Trabeculectomy Augmented with Limited Deep Sclerectomy and Cyclodialysis with Use of Scleral Tissue as a Spacer by Tanuj Dada, Jyoti Shakrawal, Priyanka Ramesh, Anin Sethi

“…This involves the creation of a cyclodialysis cleft in a controlled manner to allow additional suprachoroidal drainage of the aqueous. …”
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Ventilation and features of the lung environment dynamically alter modeled intrapulmonary aerosol exposure from inhaled electronic cigarettes by Liqiao Li, Haoxuan Chen, Yifang Zhu, Airi Harui, Michael D. Roth

“…Both respiratory rate and tidal volume modulated e-cig aerosol exposure in a manner inversely proportional to minute ventilation. …”
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A Real-Time Road Scene Semantic Segmentation Model Based on Spatial Context Learning by Xiaomei Xiao, Jialiang Tang, Xiaoyan Lu, Zhengyong Feng, Yi Li

“…The main idea is to aggregate local regions into higher-level semantic regions in a learnable manner. The proposed Spatial Context Guided Feature Alignment module (SC-FA) learns aligned features from image-level to local regions, exploring and integrating contextual information. …”
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Recurrent Flow Update Model Using Image Pyramid Structure for 4K Video Frame Interpolation by Sangjin Lee, Chajin Shin, Hong-Goo Kang, Sangyoun Lee

“…To address these issues, we propose a Recurrent Flow Update (RFU) model trained in an end-to-end manner. We introduce a global flow update module that leverages global information to mitigate the weaknesses of forward flow and gradually correct errors. …”
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Bridging a Gap between Cr(VI)-Induced Oxidative Stress and Genotoxicity in Lettuce Organs after a Long-Term Exposure by Cristina Monteiro, Sara Sario, Rafael Mendes, Nuno Mariz-Ponte, Sónia Silva, Helena Oliveira, Verónica Bastos, Conceição Santos, Maria Celeste Dias

“…Shoots and roots showed distinctive oxidative stress status and genotoxic effects, in a dose-dependent manner. While 50 mg/L stimulated antioxidant activities and no major genotoxic effects were found, plants exposed to ≥150 showed an increase of oxidative disorders, together with cytostatic and DNA damage effects, and some mitotic impairment. …”
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Inhibition of Growth and Induction of Apoptosis in Fibrosarcoma Cell Lines by Echinophora platyloba DC: In Vitro Analysis by Fatemeh Zare Shahneh, Samira Valiyari, Abbas Azadmehr, Reza Hajiaghaee, Saeid Yaripour, Ali Bandehagh, Behzad Baradaran

“…Our results demonstrated that the extract decreased cell viability, suppressed cell proliferation, and induced cell death in a time- and dose-dependent manner in WEHI-164 cells (IC50 = 196.673 ± 12.4 μg/mL) when compared with a chemotherapeutic anticancer drug, Toxol. …”
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Nanostructured lipid carriers co-encapsulating Apigenin and Melatonin: An innovative strategy against cancer by Lorena Bonilla-Vidal, Marta Świtalska, Marta Espina, Joanna Wietrzyk, María Luisa García, Eliana B Souto, Anna Gliszczyńska, Elena Sánchez-López

“…Biopharmaceutical studies demonstrated that both compounds were released from NLC in a prolonged and sustained manner, following a biphasic behaviour with an initial fast release followed by a slow phase. …”
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Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway by Dacheng Wu, Keyan Wu, Qingtian Zhu, Weiming Xiao, Qing Shan, Zhigang Yan, Jian Wu, Bin Deng, Yan Xue, Weijuan Gong, Guotao Lu, Yanbing Ding

“…By intraperitoneal injection of formononetin in mice, the disease severity of colitis was attenuated in a dose-dependent manner, mainly manifesting as relieved clinical symptoms of colitis, mitigated colonic epithelial cell injury, and upregulations of colonic tight junction proteins levels (ZO-1, claudin-1, and occludin). …”
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A multidisciplinary team-based model of palliative treatment and nursing for a patient with end-stage cancer (多学科协作模式下1例肿瘤终末期患者的姑息治疗和护理)... by CUI Lishuan (崔立爽), LI Linlin (李琳琳), SONG Dun (宋钝), ZHANG Jinhua (张金华)

“…A multidisciplinary team (MDT) is a professional group of surgeons, oncologists and other medical and nursing experts who makes decisions about a specific subject in a collective manner, and best course of treatment and nursing plan will be implemented by the multidisciplinary team. …”
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Determination of microstructural changes by severely plastically deformed copper-aluminum alloy: Optical study by Romčević N., Gilić M., Anžel I., Rudolf R., Mitrić M., Romčević M., Hadžić B., Joksimović D., Petrović-Damjanović M., Kos M.

“….% of Al sample composed of one phase copper-aluminum solid solution in the core and fine dispersed oxide particles in the same matrix in the mantle region. In this manner AFM, X-ray diffraction and Raman spectroscopy were used. …”
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Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs by Yuanyuan Zhao, Jinfeng Bi, Jianyong Yi, Jian Peng, Qiancheng Ma

“…This study confirmed the dose-sensitive manner of pectin to alleviate HF-induced obesity by modulating gut microbiota and enhancing short-chain fatty acids production.…”
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O-GlcNAcylated FTO promotes m6A modification of SOX4 to enhance MDS/AML cell proliferation by Junjie Gou, Jingjing Bi, Kexin Wang, Lei Lei, Yanli Feng, Zengqi Tan, Jiaojiao Gao, Yanan Song, Enci Kang, Feng Guan, Xiang Li

“…The O-GlcNAcylation of FTO stabilized SOX4 transcripts in an m6A-dependent manner, resulting in increased AKT and MAPK phosphorylation and decreased cell apoptosis. …”
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Characterization of patients operated on for non-syndromic craniosynostosis. Villa Clara, 2018-2022 by Miguel Ángel Cruz Díaz, Ángel Serafín Camacho Gómez, Carlos Javier Artiles Rivero, Ramón Sarduy Arana

“…Knowledge about its management is of vital importance to intervene with treatment in a timely manner.<br /><strong>Objective</strong>: to characterize the patients operated on for non-syndromic craniosynostosis.…”
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Hepatic injury and metabolic perturbations in mice exposed to perfluorodecanoic acid revealed by metabolomics and lipidomics by Lvyun Sun, Shuling He, Jiali Chen, Amei Su, Qiuyao Mao, Wenyuan Zhang, Ying Pan, Jiaqian Hu, Disheng Feng, Yang Ouyang

“…Most lipids, particularly multiple triacylglycerols, were downregulated in a dose-dependent manner in both serum and liver. Taken together, PFDA can induce changes in the amino acid metabolism pathway, disrupt fatty acid β-oxidation, and down-regulate glycolipid pathways in mice, resulting in disturbances in energy metabolism. …”
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Potential Pitfalls of the Humanized Mice in Modeling Sepsis by Krzysztof Laudanski, Michael Stentz, Matthew DiMeglio, William Furey, Toby Steinberg, Arpit Patel

“…Although certain viral and protozoan infections can be replicated in humanized mice, whether a highly complex and dynamic systemic inflammation like sepsis can be accurately represented by current humanized mouse models in a clinically translatable manner is unclear. Humanized mice are xenotransplant animals in the most general terms. …”
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Kaempferol improves glucose uptake in skeletal muscle via an AMPK-dependent mechanism by William T. Moore, Jing Luo, Dongmin Liu

“…Kaempferol stimulates Akt phosphorylation in a time-dependent manner in human SkM cells. The effect of kaempferol on glucose uptake was blunted by inhibition of glucose transporter 4, phosphoinositide 3-kinase (PI3K), or AMPK. …”
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Cu66 nanoclusters from hierarchical square motifs: Synthesis, assembly, and catalysis by Xueli Sun, Yuchen Wang, Qingyuan Wu, Ying‐Zi Han, Xuekun Gong, Xiongkai Tang, Christine M. Aikens, Hui Shen, Nanfeng Zheng

“…Additionally, the ligands (phosphine, thiolate, and halide) coordinate to the surface of the cluster in a regiospecific manner, displaying square patterns as well. The self‐assembly facilitated by the C‐H···F interaction between the cluster moieties and SbF6− anions further induces the formation of three‐dimensional cubes and eventually large nanocrystals. …”
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Simultaneous Determination of Gallic Acid, Ellagic Acid, and Eugenol in Syzygium aromaticum and Verification of Chemical Antagonistic Effect by the Combination with Curcuma aromati... by Jung-Hoon Kim, Chang-Seob Seo, Seong-Sil Kim, Hyekyung Ha

“…These results demonstrate that the components contained in CA could affect the extraction of components of SA mainly in a decreasing manner. The antagonistic effect of CA on SA was verified by chemical analysis.…”
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Sulodexide Protects Renal Tubular Epithelial Cells from Oxidative Stress-Induced Injury via Upregulating Klotho Expression at an Early Stage of Diabetic Kidney Disease by Yu Ning Liu, Jingwei Zhou, Tingting Li, Jing Wu, Shu Hua Xie, Hua-feng Liu, Zhangsuo Liu, Tae Sun Park, Yaoxian Wang, Wei Jing Liu

“…Also, H2O2 could downregulate the expression of klotho in a dose-dependent manner. However, overexpression of klotho reduced the HAVCR1 production and the cellular apoptosis level induced by AGEs or H2O2. …”
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Divergent roles of m6A in orchestrating brown and white adipocyte transcriptomes and systemic metabolism by Ling Xiao, Dario F. De Jesus, Cheng-Wei Ju, Jiang-Bo Wei, Jiang Hu, Ava DiStefano-Forti, Valeria Salerno Gonzales, Tadataka Tsuji, Siying Wei, Matthias Blüher, Yu-Hua Tseng, Chuan He, Rohit N. Kulkarni

“…These data shed light on the ability of m6A to impact metabolism in a cell-type-specific manner with implications for influencing the pathophysiology of metabolic diseases.…”
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