TEEG Induced A549 Cell Autophagy by Regulating the PI3K/AKT/mTOR Signaling Pathway by Lu Shi, Yijun Tu, Yu Xia, Siqi Ye, Chaozhi Ma, Yanwen Liu, Pengtao You

“…TEEG markedly inhibited A549 cell proliferation in a concentration-dependent manner. Immunofluorescence staining showed that TEEG induced autophagy in A549 cells. …”
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A Review of Graduate Attributes in the Oman Authority for Academic Accreditation and Quality Assurance of Education (OAAAQAE's) Quality Audit Reports by Zulaikha Talib Al-Saadi, Holi Ibrahim Holi Ali

“…Additionally, there is a need for an appropriate evaluation mechanism for GAs to be conducted in a systematic and timely manner. Moreover, GAs should be explicitly assessed and benchmarked based on the feedback obtained from relevant stakeholders. …”
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METTL3 Promotes Osteo/Odontogenic Differentiation of Stem Cells by Inhibiting miR-196b-5p Maturation by Xiao Han, Guoyue Li, Haoqing Yang, Chen Zhang, Yangyang Cao, Ning Wang, Lihua Ge, Zhipeng Fan

“…Taken together, our findings highlight the critical roles of the METTL3-miR-196b-5p signaling axis in an m6A-dependent manner in osteo/odontogenic differentiation of SCAPs, identifying some potential targets for tooth and maxillofacial bone defects.…”
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A dual-RPA based lateral flow strip for sensitive, on-site detection of CP4-EPSPS and Cry1Ab/Ac genes in genetically modified crops by Jinbin Wang, Yu Wang, Xiuwen Hu, Yifan Chen, Wei Jiang, Xiaofeng Liu, Juan Liu, Lemei Zhu, Haijuan Zeng, Hua Liu

“…In conclusion, this strategy achieved the expected purpose of simultaneous detection of the two popular targets in GM crops within 20 min at 37 ℃ in a rapid, equipment-free field manner, providing a new alternative for rapid screening for transgenic assays in the field.…”
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Modeling Behaviors for a New Compliant Mechanism by Recursive Hierarchy of Random Forest Models by Hieu Giang Le, Thanh-Phong Dao, Minh Phung Dang, Thao Nguyen-Trang

“…The numerical results demonstrate that the proposed hierarchical manner can improve the performance of component Random Forest models tuned with different values of number of trees and max-depth. …”
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Efficacy and safety of the metformin-mazindol anorectic combination in rat by Argüelles-Tello Federico, Roa-Coria José Eduardo, Zúñiga-Romero Ángel, Huerta-Cruz Juan Carlos, Quiñonez-Bastidas Geovanna Nalley, Flores-Murrieta Francisco Javier, Rocha-González Héctor Isaac, Reyes-García Juan Gerardo

“…An acute dose of mazindol and metformin administered per os, individually or as a mixture, has reduced the milk consumption in rats in a dose-dependent manner. Theoretical effective dose 40 (ED40t) did not differ from the experimental effective dose 40 (ED40e) obtained with the mazindol-metformin mixture in the anorexia experiments, by Student′s t-test. …”
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Potential antidiabetic and antioxidant activities of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves by Onoja Samuel O., Nnadi Charles O., Udem Samuel C., Anaga Aruh O.

“…It also reduced the fasting blood glucose (FBG) levels in a time-dependent manner. The highest activity was recorded within 6 h post-treatment at 0.2 mmol kg−1 bm. …”
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Developing a Clustering-Based Empirical Bayes Analysis Method for Hotspot Identification by Yajie Zou, Xinzhi Zhong, John Ash, Ziqiang Zeng, Yinhai Wang, Yanxi Hao, Yichuan Peng

“…As crash data often contain underlying heterogeneity that, in essence, can make them appear to be generated from distinct subpopulations, methods are needed to select similar sites in a principled manner. To overcome this possible heterogeneity problem, EB-based HSID methods that use common clustering methodologies (e.g., mixture models, K-means, and hierarchical clustering) to select “similar” sites for building SPFs are developed. …”
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The Influence of Mg2+ Ions on the In Vitro Efficacy of Chitosan-Titanium Dioxide Nanotubes (CTNTs) Scaffolds by Siew Shee Lim, Shui Wei Kho, Nehemiah Li Heng Ang, Cheng Heng Pang, Hwei-San Loh

“…Fluorescence-based staining, cell viability, and alkaline phosphatase assays indicated that the adsorbed Mg2+ ions onto CTNTs scaffolds aided in promoting higher proliferation and early differentiation of MG63 cells than scaffolds without Mg2+ ions in a concentration-dependent manner. Based on current results, CTNTs scaffolds with Mg2+ ions may be a potential biomaterial for bone regeneration.…”
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Mitochondrial Thioredoxin-Glutathione Reductase from Larval Taenia crassiceps (Cysticerci) by Alberto Guevara-Flores, Irene P. del Arenal, Guillermo Mendoza-Hernández, Juan Pablo Pardo, Oscar Flores-Herrera, Juan L. Rendón

“…The enzyme reduced H2O2 in a NADPH-dependent manner, although with low catalytic efficiency. In the presence of thioredoxin, mitochondrial TGR showed a thioredoxin peroxidase-like activity. …”
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Optimal Molecular Methods in Detecting p190BCR-ABL Fusion Variants in Hematologic Malignancies: A Case Report and Review of the Literature by Rebecca J. Sonu, Brian A. Jonas, Denis M. Dwyre, Jeffrey P. Gregg, Hooman H. Rashidi

“…Incorporating NGS methods in an algorithmic manner into the standard diagnostic PCR-based approach for BCR-ABL1 will aid in minimizing false negative results.…”
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Proliferation and TH1/TH2 Cytokine Production in Human Peripheral Blood Mononuclear Cells after Treatment with Cypermethrin and Mancozeb In Vitro by Rajesh Mandarapu, Rajanna Ajumeera, Vijayalakshmi Venkatesan, Balakrishna Murthy Prakhya

“…Mancozeb induced dose-dependent increases in lymphocyte proliferation, inhibition of production of TNFα and the TH2 cytokines IL-6 and IL-10, and an increase in IFNγ (TH1 cytokine) production (at least 2-fold compared to control); mancozeb also induced inhibition of IL-4 (TH2) and stimulated IL-2 (TH1) production, albeit only in dose-related manners for each. In contrast, cypermethrin exposure did not cause significant effects on proliferation or cytokine profiles. …”
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A Surgical Cryoprobe for Targeted Transcorneal Freezing and Endothelial Cell Removal by Alina Akhbanbetova, Shinichiro Nakano, Stacy L. Littlechild, Robert D. Young, Madara Zvirgzdina, Nigel J. Fullwood, Ian Weston, Philip Weston, Shigeru Kinoshita, Naoki Okumura, Noriko Koizumi, Andrew J. Quantock

“…Localized destruction of the endothelial monolayer was achieved in a consistent manner with a 3.4 mm diameter/concave profile cryoprobe and represents a potentially useful approach to remove dysfunctional corneal endothelial cells from corneas with endothelial dysfunction.…”
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Anthelmintic Activity of Crude Extract and Essential Oil of Tanacetum vulgare (Asteraceae) against Adult Worms of Schistosoma mansoni by Loyana Silva Godinho, Lara Soares Aleixo de Carvalho, Clarissa Campos Barbosa de Castro, Mirna Meana Dias, Priscila de Faria Pinto, Antônio Eduardo Miller Crotti, Pedro Luiz Silva Pinto, Josué de Moraes, Ademar A. Da Silva Filho

“…Quantitative analysis on the schistosomes tegument showed that TV caused changes in the numbers of tubercles of S. mansoni male worms in a dose-dependent manner. The findings suggest that T. vulgare is a potential source of schistosomicidal compounds.…”
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Antrodia cinnamomea ameliorates neointimal formation by inhibiting inflammatory cell infiltration through downregulation of adhesion molecule expression in vitro and in vivo by Yan Zhang, Aijin Ma, Hao Xi, Ning Chen, Rong Wang, Chenhui Yang, Jinbang Chen, Pin Lv, Fuping Zheng, Wenyi Kang

“…Herein, using carotid arterial ligation models, we found that ethanol extract from A. cinnamomea (EEAC) significantly inhibited neointimal hyperplasia in a dose-dependent manner, accompanied with the reduced expression of activated p65 and inflammatory cytokines. …”
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Environmental enrichment with nylon gnaw sticks introduces variation in Sprague Dawley rat immune and lower gastrointestinal parameters with differences between sexes by Mark Wulczynski, Stephen P. J. Brooks, Judy Green, Fernando Matias, Martin Kalmokoff, Julia M. Green-Johnson, Sandra T. Clarke

“…Conclusions These findings indicate that including GS can influence microbiota and immune-related parameters, in a sex dependent manner. This shows that environmental enrichment strategies need to be clearly reported in publications to properly evaluate and compare experimental results, especially with respect to the use of chewable EE in the context of studies examining diet, microbiome and immune parameters.…”
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Detailed Nonlinear Modeling and High-Fidelity Parallel Simulation of MMC With Embedded Energy Storage for Wind Farm Grid Integration by Bingrong Shang, Ning Lin, Venkata Dinavahi

“…Since the sequential data processing manner of the central processing unit (CPU) is prone to an extremely long simulation following an increase of component quantity with even one order of magnitude, the massively concurrent threading of the GPU is exploited. …”
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Proinflammatory Effects of Diesel Exhaust Nanoparticles on Scleroderma Skin Cells by A. Mastrofrancesco, M. Alfè, E. Rosato, V. Gargiulo, C. Beatrice, G. Di Blasio, B. Zhang, D. S. Su, M. Picardo, S. Fiorito

“…Euro 5 particle exposure increased the mRNA expression of MMP-2, -7, and -9 in SSc fibroblasts in a dose dependent manner and only at the highest concentration in normal cells. …”
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Pterostilbene antagonizes homocysteine-induced oxidative stress, apoptosis and lipid deposition in vascular endothelial cells by Qiao Jiang, Li Wang, Xu Si, Yuanyuan Bian, Weijia Zhang, Huijun Cui, Hailong Gui, Ye Zhang, Bin Li, Dehong Tan

“…Pte inhibited Hcy-induced Akt dephosphorylation, increased p53, and decreased the Bcl-2/Bax ratio and caspase-9/caspase-3 activation in a dose-dependent manner. LY294002 pretreatment partially reversed the protective effect of Pte by blocking the PI3K/Akt pathway. …”
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High-Throughput Sequencing Reveals Diverse Sets of Conserved, Nonconserved, and Species-Specific miRNAs in Jute by Md. Tariqul Islam, Ahlan Sabah Ferdous, Rifat Ara Najnin, Suprovath Kumar Sarker, Haseena Khan

“…A group of plant microRNAs are evolutionarily conserved; however, others are expressed in a species-specific manner. Jute is an agroeconomically important fibre crop; nonetheless, no practical information is available for microRNAs in jute to date. …”
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