Presynaptic CRF1 Receptors Mediate the Ethanol Enhancement of GABAergic Transmission in the Mouse Central Amygdala by Zhiguo Nie, Eric P. Zorrilla, Samuel G. Madamba, Kenner C. Rice, Marissa Roberto, George Robert Siggins

“…In whole-cell patch recordings of pharmacologically isolated GABAAergic IPSCs from slices of mouse CeA, both CRF and ethanol augmented evoked IPSCs in a concentration-dependent manner, with low EC50s. A CRF1 (but not CRF2) KO construct and the CRF1-selective nonpeptide antagonist NIH-3 (LWH-63) blocked the augmenting effect of both CRF and ethanol on evoked IPSCs. …”
Get full text

Electroporation assisted delivery of Roussin salt porphyrin-based conjugated carbon nanoparticles for sono–X-ray–photodynamic prostate cancer in vitro and in vivo treatment by Samir Ali Abd El-Kaream, Abed Elrahman Ahmad Mohamad, Sohier Mahmoud El-Kholey, Samia Abd El-Moniem Ebied

“…Furthermore, EP@RRBP-CNP is a promising SXPS that, when used in conjunction with SXPDT, can be very effective in in vitro treating PCa-DU-145 (in a dose-dependent manner cell viability declined, an increase in the cells population during the G0/G1-phase indicates that the cell cycle was arrested, and an increase in cell population in the Pre-G, autophagic cell death, as well as necrosis and early and late apoptosis, indicate that cell death was induced) and MNU/testosterone-PCa-induced mice in vivo (induced antiproliferative genes, p53, Bax, TNFalpha, caspase 3,9, repressed antiangiogenic and antiapoptotic genes, VEGF and Bcl2, respectively), successfully slowing the growth of tumors and even killing cancer cells, as well as lowering oxidative stress (MDA), improving the functions of the kidneys (urea, creatinine), liver (ALT, AST), and antioxidants (GPx, GPx, GST, CAT, GSH, TAC). …”
Get full text

Relationships between structural stigma, societal stigma, and minority stress among gender minority people by Kristen D. Clark, Mitchell R. Lunn, Jae M. Sevelius, Carol Dawson-Rose, Sandra J. Weiss, Torsten B. Neilands, Micah E. Lubensky, Juno Obedin-Maliver, Annesa Flentje

“…The application of this variable should be investigated further to explore its association with health outcomes and to inform efforts to reduce health equity barriers experienced by GM people through addressing structural stigma in a manner inclusive of societal stigma.…”
Get full text

Investigating the preventive effects of pulsed electromagnetic fields on glucocorticoid-induced osteoporosis in rats by Shuai Ding, Guangquan Zhang, Yanzheng Gao, Zhiqiang Hou, Fuqiang Shao

“…Subsequently, the rats were exposed to PEMF for 4 h daily, with the duration varying from 1 to 8 weeks. (2) Adhering to the injection schedule of the PEMF group, the MPSL group (consisting of 24 rats) was administered LPS and MPSL, omitting PEMF stimulation. (3) The PS group (n = 24) was administered injections of 0.9% saline solution in an identical manner and at the same time intervals as the other two groups. …”
Get full text

Das Hörbar-Machen von zyklischen Potentialen in der musikalischen Interpretation. Eduard Steuermanns Live-Mitschnitt der ›Diabelli-Variationen‹ vom 13. Mai 1963 by Martin Zenck

“…On the one hand, regarding the question of the cyclical and the anti-cyclical, the discussion explores the conflicting relationship between totality and fragment in the manner of Hegel and Novalis. On the other hand, it applies the concept of “voice writing” (Stimmschrift) in Novalis, according to which every notation by Beethoven, such as the sketches and the completed score of the “Diabelli Variations” Op. 120, are always writing and at the same time betraying the author’s voice, which means that scripturality and orality go hand in hand. …”
Get full text

Providing a General Model for the Successful Implementation of Digital Transformation in Organizations by Haidar Ahmadi, Najme Parsaei, Seyyed Hamed Hashemi, Hamidreza Nematollahi

“…Objective Purpose: Digital transformation involves the comprehensive integration of digital technologies into all facets of an organization's operations, fundamentally altering the manner in which the organization functions and delivers value to its stakeholders. …”
Get full text

Syrian refugee and diaspora healthcare professionals: Case studies from the eastern mediterranean and European regions by Aula Abbara, Munzer Alkhalil, Kinan Wihba, Omer Abdrabbuh, Diana Rayes, Andrew Ghobrial, Manar Marzouk, Fadi Halabi, Mahmoud Hariri, Abdulkarim Ekzayez

“…Such policies that aim to invest in refugee HCPs’ skills, further develop their aptitudes, and potentially establish a connection between them and their homeland in a mutually beneficial manner for both health systems in exile and in their homeland. …”
Get full text

Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer by Luis Aparicio, Laura Crowley, John R. Christin, Caroline J. Laplaca, Hanina Hibshoosh, Raul Rabadan, Michael M. Shen

“…Methods We have performed meta-analyses of new and previously published scRNA-seq datasets for mouse and human prostate tissues to identify and compare cell populations across datasets in a uniform manner. Using random matrix theory to denoise datasets, we have established reference cell type classifications for the normal mouse and human prostate and have used optimal transport to compare the cross-species transcriptomic similarities of epithelial cell populations. …”
Get full text

Vermicomposting of coir pith and cow manure: Influence of initial total phenolic content on earthworms’ performance by Kanokwan Pundee, Saengchai Akeprathumchai, Sudarut Tripetchkul

“…Earthworm mortality and weight loss increased as initial TPC of materials increased in a concentration dependent manner. High performance liquid chromatography (HPLC) results showed that the total numbers of water-soluble phenolics of coir pith and cow manure were, respectively, 17 and 16 out of which 5 and 4 were unique to coir pith and cow manure, respectively. …”
Get full text

Analysis of Acoustic Surface Wave Focused Unidirectional Interdigital Transducers Using Coupling-of-Mode Theory by Guopeng Hui, Tinglun Ao, Haotian Liu, Minglei Li, Chen Chen

“…The proposed EWC-FEFUDT may provide an alternative method for cell or droplet separation in an efficient manner.…”
Get full text

Design and Application of a Data-computation Integrated Database for Meteorological Grid Data by Wang Shu, Xu Yongjun, He Wenchun, Wu Huanping, Gao Feng, Liu Yuanyuan, Liu Bei, Lü Guanru, Ni Xuelei

“…When data is imported into the database, it is stored in a standardized and uniform manner. Each dataset comprises two components: A header file and entity data, both of which are stored in binary format. …”
Get full text

Intra-operative nasal compression after lateral osteotomy to minimize post-operative Peri-orbital ecchymosis and edema by L. Sowerby, L. M. Kim, W. Chow, C. Moore

“…Although the effect may be variable to some degree, this is an intervention with no additional risks involved and thus can be used in a safe manner.…”
Get full text

Respectful maternity care and associated factors among mothers who gave birth at public health institutions in Debre Tabor town, Northwest Ethiopia: a mixed-methods study by Tadesse Ayana Fentie, Abayneh Aklilu Solomon, Mihretu Molla Enyew, Meseret Mekuriaw Beyene, Ayalew Kassie Melese, Alamirew Enyew Belay, Gebrie Getu Alemu

“…BackgroundRespectful maternity care is care organized for and provided to all women in a manner that maintains their dignity, privacy, and confidentiality, ensures freedom from harm and mistreatment, and enables informed choice and continuous support during labor and childbirth. …”
Get full text

"ANAPUS KANTO": M. FOUCAULT NAUJOJI MORALĖS GENEALOGIJA by Jūratė Baranova

“…This historical theathre of changes in ethics, recontructed by Foucault was only for the reason to see the possiblity to think about ourselves in different manner as we think today. But subject of Foucault ethics is always contexualized in historical situation. …”
Get full text

Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects by Rodrigo Moraga-Amaro, Oscar Moreno, Jordi Llop, Marion Bankstahl, Marion Bankstahl, Jens P. Bankstahl

“…Understanding these differences could guide the diagnosis and treatment of CTE in a personalized manner, offering hope for more effective treatments in the future.…”
Get full text

Preconditioning of Rat Bone Marrow-Derived Mesenchymal Stromal Cells with Toll-Like Receptor Agonists by Fabiana Evaristo-Mendonça, Gabriela Sardella-Silva, Tais Hanae Kasai-Brunswick, Raquel Maria Pereira Campos, Pablo Domizi, Marcelo Felippe Santiago, Ricardo Augusto de Melo Reis, Rosalia Mendez-Otero, Victor Túlio Ribeiro-Resende, Pedro Moreno Pimentel-Coelho

“…The neurotrophic activity of the conditioned medium from unstimulated and LPS-preconditioned rBM-MSCs was investigated using dorsal root ganglion explants, showing that soluble factors produced by unstimulated and LPS-preconditioned rBM-MSCs can stimulate neurite outgrowth similarly, in a VEGF-dependent manner. LPS-preconditioned cells, however, were slightly more efficient in increasing the number of regrowing axons in a model of sciatic nerve transection in rats. …”
Get full text

Microalgae diversity in several different sub-habitats by S. Arsad, Y.W. Mulasari, N.Y. Sari, E.D. Lusiana, Y. Risjani, M. Musa, M. Mahmudi, F.S. Prasetiya, L.A. Sari

“…BACKGROUND AND OBJECTIVES: Biodiversity is the variety of life that exists on Earth, including all the organisms, species, and populations that come together in a complex manner to form communities and ecosystems. This study aimed to assess the diversity of microalgae in several different sub-habitats by identifying their types and abundance in sediments, mangroves, macroalgae, and water columns; additionally, this study analyses the environmental factors that affected the abundance of microalgae in several sub-habitats.METHODS: This study used a quantitative descriptive method with data collection techniques, incorporating the purposive sampling method. …”
Get full text

Biogenic Silver Nanoparticles of Clinacanthus nutans as Antioxidant with Antimicrobial and Cytotoxic Effects by Hock Ing Chiu, Che Nurul Azieyan Che Mood, Nur Nadhirah Mohamad Zain, Muggundha Raoov Ramachandran, Noorfatimah Yahaya, Nik Nur Syazni Nik Mohamed Kamal, Wai Hau Tung, Yoke Keong Yong, Chee Keong Lee, Vuanghao Lim

“…The AgNPs were also proven to possess cytotoxic effects on the breast (MCF-7), cervical (HeLa), and colon (HT-29) cancer cells in a dose-dependent manner. AgNP-S and AgNP-L showed significantly (p < 0.05) higher cytotoxicity against MCF-7 (117.43 μg/mL) and HT-29 (78.47 μg/mL), respectively. …”
Get full text

Mechanisms of L-citrulline on phosphodiesterase 5 in erectile dysfunction intervention by Abdulhakeem Olarewaju Sulyman, Olawale Moshood Aliyu, Emmanuel Oladipo Ajani, Yusuf Folohunsho Abdulkareem, Isaac Ade Afe, Fathia Oluwakemi Abdulyakeen, Halimat Yusuf Lukman, Saheed Sabiu, Karishma Singh, Kuben Naidoo

“…The findings suggest that citrulline effectively inhibits PDE5 in a non-competitive manner, with higher binding affinity and greater structural stability than sildenafil, highlighting its potential as a more stable and efficient PDE5 inhibitor. …”
Get full text

Single-nucleotide polymorphisms in dizygotic twin ovine fetuses are associated with discordant responses to antenatal steroid therapy by Erin L. Fee, Haruo Usuda, Sean W. D. Carter, Hideyuki Ikeda, Tsukasa Takahashi, Yuki Takahashi, Yusaku Kumagai, Michael W. Clarke, Demelza J. Ireland, John P. Newnham, Masatoshi Saito, Sebastian E. Illanes, Binny Priya Sesurajan, Liang Shen, Mahesh A. Choolani, Gokce Oguz, Adaikalavan Ramasamy, Sara Ritchie, Andrew Ritchie, Alan H. Jobe, Matthew W. Kemp

“…Twin ovine fetuses thus benefit from ANS in a similar manner to singleton fetuses, and a larger dose of betamethasone is not required. …”
Get full text