Regulation of human papillomavirus E6 oncoprotein function via a novel ubiquitin ligase FBXO4 by Arushi Vats, Luca Braga, Nezka Kavcic, Paola Massimi, Edoardo Schneider, Mauro Giacca, Laimonis A. Laimins, Lawrence Banks

“…Furthermore, our data demonstrate that the combined knockdown of FBXO4 and E6AP not only rescues the protein levels of E6 but also induces high levels of cell death in a p53-dependent manner in the HPV-positive cervical cancer cell line, HeLa. …”
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Mass Casualty Incident Training in Immersive Virtual Reality: Quasi-Experimental Evaluation of Multimethod Performance Indicators by Anke Sabine Baetzner, Yannick Hill, Benjamin Roszipal, Solène Gerwann, Matthias Beutel, Tanja Birrenbach, Markus Karlseder, Stefan Mohr, Gabriel Alexander Salg, Helmut Schrom-Feiertag, Marie Ottilie Frenkel, Cornelia Wrzus

“… BackgroundImmersive virtual reality (iVR) has emerged as a training method to prepare medical first responders (MFRs) for mass casualty incidents (MCIs) and disasters in a resource-efficient, flexible, and safe manner. However, systematic evaluations and validations of potential performance indicators for virtual MCI training are still lacking. …”
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Analisis Strategi Pemasaran Politik Kampanye Kukuh Haryanto Sebagai Calon Legislatif DPRD Kabupaten Wonogiri Dalam Kontestasi Pemilihan Umum Tahun 2024 by Shildamullah Danendra Mukti Ardana, Titin Purwaningsih

“…Data analysis was carried out using the Internet of Things approach and Adman Nursal’s political marketing theory in a descriptive manner. The results reveal that Kukuh Haryanto has had a longstanding interest in politics. …”
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Carbohydrate ligand engagement with CD11b enhances differentiation of tumor-associated myeloid cells for immunotherapy of solid cancers by Mei Zhang, Veronique Roche, Victor Sandoval, Claire Wolford, Zachary Senders, Julian Anthony Kim, Susan Pereira Ribeiro, Alex Yicheng Huang, Rafick-Pierre Sekaly, Joshua Lyons

“…We have applied peptide microarrays, multiparameter FACS (fluorescence-activated cell analysis) analysis, cellular/molecular immunological technology, advanced microscopic imaging, and transgenic mouse models of solid cancers, to study the interaction between BG34-200 carbohydrate ligand and CD11b protein and the resulting immunological changes in the context of solid cancers, including osteosarcoma, advanced melanoma, and pancreatic ductal adenocarcinoma (PDAC).Results Our results show that BG34-200 can bind directly to the activated CD11b on its I (or A) domain, at previously unreported peptide residues, in a multisite and multivalent manner. This engagement significantly impacts the biological function of tumor-associated inflammatory monocytes (TAIMs) in osteosarcoma, advanced melanoma, and PDAC backgrounds. …”
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Rescue of common and rare exon 2 skipping variants of the GAA gene using modified U1 snRNA by Paolo Peruzzo, Natascha Bergamin, Martina Bon, Sara Cappelli, Alessandra Longo, Elisa Goina, Cristiana Stuani, Emanuele Buratti, Andrea Dardis

“…Results Modified U1-3, U1+1 and U1+6 snRNAs were all able to increase, in a dose-dependent manner, the inclusion of exon 2 within the transcript derived from the GAA minigene harbouring the c.-32-13T>G variant. …”
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Perancangan dan Implementasi Sistem Informasi Deteksi Kesesuaian Pemanfaatan Ruang Berbasis Web dengan Fitur Geo-Intersection Pada POSTGIS by Issa Arwani, Widhy Hayuhardhika Nugraha Putra, Ghazian Hamdi, Tsania Dzulkarnain

“…In this case, an online application that can check and provide recommendations on the suitability of space utilization in a transparent and fast manner is very much needed by the community during applying for a space utilization permit. …”
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Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis by Jinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian-Zhi Wang, Shifeng Xiao

“…HDAC7 could modulate astrocytic uptake and lysosomal degradation of tau proteins through a transcriptional factor EB (TFEB) acetylation-dependent manner. Specifically, deacetylation of TFEB at K310 site by HDAC7 prevented TFEB nuclear translocation with reduced lysosomal biogenesis and tau clearance in astrocytes, whereas inhibiting HDAC7 restored astrocytic TFEB acetylation level at K310 with improved tau pathology and cognitive functions in PS19 mice. …”
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A dual-band microwave sensor for glucose measurements utilizing an enclosed split ring metamaterial-based array by Abhishek Kandwal, Ziheng Ju, Louis W.Y. Liu, Rohit Jasrotia, Choon Kit Chan, Zedong Nie, Ali M. Almuhlafi, Hamsakutty Vettikalladi

“…At 9.2 GHz, there was no significant resonant frequency shift with varying glucose concentrations, but the magnitude of the reflection coefficient changed with the glucose concentration nonlinearly in an amount-dependent manner, with a sensitivity of 16.6 dB per unit glucose concentration within the clinical diabetic range. …”
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Research progress on characteristics of secondary aluminum dross and its detoxification and utilization by Kun LIN, Yuanbo ZHANG, Zijian SU, Jiamei XU, Tao JIANG

“…Hence, methods for regulating the generation of these gases in a targeted manner and efficiently recycling them are also a future direction of study.…”
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The effect of single and dual task training on the intracortical inhibition in young and old adults by Michael Wälchli, Craig Tokuno, Benedikt Lauber, Wolfgang Taube

“…Previous research has also indicated that short-interval intracortical inhibition (SICI) is modulated in a task-specific manner following explosive or balance training (Taube et al., 2020). …”
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The role of health literacy in intervention studies targeting children living with overweight or obesity and their parents—a systematic mixed methods review by Heidi Holmen, Heidi Holmen, Tone Nygaard Flølo, Tone Nygaard Flølo, Christine Tørris, Astrid Torbjørnsen, Kari Almendingen, Kirsti Riiser, Kirsti Riiser

“…Future research should focus on integrating health literacy into weight management interventions in a systematic and theory-driven manner, ensuring that these interventions are tailored to the specific needs of children and their families and can sustain behavior change over time.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?…”
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Water homeostasis gene expression in the kidney of broilers divergently selected for water conversion ratio by Kentu Lassiter, Loujain Aloui, Elizabeth S. Greene, Marciela Maqaeda, Travis Tabler, Sami Dridi, Robert F. Wideman, Jr., Sara Orlowski, Walter G. Bottje

“…In Exp. 2, target genes were regulated in environment and/or line-dependent manner. The renal expression of heat shock proteins 70 and 90, AVP receptor 2 (AVPR2), AGT, renin, AT1/2, and AQP1was significantly upregulated in HS compared to TN birds, however AVPR2 expression was significantly higher in HWE compared to MRB birds. …”
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Predictive factors' modeling of entrepreneurial opportunities in international companies by Ali Farahani, Younos Vakil Alroaia, Farideh Haghshenaskashani, Ali Faez

“…The statistical population of the research includes 17 managers and experts active in the field of entrepreneurship, and the sampling was done in a purposeful and snowball manner, and the interviews continued until reaching theoretical saturation. …”
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The relationship between factors affecting the development of industrial startups using methodology Fuzzy cognitive mapping by Mirmahmood Naghibi, Changiz Valmohammadi, Kiamars Fathi Hefeshjani, mahmoud modiri

“…The statistical population of the research includes 19 professional experts in industrial startups, including senior managers and their collections, and the sampling was done in a targeted manner, and the interviews continued until reaching theoretical saturation. …”
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Application of Fuzzy Hierarchy Analysis method to identify factors on the professional development of newly graduated teachers from Farhangian University by Nader Habibzadeh, Ebrahim Salehiomran, Saeed Ghiyasinoshan

“…The statistical population of the research includes 15 experts, academic specialists, professors, elites and educational science experts who are proficient in the subject of the research, and sampling was done in a targeted manner. The information and data needed for the research were collected through a questionnaire. …”
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Presenting the fintech market development model with an emphasis on existing challenges and strategies by Seyed Mani Sadraee, Farideh Haghshenaskashani, Mehdi Karimizand

“…The sampling method is done in a judgmental manner, and the interviews continued until reaching theoretical saturation. …”
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The Role of Different Emotional States of Customers on Food Preferences by Mahmood Ghanbari, Kambiz Heidarzadeh Hanzaee, Behnaz Khodayari, Maryam Khalili Araghi

“….), and sampling was done in the targeted manner; and the quantitative part includes 448 persons who, like the qualitative part, were selected randomly available from the consumers of food. …”
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Designing and explaining the policy framework for the development of electric vehicles in Iran by Sayed Abbas Karavand, Yazdan Shirmohamadi, Mohammad Taghi Amini

“…The statistical population of the research includes 15 experts and policy makers in the field of automobiles in Iran, and the sampling was done in a targeted manner, and the interviews continued until theoretical saturation was reached. …”
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Extracellular vesicles derived from creeping fat stem cells promote lymphatic function and restrain inflammation of Crohn's disease by Weigang Shu, Yongheng Wang, Mengfan Chen, Xiaoli Zhu, Fangtao Wang, Chunqiu Chen, Peng Du, Alexandra Bartolomucci, Xin Su, Xiaolei Wang

“…Using high‐throughput sequencing, we demonstrated that CrF‐EVs significantly increased HLEC proliferation, migration, tube formation and CCL‐21 production in a miR‐132‐3p/RASA1/ERK1/2 axis‐dependent manner. Accordingly, upregulated miR‐132‐3p was observed in patient CrF, positively correlated with lymphangiogenesis while negatively correlated with inflammatory factors (tumour necrosis factor‐α and IL‐6) level. …”
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Dietary tea tree (Melaleucae Aetheroleum) oil fortifies growth, biochemical, immune-antioxidant trait, gene function, tissue reaction, and Aeromonas sobria resistance in Nile tilap... by Mohamed Shaalan, Heba H. Mahboub, Ahmed Hosny Abdelgawad, Abdelwahab A. Abdelwarith, Elsayed M. Younis, Ahmed A. Elnegiry, Asmaa W. Basher, Walaa El-Houseiny, Sherif M. Shawky, Sahar H. Orabi, Simon J. Davies, Yasmina K. Mahmoud

“…Furthermore, TTO-enriched diets enhanced the relative percentage survival post-A. sobria challenge plus enhanced the clinical picture in a dose-dependent manner. Taken together, the findings revealed that long-term exposure to dietary TTO fortified the physiological performance, oxidant/anti-oxidant stability, immune function, gene expression, histological picture, and resistance of Nile tilapia against A. sobria.…”
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