferative response to specific (islet lysate) and nonspecific (PHA) triggers in a dose-dependent manner (P<0.05). Decreased production of proinflammatory cytokines, such as IFN-γ, IL-2, and IL-17, and increased secretion of regulatory cytokines such as TGF-β, IL-4, IL-10, and IL-13 by stimulated splenocytes were also shown in response to islet lysate or PHA stimulants (P<0.05). …”
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Airborne Ultrafine Particle and Acute Physiological Effects during Maximal Aerobic Power Test by Angelo Rodio, Francesco Misiti, Alessandro Zagaglia, Luca Stabile, Giorgio Buonanno, Luigi Fattorini

“…Methods Male recreational cyclists performed tests in a manner randomized crossover in two environmental conditions: low (environmental noise exposure) and high ultrafine particle concentration. …”
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Double disaggregation of the decline of terrestrial water storage for a highly cultivated dryland partially covered by glaciers by Zongxia Wang, Suxia Liu

“…Besides the Tianshan Mountains, TWS also declined significantly downstream where it should have increased given the substantive glacier meltwater supply from upstream, implying that the evolution of TWS in NSTM has probably deviated from natural manners. Pixel-wise internal disaggregation indicated that groundwater storage was the predominant hydrological component leading to TWS depletion in most of the NSTM except for glacier-covered areas. …”
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Electroacupuncture alleviates functional constipation by upregulating host-derived miR-205-5p to modulate gut microbiota and tryptophan metabolism by Lu Wang, Lu Wang, Menghan Xi, Menghan Xi, Wei Cao, Haiyan Qin, Di Qin, Shuai Chen, Siyuan Zhou, Yujun Hou, Ying Chen, Xianjun Xiao, Qianhua Zheng, Dehua Li, Ying Li

“…Our results indicate that miR-205-5p, significantly upregulated in fecal and colonic tissues of EA-treated constipated mice, promotes intestinal motility in a microbiome-dependent manner. Specifically, EA promoted the growth of Lactobacillus reuteri, enriched in the feces of constipation-recovered mice, through host-derived miR-205-5p regulation. …”
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An Efficient Network Based on Conjugate Gradient Optimization and Approximate Observation Model for SAR Image Reconstruction by Song Zhou, Jing Chen, Zao Wang, Yuhao Wang, Pin Wen

“…However, due to the computation of the large-scale matrix, the optimal searching in an iterative manner will involve tremendous computational complexity with slow convergence, which will prevent deep learning algorithms from being efficiently applied for SAR imaging. …”
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Blood culture bottle shortage mitigation efforts: analysis of impact on ordering and patient impact by Christopher D. Doern, Melissa Whitman, Michelle Doll, Suzanne Lavoie, David Friedel, Gonzalo Bearman, Jeffrey Kim, Heather Masters, Susan Roseff, Jim Willis, Roxanne Mercer, Aaron Hill, Ramana Feeser, Harinder Dhindsa, Frank Petruzella, Anne Jackson, Michael Vitto, Josh Plauny, Alexandra Bryson

“…Conclusions: These findings strongly suggest that some basic stewardship interventions can significantly change blood culture practice in a manner that minimizes the impact on patient care. …”
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Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro by Rebecca Lotz, Christian Osterburg, Apirat Chaikuad, Sabrina Weber, Masato Akutsu, Anne Christin Machel, Ulrike Beyer, Jakob Gebel, Frank Löhr, Stefan Knapp, Matthias Dobbelstein, Xin Lu, Volker Dötsch

“…We speculate that, through the formation of hetero-complexes of both isoforms, the affinity to DNA, as well as the interaction with iASPP, can be fine-tuned in a tissue-specific manner.…”
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