Laser Acupuncture Reduces Body Fat in Obese Female Undergraduate Students by Xiao-Guang Liu, Juan Zhang, Jian-Liang Lu, Timon Cheng-Yi Liu

“…In conclusion, laser acupuncture could reduce body fat mass and lower body weight in a dose-dependent manner in obese persons. Among the doses of 358, 478, and 597 J/cm2, both the 358 and 597 J/cm2 doses were effective in the 4-week trial.…”
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Anti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development by Han Koo, Kyung Chan Park, Hyun Ahm Sohn, Minho Kang, Dong Joon Kim, Zee-Yong Park, Sehoon Park, Sang Hyun Min, Seong-Hwan Park, Yeon-Mi You, Yohan Han, Bo-Kyung Kim, Chul-Ho Lee, Yeon-Soo Kim, Sang J. Chung, Young Il Yeom, Dong Chul Lee

“…This interaction can be disrupted in a dominant-negative manner by a C-terminal NDRG3 fragment that binds KRAS but is defective in USP9X binding, highly suppressing KRAS protein expression and KRAS-driven cell growth. …”
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Evaluation of Ethnopharmacological and Antioxidant Potential of Zanthoxylum armatum DC. by Rabia Kanwal, Muhammad Arshad, Yamin Bibi, Saira Asif, Sunbal Khalil Chaudhari

“…The antioxidant potential evaluated by three assays increased in a concentration dependent manner and ascorbic acid showed better antioxidant activity than leaf extract. …”
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Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy by Constanza J. Cortes, Kefeng Qin, Eric M. Norstrom, William N. Green, Vytautas P. Bindokas, James A. Mastrianni

“…We found PrP carrying the disease-associated T182A mutation (Mut-PrP) was delivered to lysosomes in a Golgi-independent manner. Time-lapse live cell imaging revealed early formation and uptake of GFP-tagged Mut-PrP aggregates into LysoTracker labeled vesicles. …”
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Functional segregation and dynamic integration of the corticotectal descending signal in rat by Hikaru Sugino, Sho Tanno, Tatsumi Yoshida, Yoshikazu Isomura, Riichiro Hira

“…The superior colliculus (SC) receives inputs from various brain regions in a layer- and radial subregion-specific manner, but whether the SC exhibits subregion-specific dynamics remains unclear. …”
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Effect of γ-ethyl-γ-phenyl-butyrolactone (EFBL), anticonvulsant and hypnotic drug, on mouse brain catecholamine levels by Rasgado Lourdes A. Vega, Villanueva Iván, Díaz Fernando Vega

“…EFBL increased DA in a dose-dependent manner, remaining enhanced by 80 % over a period of 24 h and augmented NA by 54 % one hour after treatment. …”
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Caffeoylquinic Acid Derivatives Extract of Erigeron multiradiatus Alleviated Acute Myocardial Ischemia Reperfusion Injury in Rats through Inhibiting NF-KappaB and JNK Activations by Zhifeng Zhang, Yuan Liu, Xuecong Ren, Hua Zhou, Kaishun Wang, Hao Zhang, Pei Luo

“…AE administration (10, 20, and 40 mg/kg) inhibited I/R-induced injury as indicated by decreasing myocardial infarct size, reducing of CK and LDH activities, and preventing ST-segment depression in dose-dependent manner. AE decreased cardiac tissue levels of proinflammatory factors TNF-α and IL-6 and attenuated leukocytes infiltration. …”
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m6A Reader PRRC2A Promotes Colorectal Cancer Progression via CK1ε‐Mediated Activation of WNT and YAP Signaling Pathways by Xi Wu, Shiyang Wang, Yuwei Pan, Mengzhen Li, Manyu Song, Hanfu Zhang, Min Deng, Xu Yang, Jiuzhi Xu, Shuo Zhang, Jinhua Zhang, Fengchao Wang, Maksim V. Plikus, Cong Lv, Lu Yu, Zhengquan Yu

“…Through multiomics analysis, PRRC2A directly targeted CSNK1E (encoding CK1ε), maintaining its RNA stability in an m6A‐dependent manner, and that elevated CK1ε can concomitantly result in activation of the WNT and YAP signaling pathways. …”
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YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment by Zhenyun Yang, Xin Wang, Yizhen Fu, Weijie Wu, Zili Hu, Qingyang Lin, Wei Peng, Yangxun Pan, Juncheng Wang, Jinbin Chen, Dandan Hu, Zhongguo Zhou, Li Xu, Yaojun Zhang, Jiajie Hou, Minshan Chen

“…Ythdf2 stabilized Cx3cl1 transcripts in an m6A-dependent manner, regulating the interplay between CD8+ T cells and the progression of liver malignancies. …”
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An RGB-D-Based Cross-Field of View Pose Estimation System for a Free Flight Target in a Wind Tunnel by Sheng Liu, Yuan Feng, Kang Shen, Yangqing Wang, Shengyong Chen

“…Based on all the input multimodal information, a so-called cross-FOV model is proposed to recognize the dominating sensor and accurately extract the foreground region in an automatic manner. Second, we develop an RGB-D-based pose estimation method for a single target, by which the 3D sparse points and the pose of the target can be simultaneously obtained in real time. …”
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Characterization of Interleukin-15-Transpresenting Dendritic Cells for Clinical Use by J. M. J. Van den Bergh, E. L. J. M. Smits, M. Versteven, H. De Reu, Z. N. Berneman, V. F. I. Van Tendeloo, E. Lion

“…In view of the clinical use of DC vaccines, we evidence with a time- and cost-effective manner that clinical grade DC can be safely engineered to transpresent IL-15, hereby gaining the ability to transfer the immune-stimulating IL-15 signal towards antitumor immune effector cells.…”
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Phytochemical screening and phytotoxic activity of Pinus ponderosa (Dougl.) Lawson by Mouna Souihi, Marwa Khammassi, Habiba Kouki, Ismail Amri, Mohsen Hanana, Lamia Hamrouni, Yassine Mabrouk

“…The essential oil exhibited a significant inhibitory effect on seed germination and seedling growth in a dose-dependent manner. A low concentration of essential oil reduced the germination and seedling growth of all tested weeds. …”
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Agent-Based Modeling of Harvest Decisions by Small Scale Forest Landowners in Maine, USA by Jessica E. Leahy, Erika Gorczyca Reeves, Kathleen P. Bell, Crista L. Straub, Jeremy S. Wilson

“…The multifaceted nature of landowner decisions drives a significant need to better understand decision-making processes, reactions to policy, and combined impacts on ecosystems in a comprehensive manner. Small-scale forests require an integrated approach to modeling the social and biophysical components comprehensively. …”
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Modeling of Blood Flow Dynamics in Rat Somatosensory Cortex by Stéphanie Battini, Nicola Cantarutti, Christos Kotsalos, Yann Roussel, Alessandro Cattabiani, Alexis Arnaudon, Cyrille Favreau, Stefano Antonel, Henry Markram, Daniel Keller

“…We discovered that astrocytic activity impacted blood flow dynamics in a localized, clustered manner, with most vascular segments influenced by two to three neighboring endfeet. …”
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The effects of the integrative strategy on fostering reflective thinking and imparting basic basketball offensive techniques to female students by Missaa Nadem, Nadeema Badr Mohammed, Huda Badwe Shbeeb, Iqbal Abdul Hussein Neamah, Najlaa Abbas AL-Zuhairi, Nihad Mohammed Alwan

“…Twenty students in-group (B) represent the experimental group, which follows the curriculum that the researcher has developed in an integrated, strategic manner. Result: The method of selecting the (integrative) strategy that was given to the students is right to the level of their skills and characteristics, as well as while taking into consideration the distinct characteristics among them by means of the presentation offered by the stations—from a complete demonstration of the skill, then a slow delivery, then the appearance of the integrated strategy—is also attributed as the reason for the superiority of the members of the experimental group. …”
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Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats by Peng-zhi Chen, Hui-hui Jiang, Bo Wen, Shuan-cheng Ren, Yang Chen, Wei-gang Ji, Bo Hu, Jun Zhang, Fenglian Xu, Zhi-ru Zhu

“…The results showed that the spontaneous discharge of EC neurons was increased by local application of soluble Aβ1−42 and that GAS can effectively reverse Aβ1−42-induced facilitation of spontaneous discharge in a concentration-dependent manner. Moreover, whole-cell patch clamp results indicated that the protective function of GAS on abnormal hyperexcitability may be partially mediated by its inhibitory action on Aβ1−42-elicited inward currents in EC neurons. …”
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Dexamethasone potentiates the insulin-induced Srebp-1c expression in primary rat hepatocytes by Yan Zhang, Xiangming Fang, Fen Shuang, Guoxun Chen

“…Insulin treatment induced the Srebp-1c expression and suppressed the Pck1 expression in a time-dependent manner. Dex treatment alone reduced the Srebp-1c expression, whereas potentiated the insulin-induced its expression, which reached to a level that was higher than the insulin alone group. …”
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Flavonoids of Rosa rugosa Thunb. inhibit tumor proliferation and metastasis in human hepatocellular carcinoma HepG2 cells by Zhiguo Zhang, Meilin Wang, Shu Xing, Chen Zhang

“…The results indicated that rose flavonoids at low concentration (10–40 μg/mL) had a better inhibitory effect on migration and invasion of HepG2 cells in a dose-dependent manner, while rose flavonoids at high concentration (80–160 μg/mL) could induce apoptosis of HepG2 cells by up-regulating the expression of pro-apoptotic proteins p53 and Bax, and down-regulating the expression of anti-apoptotic proteins Bcl-2, leading to the functioning of caspase-3 and caspase-9. …”
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Nanoscale thickness Octave-spanning coherent supercontinuum light generation by Susobhan Das, Md Gius Uddin, Diao Li, Yadong Wang, Yunyun Dai, Juha Toivonen, Hao Hong, Kaihui Liu, Zhipei Sun

“…Up to octave-spanning coherent light generation with a −40dB spectral width covering from ~565 to 1906 nm is demonstrated in discreate manner via difference-frequency generation, a second-order nonlinear process in gallium selenide and niobium oxide diiodide crystals at the 100-nanometer scale. …”
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Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine by Marta Vicente-Rodríguez, Rosalía Fernández-Calle, Esther Gramage, Carmen Pérez-García, María P. Ramos, Gonzalo Herradón

“…We found that amphetamine-induced microgliosis and astrocytosis are enhanced in the striatum of MK−/− mice in a region-specific manner. Surprisingly, LPS-induced astrogliosis in the striatum was blocked in MK−/− mice. …”
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