Patient-derived cornea organoid model to study metabolomic characterization of rare disease: aniridia-associated keratopathy by Ali Can Koc, Vedat Sari, Gamze Kocak, Tuba Recber, Emirhan Nemutlu, Daniel Aberdam, Sinan Güven

“…Aniridia is inherited in an autosomal dominant manner, but its phenotype can vary significantly among individuals with the same mutation. …”
Get full text

Inhibition of Kv1.3 channel restrains macrophage M2 polarization and ameliorates renal fibrosis via regulating STAT6 phosphorylation by Yanshan Chen, Yuanxing Zhi, Hailin Zhong, Liang Ma, Xinpei Gu, Yijing Cai, Jingjing Huang, Xin Yi, Xiaoyan Wu, Ken Kin Lam Yung, Pingzheng Zhou

“…Mechanistically, we revealed that Kv1.3 was required for STAT6 phosphorylation in a mitochondria membrane potential dependent manner. Collectively, this study suggests that Kv1.3 is essential for macrophage M2 polarization and highlights the potential of Kv1.3 blockers as therapeutic agents for renal fibrosis and other M2 polarization-related diseases.…”
Get full text

A versatile cell line for establishing potency of cell type-specific AAV transgenes by Refugio A. Martinez, Yemeserach M. Bishaw, Meagan A. Quinlan, Erin L. Groce, Bryan B. Gore, Ed S. Lein, John K. Mich, Boaz P. Levi

“…Furthermore, CRAAVR cells can assess AAV transgene potency in a quantitative manner, as demonstrated by gamma-aminobutyric acid (GABA) uptake of an AAV-delivered GABA transporter (GAT-3). …”
Get full text

Exploring Methacrylated Gellan Gum 3D Bioprinted Patches Loaded with Tannic Acid or L-Ascorbic Acid as Potential Platform for Wound Dressing Application by Federica Scalia, Alessandra Maria Vitale, Domiziana Picone, Noemi De Cesare, Maria Swiontek Brzezinska, Beata Kaczmarek-Szczepanska, Alfredo Ronca, Barbara Zavan, Fabio Bucchieri, Marta Anna Szychlinska, Ugo D’Amora

“…To improve wound healing, advanced biofabrication techniques are proposed here to develop customized wound patches to release bioactive agents targeting cell function in a controlled manner. Three-dimensional (3D) bioprinted “smart” patches, based on methacrylated gellan gum (GGMA), loaded with tannic acid (TA) or L-ascorbic acid (AA) have been manufactured. …”
Get full text

Investigation of the Suitability of the DTV Method for the Online SoH Estimation of NMC Lithium-Ion Cells in Battery Management Systems by Jan Neunzling, Philipp Hainke, Hanno Winter, David Henriques, Matthias Fleckenstein, Torsten Markus

“…In this study, a batch of NMC-21700 cells were aged in calendar and cyclic manners. After a specified aging cycle was complete, a check-up measurement was performed. …”
Get full text

CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair by Luc Provencher, Wilson Nartey, Peter M. Brownlee, Austin W. Atkins, Jean-Philippe Gagné, Lou Baudrier, Nicholas S. Y. Ting, Cortt G. Piett, Shujuan Fang, Dustin D. Pearson, Shaun Moore, Pierre Billon, Zachary D. Nagel, Guy G. Poirier, Gareth J. Williams, Aaron A. Goodarzi

“…Here, we demonstrate that mutating the CHD6 chromatin remodeler sensitizes cells to PARP1/2 inhibitors in a manner distinct from BRCA1, and that CHD6 recruitment to DNA damage requires cooperation between PAR- and DNA-binding domains essential for nucleosome sliding activity. …”
Get full text

Inhibitory Effect of Cinobufagin on L-Type Ca2+ Currents, Contractility, and Ca2+ Homeostasis of Isolated Adult Rat Ventricular Myocytes by Pinya Li, Qiongtao Song, Tao Liu, Zhonglin Wu, Xi Chu, Xuan Zhang, Ying Zhang, Yonggang Gao, Jianping Zhang, Li Chu

“…CBG reduced ICa-L in a concentration-dependent manner with an IC50 of 4 × 10−10 M, upshifted the current-voltage curve of ICa-L, and shifted the activation and inactivation curves of ICa-L leftward. …”
Get full text

Development of a Recombinant Cell-Based Indirect Immunofluorescence Assay for the Determination of Autoantibodies against Soluble Liver Antigen in Autoimmune Hepatitis by Christiane Radzimski, Christian Probst, Bianca Teegen, Kristin Rentzsch, Inga Madeleine Blöcker, Cornelia Dähnrich, Wolfgang Schlumberger, Winfried Stöcker, Dimitrios P. Bogdanos, Lars Komorowski

“…Furthermore, a cytosolic fraction of HEK293 containing SLA was able to neutralize the autoantibodies in all positive sera in a dose-dependent manner. HEK293 cells expressing SLA are a valid substrate for the serodiagnosis of AIH relevant autoantibodies by IFA. …”
Get full text

Autologous Microfragmented Adipose Tissue Reduces the Catabolic and Fibrosis Response in an In Vitro Model of Tendon Cell Inflammation by Marco Viganò, Gaia Lugano, Carlotta Perucca Orfei, Alessandra Menon, Enrico Ragni, Alessandra Colombini, Paola De Luca, Pietro Randelli, Laura de Girolamo

“…IL-1β-treated TCs showed augmented collagen type III, metalloproteases, and cyclooxygenase-2 expression. μFAT was able to reduce the expression of collagen type III and metalloproteases-1 in a significant manner, and at the same time, it enhanced the production of VEGF, IL-1Ra, and IL-6. …”
Get full text

Sex disparities in the association between rare earth elements exposure and genetic mutation frequencies in lung cancer patients by Mengyuan Liu, Jiali Zhang, Xiaohong Duan, Qiming Zhou, Jing Chen, Siyao Liu, Junyan Su, Li Han, Fan Yang, Niansong Qian

“…Additionally, plasma REE levels was associated with specific mutation types and variant allele frequencies (VAFs) of particular genes in a sex-dependent manner. Mutational signature analysis revealed sex-specific associations of La with indel signatures. …”
Get full text

Antimalarial Efficacy and Antioxidant Activity of Lophira lanceolata Stem Bark Ethanol Extract Using Plasmodium berghei Induced-Malaria in Swiss Albino’s Mice by Mounvera Abdel Azizi, Noumedem Anangmo Christelle Nadia, Yamssi Cedric, Ngouyamsa Nsapkain Aboubakar Sidiki, Gamago Nkadeu Guy-Armand, Djeussi Doriane Esther, Tientcheu Noutong Jemimah Sandra, Tako Djimefo Alex Kevin, Vincent Khan Payne

“…Similarly, the extract at doses 125, 250, and 500 mg/kg showed significant decreases (P<0.05) in a dose-dependent manner during the curative test. The ethanol extract of L. lanceolata caused a reduction of tissue markers, such as hepatic oxidative stress, as it increased the enzymatic activity of antioxidant enzymes. …”
Get full text

Jurisprudential Analysis of the Nature of Money Creation with an Emphasis on Mudaraba on Debt in the Banking System by Sadegh Elham, Mohammad Mahdi Shariatinejad, Muhammad Rasul Fakhreh

“…Money creation in the banking system is an important phenomenon, the quality and manner of which creates many effects in the economic system. …”
Get full text

Age and estrogen-associated reductions in hypoxic ventilatory response and chemosensitivity in female rats by Jessica M. L. Grittner, Rebecca Barok, Edgar Juarez Lopez, Misha Shah, Brendan J. Dougherty

“…The current study aimed to interrogate whether the OVX model of hormone reduction impacted specific aspects of respiratory function [chemosensitivity and the hypoxic ventilatory response (HVR)] in a manner consistent with natural age-related declines in hormones. …”
Get full text

Cloud Service Selection Using Multicriteria Decision Analysis by Md Whaiduzzaman, Abdullah Gani, Nor Badrul Anuar, Muhammad Shiraz, Mohammad Nazmul Haque, Israat Tanzeena Haque

“…CC leverages its unique services to cloud customers in a pay-as-you-go, anytime, anywhere manner. Cloud services provide dynamically scalable services through the Internet on demand. …”
Get full text

Nonlinear Stress‐Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone‐Cartilage Unit by Waqas Badar, Sheetal R. Inamdar, Peter Fratzl, Tim Snow, Nicholas J. Terrill, Martin M. Knight, Himadri S. Gupta

“…Extracting the 3D fibril structure from 2D small‐angle X‐ray scattering before and during physiological compression reveals of dominant deformation modes, including crystallinity transitions, lateral fibril compression, and reorientation, which vary in a coupled, nonlinear, and correlated manner across the cartilage‐bone interface. A distinct intermolecular arrangement of collagen molecules, and enhanced molecular‐level disorder, is found in the cartilage (sliding) surface region. …”
Get full text

Antioxidant and hepatoprotective effects of Hypsizygus ulmarius polysaccharide on alcoholic liver injury in rats by Sudha Govindan, Angu Jayabal, Jayasakthi Shanmugam, Prasanna Ramani

“…In antioxidant scavenging assay, HUP showed moderate DMPD radical scavenging activity, cupric ion reducing antioxidant capacity and inhibitory effect against lipid peroxidation in a dose-dependent manner. Regarding in vivo hepatoprotective activity, compared with the ethanol induction group, pre-treatment of low and high doses of HUP significantly reduced the behaviours of serum enzymes, lowered the levels of hepatic oxidative stress markers, restored the levels of biochemical constituents, enhanced the levels of liver and serum enzymatic antioxidants and non-enzymatic antioxidants, and improved the serum lipid levels of alcohol-intoxicated rats. …”
Get full text

Intraperitoneal fipronil effects on liver histopathological, biochemistry and morphology in Caspian kutum, Rutilus frisii kutum (Kamenskii, 1901) by R. Alijani Ardeshir, H. Zolgharnein, A.A. Movahedinia, N. Salamat, E. Zabihi, J. Regenstein

“…Pyknosis, sinusoid dilation and vacuolization were common histological changes, and these changes became more severe in a time and dose dependent manner. This dependence was also observed for HSI and the liver biochemical test (alanine and aspartate transaminase). …”
Get full text

Fine-Grained Classification via Hierarchical Feature Covariance Attention Module by Yerim Jung, Nur Suriza Syazwany, Sujeong Kim, Sang-Chul Lee

“…We demonstrate the need for fine-grained classification in a hierarchical manner by focusing on the diverse scale representation. …”
Get full text

Ligature technique as a treatment for mucocele in an infant - Case report by Beatriz Cruz Lopes, Lucas Fernando Oliveira Tomáz Ferraresso, Mariella Padovese, Mariana Emi Nagata, Farli Aparecida Carrilho Boer, Cássia Cilene Dezan

“…The Ligature Technique is an excellent treatment option for pedicled mucoceles considering the importance of appropriate selection of dental techniques, in order to achieve the treatment goal in a less traumatic manner, and meet the specific needs of each patient. …”
Get full text

N6‐Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression by Yalan Rui, Haisheng Zhang, Kangning Yu, Shiyao Qiao, Chenglin Gao, Xiansong Wang, Weifeng Yang, Gholamreza Asadikaram, Zigang Li, Kun Zhang, Jianxin Peng, Jiexin Li, Junming He, Hongsheng Wang

“…Mechanically, METTL3 positively regulates the translation of HDAC6 in an m6A‐dependent manner, while m6A methylation of A3678 in the coding sequence (CDS) of HDAC6 ameliorates its translation efficiency via facilitating the binding with YTHDF3. …”
Get full text